Ferredoxin, 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin, 2fe-2s-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4U4_LEIDO

TriTrypDb:

LdBPK_312600.1 , LdCL_310033900 , LDHU3_31.4630

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 22
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7X4U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4U4

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	25
GO:0008152	metabolic process	1	25
GO:0009987	cellular process	1	25
GO:0022900	electron transport chain	4	25
GO:0044237	cellular metabolic process	2	25
GO:0140647	P450-containing electron transport chain	5	25

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	25
GO:0051536	iron-sulfur cluster binding	3	25
GO:0051537	2 iron, 2 sulfur cluster binding	4	25
GO:0051540	metal cluster binding	2	25
GO:0003824	catalytic activity	1	5
GO:0009055	electron transfer activity	3	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.431
CLV_NRD_NRD_1	5	7	PF00675	0.620
CLV_PCSK_KEX2_1	4	6	PF00082	0.618
DEG_Nend_Nbox_1	1	3	PF02207	0.483
DEG_SPOP_SBC_1	44	48	PF00917	0.528
DOC_MAPK_gen_1	4	13	PF00069	0.454
DOC_MAPK_HePTP_8	3	15	PF00069	0.435
DOC_MAPK_MEF2A_6	6	15	PF00069	0.461
DOC_MAPK_MEF2A_6	85	94	PF00069	0.245
DOC_PP2B_LxvP_1	13	16	PF13499	0.488
DOC_PP2B_LxvP_1	150	153	PF13499	0.301
DOC_USP7_MATH_1	138	142	PF00917	0.211
DOC_USP7_MATH_1	42	46	PF00917	0.540
DOC_WW_Pin1_4	21	26	PF00397	0.640
DOC_WW_Pin1_4	37	42	PF00397	0.546
DOC_WW_Pin1_4	51	56	PF00397	0.521
LIG_14-3-3_CanoR_1	145	153	PF00244	0.306
LIG_14-3-3_CanoR_1	17	26	PF00244	0.547
LIG_14-3-3_CanoR_1	30	39	PF00244	0.497
LIG_14-3-3_CanoR_1	5	11	PF00244	0.611
LIG_DLG_GKlike_1	6	13	PF00625	0.458
LIG_FHA_1	10	16	PF00498	0.704
LIG_FHA_1	104	110	PF00498	0.356
LIG_FHA_1	163	169	PF00498	0.612
LIG_FHA_1	45	51	PF00498	0.518
LIG_FHA_1	87	93	PF00498	0.272
LIG_FHA_2	125	131	PF00498	0.262
LIG_LIR_Gen_1	69	74	PF02991	0.233
LIG_Pex14_1	172	176	PF04695	0.486
LIG_SH2_STAP1	70	74	PF00017	0.232
LIG_SH3_3	36	42	PF00018	0.484
LIG_SH3_3	89	95	PF00018	0.280
MOD_CDK_SPxK_1	21	27	PF00069	0.456
MOD_CDK_SPxK_1	51	57	PF00069	0.584
MOD_CK1_1	141	147	PF00069	0.304
MOD_CK1_1	29	35	PF00069	0.624
MOD_CK1_1	40	46	PF00069	0.567
MOD_CK1_1	49	55	PF00069	0.579
MOD_CK1_1	9	15	PF00069	0.633
MOD_CK2_1	124	130	PF00069	0.324
MOD_DYRK1A_RPxSP_1	51	55	PF00069	0.486
MOD_GlcNHglycan	112	115	PF01048	0.276
MOD_GlcNHglycan	42	45	PF01048	0.567
MOD_GSK3_1	144	151	PF00069	0.298
MOD_GSK3_1	17	24	PF00069	0.549
MOD_GSK3_1	40	47	PF00069	0.601
MOD_GSK3_1	98	105	PF00069	0.333
MOD_N-GLC_1	98	103	PF02516	0.245
MOD_OFUCOSY	102	107	PF10250	0.359
MOD_PKA_2	144	150	PF00069	0.328
MOD_PKA_2	176	182	PF00069	0.466
MOD_PKA_2	29	35	PF00069	0.487
MOD_PKB_1	4	12	PF00069	0.440
MOD_Plk_1	141	147	PF00069	0.293
MOD_Plk_1	85	91	PF00069	0.223
MOD_Plk_2-3	66	72	PF00069	0.221
MOD_ProDKin_1	21	27	PF00069	0.645
MOD_ProDKin_1	37	43	PF00069	0.552
MOD_ProDKin_1	51	57	PF00069	0.515
TRG_DiLeu_BaEn_1	76	81	PF01217	0.251
TRG_ENDOCYTIC_2	70	73	PF00928	0.274
TRG_ER_diArg_1	3	6	PF00400	0.604
TRG_ER_diArg_1	60	63	PF00400	0.413
TRG_NES_CRM1_1	115	130	PF08389	0.198
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	44%	100%
A0A0N1ILD8	Leptomonas seymouri	55%	100%
A0A3Q8IIS3	Leishmania donovani	46%	100%
A0A3S7X4S6	Leishmania donovani	38%	100%
A0A3S7X4W8	Leishmania donovani	39%	100%
A4HJN2	Leishmania braziliensis	41%	100%
A4HJN3	Leishmania braziliensis	43%	100%
A4HJN4	Leishmania braziliensis	39%	100%
A4HJN8	Leishmania braziliensis	40%	100%
A4HJN9	Leishmania braziliensis	69%	98%
A4I755	Leishmania infantum	38%	100%
A4I756	Leishmania infantum	46%	100%
A4I757	Leishmania infantum	38%	100%
A4I758	Leishmania infantum	97%	100%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
P13216	Gallus gallus	35%	100%
P24483	Rattus norvegicus	34%	97%
P46656	Mus musculus	37%	97%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q4Q610	Leishmania major	90%	100%
Q4Q611	Leishmania major	40%	100%
Q4Q612	Leishmania major	45%	100%
Q4Q613	Leishmania major	39%	100%
Q4Q989	Leishmania major	39%	100%
Q8S904	Arabidopsis thaliana	35%	92%
Q8SZA8	Drosophila melanogaster	32%	100%
Q9M0V0	Arabidopsis thaliana	34%	92%