TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 14

Species:

Leishmania donovani

UniProt:

A0A3S7X4Z8_LEIDO

TriTrypDb:

LdBPK_313240.1 , LdCL_310040700 , LDHU3_31.5500

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X4Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4Z8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.619
CLV_C14_Caspase3-7	417	421	PF00656	0.577
CLV_C14_Caspase3-7	667	671	PF00656	0.769
CLV_NRD_NRD_1	141	143	PF00675	0.544
CLV_NRD_NRD_1	191	193	PF00675	0.540
CLV_NRD_NRD_1	243	245	PF00675	0.525
CLV_NRD_NRD_1	277	279	PF00675	0.600
CLV_NRD_NRD_1	30	32	PF00675	0.644
CLV_NRD_NRD_1	302	304	PF00675	0.663
CLV_NRD_NRD_1	384	386	PF00675	0.631
CLV_NRD_NRD_1	394	396	PF00675	0.599
CLV_NRD_NRD_1	45	47	PF00675	0.659
CLV_NRD_NRD_1	456	458	PF00675	0.574
CLV_NRD_NRD_1	471	473	PF00675	0.525
CLV_NRD_NRD_1	521	523	PF00675	0.638
CLV_NRD_NRD_1	527	529	PF00675	0.579
CLV_NRD_NRD_1	542	544	PF00675	0.585
CLV_NRD_NRD_1	60	62	PF00675	0.376
CLV_NRD_NRD_1	600	602	PF00675	0.729
CLV_NRD_NRD_1	646	648	PF00675	0.581
CLV_NRD_NRD_1	656	658	PF00675	0.615
CLV_NRD_NRD_1	709	711	PF00675	0.526
CLV_NRD_NRD_1	800	802	PF00675	0.598
CLV_PCSK_FUR_1	189	193	PF00082	0.550
CLV_PCSK_FUR_1	28	32	PF00082	0.614
CLV_PCSK_KEX2_1	140	142	PF00082	0.520
CLV_PCSK_KEX2_1	191	193	PF00082	0.601
CLV_PCSK_KEX2_1	230	232	PF00082	0.665
CLV_PCSK_KEX2_1	30	32	PF00082	0.644
CLV_PCSK_KEX2_1	304	306	PF00082	0.661
CLV_PCSK_KEX2_1	45	47	PF00082	0.688
CLV_PCSK_KEX2_1	471	473	PF00082	0.598
CLV_PCSK_KEX2_1	485	487	PF00082	0.590
CLV_PCSK_KEX2_1	492	494	PF00082	0.509
CLV_PCSK_KEX2_1	521	523	PF00082	0.561
CLV_PCSK_KEX2_1	542	544	PF00082	0.559
CLV_PCSK_KEX2_1	602	604	PF00082	0.796
CLV_PCSK_KEX2_1	800	802	PF00082	0.576
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.595
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.595
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.663
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.601
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.660
CLV_PCSK_PC7_1	598	604	PF00082	0.704
CLV_PCSK_SKI1_1	102	106	PF00082	0.471
CLV_PCSK_SKI1_1	142	146	PF00082	0.562
CLV_PCSK_SKI1_1	259	263	PF00082	0.524
CLV_PCSK_SKI1_1	338	342	PF00082	0.552
CLV_PCSK_SKI1_1	385	389	PF00082	0.661
CLV_PCSK_SKI1_1	419	423	PF00082	0.641
CLV_PCSK_SKI1_1	481	485	PF00082	0.611
CLV_PCSK_SKI1_1	528	532	PF00082	0.512
CLV_PCSK_SKI1_1	586	590	PF00082	0.773
CLV_PCSK_SKI1_1	657	661	PF00082	0.667
CLV_PCSK_SKI1_1	692	696	PF00082	0.474
CLV_PCSK_SKI1_1	786	790	PF00082	0.456
DEG_APCC_DBOX_1	691	699	PF00400	0.472
DOC_MAPK_gen_1	159	166	PF00069	0.635
DOC_MAPK_gen_1	710	717	PF00069	0.591
DOC_MAPK_MEF2A_6	5	12	PF00069	0.577
DOC_USP7_MATH_1	17	21	PF00917	0.635
DOC_USP7_MATH_1	218	222	PF00917	0.561
DOC_USP7_MATH_1	346	350	PF00917	0.688
DOC_USP7_MATH_1	370	374	PF00917	0.616
DOC_USP7_MATH_1	407	411	PF00917	0.606
