Kinetoplastid kinetochore protein 8, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 8, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4V3_LEIDO

TriTrypDb:

LdBPK_312840.1 , LdCL_310036700 , LDHU3_31.4960

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X4V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4V3

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.670
CLV_NRD_NRD_1	186	188	PF00675	0.551
CLV_NRD_NRD_1	19	21	PF00675	0.620
CLV_NRD_NRD_1	269	271	PF00675	0.509
CLV_NRD_NRD_1	282	284	PF00675	0.335
CLV_NRD_NRD_1	307	309	PF00675	0.543
CLV_NRD_NRD_1	337	339	PF00675	0.738
CLV_NRD_NRD_1	426	428	PF00675	0.708
CLV_PCSK_FUR_1	280	284	PF00082	0.536
CLV_PCSK_KEX2_1	19	21	PF00082	0.561
CLV_PCSK_KEX2_1	268	270	PF00082	0.525
CLV_PCSK_KEX2_1	280	282	PF00082	0.342
CLV_PCSK_KEX2_1	298	300	PF00082	0.389
CLV_PCSK_KEX2_1	337	339	PF00082	0.752
CLV_PCSK_KEX2_1	425	427	PF00082	0.576
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.430
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.576
CLV_PCSK_SKI1_1	315	319	PF00082	0.508
CLV_PCSK_SKI1_1	342	346	PF00082	0.574
DEG_APCC_DBOX_1	176	184	PF00400	0.508
DEG_APCC_DBOX_1	319	327	PF00400	0.628
DEG_APCC_DBOX_1	76	84	PF00400	0.549
DEG_SPOP_SBC_1	42	46	PF00917	0.678
DEG_SPOP_SBC_1	83	87	PF00917	0.553
DOC_MAPK_gen_1	177	185	PF00069	0.496
DOC_MAPK_gen_1	288	297	PF00069	0.546
DOC_MAPK_gen_1	425	431	PF00069	0.588
DOC_MAPK_MEF2A_6	210	219	PF00069	0.494
DOC_PP1_RVXF_1	340	347	PF00149	0.554
DOC_PP2B_LxvP_1	39	42	PF13499	0.601
DOC_USP7_MATH_1	161	165	PF00917	0.428
DOC_USP7_MATH_1	348	352	PF00917	0.570
DOC_USP7_MATH_1	42	46	PF00917	0.694
DOC_USP7_MATH_1	65	69	PF00917	0.673
DOC_USP7_MATH_1	8	12	PF00917	0.686
DOC_USP7_UBL2_3	305	309	PF12436	0.529
DOC_WW_Pin1_4	10	15	PF00397	0.553
DOC_WW_Pin1_4	92	97	PF00397	0.705
LIG_14-3-3_CanoR_1	10	14	PF00244	0.555
LIG_14-3-3_CanoR_1	141	145	PF00244	0.603
LIG_14-3-3_CanoR_1	210	215	PF00244	0.495
LIG_14-3-3_CanoR_1	337	344	PF00244	0.597
LIG_14-3-3_CanoR_1	40	48	PF00244	0.694
LIG_14-3-3_CanoR_1	66	72	PF00244	0.700
LIG_14-3-3_CanoR_1	77	81	PF00244	0.646
LIG_14-3-3_CanoR_1	82	92	PF00244	0.607
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_BRCT_BRCA1_1	410	414	PF00533	0.701
LIG_CaM_IQ_9	180	196	PF13499	0.556
LIG_FHA_1	11	17	PF00498	0.558
LIG_FHA_1	211	217	PF00498	0.484
LIG_FHA_1	252	258	PF00498	0.558
LIG_FHA_2	367	373	PF00498	0.732
LIG_GSK3_LRP6_1	92	97	PF00069	0.624
LIG_IBAR_NPY_1	108	110	PF08397	0.675
LIG_LIR_Apic_2	143	147	PF02991	0.679
LIG_LIR_Apic_2	209	215	PF02991	0.469
LIG_LIR_Apic_2	27	32	PF02991	0.668
LIG_LIR_Apic_2	63	67	PF02991	0.753
LIG_LIR_Apic_2	99	104	PF02991	0.696
LIG_LIR_Gen_1	198	205	PF02991	0.434
LIG_LIR_Gen_1	273	279	PF02991	0.539
LIG_LIR_Nem_3	27	31	PF02991	0.665
LIG_LIR_Nem_3	273	278	PF02991	0.497
LIG_LIR_Nem_3	290	295	PF02991	0.512
LIG_LIR_Nem_3	396	402	PF02991	0.731
LIG_LYPXL_yS_3	149	152	PF13949	0.657
LIG_MYND_1	150	154	PF01753	0.614
LIG_SH2_CRK	144	148	PF00017	0.602
LIG_SH2_CRK	29	33	PF00017	0.705
LIG_SH2_CRK	6	10	PF00017	0.673
LIG_SH2_NCK_1	29	33	PF00017	0.705
LIG_SH2_PTP2	101	104	PF00017	0.614
LIG_SH2_STAT3	132	135	PF00017	0.652
LIG_SH2_STAT5	101	104	PF00017	0.725
LIG_SH2_STAT5	132	135	PF00017	0.625
