LeishMANIAdb
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Uridine kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uridine kinase-like protein
Gene product:
uridine kinase-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X4U8_LEIDO
TriTrypDb:
LdBPK_312560.1 * , LdCL_310033500 , LDHU3_31.4590
Length:
311

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3S7X4U8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4U8

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006220 pyrimidine nucleotide metabolic process 5 2
GO:0006221 pyrimidine nucleotide biosynthetic process 6 2
GO:0006222 UMP biosynthetic process 8 2
GO:0006241 CTP biosynthetic process 8 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006753 nucleoside phosphate metabolic process 4 2
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0006807 nitrogen compound metabolic process 2 2
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 5
GO:0003824 catalytic activity 1 5
GO:0004849 uridine kinase activity 7 5
GO:0005488 binding 1 5
GO:0005524 ATP binding 5 5
GO:0016301 kinase activity 4 5
GO:0016740 transferase activity 2 5
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 5
GO:0017076 purine nucleotide binding 4 5
GO:0019205 nucleobase-containing compound kinase activity 5 5
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 17 21 PF00656 0.526
CLV_NRD_NRD_1 165 167 PF00675 0.362
CLV_PCSK_KEX2_1 165 167 PF00082 0.362
CLV_PCSK_KEX2_1 298 300 PF00082 0.507
CLV_PCSK_PC1ET2_1 298 300 PF00082 0.507
CLV_PCSK_PC7_1 294 300 PF00082 0.492
CLV_PCSK_SKI1_1 176 180 PF00082 0.292
CLV_PCSK_SKI1_1 266 270 PF00082 0.387
CLV_PCSK_SKI1_1 28 32 PF00082 0.471
DEG_APCC_DBOX_1 298 306 PF00400 0.507
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Homologs

ProteinTaxonomySequence identityCoverage
A4HJN1 Leishmania braziliensis 62% 100%
A4HJN5 Leishmania braziliensis 62% 100%
Q4Q614 Leishmania major 79% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS