Phosphatidylinositol-4-phosphate 5-kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4W4_LEIDO

TriTrypDb:

LdBPK_312790.1 , LdCL_310036000 , LDHU3_31.4910

Length:

1085

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4W4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.739
CLV_C14_Caspase3-7	62	66	PF00656	0.430
CLV_C14_Caspase3-7	764	768	PF00656	0.577
CLV_NRD_NRD_1	134	136	PF00675	0.287
CLV_NRD_NRD_1	291	293	PF00675	0.585
CLV_NRD_NRD_1	336	338	PF00675	0.623
CLV_NRD_NRD_1	357	359	PF00675	0.593
CLV_NRD_NRD_1	380	382	PF00675	0.616
CLV_NRD_NRD_1	439	441	PF00675	0.600
CLV_NRD_NRD_1	623	625	PF00675	0.755
CLV_NRD_NRD_1	636	638	PF00675	0.525
CLV_NRD_NRD_1	703	705	PF00675	0.645
CLV_NRD_NRD_1	916	918	PF00675	0.430
CLV_PCSK_KEX2_1	134	136	PF00082	0.287
CLV_PCSK_KEX2_1	293	295	PF00082	0.538
CLV_PCSK_KEX2_1	380	382	PF00082	0.493
CLV_PCSK_KEX2_1	703	705	PF00082	0.580
CLV_PCSK_KEX2_1	915	917	PF00082	0.430
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.538
CLV_PCSK_PC1ET2_1	915	917	PF00082	0.430
CLV_PCSK_SKI1_1	1074	1078	PF00082	0.629
CLV_PCSK_SKI1_1	211	215	PF00082	0.374
CLV_PCSK_SKI1_1	217	221	PF00082	0.438
CLV_PCSK_SKI1_1	391	395	PF00082	0.771
CLV_PCSK_SKI1_1	41	45	PF00082	0.635
CLV_PCSK_SKI1_1	451	455	PF00082	0.591
CLV_PCSK_SKI1_1	619	623	PF00082	0.728
CLV_PCSK_SKI1_1	696	700	PF00082	0.493
CLV_PCSK_SKI1_1	703	707	PF00082	0.529
CLV_PCSK_SKI1_1	831	835	PF00082	0.440
CLV_PCSK_SKI1_1	851	855	PF00082	0.171
CLV_Separin_Metazoa	577	581	PF03568	0.612
DEG_APCC_DBOX_1	251	259	PF00400	0.558
DEG_APCC_DBOX_1	291	299	PF00400	0.684
DEG_SCF_FBW7_1	14	20	PF00400	0.592
DOC_AGCK_PIF_1	853	858	PF00069	0.501
DOC_CKS1_1	14	19	PF01111	0.589
DOC_CYCLIN_RxL_1	366	379	PF00134	0.461
DOC_CYCLIN_yClb1_LxF_4	849	854	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	801	807	PF00134	0.501
DOC_MAPK_FxFP_2	51	54	PF00069	0.523
DOC_MAPK_gen_1	114	124	PF00069	0.287
DOC_MAPK_gen_1	215	222	PF00069	0.460
DOC_MAPK_gen_1	292	301	PF00069	0.601
DOC_MAPK_gen_1	337	345	PF00069	0.612
DOC_MAPK_gen_1	637	647	PF00069	0.656
DOC_MAPK_JIP1_4	848	854	PF00069	0.287
DOC_PP1_RVXF_1	215	222	PF00149	0.462
DOC_PP1_RVXF_1	849	855	PF00149	0.424
DOC_PP1_RVXF_1	891	898	PF00149	0.501
DOC_PP1_SILK_1	288	293	PF00149	0.589
DOC_PP4_FxxP_1	51	54	PF00568	0.523
DOC_PP4_FxxP_1	889	892	PF00568	0.501
DOC_USP7_MATH_1	1065	1069	PF00917	0.714
DOC_USP7_MATH_1	17	21	PF00917	0.623
DOC_USP7_MATH_1	264	268	PF00917	0.752
