Hypothetical_protein_conserved

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4X5_LEIDO

TriTrypDb:

LdBPK_312800.1 , LdCL_310036100 , LDHU3_31.4920

Length:

146

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Phosphorylation

Amastigote: 130

Expansion

Sequence features

A0A3S7X4X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4X5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.479
CLV_PCSK_KEX2_1	126	128	PF00082	0.508
CLV_PCSK_KEX2_1	92	94	PF00082	0.621
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.641
CLV_PCSK_SKI1_1	115	119	PF00082	0.409
DOC_CDC14_PxL_1	11	19	PF14671	0.447
DOC_MAPK_gen_1	77	85	PF00069	0.391
DOC_MAPK_gen_1	92	102	PF00069	0.340
DOC_MAPK_MEF2A_6	79	87	PF00069	0.387
DOC_MAPK_MEF2A_6	95	104	PF00069	0.402
DOC_MAPK_RevD_3	100	115	PF00069	0.362
DOC_USP7_UBL2_3	73	77	PF12436	0.445
LIG_14-3-3_CanoR_1	28	33	PF00244	0.688
LIG_14-3-3_CanoR_1	79	87	PF00244	0.475
LIG_BRCT_BRCA1_1	59	63	PF00533	0.447
LIG_FHA_1	16	22	PF00498	0.424
LIG_FHA_1	36	42	PF00498	0.623
LIG_LIR_Gen_1	3	12	PF02991	0.446
LIG_LIR_Gen_1	59	68	PF02991	0.379
LIG_LIR_Nem_3	18	23	PF02991	0.495
LIG_LIR_Nem_3	3	7	PF02991	0.439
LIG_LIR_Nem_3	59	64	PF02991	0.341
LIG_PCNA_PIPBox_1	13	22	PF02747	0.402
LIG_Pex14_1	70	74	PF04695	0.362
LIG_Pex14_2	61	65	PF04695	0.384
LIG_SH2_CRK	23	27	PF00017	0.480
LIG_SH2_PTP2	101	104	PF00017	0.362
LIG_SH2_STAT5	101	104	PF00017	0.282
LIG_SH2_STAT5	23	26	PF00017	0.484
LIG_SH3_3	9	15	PF00018	0.447
LIG_UBA3_1	64	73	PF00899	0.540
LIG_WRC_WIRS_1	1	6	PF05994	0.515
LIG_WRC_WIRS_1	58	63	PF05994	0.381
MOD_CK1_1	59	65	PF00069	0.435
MOD_GlcNHglycan	128	132	PF01048	0.486
MOD_GlcNHglycan	52	55	PF01048	0.456
MOD_NEK2_2	15	20	PF00069	0.480
MOD_PK_1	28	34	PF00069	0.529
MOD_PKA_2	35	41	PF00069	0.633
MOD_PKA_2	78	84	PF00069	0.473
MOD_Plk_1	81	87	PF00069	0.385
MOD_Plk_4	115	121	PF00069	0.379
MOD_Plk_4	15	21	PF00069	0.426
MOD_Plk_4	47	53	PF00069	0.325
MOD_SUMO_rev_2	84	94	PF00179	0.440
TRG_ENDOCYTIC_2	101	104	PF00928	0.343
TRG_ER_diArg_1	125	127	PF00400	0.722
TRG_ER_diArg_1	93	96	PF00400	0.410
TRG_NLS_MonoExtC_3	91	97	PF00514	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A6	Leptomonas seymouri	70%	99%
A0A0S4IVS1	Bodo saltans	26%	90%
A0A1X0NIN7	Trypanosomatidae	37%	100%
A0A3R7L4C4	Trypanosoma rangeli	33%	87%
A4HJQ9	Leishmania braziliensis	84%	100%
A4I776	Leishmania infantum	100%	100%
C9ZMF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B270	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5Y9	Leishmania major	95%	100%