Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4S0_LEIDO

TriTrypDb:

LdBPK_312550.1 , LdCL_310033450 , LDHU3_31.4580

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X4S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.547
CLV_C14_Caspase3-7	421	425	PF00656	0.413
CLV_NRD_NRD_1	431	433	PF00675	0.493
CLV_NRD_NRD_1	490	492	PF00675	0.647
CLV_PCSK_KEX2_1	431	433	PF00082	0.493
CLV_PCSK_KEX2_1	490	492	PF00082	0.596
CLV_PCSK_SKI1_1	245	249	PF00082	0.504
CLV_PCSK_SKI1_1	431	435	PF00082	0.495
CLV_PCSK_SKI1_1	443	447	PF00082	0.501
DEG_APCC_DBOX_1	175	183	PF00400	0.352
DEG_Nend_Nbox_1	1	3	PF02207	0.369
DEG_SPOP_SBC_1	283	287	PF00917	0.545
DOC_ANK_TNKS_1	419	426	PF00023	0.414
DOC_CDC14_PxL_1	98	106	PF14671	0.458
DOC_CKS1_1	2	7	PF01111	0.355
DOC_CKS1_1	444	449	PF01111	0.552
DOC_CYCLIN_RxL_1	255	266	PF00134	0.345
DOC_MAPK_gen_1	228	235	PF00069	0.381
DOC_MAPK_gen_1	40	48	PF00069	0.373
DOC_MAPK_JIP1_4	404	410	PF00069	0.452
DOC_MAPK_MEF2A_6	228	235	PF00069	0.381
DOC_PP1_RVXF_1	243	250	PF00149	0.312
DOC_PP2B_LxvP_1	312	315	PF13499	0.304
DOC_PP2B_LxvP_1	461	464	PF13499	0.444
DOC_PP2B_PxIxI_1	334	340	PF00149	0.416
DOC_PP4_FxxP_1	392	395	PF00568	0.517
DOC_USP7_MATH_1	14	18	PF00917	0.422
DOC_USP7_MATH_1	284	288	PF00917	0.615
DOC_USP7_MATH_1	360	364	PF00917	0.675
DOC_USP7_MATH_1	448	452	PF00917	0.555
DOC_WW_Pin1_4	1	6	PF00397	0.353
DOC_WW_Pin1_4	285	290	PF00397	0.670
DOC_WW_Pin1_4	443	448	PF00397	0.621
LIG_14-3-3_CanoR_1	108	114	PF00244	0.601
LIG_14-3-3_CanoR_1	194	199	PF00244	0.488
LIG_14-3-3_CanoR_1	350	357	PF00244	0.551
LIG_14-3-3_CanoR_1	45	49	PF00244	0.450
LIG_14-3-3_CanoR_1	466	476	PF00244	0.412
LIG_Actin_WH2_2	168	186	PF00022	0.383
LIG_BRCT_BRCA1_1	128	132	PF00533	0.469
LIG_BRCT_BRCA1_1	16	20	PF00533	0.435
LIG_FHA_1	113	119	PF00498	0.641
LIG_FHA_1	162	168	PF00498	0.331
LIG_FHA_1	444	450	PF00498	0.565
LIG_FHA_2	183	189	PF00498	0.395
LIG_FHA_2	2	8	PF00498	0.363
LIG_FHA_2	302	308	PF00498	0.554
LIG_LIR_Apic_2	269	273	PF02991	0.374
LIG_LIR_Apic_2	389	395	PF02991	0.577
LIG_LIR_Gen_1	17	26	PF02991	0.339
LIG_LIR_Gen_1	236	247	PF02991	0.316
LIG_LIR_Gen_1	296	303	PF02991	0.410
LIG_LIR_Gen_1	47	56	PF02991	0.378
LIG_LIR_Gen_1	473	480	PF02991	0.349
LIG_LIR_Nem_3	17	23	PF02991	0.350
LIG_LIR_Nem_3	197	201	PF02991	0.396
LIG_LIR_Nem_3	236	242	PF02991	0.305
LIG_LIR_Nem_3	296	302	PF02991	0.365
LIG_LIR_Nem_3	473	478	PF02991	0.402
LIG_PCNA_yPIPBox_3	65	75	PF02747	0.501
LIG_PDZ_Class_3	491	496	PF00595	0.486
LIG_REV1ctd_RIR_1	139	148	PF16727	0.447
LIG_SH2_CRK	215	219	PF00017	0.271
LIG_SH2_CRK	239	243	PF00017	0.276
LIG_SH2_CRK	270	274	PF00017	0.395
LIG_SH2_NCK_1	215	219	PF00017	0.288
LIG_SH2_NCK_1	239	243	PF00017	0.276
LIG_SH2_SRC	12	15	PF00017	0.527
LIG_SH2_SRC	383	386	PF00017	0.508
LIG_SH2_SRC	422	425	PF00017	0.469
LIG_SH2_STAP1	215	219	PF00017	0.288
LIG_SH2_STAP1	299	303	PF00017	0.318
LIG_SH2_STAT5	119	122	PF00017	0.513
LIG_SH2_STAT5	201	204	PF00017	0.347
