TerD domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TerD domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4T6_LEIDO

TriTrypDb:

LdBPK_312660.1 , LdCL_310034600 , LDHU3_31.4730

Length:

924

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.517
CLV_C14_Caspase3-7	486	490	PF00656	0.613
CLV_MEL_PAP_1	872	878	PF00089	0.499
CLV_NRD_NRD_1	106	108	PF00675	0.558
CLV_NRD_NRD_1	113	115	PF00675	0.576
CLV_NRD_NRD_1	179	181	PF00675	0.651
CLV_NRD_NRD_1	315	317	PF00675	0.607
CLV_NRD_NRD_1	521	523	PF00675	0.566
CLV_NRD_NRD_1	617	619	PF00675	0.659
CLV_NRD_NRD_1	626	628	PF00675	0.676
CLV_NRD_NRD_1	675	677	PF00675	0.746
CLV_PCSK_KEX2_1	106	108	PF00082	0.561
CLV_PCSK_KEX2_1	112	114	PF00082	0.584
CLV_PCSK_KEX2_1	178	180	PF00082	0.684
CLV_PCSK_KEX2_1	315	317	PF00082	0.541
CLV_PCSK_KEX2_1	436	438	PF00082	0.662
CLV_PCSK_KEX2_1	521	523	PF00082	0.580
CLV_PCSK_KEX2_1	616	618	PF00082	0.673
CLV_PCSK_KEX2_1	626	628	PF00082	0.677
CLV_PCSK_KEX2_1	675	677	PF00082	0.740
CLV_PCSK_KEX2_1	886	888	PF00082	0.486
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.662
CLV_PCSK_PC1ET2_1	886	888	PF00082	0.496
CLV_PCSK_PC7_1	175	181	PF00082	0.669
CLV_PCSK_SKI1_1	316	320	PF00082	0.597
CLV_PCSK_SKI1_1	440	444	PF00082	0.440
CLV_PCSK_SKI1_1	654	658	PF00082	0.741
CLV_PCSK_SKI1_1	807	811	PF00082	0.456
DEG_APCC_DBOX_1	314	322	PF00400	0.570
DEG_APCC_DBOX_1	586	594	PF00400	0.399
DEG_APCC_DBOX_1	717	725	PF00400	0.542
DEG_COP1_1	438	448	PF00400	0.527
DEG_SPOP_SBC_1	788	792	PF00917	0.550
DOC_CDC14_PxL_1	442	450	PF14671	0.410
DOC_CYCLIN_RxL_1	313	320	PF00134	0.577
DOC_MAPK_DCC_7	440	450	PF00069	0.418
DOC_MAPK_gen_1	315	321	PF00069	0.507
DOC_MAPK_gen_1	44	54	PF00069	0.505
DOC_MAPK_gen_1	770	778	PF00069	0.526
DOC_MAPK_gen_1	802	811	PF00069	0.385
DOC_MAPK_gen_1	873	881	PF00069	0.448
DOC_MAPK_gen_1	9	19	PF00069	0.404
DOC_MAPK_MEF2A_6	12	21	PF00069	0.424
DOC_MAPK_MEF2A_6	44	53	PF00069	0.503
DOC_MAPK_MEF2A_6	802	810	PF00069	0.381
DOC_PP1_RVXF_1	780	786	PF00149	0.560
DOC_PP2B_LxvP_1	311	314	PF13499	0.489
DOC_PP4_FxxP_1	11	14	PF00568	0.391
DOC_PP4_FxxP_1	443	446	PF00568	0.433
DOC_USP7_MATH_1	314	318	PF00917	0.563
DOC_USP7_MATH_1	389	393	PF00917	0.427
DOC_USP7_MATH_1	551	555	PF00917	0.692
DOC_USP7_MATH_1	668	672	PF00917	0.739
DOC_USP7_MATH_1	760	764	PF00917	0.561
DOC_USP7_MATH_1	786	790	PF00917	0.580
DOC_USP7_MATH_2	586	592	PF00917	0.555
DOC_USP7_UBL2_3	436	440	PF12436	0.509
DOC_WW_Pin1_4	628	633	PF00397	0.780
DOC_WW_Pin1_4	771	776	PF00397	0.450
LIG_14-3-3_CanoR_1	116	126	PF00244	0.657
LIG_14-3-3_CanoR_1	315	319	PF00244	0.618
LIG_14-3-3_CanoR_1	532	537	PF00244	0.709
