Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4Y5_LEIDO

TriTrypDb:

LdBPK_313160.1 , LdCL_310039900 , LDHU3_31.5370

Length:

248

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X4Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4Y5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.545
CLV_C14_Caspase3-7	52	56	PF00656	0.532
CLV_C14_Caspase3-7	78	82	PF00656	0.389
CLV_NRD_NRD_1	128	130	PF00675	0.338
CLV_NRD_NRD_1	132	134	PF00675	0.361
CLV_NRD_NRD_1	6	8	PF00675	0.638
CLV_PCSK_KEX2_1	128	130	PF00082	0.336
CLV_PCSK_KEX2_1	132	134	PF00082	0.363
CLV_PCSK_KEX2_1	215	217	PF00082	0.504
CLV_PCSK_KEX2_1	6	8	PF00082	0.656
CLV_PCSK_KEX2_1	85	87	PF00082	0.646
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.541
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.683
CLV_PCSK_PC7_1	128	134	PF00082	0.407
CLV_PCSK_SKI1_1	154	158	PF00082	0.401
CLV_PCSK_SKI1_1	40	44	PF00082	0.723
CLV_Separin_Metazoa	151	155	PF03568	0.606
DEG_MDM2_SWIB_1	117	124	PF02201	0.446
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DOC_CKS1_1	51	56	PF01111	0.504
DOC_USP7_MATH_1	191	195	PF00917	0.612
DOC_USP7_MATH_1	209	213	PF00917	0.551
DOC_USP7_MATH_1	233	237	PF00917	0.727
DOC_USP7_MATH_1	45	49	PF00917	0.513
DOC_USP7_MATH_1	62	66	PF00917	0.469
DOC_USP7_UBL2_3	139	143	PF12436	0.601
DOC_WW_Pin1_4	50	55	PF00397	0.450
LIG_14-3-3_CanoR_1	154	162	PF00244	0.641
LIG_14-3-3_CanoR_1	6	11	PF00244	0.449
LIG_FHA_1	180	186	PF00498	0.545
LIG_FHA_1	187	193	PF00498	0.547
LIG_FHA_1	208	214	PF00498	0.725
LIG_FHA_1	94	100	PF00498	0.400
LIG_FHA_2	41	47	PF00498	0.522
LIG_LIR_Apic_2	105	110	PF02991	0.401
LIG_LIR_Apic_2	69	75	PF02991	0.388
LIG_LIR_Gen_1	87	95	PF02991	0.371
LIG_Pex14_1	103	107	PF04695	0.416
LIG_Pex14_2	117	121	PF04695	0.347
LIG_SH2_CRK	107	111	PF00017	0.312
LIG_SH2_CRK	72	76	PF00017	0.383
LIG_SH2_NCK_1	107	111	PF00017	0.312
LIG_SH3_3	48	54	PF00018	0.500
LIG_SUMO_SIM_anti_2	146	154	PF11976	0.557
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.676
MOD_CK1_1	179	185	PF00069	0.567
MOD_CK1_1	50	56	PF00069	0.564
MOD_CK1_1	66	72	PF00069	0.434
MOD_CMANNOS	123	126	PF00535	0.391
MOD_GlcNHglycan	202	205	PF01048	0.452
MOD_GlcNHglycan	23	26	PF01048	0.714
MOD_GlcNHglycan	46	50	PF01048	0.720
MOD_GlcNHglycan	60	63	PF01048	0.623
MOD_GlcNHglycan	65	68	PF01048	0.690
MOD_GSK3_1	1	8	PF00069	0.520
MOD_GSK3_1	187	194	PF00069	0.606
MOD_GSK3_1	36	43	PF00069	0.500
MOD_GSK3_1	58	65	PF00069	0.504
MOD_N-GLC_1	154	159	PF02516	0.401
MOD_N-GLC_1	36	41	PF02516	0.752
MOD_NEK2_1	1	6	PF00069	0.485
MOD_NEK2_1	98	103	PF00069	0.396
MOD_PIKK_1	98	104	PF00454	0.463
MOD_PK_1	193	199	PF00069	0.642
MOD_PKA_1	6	12	PF00069	0.467
MOD_PKA_2	127	133	PF00069	0.554
MOD_PKA_2	186	192	PF00069	0.544
MOD_PKA_2	197	203	PF00069	0.604
MOD_PKA_2	5	11	PF00069	0.441
MOD_Plk_4	209	215	PF00069	0.674
MOD_ProDKin_1	50	56	PF00069	0.450
TRG_ER_diArg_1	131	133	PF00400	0.563
TRG_ER_diArg_1	5	7	PF00400	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR85	Leptomonas seymouri	62%	100%
A0A3R7MDV3	Trypanosoma rangeli	42%	100%
A4HJU4	Leishmania braziliensis	79%	100%
A4I7A9	Leishmania infantum	100%	100%
C9ZWJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E8NHP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5V3	Leishmania major	93%	100%