DOC_USP7_MATH_1	441	445	PF00917	0.670
DOC_USP7_MATH_1	669	673	PF00917	0.671
DOC_USP7_MATH_1	676	680	PF00917	0.683
DOC_USP7_MATH_1	76	80	PF00917	0.553
DOC_USP7_MATH_1	770	774	PF00917	0.673
DOC_USP7_MATH_1	825	829	PF00917	0.651
DOC_USP7_UBL2_3	481	485	PF12436	0.559
DOC_USP7_UBL2_3	817	821	PF12436	0.605
DOC_WW_Pin1_4	13	18	PF00397	0.757
DOC_WW_Pin1_4	312	317	PF00397	0.488
DOC_WW_Pin1_4	581	586	PF00397	0.659
DOC_WW_Pin1_4	588	593	PF00397	0.666
DOC_WW_Pin1_4	672	677	PF00397	0.769
LIG_14-3-3_CanoR_1	45	50	PF00244	0.583
LIG_14-3-3_CanoR_1	595	601	PF00244	0.733
LIG_14-3-3_CanoR_1	786	794	PF00244	0.426
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	35	39	PF00533	0.620
LIG_deltaCOP1_diTrp_1	87	92	PF00928	0.435
LIG_FHA_1	143	149	PF00498	0.565
LIG_FHA_1	210	216	PF00498	0.489
LIG_FHA_1	750	756	PF00498	0.639
LIG_FHA_1	772	778	PF00498	0.601
LIG_FHA_2	103	109	PF00498	0.466
LIG_FHA_2	183	189	PF00498	0.511
LIG_FHA_2	211	217	PF00498	0.525
LIG_FHA_2	241	247	PF00498	0.598
LIG_FHA_2	270	276	PF00498	0.583
LIG_FHA_2	767	773	PF00498	0.718
LIG_IRF3_LxIS_1	527	534	PF10401	0.623
LIG_LIR_Gen_1	87	96	PF02991	0.433
LIG_LIR_LC3C_4	713	717	PF02991	0.608
LIG_LIR_Nem_3	87	92	PF02991	0.434
LIG_Pex14_2	88	92	PF04695	0.569
LIG_RPA_C_Fungi	214	226	PF08784	0.549
LIG_RPA_C_Plants	692	703	PF08784	0.551
LIG_SH2_STAP1	712	716	PF00017	0.566
LIG_SH2_STAP1	751	755	PF00017	0.659
LIG_SH2_STAT5	751	754	PF00017	0.658
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.535
LIG_SUMO_SIM_anti_2	555	560	PF11976	0.480
LIG_TRAF2_1	105	108	PF00917	0.508
LIG_TRAF2_1	329	332	PF00917	0.609
LIG_TRAF2_1	579	582	PF00917	0.663
LIG_TRAF2_1	776	779	PF00917	0.624
LIG_TRAF2_2	377	382	PF00917	0.682
MOD_CDK_SPK_2	312	317	PF00069	0.488
MOD_CDK_SPK_2	581	586	PF00069	0.659
MOD_CDK_SPK_2	593	598	PF00069	0.705
MOD_CDK_SPxxK_3	588	595	PF00069	0.724
MOD_CK1_1	33	39	PF00069	0.638
MOD_CK1_1	41	47	PF00069	0.582
MOD_CK1_1	663	669	PF00069	0.679
MOD_CK1_1	672	678	PF00069	0.759
MOD_CK1_1	750	756	PF00069	0.665
MOD_CK2_1	102	108	PF00069	0.495
MOD_CK2_1	182	188	PF00069	0.575
MOD_CK2_1	210	216	PF00069	0.524
MOD_CK2_1	240	246	PF00069	0.633
MOD_CK2_1	269	275	PF00069	0.618
MOD_CK2_1	346	352	PF00069	0.686
MOD_CK2_1	52	58	PF00069	0.536
MOD_CK2_1	576	582	PF00069	0.649
MOD_CK2_1	758	764	PF00069	0.781
MOD_CK2_1	766	772	PF00069	0.716
MOD_GlcNHglycan	152	157	PF01048	0.535
MOD_GlcNHglycan	220	223	PF01048	0.563
MOD_GlcNHglycan	307	312	PF01048	0.490
MOD_GlcNHglycan	372	375	PF01048	0.640
MOD_GlcNHglycan	409	412	PF01048	0.572
MOD_GlcNHglycan	496	502	PF01048	0.546
MOD_GlcNHglycan	513	516	PF01048	0.658
MOD_GlcNHglycan	752	755	PF01048	0.662
MOD_GlcNHglycan	774	777	PF01048	0.528
MOD_GlcNHglycan	817	820	PF01048	0.665
MOD_GlcNHglycan	829	832	PF01048	0.612
MOD_GlcNHglycan	842	845	PF01048	0.600
MOD_GSK3_1	13	20	PF00069	0.744
MOD_GSK3_1	26	33	PF00069	0.569
MOD_GSK3_1	307	314	PF00069	0.517
MOD_GSK3_1	34	41	PF00069	0.566
