Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4W5_LEIDO

TriTrypDb:

LdBPK_312940.1 , LdCL_310037700 , LDHU3_31.5110

Length:

324

Annotations

LeishMANIAdb annotations

Appears to be unique to Kinetoplastids, with very unclear topology, localization and function.. Despite the topology, no signal peptides are present, although a mitochondrial transit signal cannot be excluded

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7X4W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	310	312	PF00082	0.528
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.528
DEG_SPOP_SBC_1	30	34	PF00917	0.542
DOC_ANK_TNKS_1	299	306	PF00023	0.677
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.446
DOC_SPAK_OSR1_1	193	197	PF12202	0.429
DOC_USP7_MATH_1	216	220	PF00917	0.476
DOC_USP7_MATH_1	31	35	PF00917	0.463
DOC_USP7_MATH_1	51	55	PF00917	0.384
DOC_WW_Pin1_4	130	135	PF00397	0.707
DOC_WW_Pin1_4	25	30	PF00397	0.479
DOC_WW_Pin1_4	33	38	PF00397	0.445
DOC_WW_Pin1_4	95	100	PF00397	0.660
LIG_AP2alpha_2	4	6	PF02296	0.384
LIG_BRCT_BRCA1_1	6	10	PF00533	0.481
LIG_Clathr_ClatBox_1	275	279	PF01394	0.651
LIG_deltaCOP1_diTrp_1	232	238	PF00928	0.511
LIG_eIF4E_1	270	276	PF01652	0.535
LIG_FHA_1	101	107	PF00498	0.692
LIG_FHA_1	164	170	PF00498	0.539
LIG_FHA_1	177	183	PF00498	0.388
LIG_FHA_1	229	235	PF00498	0.601
LIG_FHA_1	287	293	PF00498	0.598
LIG_FHA_1	297	303	PF00498	0.617
LIG_FHA_1	34	40	PF00498	0.554
LIG_FHA_2	111	117	PF00498	0.502
LIG_FHA_2	227	233	PF00498	0.641
LIG_FHA_2	95	101	PF00498	0.732
LIG_LIR_Gen_1	136	145	PF02991	0.746
LIG_LIR_Gen_1	231	241	PF02991	0.500
LIG_LIR_Nem_3	136	140	PF02991	0.738
LIG_LIR_Nem_3	317	322	PF02991	0.685
LIG_LIR_Nem_3	7	13	PF02991	0.384
LIG_Pex14_2	6	10	PF04695	0.381
LIG_Pex14_2	70	74	PF04695	0.366
LIG_REV1ctd_RIR_1	72	83	PF16727	0.510
LIG_SH2_CRK	137	141	PF00017	0.775
LIG_SH2_CRK	319	323	PF00017	0.605
LIG_SH2_NCK_1	137	141	PF00017	0.783
LIG_SH2_STAP1	76	80	PF00017	0.577
LIG_SH2_STAT5	202	205	PF00017	0.350
LIG_SH2_STAT5	270	273	PF00017	0.404
LIG_SH3_3	125	131	PF00018	0.724
LIG_SH3_3	298	304	PF00018	0.638
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.624
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.444
LIG_SUMO_SIM_par_1	102	109	PF11976	0.637
LIG_SUMO_SIM_par_1	166	172	PF11976	0.472
LIG_UBA3_1	275	280	PF00899	0.656
MOD_CK1_1	33	39	PF00069	0.571
MOD_CK2_1	130	136	PF00069	0.719
MOD_CK2_1	226	232	PF00069	0.608
MOD_GlcNHglycan	247	250	PF01048	0.445
MOD_GlcNHglycan	312	315	PF01048	0.488
MOD_GlcNHglycan	319	322	PF01048	0.517
MOD_GSK3_1	106	113	PF00069	0.627
MOD_GSK3_1	159	166	PF00069	0.640
MOD_GSK3_1	216	223	PF00069	0.516
MOD_GSK3_1	25	32	PF00069	0.567
MOD_GSK3_1	306	313	PF00069	0.716
MOD_GSK3_1	317	324	PF00069	0.741
MOD_GSK3_1	33	40	PF00069	0.560
MOD_N-GLC_1	25	30	PF02516	0.679
MOD_NEK2_1	110	115	PF00069	0.614
MOD_NEK2_1	189	194	PF00069	0.403
MOD_NEK2_1	209	214	PF00069	0.415
MOD_NEK2_1	226	231	PF00069	0.569
MOD_NEK2_1	245	250	PF00069	0.198
MOD_NEK2_1	264	269	PF00069	0.194
MOD_NEK2_1	53	58	PF00069	0.422
MOD_NEK2_1	6	11	PF00069	0.439
MOD_PIKK_1	220	226	PF00454	0.658
MOD_PIKK_1	286	292	PF00454	0.611
MOD_PKA_1	310	316	PF00069	0.732
MOD_PKA_2	123	129	PF00069	0.692
MOD_PKA_2	286	292	PF00069	0.653
MOD_PKA_2	310	316	PF00069	0.732
MOD_PKA_2	41	47	PF00069	0.462
MOD_Plk_1	220	226	PF00069	0.648
MOD_Plk_1	296	302	PF00069	0.729
MOD_Plk_4	159	165	PF00069	0.657
MOD_Plk_4	176	182	PF00069	0.382
MOD_Plk_4	184	190	PF00069	0.572
MOD_ProDKin_1	130	136	PF00069	0.708
MOD_ProDKin_1	25	31	PF00069	0.477
MOD_ProDKin_1	33	39	PF00069	0.446
MOD_ProDKin_1	95	101	PF00069	0.655
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.258
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.447
TRG_ENDOCYTIC_2	137	140	PF00928	0.734
TRG_ENDOCYTIC_2	319	322	PF00928	0.628
TRG_ER_diArg_1	122	125	PF00400	0.654
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U5	Leptomonas seymouri	70%	100%
A0A0S4JIB3	Bodo saltans	32%	100%
A0A1X0NIE1	Trypanosomatidae	44%	100%
A0A3R7NC34	Trypanosoma rangeli	43%	100%
A4HJS2	Leishmania braziliensis	80%	100%
A4I788	Leishmania infantum	99%	100%
C9ZMG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZWL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B283	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5X5	Leishmania major	95%	100%
V5BC20	Trypanosoma cruzi	43%	100%