LeishMANIAdb
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EGF-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EGF-like domain-containing protein
Gene product:
hypothetical protein, conserved (fragment)
Species:
Leishmania donovani
UniProt:
A0A3S7X4W3_LEIDO
TriTrypDb:
LdBPK_013350.1 , LdBPK_312610.1 * , LdCL_310034100 , LDHU3_31.4640
Length:
803

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 5
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

A0A3S7X4W3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4W3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 173 177 PF00656 0.297
CLV_C14_Caspase3-7 623 627 PF00656 0.446
CLV_NRD_NRD_1 66 68 PF00675 0.590
CLV_NRD_NRD_1 734 736 PF00675 0.444
CLV_NRD_NRD_1 769 771 PF00675 0.529
CLV_NRD_NRD_1 789 791 PF00675 0.526
CLV_NRD_NRD_1 794 796 PF00675 0.500
CLV_PCSK_KEX2_1 734 736 PF00082 0.447
CLV_PCSK_KEX2_1 771 773 PF00082 0.544
CLV_PCSK_KEX2_1 789 791 PF00082 0.526
CLV_PCSK_KEX2_1 793 795 PF00082 0.464
CLV_PCSK_PC1ET2_1 771 773 PF00082 0.496
CLV_PCSK_PC1ET2_1 793 795 PF00082 0.530
CLV_PCSK_PC7_1 789 795 PF00082 0.507
CLV_PCSK_SKI1_1 452 456 PF00082 0.434
CLV_PCSK_SKI1_1 789 793 PF00082 0.492
DEG_SCF_FBW7_1 364 371 PF00400 0.342
DEG_SPOP_SBC_1 222 226 PF00917 0.399
DEG_SPOP_SBC_1 311 315 PF00917 0.458
DOC_CDC14_PxL_1 186 194 PF14671 0.432
DOC_CKS1_1 246 251 PF01111 0.422
DOC_CKS1_1 308 313 PF01111 0.435
DOC_CKS1_1 330 335 PF01111 0.384
DOC_CKS1_1 365 370 PF01111 0.377
DOC_CKS1_1 682 687 PF01111 0.390
DOC_CYCLIN_yCln2_LP_2 718 724 PF00134 0.252
DOC_MAPK_gen_1 770 781 PF00069 0.630
DOC_MAPK_MEF2A_6 322 330 PF00069 0.437
DOC_MAPK_MEF2A_6 521 528 PF00069 0.383
DOC_MAPK_MEF2A_6 774 783 PF00069 0.671
DOC_MAPK_RevD_3 721 735 PF00069 0.376
DOC_MAPK_RevD_3 781 795 PF00069 0.724
DOC_PP1_RVXF_1 450 456 PF00149 0.227
DOC_PP2B_LxvP_1 718 721 PF13499 0.252
DOC_PP4_FxxP_1 106 109 PF00568 0.343
DOC_PP4_FxxP_1 330 333 PF00568 0.489
DOC_PP4_FxxP_1 365 368 PF00568 0.349
DOC_USP7_MATH_1 222 226 PF00917 0.475
DOC_USP7_MATH_1 28 32 PF00917 0.431
DOC_USP7_MATH_1 311 315 PF00917 0.493
DOC_USP7_MATH_1 368 372 PF00917 0.351
DOC_USP7_MATH_1 377 381 PF00917 0.421
DOC_USP7_MATH_1 408 412 PF00917 0.344
DOC_USP7_MATH_1 530 534 PF00917 0.440
DOC_USP7_MATH_1 631 635 PF00917 0.416
DOC_USP7_MATH_1 93 97 PF00917 0.326
DOC_WW_Pin1_4 105 110 PF00397 0.364
DOC_WW_Pin1_4 245 250 PF00397 0.391
DOC_WW_Pin1_4 307 312 PF00397 0.382
DOC_WW_Pin1_4 329 334 PF00397 0.392
DOC_WW_Pin1_4 364 369 PF00397 0.372
DOC_WW_Pin1_4 681 686 PF00397 0.452
LIG_14-3-3_CanoR_1 217 222 PF00244 0.380
LIG_14-3-3_CanoR_1 305 311 PF00244 0.410
LIG_14-3-3_CanoR_1 394 402 PF00244 0.256
LIG_14-3-3_CanoR_1 456 465 PF00244 0.348