MOD_GSK3_1	346	353	PF00069	0.686
MOD_GSK3_1	507	514	PF00069	0.665
MOD_GSK3_1	584	591	PF00069	0.716
MOD_GSK3_1	660	667	PF00069	0.715
MOD_GSK3_1	668	675	PF00069	0.788
MOD_GSK3_1	715	722	PF00069	0.348
MOD_GSK3_1	766	773	PF00069	0.603
MOD_N-GLC_1	26	31	PF02516	0.697
MOD_N-GLC_1	825	830	PF02516	0.659
MOD_NEK2_1	26	31	PF00069	0.648
MOD_NEK2_1	34	39	PF00069	0.607
MOD_NEK2_1	440	445	PF00069	0.666
MOD_NEK2_1	660	665	PF00069	0.598
MOD_NEK2_1	715	720	PF00069	0.353
MOD_PIKK_1	507	513	PF00454	0.533
MOD_PIKK_1	531	537	PF00454	0.561
MOD_PK_1	175	181	PF00069	0.545
MOD_PK_1	45	51	PF00069	0.722
MOD_PKA_1	30	36	PF00069	0.655
MOD_PKA_1	45	51	PF00069	0.699
MOD_PKA_1	542	548	PF00069	0.546
MOD_PKA_2	121	127	PF00069	0.579
MOD_PKA_2	174	180	PF00069	0.666
MOD_PKA_2	218	224	PF00069	0.548
MOD_PKA_2	30	36	PF00069	0.602
MOD_PKA_2	37	43	PF00069	0.625
MOD_PKA_2	407	413	PF00069	0.588
MOD_PKA_2	44	50	PF00069	0.605
MOD_PKA_2	542	548	PF00069	0.522
MOD_PKA_2	719	725	PF00069	0.613
MOD_PKB_1	140	148	PF00069	0.608
MOD_PKB_1	238	246	PF00069	0.512
MOD_PKB_1	28	36	PF00069	0.661
MOD_PKB_1	348	356	PF00069	0.577
MOD_Plk_1	152	158	PF00069	0.580
MOD_Plk_1	175	181	PF00069	0.601
MOD_Plk_1	297	303	PF00069	0.641
MOD_Plk_1	6	12	PF00069	0.560
MOD_Plk_2-3	182	188	PF00069	0.470
MOD_Plk_2-3	52	58	PF00069	0.536
MOD_Plk_4	175	181	PF00069	0.580
MOD_ProDKin_1	13	19	PF00069	0.759
MOD_ProDKin_1	312	318	PF00069	0.491
MOD_ProDKin_1	581	587	PF00069	0.660
MOD_ProDKin_1	588	594	PF00069	0.665
MOD_ProDKin_1	672	678	PF00069	0.768
MOD_SUMO_for_1	160	163	PF00179	0.617
MOD_SUMO_for_1	484	487	PF00179	0.495
MOD_SUMO_rev_2	274	281	PF00179	0.626
MOD_SUMO_rev_2	332	336	PF00179	0.554
MOD_SUMO_rev_2	373	380	PF00179	0.575
MOD_SUMO_rev_2	454	460	PF00179	0.649
MOD_SUMO_rev_2	462	467	PF00179	0.547
MOD_SUMO_rev_2	640	650	PF00179	0.540
TRG_DiLeu_BaEn_1	108	113	PF01217	0.484
TRG_DiLeu_BaEn_1	77	82	PF01217	0.595
TRG_DiLeu_BaEn_4	152	158	PF01217	0.607
TRG_DiLeu_BaEn_4	297	303	PF01217	0.449
TRG_DiLeu_BaEn_4	803	809	PF01217	0.540
TRG_ENDOCYTIC_2	712	715	PF00928	0.572
TRG_ER_diArg_1	139	142	PF00400	0.513
TRG_ER_diArg_1	189	192	PF00400	0.642
TRG_ER_diArg_1	28	31	PF00400	0.616
TRG_ER_diArg_1	302	305	PF00400	0.659
TRG_ER_diArg_1	470	472	PF00400	0.547
TRG_ER_diArg_1	520	522	PF00400	0.566
TRG_ER_diArg_1	600	603	PF00400	0.801
TRG_NLS_Bipartite_1	45	65	PF00514	0.642
TRG_NLS_MonoExtC_3	600	605	PF00514	0.683
TRG_NLS_MonoExtN_4	598	605	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	493	497	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	786	790	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I335	Leptomonas seymouri	53%	97%
A0A1X0NIP5	Trypanosomatidae	28%	100%
A0A3R7NBX7	Trypanosoma rangeli	30%	100%
A4HJV6	Leishmania braziliensis	66%	98%
A4I7B8	Leishmania infantum	100%	100%
E9B2B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5U5	Leishmania major	91%	100%