Ferredoxin_2fe-2s-like_protein/GeneDB:LmjF.31.250 0

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adrenodoxin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4W8_LEIDO

TriTrypDb:

LdBPK_312590.1 , LdCL_310033800 , LDHU3_31.4620

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 20
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S7X4W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4W8

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	22
GO:0008152	metabolic process	1	22
GO:0009987	cellular process	1	22
GO:0022900	electron transport chain	4	22
GO:0044237	cellular metabolic process	2	22
GO:0140647	P450-containing electron transport chain	5	22

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	22
GO:0051536	iron-sulfur cluster binding	3	22
GO:0051537	2 iron, 2 sulfur cluster binding	4	22
GO:0051540	metal cluster binding	2	22
GO:0003824	catalytic activity	1	3
GO:0009055	electron transfer activity	3	3
GO:0016491	oxidoreductase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.545
CLV_PCSK_KEX2_1	40	42	PF00082	0.530
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.530
CLV_PCSK_SKI1_1	3	7	PF00082	0.580
DEG_APCC_DBOX_1	12	20	PF00400	0.445
DEG_SPOP_SBC_1	26	30	PF00917	0.651
DOC_USP7_MATH_1	26	30	PF00917	0.633
DOC_WW_Pin1_4	120	125	PF00397	0.572
DOC_WW_Pin1_4	27	32	PF00397	0.559
LIG_14-3-3_CanoR_1	13	17	PF00244	0.543
LIG_14-3-3_CanoR_1	25	31	PF00244	0.566
LIG_Actin_WH2_2	47	63	PF00022	0.239
LIG_FHA_1	111	117	PF00498	0.309
LIG_FHA_1	121	127	PF00498	0.476
LIG_FHA_1	13	19	PF00498	0.507
LIG_FHA_1	78	84	PF00498	0.343
LIG_SH2_PTP2	49	52	PF00017	0.206
LIG_SH2_SRC	49	52	PF00017	0.206
LIG_SH2_STAT5	49	52	PF00017	0.206
LIG_SH3_3	128	134	PF00018	0.535
LIG_SH3_3	45	51	PF00018	0.370
LIG_SUMO_SIM_anti_2	15	20	PF11976	0.406
LIG_TRAF2_1	96	99	PF00917	0.301
LIG_UBA3_1	56	65	PF00899	0.400
MOD_CDK_SPxK_1	27	33	PF00069	0.578
MOD_CK1_1	86	92	PF00069	0.330
MOD_CK2_1	94	100	PF00069	0.297
MOD_GlcNHglycan	21	24	PF01048	0.514
MOD_GlcNHglycan	85	88	PF01048	0.251
MOD_GSK3_1	21	28	PF00069	0.555
MOD_NEK2_1	21	26	PF00069	0.528
MOD_NEK2_2	77	82	PF00069	0.304
MOD_PKA_2	12	18	PF00069	0.520
MOD_Plk_1	111	117	PF00069	0.322
MOD_Plk_2-3	132	138	PF00069	0.399
MOD_Plk_2-3	94	100	PF00069	0.301
MOD_ProDKin_1	120	126	PF00069	0.568
MOD_ProDKin_1	27	33	PF00069	0.563
TRG_DiLeu_BaEn_4	111	117	PF01217	0.393
TRG_DiLeu_BaEn_4	99	105	PF01217	0.321
TRG_ENDOCYTIC_2	49	52	PF00928	0.206
TRG_NES_CRM1_1	121	132	PF08389	0.413
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.216

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	63%	97%
A0A0N0P799	Leptomonas seymouri	44%	85%
A0A0N1HYR7	Leptomonas seymouri	40%	96%
A0A0N1I5P4	Leptomonas seymouri	51%	100%
A0A0N1ILD8	Leptomonas seymouri	38%	83%
A0A0N1PE81	Leptomonas seymouri	55%	98%
A0A0S4J024	Bodo saltans	49%	91%
A0A1X0NSB1	Trypanosomatidae	35%	78%
A0A3Q8IIS3	Leishmania donovani	50%	100%
A0A3R7MK78	Trypanosoma rangeli	45%	87%
A0A3R7NM96	Trypanosoma rangeli	37%	73%
A0A3S7X4S6	Leishmania donovani	48%	100%
A0A3S7X4U4	Leishmania donovani	39%	77%
A4HJN2	Leishmania braziliensis	44%	100%
A4HJN3	Leishmania braziliensis	54%	100%
A4HJN4	Leishmania braziliensis	71%	100%
A4HJN8	Leishmania braziliensis	71%	100%
A4HJN9	Leishmania braziliensis	40%	100%
A4I755	Leishmania infantum	48%	100%
A4I756	Leishmania infantum	50%	100%
A4I757	Leishmania infantum	99%	100%
A4I758	Leishmania infantum	38%	77%
D5IGG4	Sphingomonas sp.	37%	100%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	77%
G2IN77	Sphingobium sp. (strain NBRC 103272 / SYK-6)	34%	100%
P00257	Bos taurus	35%	76%
P00258	Sus scrofa	35%	76%
P00259	Pseudomonas putida	38%	100%
P10109	Homo sapiens	33%	77%
P13216	Gallus gallus	35%	99%
P24483	Rattus norvegicus	36%	75%
P29330	Ovis aries	34%	100%
P37098	Caulobacter vibrioides (strain ATCC 19089 / CB15)	38%	100%
P37193	Drosophila melanogaster	33%	82%
P43493	Rhodococcus erythropolis	36%	100%
P46656	Mus musculus	34%	75%
P80306	Rhodobacter capsulatus	35%	100%
Q05B51	Bos taurus	40%	76%
Q08C57	Danio rerio	40%	72%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	82%
Q1RJ69	Rickettsia bellii (strain RML369-C)	44%	100%
Q4Q610	Leishmania major	39%	100%
Q4Q611	Leishmania major	89%	100%
Q4Q612	Leishmania major	52%	100%
Q4Q613	Leishmania major	48%	100%
Q4UKL2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	43%	100%
Q5FWQ0	Xenopus laevis	38%	73%
Q5S3I4	Stenotrophomonas maltophilia	33%	100%
Q6P4F2	Homo sapiens	40%	76%
Q8S904	Arabidopsis thaliana	38%	72%
Q8SV19	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q8SZA8	Drosophila melanogaster	34%	93%
Q92J08	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	41%	100%
Q9AKC4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	41%	100%
Q9AKH1	Rickettsia rickettsii	42%	100%
Q9AKM6	Rickettsia montanensis	43%	100%
Q9CPW2	Mus musculus	40%	81%
Q9M0V0	Arabidopsis thaliana	38%	72%
Q9ZDW6	Rickettsia prowazekii (strain Madrid E)	41%	100%
X5CFH4	Rhizorhabdus wittichii (strain DC-6 / KACC 16600)	36%	100%
X5CWH9	Rhizorhabdus wittichii (strain DC-6 / KACC 16600)	34%	100%