Ferredoxin 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin 2fe-2s-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4S6_LEIDO

TriTrypDb:

LdBPK_312570.1 , LdCL_310033600 , LDHU3_31.4600

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X4S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4S6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0022900	electron transport chain	4	13
GO:0044237	cellular metabolic process	2	13
GO:0140647	P450-containing electron transport chain	5	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0051536	iron-sulfur cluster binding	3	13
GO:0051537	2 iron, 2 sulfur cluster binding	4	13
GO:0051540	metal cluster binding	2	13
GO:0003824	catalytic activity	1	1
GO:0009055	electron transfer activity	3	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.589
CLV_PCSK_KEX2_1	14	16	PF00082	0.577
CLV_PCSK_SKI1_1	3	7	PF00082	0.597
DEG_APCC_DBOX_1	2	10	PF00400	0.542
DEG_ODPH_VHL_1	139	150	PF01847	0.364
DEG_SPOP_SBC_1	21	25	PF00917	0.690
DOC_MAPK_gen_1	129	139	PF00069	0.363
DOC_PP2B_LxvP_1	110	113	PF13499	0.333
DOC_USP7_MATH_1	16	20	PF00917	0.643
DOC_USP7_UBL2_3	50	54	PF12436	0.486
DOC_WW_Pin1_4	32	37	PF00397	0.646
DOC_WW_Pin1_4	38	43	PF00397	0.540
LIG_14-3-3_CanoR_1	132	139	PF00244	0.303
LIG_14-3-3_CanoR_1	15	21	PF00244	0.579
LIG_14-3-3_CanoR_1	31	36	PF00244	0.609
LIG_CtBP_PxDLS_1	37	41	PF00389	0.497
LIG_FHA_1	128	134	PF00498	0.301
LIG_FHA_1	94	100	PF00498	0.345
LIG_FHA_2	69	75	PF00498	0.332
LIG_LIR_Gen_1	105	113	PF02991	0.326
LIG_LIR_Nem_3	105	109	PF02991	0.286
LIG_MAD2	8	16	PF02301	0.490
LIG_MYND_1	38	42	PF01753	0.501
LIG_SH2_CRK	106	110	PF00017	0.338
LIG_SH3_3	1	7	PF00018	0.430
LIG_SH3_3	145	151	PF00018	0.433
LIG_UBA3_1	120	126	PF00899	0.391
LIG_UBA3_1	72	81	PF00899	0.420
MOD_CDK_SPxK_1	42	48	PF00069	0.602
MOD_CK1_1	131	137	PF00069	0.282
MOD_CK1_1	26	32	PF00069	0.586
MOD_CK1_1	41	47	PF00069	0.618
MOD_CK2_1	111	117	PF00069	0.322
MOD_CK2_1	52	58	PF00069	0.446
MOD_CK2_1	68	74	PF00069	0.185
MOD_GlcNHglycan	18	21	PF01048	0.630
MOD_GlcNHglycan	25	28	PF01048	0.505
MOD_GSK3_1	127	134	PF00069	0.287
MOD_GSK3_1	16	23	PF00069	0.539
MOD_GSK3_1	32	39	PF00069	0.581
MOD_GSK3_1	88	95	PF00069	0.305
MOD_LATS_1	52	58	PF00433	0.467
MOD_NEK2_1	22	27	PF00069	0.634
MOD_NEK2_1	68	73	PF00069	0.435
MOD_NEK2_2	93	98	PF00069	0.327
MOD_OFUCOSY	92	97	PF10250	0.279
MOD_PKA_2	131	137	PF00069	0.303
MOD_Plk_1	144	150	PF00069	0.550
MOD_Plk_2-3	111	117	PF00069	0.381
MOD_Plk_4	68	74	PF00069	0.300
MOD_ProDKin_1	32	38	PF00069	0.649
MOD_ProDKin_1	42	48	PF00069	0.603
MOD_SUMO_for_1	53	56	PF00179	0.453
TRG_ENDOCYTIC_2	106	109	PF00928	0.313
TRG_ER_diArg_1	14	16	PF00400	0.537
TRG_NES_CRM1_1	74	85	PF08389	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	44%	100%
A0A0N0P799	Leptomonas seymouri	59%	97%
A0A0N1HYR7	Leptomonas seymouri	37%	100%
A0A0N1I5P4	Leptomonas seymouri	47%	100%
A0A0N1ILD8	Leptomonas seymouri	41%	94%
A0A0N1PE81	Leptomonas seymouri	40%	100%
A0A0S4J024	Bodo saltans	56%	100%
A0A1X0NSB1	Trypanosomatidae	35%	89%
A0A3Q8IIS3	Leishmania donovani	44%	100%
A0A3R7MK78	Trypanosoma rangeli	62%	98%
A0A3S7X4U4	Leishmania donovani	38%	88%
A0A3S7X4W8	Leishmania donovani	48%	100%
A4HJN2	Leishmania braziliensis	79%	100%
A4HJN3	Leishmania braziliensis	44%	100%
A4HJN4	Leishmania braziliensis	40%	100%
A4HJN8	Leishmania braziliensis	46%	100%
A4HJN9	Leishmania braziliensis	40%	89%
A4I755	Leishmania infantum	100%	100%
A4I756	Leishmania infantum	44%	100%
A4I757	Leishmania infantum	46%	100%
A4I758	Leishmania infantum	43%	88%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	88%
P00257	Bos taurus	36%	86%
P00258	Sus scrofa	36%	86%
P13216	Gallus gallus	40%	100%
P29330	Ovis aries	38%	100%
P46656	Mus musculus	37%	85%
Q05B51	Bos taurus	35%	86%
Q4Q610	Leishmania major	37%	100%
Q4Q611	Leishmania major	46%	100%
Q4Q612	Leishmania major	45%	100%
Q4Q613	Leishmania major	98%	100%
Q4UKL2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	46%	100%
Q6P4F2	Homo sapiens	35%	86%
Q8SV19	Encephalitozoon cuniculi (strain GB-M1)	35%	100%
Q9AKC4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	46%	100%
Q9AKM6	Rickettsia montanensis	46%	100%
Q9M0V0	Arabidopsis thaliana	35%	81%
Q9ZDW6	Rickettsia prowazekii (strain Madrid E)	45%	100%