LIG_14-3-3_CanoR_1 47 56 PF00244 0.253
LIG_14-3-3_CanoR_1 642 647 PF00244 0.446
LIG_Actin_WH2_2 506 523 PF00022 0.263
LIG_APCC_ABBA_1 467 472 PF00400 0.375
LIG_BIR_III_4 61 65 PF00653 0.294
LIG_BIR_III_4 611 615 PF00653 0.435
LIG_BRCT_BRCA1_1 102 106 PF00533 0.317
LIG_BRCT_BRCA1_1 164 168 PF00533 0.305
LIG_BRCT_BRCA1_1 663 667 PF00533 0.456
LIG_deltaCOP1_diTrp_1 146 152 PF00928 0.407
LIG_EH1_1 8 16 PF00400 0.397
LIG_eIF4E_1 459 465 PF01652 0.457
LIG_EVH1_2 120 124 PF00568 0.330
LIG_FHA_1 135 141 PF00498 0.547
LIG_FHA_1 157 163 PF00498 0.331
LIG_FHA_1 201 207 PF00498 0.343
LIG_FHA_1 222 228 PF00498 0.462
LIG_FHA_1 232 238 PF00498 0.319
LIG_FHA_1 330 336 PF00498 0.386
LIG_FHA_1 401 407 PF00498 0.403
LIG_FHA_1 420 426 PF00498 0.230
LIG_FHA_1 82 88 PF00498 0.299
LIG_FHA_2 180 186 PF00498 0.404
LIG_FHA_2 224 230 PF00498 0.329
LIG_FHA_2 278 284 PF00498 0.452
LIG_FHA_2 381 387 PF00498 0.346
LIG_FHA_2 56 62 PF00498 0.368
LIG_LIR_Apic_2 103 109 PF02991 0.326
LIG_LIR_Apic_2 116 121 PF02991 0.327
LIG_LIR_Apic_2 151 156 PF02991 0.343
LIG_LIR_Apic_2 327 333 PF02991 0.381
LIG_LIR_Apic_2 679 685 PF02991 0.428
LIG_LIR_Gen_1 178 189 PF02991 0.410
LIG_LIR_Gen_1 331 342 PF02991 0.419
LIG_LIR_Gen_1 458 467 PF02991 0.365
LIG_LIR_Gen_1 709 718 PF02991 0.335
LIG_LIR_Gen_1 744 754 PF02991 0.610
LIG_LIR_Nem_3 146 150 PF02991 0.367
LIG_LIR_Nem_3 178 184 PF02991 0.369
LIG_LIR_Nem_3 185 189 PF02991 0.307
LIG_LIR_Nem_3 347 353 PF02991 0.429
LIG_LIR_Nem_3 50 56 PF02991 0.344
LIG_LIR_Nem_3 709 713 PF02991 0.275
LIG_LIR_Nem_3 744 749 PF02991 0.653
LIG_LIR_Nem_3 753 757 PF02991 0.735
LIG_LYPXL_yS_3 495 498 PF13949 0.396
LIG_PCNA_PIPBox_1 785 794 PF02747 0.640
LIG_PCNA_yPIPBox_3 784 792 PF02747 0.643
LIG_Pex14_2 260 264 PF04695 0.339
LIG_Pex14_2 330 334 PF04695 0.474
LIG_SH2_CRK 118 122 PF00017 0.441
LIG_SH2_CRK 153 157 PF00017 0.414
LIG_SH2_CRK 186 190 PF00017 0.410
LIG_SH2_CRK 218 222 PF00017 0.423
LIG_SH2_CRK 682 686 PF00017 0.415
LIG_SH2_GRB2like 209 212 PF00017 0.412
LIG_SH2_NCK_1 153 157 PF00017 0.414
LIG_SH2_NCK_1 181 185 PF00017 0.337
LIG_SH2_NCK_1 35 39 PF00017 0.225
LIG_SH2_NCK_1 682 686 PF00017 0.384
LIG_SH2_PTP2 470 473 PF00017 0.187
LIG_SH2_SRC 209 212 PF00017 0.412
LIG_SH2_SRC 470 473 PF00017 0.324
LIG_SH2_STAP1 100 104 PF00017 0.221
LIG_SH2_STAP1 238 242 PF00017 0.451
LIG_SH2_STAP1 324 328 PF00017 0.355
LIG_SH2_STAP1 342 346 PF00017 0.369
LIG_SH2_STAP1 402 406 PF00017 0.315
LIG_SH2_STAP1 678 682 PF00017 0.455
LIG_SH2_STAT3 357 360 PF00017 0.285
LIG_SH2_STAT5 118 121 PF00017 0.460
LIG_SH2_STAT5 181 184 PF00017 0.396
LIG_SH2_STAT5 186 189 PF00017 0.361
LIG_SH2_STAT5 344 347 PF00017 0.426
LIG_SH2_STAT5 35 38 PF00017 0.401
LIG_SH2_STAT5 350 353 PF00017 0.337
