Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X4S8_LEIDO

TriTrypDb:

LdBPK_312300.1 , LdCL_310031000 , LDHU3_31.4100

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.629
CLV_C14_Caspase3-7	400	404	PF00656	0.754
CLV_C14_Caspase3-7	84	88	PF00656	0.647
CLV_C14_Caspase3-7	9	13	PF00656	0.855
CLV_NRD_NRD_1	247	249	PF00675	0.743
CLV_NRD_NRD_1	281	283	PF00675	0.625
CLV_PCSK_FUR_1	245	249	PF00082	0.736
CLV_PCSK_KEX2_1	245	247	PF00082	0.761
CLV_PCSK_KEX2_1	281	283	PF00082	0.625
CLV_PCSK_SKI1_1	281	285	PF00082	0.743
CLV_PCSK_SKI1_1	289	293	PF00082	0.643
CLV_PCSK_SKI1_1	309	313	PF00082	0.611
CLV_PCSK_SKI1_1	37	41	PF00082	0.581
CLV_PCSK_SKI1_1	438	442	PF00082	0.780
CLV_Separin_Metazoa	339	343	PF03568	0.592
DOC_CDC14_PxL_1	38	46	PF14671	0.713
DOC_USP7_MATH_1	119	123	PF00917	0.613
DOC_USP7_MATH_1	136	140	PF00917	0.667
DOC_USP7_MATH_1	19	23	PF00917	0.768
DOC_USP7_MATH_1	32	36	PF00917	0.673
DOC_USP7_MATH_1	65	69	PF00917	0.771
DOC_WW_Pin1_4	160	165	PF00397	0.785
DOC_WW_Pin1_4	191	196	PF00397	0.748
DOC_WW_Pin1_4	350	355	PF00397	0.672
DOC_WW_Pin1_4	379	384	PF00397	0.629
DOC_WW_Pin1_4	413	418	PF00397	0.684
DOC_WW_Pin1_4	63	68	PF00397	0.744
DOC_WW_Pin1_4	94	99	PF00397	0.788
LIG_14-3-3_CanoR_1	15	24	PF00244	0.728
LIG_14-3-3_CanoR_1	309	314	PF00244	0.670
LIG_14-3-3_CanoR_1	37	42	PF00244	0.717
LIG_BRCT_BRCA1_1	138	142	PF00533	0.603
LIG_BRCT_BRCA1_1	367	371	PF00533	0.680
LIG_BRCT_BRCA1_1	6	10	PF00533	0.664
LIG_eIF4E_1	38	44	PF01652	0.574
LIG_eIF4E_1	71	77	PF01652	0.684
LIG_FHA_1	199	205	PF00498	0.728
LIG_FHA_1	274	280	PF00498	0.653
LIG_FHA_1	335	341	PF00498	0.611
LIG_FHA_1	38	44	PF00498	0.634
LIG_FHA_1	54	60	PF00498	0.728
LIG_FHA_2	152	158	PF00498	0.719
LIG_FHA_2	416	422	PF00498	0.707
LIG_FHA_2	9	15	PF00498	0.780
LIG_LIR_Apic_2	68	74	PF02991	0.593
LIG_LIR_Gen_1	138	146	PF02991	0.695
LIG_LIR_Gen_1	268	279	PF02991	0.707
LIG_LIR_Gen_1	368	377	PF02991	0.683
LIG_LIR_Nem_3	138	143	PF02991	0.697
LIG_LIR_Nem_3	176	180	PF02991	0.816
LIG_LIR_Nem_3	202	208	PF02991	0.829
LIG_LIR_Nem_3	268	274	PF02991	0.708
LIG_LIR_Nem_3	368	374	PF02991	0.597
LIG_PAM2_1	15	27	PF00658	0.691
LIG_Pex14_1	155	159	PF04695	0.813
LIG_SH2_NCK_1	38	42	PF00017	0.754
LIG_SH2_NCK_1	49	53	PF00017	0.665
LIG_SH2_PTP2	71	74	PF00017	0.595
LIG_SH2_SRC	71	74	PF00017	0.682
LIG_SH2_STAP1	49	53	PF00017	0.660
LIG_SH2_STAT5	153	156	PF00017	0.779
LIG_SH2_STAT5	159	162	PF00017	0.723
LIG_SH2_STAT5	71	74	PF00017	0.682
LIG_SH3_2	380	385	PF14604	0.594
LIG_SH3_2	64	69	PF14604	0.710
LIG_SH3_3	115	121	PF00018	0.671
LIG_SH3_3	192	198	PF00018	0.742
LIG_SH3_3	220	226	PF00018	0.751
LIG_SH3_3	310	316	PF00018	0.734
LIG_SH3_3	377	383	PF00018	0.713
LIG_SH3_3	61	67	PF00018	0.782
LIG_WW_3	433	437	PF00397	0.784
MOD_CDC14_SPxK_1	382	385	PF00782	0.642
MOD_CDC14_SPxK_1	66	69	PF00782	0.713
MOD_CDK_SPK_2	191	196	PF00069	0.748
MOD_CDK_SPxK_1	379	385	PF00069	0.634
MOD_CDK_SPxK_1	63	69	PF00069	0.709
MOD_CK1_1	129	135	PF00069	0.683
MOD_CK1_1	163	169	PF00069	0.703
MOD_CK1_1	189	195	PF00069	0.852
MOD_CK1_1	235	241	PF00069	0.722
MOD_CK1_1	297	303	PF00069	0.646
MOD_CK1_1	304	310	PF00069	0.647
MOD_CK1_1	355	361	PF00069	0.817
MOD_CK1_1	398	404	PF00069	0.783
MOD_CK1_1	415	421	PF00069	0.565
MOD_CK1_1	8	14	PF00069	0.818
MOD_CK2_1	413	419	PF00069	0.754
MOD_Cter_Amidation	279	282	PF01082	0.622
MOD_DYRK1A_RPxSP_1	379	383	PF00069	0.586
MOD_GlcNHglycan	121	124	PF01048	0.720
MOD_GlcNHglycan	127	131	PF01048	0.726
MOD_GlcNHglycan	17	20	PF01048	0.775
MOD_GlcNHglycan	211	214	PF01048	0.747
MOD_GlcNHglycan	28	32	PF01048	0.694
MOD_GlcNHglycan	368	371	PF01048	0.749
MOD_GlcNHglycan	94	97	PF01048	0.743
MOD_GSK3_1	147	154	PF00069	0.702
MOD_GSK3_1	15	22	PF00069	0.707
MOD_GSK3_1	160	167	PF00069	0.542
MOD_GSK3_1	185	192	PF00069	0.784
MOD_GSK3_1	296	303	PF00069	0.713
MOD_GSK3_1	305	312	PF00069	0.604
MOD_GSK3_1	350	357	PF00069	0.734
MOD_GSK3_1	375	382	PF00069	0.809
MOD_GSK3_1	395	402	PF00069	0.525
MOD_GSK3_1	4	11	PF00069	0.794
MOD_GSK3_1	92	99	PF00069	0.692
MOD_N-GLC_1	24	29	PF02516	0.719
MOD_N-GLC_1	294	299	PF02516	0.680
MOD_N-GLC_1	304	309	PF02516	0.668
MOD_N-GLC_2	406	408	PF02516	0.629
MOD_NEK2_1	151	156	PF00069	0.804
MOD_NEK2_1	26	31	PF00069	0.808
MOD_NEK2_1	420	425	PF00069	0.787
MOD_NEK2_1	427	432	PF00069	0.726
MOD_PIKK_1	82	88	PF00454	0.695
MOD_PKA_2	235	241	PF00069	0.670
MOD_PKA_2	398	404	PF00069	0.815
MOD_PKA_2	427	433	PF00069	0.709
MOD_PKA_2	47	53	PF00069	0.799
MOD_PKB_1	397	405	PF00069	0.756
MOD_Plk_1	126	132	PF00069	0.708
MOD_Plk_1	297	303	PF00069	0.727
MOD_Plk_4	155	161	PF00069	0.721
MOD_Plk_4	19	25	PF00069	0.799
MOD_ProDKin_1	160	166	PF00069	0.782
MOD_ProDKin_1	191	197	PF00069	0.743
MOD_ProDKin_1	350	356	PF00069	0.671
MOD_ProDKin_1	379	385	PF00069	0.634
MOD_ProDKin_1	413	419	PF00069	0.684
MOD_ProDKin_1	63	69	PF00069	0.745
MOD_ProDKin_1	94	100	PF00069	0.789
MOD_SUMO_rev_2	345	350	PF00179	0.765
TRG_AP2beta_CARGO_1	138	147	PF09066	0.690
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.659
TRG_ER_diArg_1	245	248	PF00400	0.719
TRG_ER_diArg_1	396	399	PF00400	0.758
TRG_ER_diArg_1	435	438	PF00400	0.785

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJK4	Leishmania braziliensis	53%	100%
A4HJK7	Leishmania braziliensis	52%	100%
A4I706	Leishmania infantum	98%	100%
E9B224	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q638	Leishmania major	83%	100%