LIG_SH2_STAT5	215	218	PF00017	0.270
LIG_SH2_STAT5	234	237	PF00017	0.350
LIG_SH2_STAT5	31	34	PF00017	0.299
LIG_SH2_STAT5	383	386	PF00017	0.508
LIG_SH2_STAT5	422	425	PF00017	0.407
LIG_SH3_3	286	292	PF00018	0.699
LIG_SH3_3	3	9	PF00018	0.368
LIG_SH3_3	392	398	PF00018	0.626
LIG_SH3_3	399	405	PF00018	0.660
LIG_SH3_3	408	414	PF00018	0.436
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.577
LIG_SUMO_SIM_par_1	163	169	PF11976	0.333
LIG_SUMO_SIM_par_1	259	266	PF11976	0.417
LIG_TYR_ITIM	213	218	PF00017	0.273
LIG_TYR_ITIM	82	87	PF00017	0.445
LIG_WRC_WIRS_1	475	480	PF05994	0.344
MOD_CDK_SPxxK_3	1	8	PF00069	0.364
MOD_CK1_1	112	118	PF00069	0.505
MOD_CK1_1	126	132	PF00069	0.606
MOD_CK1_1	240	246	PF00069	0.439
MOD_CK1_1	305	311	PF00069	0.421
MOD_CK1_1	329	335	PF00069	0.630
MOD_CK1_1	338	344	PF00069	0.418
MOD_CK1_1	353	359	PF00069	0.612
MOD_CK1_1	390	396	PF00069	0.531
MOD_CK1_1	415	421	PF00069	0.424
MOD_CK1_1	451	457	PF00069	0.473
MOD_CK2_1	1	7	PF00069	0.419
MOD_CK2_1	124	130	PF00069	0.710
MOD_CK2_1	260	266	PF00069	0.489
MOD_CK2_1	301	307	PF00069	0.378
MOD_CK2_1	87	93	PF00069	0.402
MOD_GlcNHglycan	156	159	PF01048	0.366
MOD_GlcNHglycan	304	307	PF01048	0.459
MOD_GlcNHglycan	316	319	PF01048	0.515
MOD_GlcNHglycan	32	35	PF01048	0.346
MOD_GlcNHglycan	325	329	PF01048	0.670
MOD_GlcNHglycan	331	334	PF01048	0.563
MOD_GlcNHglycan	369	373	PF01048	0.655
MOD_GlcNHglycan	450	453	PF01048	0.481
MOD_GlcNHglycan	79	82	PF01048	0.431
MOD_GSK3_1	108	115	PF00069	0.473
MOD_GSK3_1	233	240	PF00069	0.485
MOD_GSK3_1	256	263	PF00069	0.415
MOD_GSK3_1	278	285	PF00069	0.770
MOD_GSK3_1	30	37	PF00069	0.333
MOD_GSK3_1	301	308	PF00069	0.450
MOD_GSK3_1	451	458	PF00069	0.419
MOD_GSK3_1	470	477	PF00069	0.405
MOD_GSK3_1	87	94	PF00069	0.502
MOD_N-GLC_1	360	365	PF02516	0.515
MOD_N-GLC_2	324	326	PF02516	0.431
MOD_N-GLC_2	368	370	PF02516	0.546
MOD_NEK2_1	426	431	PF00069	0.498
MOD_NEK2_1	75	80	PF00069	0.408
MOD_NEK2_2	14	19	PF00069	0.406
MOD_PIKK_1	412	418	PF00454	0.666
MOD_PKA_2	275	281	PF00069	0.568
MOD_PKA_2	44	50	PF00069	0.462
MOD_Plk_2-3	91	97	PF00069	0.372
MOD_Plk_4	166	172	PF00069	0.421
MOD_Plk_4	260	266	PF00069	0.500
MOD_Plk_4	387	393	PF00069	0.501
MOD_Plk_4	44	50	PF00069	0.393
MOD_Plk_4	474	480	PF00069	0.348
MOD_ProDKin_1	1	7	PF00069	0.357
MOD_ProDKin_1	285	291	PF00069	0.666
MOD_ProDKin_1	443	449	PF00069	0.616
MOD_SUMO_rev_2	147	151	PF00179	0.371
TRG_DiLeu_BaEn_1	70	75	PF01217	0.421
TRG_ENDOCYTIC_2	156	159	PF00928	0.512
TRG_ENDOCYTIC_2	215	218	PF00928	0.286
TRG_ENDOCYTIC_2	219	222	PF00928	0.309
TRG_ENDOCYTIC_2	239	242	PF00928	0.255
TRG_ENDOCYTIC_2	299	302	PF00928	0.390
TRG_ENDOCYTIC_2	49	52	PF00928	0.502
TRG_ENDOCYTIC_2	84	87	PF00928	0.428
TRG_ER_diArg_1	227	230	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD80	Leptomonas seymouri	48%	87%
A0A3R7M4U1	Trypanosoma rangeli	23%	100%
A4I753	Leishmania infantum	97%	100%
V5D2Y5	Trypanosoma cruzi	25%	100%