DOC_USP7_MATH_1	286	290	PF00917	0.582
DOC_USP7_MATH_1	499	503	PF00917	0.722
DOC_USP7_MATH_1	519	523	PF00917	0.707
DOC_USP7_MATH_1	567	571	PF00917	0.704
DOC_USP7_MATH_1	971	975	PF00917	0.419
DOC_USP7_UBL2_3	114	118	PF12436	0.326
DOC_USP7_UBL2_3	272	276	PF12436	0.507
DOC_USP7_UBL2_3	366	370	PF12436	0.630
DOC_USP7_UBL2_3	38	42	PF12436	0.738
DOC_USP7_UBL2_3	451	455	PF12436	0.644
DOC_USP7_UBL2_3	696	700	PF12436	0.472
DOC_USP7_UBL2_3	839	843	PF12436	0.501
DOC_USP7_UBL2_3	88	92	PF12436	0.430
DOC_WW_Pin1_4	13	18	PF00397	0.709
DOC_WW_Pin1_4	312	317	PF00397	0.653
DOC_WW_Pin1_4	393	398	PF00397	0.654
DOC_WW_Pin1_4	508	513	PF00397	0.774
DOC_WW_Pin1_4	515	520	PF00397	0.661
DOC_WW_Pin1_4	563	568	PF00397	0.706
LIG_14-3-3_CanoR_1	1018	1026	PF00244	0.430
LIG_14-3-3_CanoR_1	440	445	PF00244	0.480
LIG_14-3-3_CanoR_1	472	478	PF00244	0.720
LIG_14-3-3_CanoR_1	637	645	PF00244	0.642
LIG_14-3-3_CanoR_1	666	672	PF00244	0.642
LIG_14-3-3_CanoR_1	712	722	PF00244	0.534
LIG_14-3-3_CanoR_1	725	733	PF00244	0.550
LIG_14-3-3_CanoR_1	739	743	PF00244	0.459
LIG_14-3-3_CanoR_1	851	857	PF00244	0.430
LIG_14-3-3_CanoR_1	923	928	PF00244	0.430
LIG_14-3-3_CanoR_1	934	938	PF00244	0.430
LIG_Actin_WH2_2	350	367	PF00022	0.518
LIG_BIR_II_1	1	5	PF00653	0.752
LIG_BRCT_BRCA1_1	1000	1004	PF00533	0.501
LIG_BRCT_BRCA1_1	885	889	PF00533	0.501
LIG_BRCT_BRCA1_1	966	970	PF00533	0.430
LIG_CaM_IQ_9	698	714	PF13499	0.564
LIG_Clathr_ClatBox_1	220	224	PF01394	0.478
LIG_Clathr_ClatBox_1	410	414	PF01394	0.562
LIG_eIF4E_1	225	231	PF01652	0.528
LIG_FHA_1	1011	1017	PF00498	0.461
LIG_FHA_1	1021	1027	PF00498	0.430
LIG_FHA_1	1030	1036	PF00498	0.430
LIG_FHA_1	490	496	PF00498	0.596
LIG_FHA_1	714	720	PF00498	0.593
LIG_FHA_1	767	773	PF00498	0.541
LIG_FHA_1	77	83	PF00498	0.515
LIG_FHA_1	825	831	PF00498	0.420
LIG_FHA_1	836	842	PF00498	0.445
LIG_FHA_1	855	861	PF00498	0.214
LIG_FHA_1	993	999	PF00498	0.424
LIG_FHA_2	1051	1057	PF00498	0.656
LIG_FHA_2	241	247	PF00498	0.641
LIG_FHA_2	268	274	PF00498	0.634
LIG_FHA_2	347	353	PF00498	0.556
LIG_FHA_2	657	663	PF00498	0.556
LIG_FHA_2	946	952	PF00498	0.430
LIG_GBD_Chelix_1	582	590	PF00786	0.703
LIG_GBD_Chelix_1	981	989	PF00786	0.462
LIG_Integrin_isoDGR_2	921	923	PF01839	0.430
LIG_LIR_Apic_2	886	892	PF02991	0.501
LIG_LIR_Gen_1	1001	1012	PF02991	0.501
LIG_LIR_Gen_1	460	470	PF02991	0.650
LIG_LIR_Gen_1	741	751	PF02991	0.379
LIG_LIR_Gen_1	795	806	PF02991	0.440
LIG_LIR_Gen_1	924	933	PF02991	0.430