LIG_SH2_STAT5 402 405 PF00017 0.374
LIG_SH2_STAT5 470 473 PF00017 0.207
LIG_SH2_STAT5 678 681 PF00017 0.438
LIG_SH3_3 243 249 PF00018 0.426
LIG_SH3_3 510 516 PF00018 0.362
LIG_SH3_3 559 565 PF00018 0.392
LIG_SH3_3 84 90 PF00018 0.449
LIG_Sin3_3 12 19 PF02671 0.366
LIG_SUMO_SIM_anti_2 403 408 PF11976 0.355
LIG_SUMO_SIM_anti_2 709 715 PF11976 0.376
LIG_SUMO_SIM_par_1 167 176 PF11976 0.296
LIG_SUMO_SIM_par_1 18 24 PF11976 0.542
LIG_SUMO_SIM_par_1 405 411 PF11976 0.354
LIG_SUMO_SIM_par_1 475 480 PF11976 0.315
LIG_TYR_ITIM 184 189 PF00017 0.432
LIG_UBA3_1 778 784 PF00899 0.612
LIG_Vh1_VBS_1 8 26 PF01044 0.415
LIG_WRC_WIRS_1 149 154 PF05994 0.532
LIG_WRC_WIRS_1 412 417 PF05994 0.257
LIG_WW_1 702 705 PF00397 0.577
LIG_WW_3 119 123 PF00397 0.400
LIG_WW_3 602 606 PF00397 0.532
MOD_CK1_1 134 140 PF00069 0.557
MOD_CK1_1 164 170 PF00069 0.456
MOD_CK1_1 175 181 PF00069 0.425
MOD_CK1_1 197 203 PF00069 0.528
MOD_CK1_1 274 280 PF00069 0.548
MOD_CK1_1 288 294 PF00069 0.223
MOD_CK1_1 380 386 PF00069 0.458
MOD_CK1_1 411 417 PF00069 0.337
MOD_CK1_1 458 464 PF00069 0.556
MOD_CK1_1 598 604 PF00069 0.633
MOD_CK1_1 681 687 PF00069 0.640
MOD_CK1_1 697 703 PF00069 0.481
MOD_CK2_1 179 185 PF00069 0.554
MOD_CK2_1 223 229 PF00069 0.395
MOD_GlcNHglycan 115 118 PF01048 0.416
MOD_GlcNHglycan 176 180 PF01048 0.590
MOD_GlcNHglycan 196 199 PF01048 0.648
MOD_GlcNHglycan 290 293 PF01048 0.533
MOD_GlcNHglycan 299 302 PF01048 0.515
MOD_GlcNHglycan 521 524 PF01048 0.475
MOD_GlcNHglycan 546 549 PF01048 0.572
MOD_GlcNHglycan 579 582 PF01048 0.471
MOD_GlcNHglycan 598 601 PF01048 0.627
MOD_GlcNHglycan 628 631 PF01048 0.446
MOD_GlcNHglycan 64 67 PF01048 0.408
MOD_GlcNHglycan 671 674 PF01048 0.603
MOD_GlcNHglycan 718 721 PF01048 0.320
MOD_GSK3_1 127 134 PF00069 0.576
MOD_GSK3_1 156 163 PF00069 0.416
MOD_GSK3_1 164 171 PF00069 0.460
MOD_GSK3_1 175 182 PF00069 0.546
MOD_GSK3_1 217 224 PF00069 0.553
MOD_GSK3_1 241 248 PF00069 0.496
MOD_GSK3_1 293 300 PF00069 0.445
MOD_GSK3_1 306 313 PF00069 0.468
MOD_GSK3_1 329 336 PF00069 0.512
MOD_GSK3_1 364 371 PF00069 0.464
MOD_GSK3_1 380 387 PF00069 0.422
MOD_GSK3_1 43 50 PF00069 0.526
MOD_GSK3_1 676 683 PF00069 0.544
MOD_GSK3_1 95 102 PF00069 0.410
MOD_N-GLC_1 210 215 PF02516 0.402
MOD_N-GLC_1 340 345 PF02516 0.472
MOD_N-GLC_1 400 405 PF02516 0.443
MOD_N-GLC_1 577 582 PF02516 0.443
MOD_N-GLC_1 595 600 PF02516 0.651
MOD_N-GLC_1 94 99 PF02516 0.333
MOD_NEK2_1 127 132 PF00069 0.580
MOD_NEK2_1 192 197 PF00069 0.612
MOD_NEK2_1 21 26 PF00069 0.635
MOD_NEK2_1 236 241 PF00069 0.497
MOD_NEK2_1 392 397 PF00069 0.534
MOD_NEK2_1 455 460 PF00069 0.506
MOD_NEK2_1 519 524 PF00069 0.411
MOD_NEK2_1 71 76 PF00069 0.393
MOD_NEK2_1 716 721 PF00069 0.285
