Uridine kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

uridine kinase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4U8_LEIDO

TriTrypDb:

LdBPK_312560.1 , LdCL_310033500 , LDHU3_31.4590

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X4U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4U8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0044237	cellular metabolic process	2	5
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006220	pyrimidine nucleotide metabolic process	5	2
GO:0006221	pyrimidine nucleotide biosynthetic process	6	2
GO:0006222	UMP biosynthetic process	8	2
GO:0006241	CTP biosynthetic process	8	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008655	pyrimidine-containing compound salvage	4	2
GO:0009058	biosynthetic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009123	nucleoside monophosphate metabolic process	5	2
GO:0009124	nucleoside monophosphate biosynthetic process	6	2
GO:0009129	pyrimidine nucleoside monophosphate metabolic process	6	2
GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	7	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009142	nucleoside triphosphate biosynthetic process	6	2
GO:0009147	pyrimidine nucleoside triphosphate metabolic process	6	2
GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process	7	2
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	2
GO:0009161	ribonucleoside monophosphate metabolic process	6	2
GO:0009165	nucleotide biosynthetic process	6	2
GO:0009173	pyrimidine ribonucleoside monophosphate metabolic process	7	2
GO:0009174	pyrimidine ribonucleoside monophosphate biosynthetic process	8	2
GO:0009199	ribonucleoside triphosphate metabolic process	6	2
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	2
GO:0009208	pyrimidine ribonucleoside triphosphate metabolic process	7	2
GO:0009209	pyrimidine ribonucleoside triphosphate biosynthetic process	8	2
GO:0009218	pyrimidine ribonucleotide metabolic process	6	2
GO:0009220	pyrimidine ribonucleotide biosynthetic process	7	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009260	ribonucleotide biosynthetic process	6	2
GO:0010138	pyrimidine ribonucleotide salvage	6	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0032262	pyrimidine nucleotide salvage	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043094	cellular metabolic compound salvage	3	2
GO:0043173	nucleotide salvage	4	2
GO:0044206	UMP salvage	7	2
GO:0044211	CTP salvage	7	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046036	CTP metabolic process	7	2
GO:0046049	UMP metabolic process	7	2
GO:0046390	ribose phosphate biosynthetic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072527	pyrimidine-containing compound metabolic process	4	2
GO:0072528	pyrimidine-containing compound biosynthetic process	5	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004849	uridine kinase activity	7	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0017076	purine nucleotide binding	4	5
GO:0019205	nucleobase-containing compound kinase activity	5	5
GO:0019206	nucleoside kinase activity	6	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.526
CLV_NRD_NRD_1	165	167	PF00675	0.362
CLV_PCSK_KEX2_1	165	167	PF00082	0.362
CLV_PCSK_KEX2_1	298	300	PF00082	0.507
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.507
CLV_PCSK_PC7_1	294	300	PF00082	0.492
CLV_PCSK_SKI1_1	176	180	PF00082	0.292
CLV_PCSK_SKI1_1	266	270	PF00082	0.387
CLV_PCSK_SKI1_1	28	32	PF00082	0.471
DEG_APCC_DBOX_1	298	306	PF00400	0.507
DEG_APCC_DBOX_1	31	39	PF00400	0.424