LIG_LIR_LC3C_4	768	773	PF02991	0.362
LIG_LIR_Nem_3	1001	1007	PF02991	0.501
LIG_LIR_Nem_3	1056	1062	PF02991	0.651
LIG_LIR_Nem_3	151	156	PF02991	0.390
LIG_LIR_Nem_3	460	466	PF02991	0.654
LIG_LIR_Nem_3	69	74	PF02991	0.399
LIG_LIR_Nem_3	741	746	PF02991	0.324
LIG_LIR_Nem_3	795	801	PF02991	0.393
LIG_LIR_Nem_3	924	930	PF02991	0.430
LIG_MYND_1	512	516	PF01753	0.553
LIG_NRBOX	1002	1008	PF00104	0.430
LIG_NRBOX	294	300	PF00104	0.603
LIG_NRBOX	651	657	PF00104	0.557
LIG_PCNA_yPIPBox_3	574	583	PF02747	0.650
LIG_PCNA_yPIPBox_3	649	660	PF02747	0.554
LIG_Pex14_1	247	251	PF04695	0.460
LIG_PTAP_UEV_1	403	408	PF05743	0.564
LIG_SH2_CRK	463	467	PF00017	0.723
LIG_SH2_GRB2like	156	159	PF00017	0.385
LIG_SH2_SRC	229	232	PF00017	0.529
LIG_SH2_STAP1	463	467	PF00017	0.636
LIG_SH2_STAP1	720	724	PF00017	0.537
LIG_SH2_STAP1	784	788	PF00017	0.498
LIG_SH2_STAP1	994	998	PF00017	0.430
LIG_SH2_STAT3	106	109	PF00017	0.430
LIG_SH2_STAT3	199	202	PF00017	0.501
LIG_SH2_STAT3	720	723	PF00017	0.538
LIG_SH2_STAT5	106	109	PF00017	0.351
LIG_SH2_STAT5	129	132	PF00017	0.372
LIG_SH2_STAT5	199	202	PF00017	0.357
LIG_SH2_STAT5	225	228	PF00017	0.515
LIG_SH2_STAT5	229	232	PF00017	0.537
LIG_SH2_STAT5	254	257	PF00017	0.523
LIG_SH2_STAT5	74	77	PF00017	0.346
LIG_SH2_STAT5	786	789	PF00017	0.410
LIG_SH2_STAT5	840	843	PF00017	0.501
LIG_SH2_STAT5	98	101	PF00017	0.417
LIG_SH2_STAT5	994	997	PF00017	0.404
LIG_SH3_3	1043	1049	PF00018	0.566
LIG_SH3_3	11	17	PF00018	0.774
LIG_SH3_3	401	407	PF00018	0.656
LIG_SH3_3	506	512	PF00018	0.692
LIG_SH3_3	513	519	PF00018	0.673
LIG_SH3_3	987	993	PF00018	0.390
LIG_SUMO_SIM_anti_2	589	595	PF11976	0.632
LIG_SUMO_SIM_par_1	861	866	PF11976	0.421
LIG_SUMO_SIM_par_1	904	910	PF11976	0.385
LIG_TRAF2_1	323	326	PF00917	0.620
LIG_TRAF2_1	458	461	PF00917	0.632
LIG_TRAF2_1	524	527	PF00917	0.671
LIG_UBA3_1	298	305	PF00899	0.648
LIG_UBA3_1	833	839	PF00899	0.424
LIG_WRC_WIRS_1	562	567	PF05994	0.552
LIG_WRC_WIRS_1	853	858	PF05994	0.501
MOD_CDK_SPK_2	13	18	PF00069	0.590
MOD_CK1_1	2	8	PF00069	0.755
MOD_CK1_1	267	273	PF00069	0.657
MOD_CK1_1	308	314	PF00069	0.729
MOD_CK1_1	315	321	PF00069	0.758
MOD_CK1_1	55	61	PF00069	0.484
MOD_CK1_1	555	561	PF00069	0.625
MOD_CK1_1	563	569	PF00069	0.636
MOD_CK1_1	670	676	PF00069	0.646
MOD_CK1_1	678	684	PF00069	0.618
MOD_CK1_1	824	830	PF00069	0.430
MOD_CK1_1	997	1003	PF00069	0.410
MOD_CK2_1	1018	1024	PF00069	0.430
MOD_CK2_1	1050	1056	PF00069	0.654
MOD_CK2_1	240	246	PF00069	0.675
MOD_CK2_1	267	273	PF00069	0.715
MOD_CK2_1	308	314	PF00069	0.659
MOD_CK2_1	346	352	PF00069	0.555
MOD_CK2_1	389	395	PF00069	0.646
MOD_CK2_1	555	561	PF00069	0.609
MOD_CK2_1	711	717	PF00069	0.521
MOD_Cter_Amidation	112	115	PF01082	0.371
MOD_GlcNHglycan	181	184	PF01048	0.498
MOD_GlcNHglycan	19	22	PF01048	0.604
MOD_GlcNHglycan	309	313	PF01048	0.714
MOD_GlcNHglycan	320	323	PF01048	0.604
MOD_GlcNHglycan	390	394	PF01048	0.734
MOD_GlcNHglycan	404	407	PF01048	0.641
MOD_GlcNHglycan	5	8	PF01048	0.787
MOD_GlcNHglycan	54	57	PF01048	0.475
MOD_GlcNHglycan	594	597	PF01048	0.639
MOD_GlcNHglycan	638	641	PF01048	0.632
MOD_GlcNHglycan	733	736	PF01048	0.457
MOD_GlcNHglycan	751	754	PF01048	0.571
MOD_GlcNHglycan	809	812	PF01048	0.430
MOD_GlcNHglycan	823	826	PF01048	0.430
MOD_GlcNHglycan	864	868	PF01048	0.425
MOD_GlcNHglycan	874	877	PF01048	0.437
MOD_GlcNHglycan	901	904	PF01048	0.438
MOD_GlcNHglycan	954	957	PF01048	0.478
MOD_GlcNHglycan	966	969	PF01048	0.357
MOD_GSK3_1	13	20	PF00069	0.726
MOD_GSK3_1	308	315	PF00069	0.687
MOD_GSK3_1	385	392	PF00069	0.704
MOD_GSK3_1	440	447	PF00069	0.542
MOD_GSK3_1	495	502	PF00069	0.735
MOD_GSK3_1	515	522	PF00069	0.664
MOD_GSK3_1	55	62	PF00069	0.519
MOD_GSK3_1	563	570	PF00069	0.672
MOD_GSK3_1	578	585	PF00069	0.567
MOD_GSK3_1	670	677	PF00069	0.586
MOD_GSK3_1	72	79	PF00069	0.430
MOD_GSK3_1	738	745	PF00069	0.509
MOD_GSK3_1	762	769	PF00069	0.340
MOD_GSK3_1	835	842	PF00069	0.462
MOD_GSK3_1	994	1001	PF00069	0.501
MOD_N-GLC_1	1050	1055	PF02516	0.727
MOD_N-GLC_1	3	8	PF02516	0.715
MOD_N-GLC_1	483	488	PF02516	0.762
MOD_N-GLC_1	877	882	PF02516	0.424
MOD_N-GLC_1	971	976	PF02516	0.430
MOD_NEK2_1	145	150	PF00069	0.390
MOD_NEK2_1	346	351	PF00069	0.574
MOD_NEK2_1	376	381	PF00069	0.475
MOD_NEK2_1	473	478	PF00069	0.494
MOD_NEK2_1	549	554	PF00069	0.763
MOD_NEK2_1	578	583	PF00069	0.598
MOD_NEK2_1	614	619	PF00069	0.617
MOD_NEK2_1	656	661	PF00069	0.508
MOD_NEK2_1	679	684	PF00069	0.711
MOD_NEK2_1	807	812	PF00069	0.387
MOD_NEK2_1	852	857	PF00069	0.436
MOD_NEK2_1	957	962	PF00069	0.424
MOD_NEK2_2	332	337	PF00069	0.632
MOD_NEK2_2	59	64	PF00069	0.376
MOD_NEK2_2	738	743	PF00069	0.343
MOD_NEK2_2	945	950	PF00069	0.430
MOD_PIKK_1	957	963	PF00454	0.492
MOD_PIKK_1	972	978	PF00454	0.316
MOD_PK_1	790	796	PF00069	0.424
MOD_PKA_1	440	446	PF00069	0.480
MOD_PKA_1	706	712	PF00069	0.578
MOD_PKA_2	1019	1025	PF00069	0.501
MOD_PKA_2	234	240	PF00069	0.690
MOD_PKA_2	385	391	PF00069	0.673
MOD_PKA_2	473	479	PF00069	0.737
MOD_PKA_2	636	642	PF00069	0.592
MOD_PKA_2	711	717	PF00069	0.570
MOD_PKA_2	738	744	PF00069	0.437
MOD_PKA_2	933	939	PF00069	0.471
MOD_PKA_2	945	951	PF00069	0.383
MOD_PKB_1	1018	1026	PF00069	0.385
MOD_Plk_1	1026	1032	PF00069	0.430
MOD_Plk_1	286	292	PF00069	0.607
MOD_Plk_1	346	352	PF00069	0.595
MOD_Plk_1	483	489	PF00069	0.653
MOD_Plk_1	519	525	PF00069	0.680
MOD_Plk_1	560	566	PF00069	0.476
MOD_Plk_1	614	620	PF00069	0.654
MOD_Plk_1	729	735	PF00069	0.569
MOD_Plk_1	777	783	PF00069	0.473
MOD_Plk_1	790	796	PF00069	0.349
MOD_Plk_1	998	1004	PF00069	0.501
MOD_Plk_2-3	711	717	PF00069	0.570
MOD_Plk_4	1035	1041	PF00069	0.558
MOD_Plk_4	286	292	PF00069	0.589
MOD_Plk_4	315	321	PF00069	0.594
MOD_Plk_4	440	446	PF00069	0.480
MOD_Plk_4	738	744	PF00069	0.467
MOD_Plk_4	923	929	PF00069	0.485
MOD_Plk_4	945	951	PF00069	0.427
MOD_Plk_4	998	1004	PF00069	0.426
MOD_ProDKin_1	13	19	PF00069	0.710
MOD_ProDKin_1	312	318	PF00069	0.651
MOD_ProDKin_1	393	399	PF00069	0.657
MOD_ProDKin_1	508	514	PF00069	0.773
MOD_ProDKin_1	515	521	PF00069	0.661
MOD_ProDKin_1	563	569	PF00069	0.706
MOD_SUMO_for_1	454	457	PF00179	0.655
MOD_SUMO_for_1	477	480	PF00179	0.485
MOD_SUMO_for_1	586	589	PF00179	0.705
MOD_SUMO_rev_2	1069	1079	PF00179	0.627
MOD_SUMO_rev_2	204	213	PF00179	0.389
MOD_SUMO_rev_2	362	371	PF00179	0.549
MOD_SUMO_rev_2	633	640	PF00179	0.626
MOD_SUMO_rev_2	692	701	PF00179	0.594
MOD_SUMO_rev_2	81	89	PF00179	0.380
TRG_DiLeu_BaEn_1	651	656	PF01217	0.552
TRG_DiLeu_BaEn_3	615	621	PF01217	0.630
TRG_DiLeu_BaEn_4	468	474	PF01217	0.640
TRG_DiLeu_LyEn_5	651	656	PF01217	0.552
TRG_ENDOCYTIC_2	141	144	PF00928	0.372
TRG_ENDOCYTIC_2	463	466	PF00928	0.651
TRG_ER_diArg_1	133	135	PF00400	0.287
TRG_ER_diArg_1	291	294	PF00400	0.598
TRG_ER_diArg_1	472	475	PF00400	0.639
TRG_ER_diArg_1	542	545	PF00400	0.654
TRG_ER_diArg_1	703	705	PF00400	0.645
TRG_NES_CRM1_1	334	347	PF08389	0.689
TRG_NES_CRM1_1	850	864	PF08389	0.424
TRG_NLS_MonoCore_2	37	42	PF00514	0.644
TRG_NLS_MonoExtC_3	37	42	PF00514	0.670
TRG_NLS_MonoExtN_4	35	42	PF00514	0.674
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	654	658	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAY9	Leptomonas seymouri	51%	100%
A0A1X0NJ05	Trypanosomatidae	31%	100%
A4HJQ8	Leishmania braziliensis	71%	100%
A4I775	Leishmania infantum	99%	100%
E9B269	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q5Z0	Leishmania major	87%	100%