Squalene synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Squalene synthase

Gene product:

farnesyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4Z6_LEIDO

TriTrypDb:

LdBPK_313050.1 , LdCL_310038800 , LDHU3_31.5250

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A0A3S7X4Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4Z6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006644	phospholipid metabolic process	4	1
GO:0006720	isoprenoid metabolic process	4	1
GO:0006721	terpenoid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045338	farnesyl diphosphate metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004310	farnesyl-diphosphate farnesyltransferase activity	6	11
GO:0004311	farnesyltranstransferase activity	5	11
GO:0004659	prenyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0051996	squalene synthase activity	6	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.543
CLV_NRD_NRD_1	406	408	PF00675	0.618
CLV_PCSK_KEX2_1	152	154	PF00082	0.366
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.366
CLV_PCSK_SKI1_1	112	116	PF00082	0.299
CLV_PCSK_SKI1_1	123	127	PF00082	0.299
CLV_PCSK_SKI1_1	18	22	PF00082	0.503
CLV_PCSK_SKI1_1	239	243	PF00082	0.408
CLV_PCSK_SKI1_1	318	322	PF00082	0.402
CLV_PCSK_SKI1_1	379	383	PF00082	0.505
CLV_Separin_Metazoa	220	224	PF03568	0.411
DEG_SPOP_SBC_1	349	353	PF00917	0.427
DOC_CDC14_PxL_1	382	390	PF14671	0.464
DOC_CYCLIN_RxL_1	109	116	PF00134	0.313
DOC_PP1_RVXF_1	10	16	PF00149	0.446
DOC_PP4_FxxP_1	185	188	PF00568	0.397
DOC_USP7_MATH_1	119	123	PF00917	0.366
DOC_USP7_UBL2_3	126	130	PF12436	0.456
DOC_USP7_UBL2_3	87	91	PF12436	0.411
LIG_Actin_WH2_2	283	298	PF00022	0.443
LIG_Actin_WH2_2	42	60	PF00022	0.346
LIG_APCC_ABBA_1	1	6	PF00400	0.377
LIG_BRCT_BRCA1_1	121	125	PF00533	0.397
LIG_BRCT_BRCA1_1	41	45	PF00533	0.318
LIG_BRCT_BRCA1_2	121	127	PF00533	0.397
LIG_EH1_1	165	173	PF00400	0.299
LIG_EVH1_2	221	225	PF00568	0.299
LIG_FHA_1	205	211	PF00498	0.317
LIG_FHA_1	302	308	PF00498	0.359
LIG_FHA_1	376	382	PF00498	0.577
LIG_FHA_2	155	161	PF00498	0.299
LIG_FHA_2	292	298	PF00498	0.455
LIG_FHA_2	393	399	PF00498	0.520
LIG_FHA_2	71	77	PF00498	0.342
LIG_LIR_Apic_2	297	302	PF02991	0.443
LIG_LIR_Gen_1	212	222	PF02991	0.299
LIG_LIR_Gen_1	324	333	PF02991	0.450
LIG_LIR_Gen_1	42	53	PF02991	0.318
LIG_LIR_Nem_3	116	121	PF02991	0.317
LIG_LIR_Nem_3	122	128	PF02991	0.320
LIG_LIR_Nem_3	159	164	PF02991	0.302
LIG_LIR_Nem_3	212	217	PF02991	0.299
LIG_LIR_Nem_3	229	234	PF02991	0.299
LIG_LIR_Nem_3	324	330	PF02991	0.458
LIG_LIR_Nem_3	42	48	PF02991	0.318
LIG_LYPXL_yS_3	118	121	PF13949	0.443
LIG_LYPXL_yS_3	385	388	PF13949	0.483
LIG_PCNA_PIPBox_1	397	406	PF02747	0.596
LIG_PDZ_Class_3	409	414	PF00595	0.471
LIG_REV1ctd_RIR_1	401	412	PF16727	0.631
LIG_SH2_CRK	327	331	PF00017	0.477
LIG_SH2_NCK_1	299	303	PF00017	0.372
LIG_SH2_SRC	132	135	PF00017	0.318
LIG_SH2_SRC	214	217	PF00017	0.342
LIG_SH2_STAP1	377	381	PF00017	0.549
LIG_SH2_STAT5	164	167	PF00017	0.312
LIG_SH2_STAT5	234	237	PF00017	0.320
LIG_SH2_STAT5	267	270	PF00017	0.353
LIG_SH2_STAT5	271	274	PF00017	0.329
LIG_SH2_STAT5	336	339	PF00017	0.352
LIG_SH2_STAT5	377	380	PF00017	0.633
LIG_SH2_STAT5	65	68	PF00017	0.318
LIG_SH3_3	260	266	PF00018	0.342
LIG_SH3_3	308	314	PF00018	0.443
LIG_SUMO_SIM_par_1	392	399	PF11976	0.555
LIG_TRAF2_1	25	28	PF00917	0.510
LIG_TYR_ITIM	63	68	PF00017	0.318
LIG_WW_3	220	224	PF00397	0.299
MOD_CK1_1	328	334	PF00069	0.402
MOD_CK1_1	350	356	PF00069	0.509
MOD_CK1_1	97	103	PF00069	0.403
MOD_CK2_1	291	297	PF00069	0.457
MOD_CK2_1	309	315	PF00069	0.239