LIG_SH2_STAT5	196	199	PF00017	0.558
LIG_SH2_STAT5	212	215	PF00017	0.331
LIG_SH2_STAT5	256	259	PF00017	0.562
LIG_SH2_STAT5	29	32	PF00017	0.598
LIG_SH2_STAT5	292	295	PF00017	0.541
LIG_SH2_STAT5	381	384	PF00017	0.698
LIG_SH3_1	144	150	PF00018	0.494
LIG_SH3_3	103	109	PF00018	0.539
LIG_SH3_3	120	126	PF00018	0.603
LIG_SH3_3	144	150	PF00018	0.691
LIG_SH3_3	90	96	PF00018	0.641
LIG_SH3_CIN85_PxpxPR_1	92	97	PF14604	0.624
LIG_SUMO_SIM_par_1	366	374	PF11976	0.692
LIG_TRAF2_1	170	173	PF00917	0.530
LIG_TRAF2_1	274	277	PF00917	0.537
LIG_WW_1	14	17	PF00397	0.560
MOD_CDK_SPK_2	92	97	PF00069	0.690
MOD_CK1_1	27	33	PF00069	0.694
MOD_CK1_1	361	367	PF00069	0.713
MOD_CK1_1	380	386	PF00069	0.689
MOD_CK1_1	43	49	PF00069	0.445
MOD_CK2_1	360	366	PF00069	0.657
MOD_Cter_Amidation	335	338	PF01082	0.691
MOD_DYRK1A_RPxSP_1	10	14	PF00069	0.555
MOD_GlcNHglycan	1	4	PF01048	0.732
MOD_GlcNHglycan	338	341	PF01048	0.706
MOD_GlcNHglycan	359	363	PF01048	0.645
MOD_GlcNHglycan	371	376	PF01048	0.715
MOD_GlcNHglycan	382	385	PF01048	0.727
MOD_GlcNHglycan	6	9	PF01048	0.684
MOD_GlcNHglycan	67	70	PF01048	0.702
MOD_GlcNHglycan	98	101	PF01048	0.692
MOD_GSK3_1	108	115	PF00069	0.532
MOD_GSK3_1	332	339	PF00069	0.635
MOD_GSK3_1	371	378	PF00069	0.722
MOD_GSK3_1	380	387	PF00069	0.647
MOD_GSK3_1	4	11	PF00069	0.701
MOD_GSK3_1	408	415	PF00069	0.566
MOD_GSK3_1	67	74	PF00069	0.585
MOD_GSK3_1	92	99	PF00069	0.668
MOD_N-GLC_1	416	421	PF02516	0.646
MOD_NEK2_1	183	188	PF00069	0.446
MOD_NEK2_1	195	200	PF00069	0.476
MOD_NEK2_1	377	382	PF00069	0.641
MOD_NEK2_1	9	14	PF00069	0.558
MOD_NEK2_2	67	72	PF00069	0.640
MOD_PIKK_1	108	114	PF00454	0.660
MOD_PIKK_1	246	252	PF00454	0.530
MOD_PIKK_1	309	315	PF00454	0.519
MOD_PKA_2	140	146	PF00069	0.556
MOD_PKA_2	336	342	PF00069	0.641
MOD_PKA_2	419	425	PF00069	0.700
MOD_PKA_2	65	71	PF00069	0.676
MOD_PKA_2	76	82	PF00069	0.658
MOD_PKA_2	9	15	PF00069	0.555
MOD_PKA_2	96	102	PF00069	0.737
MOD_Plk_1	172	178	PF00069	0.433
MOD_Plk_1	348	354	PF00069	0.659
MOD_Plk_1	75	81	PF00069	0.672
MOD_Plk_2-3	260	266	PF00069	0.469
MOD_Plk_2-3	366	372	PF00069	0.692
MOD_Plk_4	102	108	PF00069	0.638
MOD_Plk_4	128	134	PF00069	0.685
MOD_Plk_4	24	30	PF00069	0.642
MOD_Plk_4	348	354	PF00069	0.553
MOD_Plk_4	419	425	PF00069	0.647
MOD_ProDKin_1	10	16	PF00069	0.555
MOD_ProDKin_1	92	98	PF00069	0.705
MOD_SUMO_rev_2	290	300	PF00179	0.431
TRG_DiLeu_BaEn_4	192	198	PF01217	0.557
TRG_ENDOCYTIC_2	149	152	PF00928	0.657
TRG_ENDOCYTIC_2	28	31	PF00928	0.726
TRG_ENDOCYTIC_2	292	295	PF00928	0.545
TRG_ENDOCYTIC_2	6	9	PF00928	0.745
TRG_ER_diArg_1	18	20	PF00400	0.637
TRG_ER_diArg_1	268	270	PF00400	0.477
TRG_ER_diArg_1	280	283	PF00400	0.383
TRG_ER_FFAT_2	376	387	PF00635	0.663
TRG_NLS_MonoCore_2	424	429	PF00514	0.698
TRG_NLS_MonoExtC_3	424	430	PF00514	0.588
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH8	Leptomonas seymouri	64%	100%
A0A1X0NJ59	Trypanosomatidae	38%	100%
A0A422NPB6	Trypanosoma rangeli	40%	100%
A4HJR3	Leishmania braziliensis	85%	99%
A4I780	Leishmania infantum	100%	100%
C9ZMG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B274	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5Y5	Leishmania major	95%	100%
V5D822	Trypanosoma cruzi	42%	100%