MOD_NEK2_2 148 153 PF00069 0.398
MOD_NEK2_2 238 243 PF00069 0.581
MOD_NEK2_2 408 413 PF00069 0.224
MOD_NEK2_2 530 535 PF00069 0.564
MOD_OFUCOSY 375 381 PF10250 0.501
MOD_OFUCOSY 390 397 PF10250 0.416
MOD_OFUCOSY 543 550 PF10250 0.561
MOD_OFUCOSY 661 666 PF10250 0.554
MOD_PIKK_1 197 203 PF00454 0.633
MOD_PIKK_1 366 372 PF00454 0.405
MOD_PIKK_1 380 386 PF00454 0.510
MOD_PIKK_1 686 692 PF00454 0.654
MOD_PKA_2 127 133 PF00069 0.525
MOD_PKA_2 393 399 PF00069 0.310
MOD_PKA_2 455 461 PF00069 0.457
MOD_PKA_2 697 703 PF00069 0.492
MOD_Plk_1 134 140 PF00069 0.643
MOD_Plk_1 222 228 PF00069 0.556
MOD_Plk_1 271 277 PF00069 0.589
MOD_Plk_1 324 330 PF00069 0.495
MOD_Plk_1 33 39 PF00069 0.570
MOD_Plk_1 340 346 PF00069 0.373
MOD_Plk_1 400 406 PF00069 0.411
MOD_Plk_1 477 483 PF00069 0.518
MOD_Plk_1 508 514 PF00069 0.512
MOD_Plk_1 662 668 PF00069 0.608
MOD_Plk_1 94 100 PF00069 0.384
MOD_Plk_2-3 223 229 PF00069 0.392
MOD_Plk_4 164 170 PF00069 0.506
MOD_Plk_4 210 216 PF00069 0.410
MOD_Plk_4 28 34 PF00069 0.565
MOD_Plk_4 368 374 PF00069 0.519
MOD_Plk_4 402 408 PF00069 0.441
MOD_Plk_4 509 515 PF00069 0.427
MOD_Plk_4 95 101 PF00069 0.383
MOD_ProDKin_1 105 111 PF00069 0.445
MOD_ProDKin_1 245 251 PF00069 0.490
MOD_ProDKin_1 307 313 PF00069 0.477
MOD_ProDKin_1 329 335 PF00069 0.478
MOD_ProDKin_1 364 370 PF00069 0.457
MOD_ProDKin_1 681 687 PF00069 0.575
TRG_ENDOCYTIC_2 181 184 PF00928 0.422
TRG_ENDOCYTIC_2 186 189 PF00928 0.400
TRG_ENDOCYTIC_2 218 221 PF00928 0.453
TRG_ENDOCYTIC_2 350 353 PF00928 0.407
TRG_ENDOCYTIC_2 459 462 PF00928 0.495
TRG_ENDOCYTIC_2 470 473 PF00928 0.231
TRG_ENDOCYTIC_2 495 498 PF00928 0.554
TRG_ENDOCYTIC_2 56 59 PF00928 0.548
TRG_ENDOCYTIC_2 705 708 PF00928 0.603
TRG_ER_diArg_1 695 698 PF00400 0.664
TRG_ER_diArg_1 733 735 PF00400 0.521
TRG_ER_diArg_1 770 773 PF00400 0.730
TRG_ER_diArg_1 788 790 PF00400 0.638
TRG_NLS_MonoExtC_3 769 774 PF00514 0.632
TRG_Pf-PMV_PEXEL_1 424 428 PF00026 0.435
TRG_Pf-PMV_PEXEL_1 755 760 PF00026 0.664

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JPQ5 Bodo saltans 27% 96%
A0A0S4KNZ3 Bodo saltans 26% 95%
A0A1X0NFL6 Trypanosomatidae 32% 100%
A0A3Q8IFR8 Leishmania donovani 70% 100%
A4HJP2 Leishmania braziliensis 69% 100%
A4I711 Leishmania infantum 72% 100%
A4I759 Leishmania infantum 99% 100%
C9ZIV1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZIW8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9B252 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 100%
E9B253 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q607 Leishmania major 79% 100%
Q4Q608 Leishmania major 78% 100%
Q4Q609 Leishmania major 78% 100%
V5BQ27 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS