DUF447 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X4T4_LEIDO

TriTrypDb:

LdBPK_312500.1 , LdCL_310033000 , LDHU3_31.4500

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.557
CLV_NRD_NRD_1	104	106	PF00675	0.627
CLV_PCSK_KEX2_1	104	106	PF00082	0.532
CLV_PCSK_SKI1_1	188	192	PF00082	0.501
CLV_PCSK_SKI1_1	50	54	PF00082	0.480
DOC_MAPK_MEF2A_6	179	186	PF00069	0.466
DOC_SPAK_OSR1_1	179	183	PF12202	0.468
DOC_USP7_MATH_1	147	151	PF00917	0.610
DOC_USP7_MATH_1	173	177	PF00917	0.580
DOC_USP7_MATH_1	207	211	PF00917	0.525
DOC_WW_Pin1_4	19	24	PF00397	0.698
LIG_14-3-3_CanoR_1	104	108	PF00244	0.650
LIG_14-3-3_CanoR_1	188	193	PF00244	0.541
LIG_CaMK_CASK_1	183	188	PF00069	0.581
LIG_deltaCOP1_diTrp_1	84	89	PF00928	0.603
LIG_FHA_1	104	110	PF00498	0.548
LIG_FHA_1	130	136	PF00498	0.646
LIG_FHA_1	47	53	PF00498	0.514
LIG_FHA_2	189	195	PF00498	0.528
LIG_FHA_2	6	12	PF00498	0.627
LIG_LIR_Gen_1	176	184	PF02991	0.551
LIG_LIR_Nem_3	16	21	PF02991	0.649
LIG_LIR_Nem_3	176	180	PF02991	0.565
LIG_LIR_Nem_3	84	89	PF02991	0.635
LIG_MYND_1	2	6	PF01753	0.621
LIG_NBox_RRM_1	202	212	PF00076	0.523
LIG_Pex14_2	120	124	PF04695	0.639
LIG_REV1ctd_RIR_1	118	127	PF16727	0.552
LIG_SH2_CRK	216	220	PF00017	0.556
LIG_SH2_STAT5	62	65	PF00017	0.609
LIG_SH3_3	167	173	PF00018	0.656
LIG_SH3_3	20	26	PF00018	0.657
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.541
LIG_SUMO_SIM_par_1	49	56	PF11976	0.490
MOD_CK1_1	22	28	PF00069	0.555
MOD_CK2_1	5	11	PF00069	0.626
MOD_GlcNHglycan	147	150	PF01048	0.669
MOD_GSK3_1	125	132	PF00069	0.650
MOD_GSK3_1	145	152	PF00069	0.647
MOD_GSK3_1	162	169	PF00069	0.646
MOD_GSK3_1	219	226	PF00069	0.466
MOD_GSK3_1	38	45	PF00069	0.573
MOD_GSK3_1	46	53	PF00069	0.502
MOD_LATS_1	48	54	PF00433	0.572
MOD_NEK2_1	219	224	PF00069	0.489
MOD_NEK2_1	42	47	PF00069	0.730
MOD_NEK2_1	61	66	PF00069	0.524
MOD_PIKK_1	114	120	PF00454	0.643
MOD_PIKK_1	149	155	PF00454	0.529
MOD_PK_1	79	85	PF00069	0.579
MOD_PKA_2	103	109	PF00069	0.575
MOD_PKA_2	125	131	PF00069	0.599
MOD_PKA_2	13	19	PF00069	0.604
MOD_PKA_2	162	168	PF00069	0.607
MOD_Plk_1	166	172	PF00069	0.590
MOD_Plk_1	207	213	PF00069	0.549
MOD_Plk_1	42	48	PF00069	0.585
MOD_Plk_4	116	122	PF00069	0.609
MOD_Plk_4	166	172	PF00069	0.569
MOD_Plk_4	173	179	PF00069	0.495
MOD_Plk_4	208	214	PF00069	0.479
MOD_ProDKin_1	19	25	PF00069	0.693
TRG_ENDOCYTIC_2	177	180	PF00928	0.688
TRG_ENDOCYTIC_2	216	219	PF00928	0.547
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W0	Leptomonas seymouri	32%	100%
A0A0N1ILD5	Leptomonas seymouri	41%	80%
A4HJM6	Leishmania braziliensis	51%	100%
A4I748	Leishmania infantum	100%	100%
E9B242	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q619	Leishmania major	87%	100%