MOD_Cter_Amidation	405	408	PF01082	0.642
MOD_GlcNHglycan	103	106	PF01048	0.392
MOD_GlcNHglycan	272	275	PF01048	0.375
MOD_GSK3_1	309	316	PF00069	0.349
MOD_GSK3_1	321	328	PF00069	0.402
MOD_GSK3_1	350	357	PF00069	0.510
MOD_GSK3_1	373	380	PF00069	0.476
MOD_GSK3_1	392	399	PF00069	0.551
MOD_GSK3_1	93	100	PF00069	0.325
MOD_N-GLC_2	138	140	PF02516	0.443
MOD_NEK2_1	194	199	PF00069	0.352
MOD_NEK2_1	204	209	PF00069	0.248
MOD_NEK2_1	321	326	PF00069	0.414
MOD_NEK2_1	392	397	PF00069	0.470
MOD_NEK2_1	4	9	PF00069	0.543
MOD_NEK2_2	291	296	PF00069	0.443
MOD_PIKK_1	174	180	PF00454	0.366
MOD_PK_1	276	282	PF00069	0.352
MOD_Plk_1	373	379	PF00069	0.533
MOD_Plk_1	76	82	PF00069	0.342
MOD_Plk_1	97	103	PF00069	0.337
MOD_Plk_2-3	186	192	PF00069	0.366
MOD_Plk_4	230	236	PF00069	0.366
MOD_Plk_4	276	282	PF00069	0.299
MOD_Plk_4	322	328	PF00069	0.446
MOD_Plk_4	392	398	PF00069	0.467
MOD_SUMO_for_1	241	244	PF00179	0.342
MOD_SUMO_rev_2	237	243	PF00179	0.390
MOD_SUMO_rev_2	77	86	PF00179	0.327
TRG_ENDOCYTIC_2	118	121	PF00928	0.315
TRG_ENDOCYTIC_2	132	135	PF00928	0.272
TRG_ENDOCYTIC_2	214	217	PF00928	0.342
TRG_ENDOCYTIC_2	327	330	PF00928	0.444
TRG_ENDOCYTIC_2	35	38	PF00928	0.359
TRG_ENDOCYTIC_2	385	388	PF00928	0.483
TRG_ENDOCYTIC_2	65	68	PF00928	0.318
TRG_NES_CRM1_1	36	51	PF08389	0.320
TRG_NLS_MonoExtC_3	125	130	PF00514	0.405
TRG_NLS_MonoExtN_4	123	130	PF00514	0.405
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVG2	Leptomonas seymouri	78%	100%
A0A0S4JW07	Bodo saltans	54%	100%
A0A142ZC57	Botryococcus braunii	44%	93%
A0A144YEA5	Botryococcus braunii	52%	90%
A0A1D8PI71	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	92%
A0A1P7Y0A2	Panax ginseng	47%	100%
A0A1P7Y0A8	Panax ginseng	47%	100%
A0A1P7Y0C9	Panax ginseng	47%	100%
A0A1P7Y0D0	Panax ginseng	47%	100%
A0A1P7Y0D4	Panax ginseng	47%	100%
A0A1X0NJX0	Trypanosomatidae	54%	100%
A0A345BJQ0	Cochliobolus lunatus	39%	100%
A0A3G1DJL2	Phoma sp. (strain ATCC 20986 / MF5453)	41%	99%
A0A3R7KLT3	Trypanosoma rangeli	57%	100%
A0SJQ5	Ganoderma lucidum	38%	89%
A4HJT3	Leishmania braziliensis	86%	100%
A4I799	Leishmania infantum	100%	100%
C9E894	Panax ginseng	47%	100%
C9ZWK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	91%
D0VFU8	Solanum lycopersicum	47%	100%
D2K762	Panax ginseng	47%	100%
E9B294	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G0Y286	Botryococcus braunii	38%	100%
G0Y287	Botryococcus braunii	43%	89%
G0Y288	Botryococcus braunii	40%	100%
O48666	Panax ginseng	48%	100%
O65688	Arabidopsis thaliana	45%	100%
O74165	Cyberlindnera jadinii	39%	93%
P29704	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	93%
P36596	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	90%
P37268	Homo sapiens	43%	99%
P53798	Mus musculus	44%	100%
P53799	Arabidopsis thaliana	47%	100%
P53800	Nicotiana benthamiana	48%	100%
P78589	Candida albicans	43%	92%
Q02769	Rattus norvegicus	43%	100%
Q32KR6	Bos taurus	40%	99%
Q4Q5W4	Leishmania major	98%	100%
Q4WAG4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	88%
Q54DR1	Dictyostelium discoideum	41%	100%
Q5R6U3	Pongo abelii	43%	99%
Q752X9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	94%
Q7S4Z6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	86%
Q92459	Ustilago maydis (strain 521 / FGSC 9021)	38%	72%
Q9HGZ6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	93%
Q9SDW9	Botryococcus braunii	47%	90%
Q9Y753	Yarrowia lipolytica (strain CLIB 122 / E 150)	41%	93%
V5D833	Trypanosoma cruzi	59%	100%
V6RPN0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	38%	90%