LIG_14-3-3_CanoR_1	543	548	PF00244	0.614
LIG_APCC_ABBA_1	226	231	PF00400	0.435
LIG_APCC_ABBA_1	360	365	PF00400	0.473
LIG_APCC_ABBAyCdc20_2	225	231	PF00400	0.437
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BRCT_BRCA1_1	23	27	PF00533	0.515
LIG_Clathr_ClatBox_1	361	365	PF01394	0.475
LIG_Clathr_ClatBox_1	823	827	PF01394	0.445
LIG_deltaCOP1_diTrp_1	747	751	PF00928	0.511
LIG_eIF4E_1	772	778	PF01652	0.537
LIG_FHA_1	248	254	PF00498	0.423
LIG_FHA_1	301	307	PF00498	0.555
LIG_FHA_1	410	416	PF00498	0.444
LIG_FHA_1	651	657	PF00498	0.699
LIG_FHA_1	696	702	PF00498	0.639
LIG_FHA_1	752	758	PF00498	0.610
LIG_FHA_1	811	817	PF00498	0.519
LIG_FHA_1	861	867	PF00498	0.593
LIG_FHA_2	163	169	PF00498	0.536
LIG_FHA_2	212	218	PF00498	0.420
LIG_FHA_2	339	345	PF00498	0.516
LIG_FHA_2	425	431	PF00498	0.437
LIG_FHA_2	838	844	PF00498	0.652
LIG_HCF-1_HBM_1	372	375	PF13415	0.460
LIG_Integrin_isoDGR_2	519	521	PF01839	0.634
LIG_LIR_Apic_2	412	416	PF02991	0.409
LIG_LIR_Apic_2	441	446	PF02991	0.400
LIG_LIR_Gen_1	204	213	PF02991	0.384
LIG_LIR_Gen_1	217	226	PF02991	0.376
LIG_LIR_Gen_1	24	33	PF02991	0.565
LIG_LIR_Gen_1	295	306	PF02991	0.378
LIG_LIR_Gen_1	358	364	PF02991	0.332
LIG_LIR_Gen_1	404	415	PF02991	0.383
LIG_LIR_Gen_1	447	457	PF02991	0.531
LIG_LIR_Gen_1	45	54	PF02991	0.500
LIG_LIR_Gen_1	703	712	PF02991	0.501
LIG_LIR_Nem_3	204	210	PF02991	0.370
LIG_LIR_Nem_3	217	221	PF02991	0.385
LIG_LIR_Nem_3	24	28	PF02991	0.545
LIG_LIR_Nem_3	272	277	PF02991	0.727
LIG_LIR_Nem_3	295	301	PF02991	0.395
LIG_LIR_Nem_3	358	363	PF02991	0.423
LIG_LIR_Nem_3	404	410	PF02991	0.398
LIG_LIR_Nem_3	447	452	PF02991	0.500
LIG_LIR_Nem_3	45	51	PF02991	0.502
LIG_LIR_Nem_3	510	516	PF02991	0.502
LIG_LIR_Nem_3	843	848	PF02991	0.506
LIG_MYND_1	75	79	PF01753	0.571
LIG_Pex14_1	428	432	PF04695	0.522
LIG_Pex14_2	296	300	PF04695	0.419
LIG_Pex14_2	513	517	PF04695	0.580
LIG_Pex14_2	54	58	PF04695	0.416
LIG_PTB_Apo_2	52	59	PF02174	0.397
LIG_PTB_Apo_2	766	773	PF02174	0.560
LIG_PTB_Apo_2	912	919	PF02174	0.589
LIG_PTB_Phospho_1	766	772	PF10480	0.560
LIG_PTB_Phospho_1	912	918	PF10480	0.585
LIG_SH2_CRK	413	417	PF00017	0.372
LIG_SH2_CRK	772	776	PF00017	0.476
LIG_SH2_CRK	80	84	PF00017	0.431
LIG_SH2_CRK	803	807	PF00017	0.449
LIG_SH2_GRB2like	131	134	PF00017	0.656
LIG_SH2_GRB2like	715	718	PF00017	0.587
LIG_SH2_GRB2like	913	916	PF00017	0.578
LIG_SH2_NCK_1	131	135	PF00017	0.633
LIG_SH2_PTP2	581	584	PF00017	0.466
LIG_SH2_SRC	370	373	PF00017	0.393
LIG_SH2_SRC	581	584	PF00017	0.427
LIG_SH2_STAP1	131	135	PF00017	0.669
LIG_SH2_STAP1	603	607	PF00017	0.570
LIG_SH2_STAP1	705	709	PF00017	0.610
