Ubiquinol-cytochrome-c_reductase-like_protein/Gen eDB:LmjF.31.2580

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquinol-cytochrome-c reductase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4V9_LEIDO

TriTrypDb:

LdBPK_312650.1 , LdCL_310034500 , LDHU3_31.4720

Length:

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), Ubiquinol-cytochrome-c reductase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005750	mitochondrial respiratory chain complex III	4	7
GO:0032991	protein-containing complex	1	7
GO:0045275	respiratory chain complex III	4	7
GO:0070069	cytochrome complex	3	7
GO:0098796	membrane protein complex	2	7
GO:0098798	mitochondrial protein-containing complex	2	7
GO:0098800	inner mitochondrial membrane protein complex	3	7
GO:0098803	respiratory chain complex	3	7
GO:1902494	catalytic complex	2	7
GO:1902495	transmembrane transporter complex	3	7
GO:1990204	oxidoreductase complex	3	7
GO:1990351	transporter complex	2	7

Expansion

Sequence features

A0A3S7X4V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4V9

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	7
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	7	7
GO:0008152	metabolic process	1	7
GO:0009060	aerobic respiration	6	7
GO:0009987	cellular process	1	7
GO:0015980	energy derivation by oxidation of organic compounds	4	7
GO:0019646	aerobic electron transport chain	6	7
GO:0022900	electron transport chain	4	7
GO:0022904	respiratory electron transport chain	5	7
GO:0044237	cellular metabolic process	2	7
GO:0045333	cellular respiration	5	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_WW_Pin1_4	36	41	PF00397	0.258
LIG_14-3-3_CanoR_1	34	39	PF00244	0.330
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_MYND_1	63	67	PF01753	0.270
LIG_SH2_STAT5	50	53	PF00017	0.236
MOD_CDC14_SPxK_1	39	42	PF00782	0.238
MOD_CDK_SPxK_1	36	42	PF00069	0.238
MOD_N-GLC_2	19	21	PF02516	0.270
MOD_N-GLC_2	29	31	PF02516	0.270
MOD_ProDKin_1	36	42	PF00069	0.258
MOD_SUMO_rev_2	3	10	PF00179	0.358
MOD_SUMO_rev_2	58	65	PF00179	0.270
TRG_ENDOCYTIC_2	50	53	PF00928	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z7	Leptomonas seymouri	88%	100%
A0A0S4KMS1	Bodo saltans	63%	100%
A4HJP6	Leishmania braziliensis	89%	100%
A4I763	Leishmania infantum	100%	100%
C9ZME8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	99%
Q0WWE3	Arabidopsis thaliana	42%	100%
Q1ZXP3	Dictyostelium discoideum	33%	100%