DEG_Nend_UBRbox_4	1	3	PF02207	0.449
DEG_SPOP_SBC_1	268	272	PF00917	0.377
DOC_MAPK_DCC_7	298	307	PF00069	0.506
DOC_MAPK_gen_1	210	218	PF00069	0.437
DOC_MAPK_gen_1	298	307	PF00069	0.506
DOC_MAPK_MEF2A_6	28	35	PF00069	0.436
DOC_MAPK_MEF2A_6	298	307	PF00069	0.506
DOC_USP7_MATH_1	197	201	PF00917	0.412
DOC_WW_Pin1_4	124	129	PF00397	0.562
LIG_14-3-3_CanoR_1	176	182	PF00244	0.547
LIG_14-3-3_CanoR_1	222	231	PF00244	0.526
LIG_14-3-3_CanoR_1	283	289	PF00244	0.438
LIG_14-3-3_CanoR_1	294	302	PF00244	0.488
LIG_14-3-3_CanoR_1	78	86	PF00244	0.462
LIG_14-3-3_CanoR_1	94	101	PF00244	0.464
LIG_Actin_WH2_2	86	104	PF00022	0.562
LIG_APCC_ABBAyCdc20_2	57	63	PF00400	0.412
LIG_BIR_III_2	237	241	PF00653	0.489
LIG_BRCT_BRCA1_1	12	16	PF00533	0.459
LIG_eIF4E_1	9	15	PF01652	0.464
LIG_FHA_1	127	133	PF00498	0.475
LIG_FHA_2	139	145	PF00498	0.562
LIG_FHA_2	15	21	PF00498	0.522
LIG_FHA_2	79	85	PF00498	0.500
LIG_LIR_Apic_2	80	86	PF02991	0.557
LIG_LIR_Nem_3	177	181	PF02991	0.500
LIG_NRBOX	272	278	PF00104	0.376
LIG_PDZ_Class_1	306	311	PF00595	0.486
LIG_Pex14_1	284	288	PF04695	0.433
LIG_Pex14_2	61	65	PF04695	0.303
LIG_Rb_LxCxE_1	58	76	PF01857	0.428
LIG_SH2_CRK	112	116	PF00017	0.562
LIG_SH2_NCK_1	196	200	PF00017	0.412
LIG_SH2_SRC	112	115	PF00017	0.637
LIG_SH2_SRC	196	199	PF00017	0.491
LIG_SH2_SRC	4	7	PF00017	0.394
LIG_SH2_SRC	83	86	PF00017	0.500
LIG_SH2_STAP1	185	189	PF00017	0.562
LIG_SH2_STAT5	114	117	PF00017	0.562
LIG_SH2_STAT5	4	7	PF00017	0.394
LIG_SH3_3	104	110	PF00018	0.637
LIG_SH3_3	238	244	PF00018	0.465
LIG_SH3_3	248	254	PF00018	0.435
LIG_SH3_3	297	303	PF00018	0.505
LIG_SH3_5	110	114	PF00018	0.562
LIG_SH3_5	79	83	PF00018	0.475
LIG_SUMO_SIM_par_1	129	135	PF11976	0.557
LIG_TRFH_1	255	259	PF08558	0.416
MOD_CDK_SPxK_1	124	130	PF00069	0.305
MOD_CK1_1	120	126	PF00069	0.323
MOD_CK1_1	200	206	PF00069	0.217
MOD_CK2_1	138	144	PF00069	0.427
MOD_CK2_1	177	183	PF00069	0.339
MOD_CK2_1	247	253	PF00069	0.439
MOD_CK2_1	284	290	PF00069	0.441
MOD_GlcNHglycan	119	122	PF01048	0.323
MOD_GlcNHglycan	205	209	PF01048	0.305
MOD_GlcNHglycan	290	293	PF01048	0.458
MOD_GlcNHglycan	6	9	PF01048	0.430
MOD_GSK3_1	10	17	PF00069	0.526
MOD_GSK3_1	119	126	PF00069	0.398
MOD_GSK3_1	200	207	PF00069	0.217
MOD_GSK3_1	243	250	PF00069	0.437
MOD_GSK3_1	278	285	PF00069	0.401
MOD_GSK3_1	73	80	PF00069	0.473
MOD_LATS_1	117	123	PF00433	0.339
MOD_N-GLC_1	55	60	PF02516	0.458
MOD_NEK2_1	138	143	PF00069	0.427
MOD_NEK2_1	14	19	PF00069	0.506
MOD_NEK2_1	154	159	PF00069	0.245
MOD_NEK2_1	221	226	PF00069	0.397
MOD_NEK2_1	260	265	PF00069	0.403
MOD_NEK2_1	269	274	PF00069	0.369
MOD_NEK2_1	278	283	PF00069	0.375
MOD_NEK2_1	93	98	PF00069	0.427
MOD_NEK2_2	174	179	PF00069	0.311
MOD_NEK2_2	185	190	PF00069	0.417
MOD_NEK2_2	284	289	PF00069	0.438
MOD_PIKK_1	221	227	PF00454	0.404
MOD_PKA_2	221	227	PF00069	0.404
MOD_PKA_2	282	288	PF00069	0.429
MOD_PKA_2	293	299	PF00069	0.477
MOD_PKA_2	77	83	PF00069	0.287
MOD_PKA_2	93	99	PF00069	0.291
MOD_Plk_1	10	16	PF00069	0.447
MOD_Plk_4	10	16	PF00069	0.530
MOD_Plk_4	177	183	PF00069	0.339
MOD_Plk_4	243	249	PF00069	0.434
MOD_Plk_4	284	290	PF00069	0.441
MOD_ProDKin_1	124	130	PF00069	0.427
TRG_DiLeu_BaEn_1	148	153	PF01217	0.339
TRG_DiLeu_BaEn_2	134	140	PF01217	0.217
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.424
TRG_ENDOCYTIC_2	112	115	PF00928	0.427
TRG_ER_diArg_1	299	302	PF00400	0.512
TRG_NLS_MonoCore_2	297	302	PF00514	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJN1	Leishmania braziliensis	62%	100%
A4HJN5	Leishmania braziliensis	62%	100%
Q4Q614	Leishmania major	79%	100%