LIG_SH2_STAP1	868	872	PF00017	0.429
LIG_SH2_STAP1	909	913	PF00017	0.611
LIG_SH2_STAT3	213	216	PF00017	0.563
LIG_SH2_STAT3	914	917	PF00017	0.640
LIG_SH2_STAT5	131	134	PF00017	0.678
LIG_SH2_STAT5	213	216	PF00017	0.451
LIG_SH2_STAT5	370	373	PF00017	0.393
LIG_SH2_STAT5	449	452	PF00017	0.418
LIG_SH2_STAT5	526	529	PF00017	0.503
LIG_SH2_STAT5	581	584	PF00017	0.441
LIG_SH2_STAT5	596	599	PF00017	0.329
LIG_SH2_STAT5	797	800	PF00017	0.488
LIG_SH3_2	736	741	PF14604	0.505
LIG_SH3_3	454	460	PF00018	0.586
LIG_SH3_3	580	586	PF00018	0.535
LIG_SH3_3	733	739	PF00018	0.434
LIG_SUMO_SIM_anti_2	317	323	PF11976	0.587
LIG_SUMO_SIM_anti_2	404	412	PF11976	0.403
LIG_SUMO_SIM_anti_2	820	825	PF11976	0.428
LIG_SUMO_SIM_par_1	31	36	PF11976	0.393
LIG_SUMO_SIM_par_1	532	537	PF11976	0.571
LIG_SUMO_SIM_par_1	774	779	PF11976	0.573
LIG_TRAF2_1	262	265	PF00917	0.638
LIG_TRAF2_1	282	285	PF00917	0.572
LIG_TRFH_1	573	577	PF08558	0.555
LIG_TYR_ITIM	78	83	PF00017	0.428
LIG_WRC_WIRS_1	191	196	PF05994	0.498
LIG_WRC_WIRS_1	293	298	PF05994	0.425
LIG_WRC_WIRS_1	429	434	PF05994	0.453
MOD_CAAXbox	921	924	PF01239	0.549
MOD_CK1_1	211	217	PF00069	0.525
MOD_CK1_1	546	552	PF00069	0.717
MOD_CK1_1	789	795	PF00069	0.582
MOD_CK1_1	84	90	PF00069	0.475
MOD_CK2_1	229	235	PF00069	0.484
MOD_CK2_1	260	266	PF00069	0.698
MOD_CK2_1	424	430	PF00069	0.434
MOD_CK2_1	557	563	PF00069	0.706
MOD_CK2_1	631	637	PF00069	0.666
MOD_Cter_Amidation	104	107	PF01082	0.511
MOD_Cter_Amidation	519	522	PF01082	0.619
MOD_GlcNHglycan	351	354	PF01048	0.422
MOD_GlcNHglycan	36	40	PF01048	0.364
MOD_GlcNHglycan	391	394	PF01048	0.445
MOD_GlcNHglycan	536	539	PF01048	0.705
MOD_GlcNHglycan	543	546	PF01048	0.725
MOD_GlcNHglycan	552	556	PF01048	0.637
MOD_GlcNHglycan	633	636	PF01048	0.739
MOD_GlcNHglycan	670	673	PF01048	0.708
MOD_GlcNHglycan	792	795	PF01048	0.421
MOD_GlcNHglycan	83	86	PF01048	0.472
MOD_GlcNHglycan	868	871	PF01048	0.467
MOD_GSK3_1	125	132	PF00069	0.700
MOD_GSK3_1	13	20	PF00069	0.464
MOD_GSK3_1	190	197	PF00069	0.503
MOD_GSK3_1	243	250	PF00069	0.471
MOD_GSK3_1	269	276	PF00069	0.634
MOD_GSK3_1	292	299	PF00069	0.410
MOD_GSK3_1	336	343	PF00069	0.545
MOD_GSK3_1	424	431	PF00069	0.456
MOD_GSK3_1	532	539	PF00069	0.735
MOD_GSK3_1	541	548	PF00069	0.592
MOD_GSK3_1	631	638	PF00069	0.789
MOD_GSK3_1	643	650	PF00069	0.570
MOD_GSK3_1	692	699	PF00069	0.595
MOD_GSK3_1	786	793	PF00069	0.473
MOD_GSK3_1	81	88	PF00069	0.489
MOD_LATS_1	530	536	PF00433	0.614
MOD_N-GLC_1	229	234	PF02516	0.468
MOD_N-GLC_1	247	252	PF02516	0.427
MOD_N-GLC_1	417	422	PF02516	0.530
MOD_N-GLC_1	453	458	PF02516	0.503
MOD_N-GLC_1	628	633	PF02516	0.726
MOD_N-GLC_1	716	721	PF02516	0.573
MOD_NEK2_1	194	199	PF00069	0.502
MOD_NEK2_1	296	301	PF00069	0.433
MOD_NEK2_1	35	40	PF00069	0.348
MOD_NEK2_1	396	401	PF00069	0.600
MOD_NEK2_1	505	510	PF00069	0.511
MOD_NEK2_1	534	539	PF00069	0.655
MOD_NEK2_1	644	649	PF00069	0.690
MOD_NEK2_1	751	756	PF00069	0.603
MOD_NEK2_1	810	815	PF00069	0.482
MOD_NEK2_1	874	879	PF00069	0.439
MOD_NEK2_2	680	685	PF00069	0.556
MOD_NEK2_2	762	767	PF00069	0.584
MOD_PIKK_1	260	266	PF00454	0.559
MOD_PIKK_1	507	513	PF00454	0.558
MOD_PK_1	532	538	PF00069	0.783
MOD_PK_1	543	549	PF00069	0.630
MOD_PKA_2	242	248	PF00069	0.536
MOD_PKA_2	314	320	PF00069	0.598
MOD_PKA_2	389	395	PF00069	0.447
MOD_PKA_2	608	614	PF00069	0.625
MOD_PKA_2	874	880	PF00069	0.460
MOD_Plk_1	216	222	PF00069	0.425
MOD_Plk_1	326	332	PF00069	0.499
MOD_Plk_1	35	41	PF00069	0.333
MOD_Plk_1	417	423	PF00069	0.309
MOD_Plk_1	453	459	PF00069	0.570
MOD_Plk_1	62	68	PF00069	0.596
MOD_Plk_1	680	686	PF00069	0.634
MOD_Plk_1	696	702	PF00069	0.709
MOD_Plk_1	85	91	PF00069	0.608
MOD_Plk_2-3	822	828	PF00069	0.514
MOD_Plk_4	13	19	PF00069	0.512
MOD_Plk_4	190	196	PF00069	0.394
MOD_Plk_4	296	302	PF00069	0.409
MOD_Plk_4	418	424	PF00069	0.375
MOD_Plk_4	438	444	PF00069	0.243
MOD_Plk_4	696	702	PF00069	0.583
MOD_Plk_4	762	768	PF00069	0.480
MOD_ProDKin_1	628	634	PF00069	0.782
MOD_ProDKin_1	771	777	PF00069	0.445
MOD_SUMO_rev_2	473	479	PF00179	0.601
MOD_SUMO_rev_2	763	771	PF00179	0.571
TRG_AP2beta_CARGO_1	404	414	PF09066	0.402
TRG_DiLeu_BaEn_1	406	411	PF01217	0.398
TRG_DiLeu_BaEn_2	189	195	PF01217	0.370
TRG_ENDOCYTIC_2	298	301	PF00928	0.390
TRG_ENDOCYTIC_2	449	452	PF00928	0.383
TRG_ENDOCYTIC_2	581	584	PF00928	0.422
TRG_ENDOCYTIC_2	705	708	PF00928	0.567
TRG_ENDOCYTIC_2	797	800	PF00928	0.434
TRG_ENDOCYTIC_2	80	83	PF00928	0.423
TRG_ENDOCYTIC_2	803	806	PF00928	0.391
TRG_ER_diArg_1	111	114	PF00400	0.672
TRG_ER_diArg_1	177	180	PF00400	0.715
TRG_ER_diArg_1	314	316	PF00400	0.606
TRG_ER_diArg_1	521	523	PF00400	0.572
TRG_ER_diArg_1	616	618	PF00400	0.673
TRG_ER_diArg_1	674	676	PF00400	0.737
TRG_ER_diArg_1	805	808	PF00400	0.365
TRG_ER_diArg_1	872	875	PF00400	0.395
TRG_NES_CRM1_1	574	588	PF08389	0.543
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P463	Leptomonas seymouri	66%	99%
A0A0S4KIE0	Bodo saltans	26%	100%
A0A1X0NIL2	Trypanosomatidae	41%	100%
A0A422NPC4	Trypanosoma rangeli	39%	100%
A4HJP7	Leishmania braziliensis	78%	98%
A4I764	Leishmania infantum	100%	100%
C9ZME9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B258	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q602	Leishmania major	93%	100%
V5B2Y1	Trypanosoma cruzi	48%	100%