Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X4R8_LEIDO

TriTrypDb:

LdBPK_312080.1 , LdCL_310028800 , LDHU3_31.3750

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4R8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.677
CLV_C14_Caspase3-7	75	79	PF00656	0.559
CLV_MEL_PAP_1	7	13	PF00089	0.593
CLV_NRD_NRD_1	106	108	PF00675	0.671
CLV_NRD_NRD_1	301	303	PF00675	0.733
CLV_NRD_NRD_1	41	43	PF00675	0.652
CLV_NRD_NRD_1	472	474	PF00675	0.678
CLV_PCSK_KEX2_1	106	108	PF00082	0.671
CLV_PCSK_KEX2_1	301	303	PF00082	0.733
CLV_PCSK_KEX2_1	41	43	PF00082	0.652
CLV_PCSK_KEX2_1	472	474	PF00082	0.678
CLV_PCSK_PC7_1	468	474	PF00082	0.678
CLV_PCSK_SKI1_1	335	339	PF00082	0.705
CLV_PCSK_SKI1_1	369	373	PF00082	0.666
CLV_PCSK_SKI1_1	375	379	PF00082	0.606
CLV_PCSK_SKI1_1	42	46	PF00082	0.656
CLV_PCSK_SKI1_1	492	496	PF00082	0.533
DEG_SPOP_SBC_1	203	207	PF00917	0.706
DOC_CKS1_1	244	249	PF01111	0.597
DOC_CKS1_1	354	359	PF01111	0.660
DOC_CKS1_1	416	421	PF01111	0.623
DOC_CYCLIN_RxL_1	42	56	PF00134	0.692
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.653
DOC_MAPK_gen_1	290	300	PF00069	0.640
DOC_MAPK_gen_1	318	328	PF00069	0.689
DOC_MAPK_gen_1	335	345	PF00069	0.579
DOC_PP1_RVXF_1	367	373	PF00149	0.671
DOC_PP1_SILK_1	30	35	PF00149	0.521
DOC_PP2B_LxvP_1	235	238	PF13499	0.576
DOC_PP2B_LxvP_1	3	6	PF13499	0.655
DOC_PP2B_LxvP_1	343	346	PF13499	0.737
DOC_PP2B_LxvP_1	50	53	PF13499	0.699
DOC_PP2B_LxvP_1	59	62	PF13499	0.610
DOC_PP2B_LxvP_1	67	70	PF13499	0.524
DOC_PP2B_PxIxI_1	273	279	PF00149	0.601
DOC_PP4_FxxP_1	244	247	PF00568	0.621
DOC_USP7_MATH_1	124	128	PF00917	0.597
DOC_USP7_MATH_1	181	185	PF00917	0.701
DOC_USP7_MATH_1	198	202	PF00917	0.565
DOC_USP7_MATH_1	304	308	PF00917	0.681
DOC_USP7_MATH_1	336	340	PF00917	0.676
DOC_USP7_MATH_1	404	408	PF00917	0.623
DOC_USP7_MATH_1	446	450	PF00917	0.699
DOC_USP7_MATH_1	494	498	PF00917	0.530
DOC_USP7_MATH_1	53	57	PF00917	0.491
DOC_USP7_MATH_1	73	77	PF00917	0.654
DOC_USP7_MATH_2	419	425	PF00917	0.626
DOC_WW_Pin1_4	159	164	PF00397	0.704
DOC_WW_Pin1_4	243	248	PF00397	0.629
DOC_WW_Pin1_4	300	305	PF00397	0.699
DOC_WW_Pin1_4	353	358	PF00397	0.665
DOC_WW_Pin1_4	415	420	PF00397	0.619
LIG_14-3-3_CanoR_1	170	180	PF00244	0.677
LIG_14-3-3_CanoR_1	293	298	PF00244	0.723
LIG_14-3-3_CanoR_1	318	324	PF00244	0.653
LIG_14-3-3_CanoR_1	330	337	PF00244	0.601
LIG_14-3-3_CanoR_1	369	377	PF00244	0.670
LIG_Actin_WH2_2	325	340	PF00022	0.722
LIG_AP2alpha_1	372	376	PF02296	0.673
LIG_BRCT_BRCA1_1	198	202	PF00533	0.664
LIG_BRCT_BRCA1_1	486	490	PF00533	0.630
LIG_BRCT_BRCA1_2	486	492	PF00533	0.632
LIG_CtBP_PxDLS_1	225	229	PF00389	0.511
LIG_FHA_1	203	209	PF00498	0.677
LIG_FHA_1	246	252	PF00498	0.707
LIG_FHA_1	327	333	PF00498	0.665
LIG_FHA_1	411	417	PF00498	0.642
LIG_FHA_1	62	68	PF00498	0.722
LIG_FHA_2	205	211	PF00498	0.696
LIG_FHA_2	263	269	PF00498	0.700
LIG_FHA_2	270	276	PF00498	0.609
LIG_FHA_2	416	422	PF00498	0.708
LIG_FHA_2	450	456	PF00498	0.664
LIG_LIR_Apic_2	241	247	PF02991	0.620
LIG_LIR_Gen_1	114	122	PF02991	0.654
LIG_LIR_Gen_1	291	300	PF02991	0.714
LIG_LIR_Gen_1	421	431	PF02991	0.722
LIG_LIR_Gen_1	487	496	PF02991	0.566
LIG_LIR_Nem_3	114	118	PF02991	0.665
LIG_LIR_Nem_3	291	297	PF02991	0.761
LIG_LIR_Nem_3	390	395	PF02991	0.665
LIG_LIR_Nem_3	415	420	PF02991	0.695
LIG_LIR_Nem_3	421	426	PF02991	0.712
LIG_LIR_Nem_3	487	493	PF02991	0.637
LIG_LIR_Nem_3	83	89	PF02991	0.632
LIG_PDZ_Class_1	495	500	PF00595	0.632
LIG_Pex14_2	372	376	PF04695	0.673
LIG_SH2_CRK	4	8	PF00017	0.597
LIG_SH2_SRC	221	224	PF00017	0.727
LIG_SH2_STAP1	115	119	PF00017	0.668
LIG_SH2_STAT5	221	224	PF00017	0.727
LIG_SH2_STAT5	417	420	PF00017	0.655
LIG_SH2_STAT5	485	488	PF00017	0.739
LIG_SH3_3	118	124	PF00018	0.617
LIG_SH3_3	131	137	PF00018	0.556
LIG_SH3_3	219	225	PF00018	0.720
LIG_SH3_3	248	254	PF00018	0.726
LIG_SH3_3	490	496	PF00018	0.554
LIG_SH3_3	82	88	PF00018	0.699
LIG_SUMO_SIM_par_1	411	418	PF11976	0.617
LIG_TRFH_1	283	287	PF08558	0.566
LIG_Vh1_VBS_1	445	463	PF01044	0.642
LIG_WRC_WIRS_1	297	302	PF05994	0.649
MOD_CDK_SPK_2	159	164	PF00069	0.675
MOD_CK1_1	148	154	PF00069	0.674
MOD_CK1_1	158	164	PF00069	0.640
MOD_CK1_1	206	212	PF00069	0.725
MOD_CK1_1	236	242	PF00069	0.620
MOD_CK1_1	279	285	PF00069	0.678
MOD_CK1_1	288	294	PF00069	0.612
MOD_CK1_1	296	302	PF00069	0.576
MOD_CK1_1	305	311	PF00069	0.572
MOD_CK1_1	341	347	PF00069	0.670
MOD_CK1_1	348	354	PF00069	0.634
MOD_CK1_1	398	404	PF00069	0.681
MOD_CK1_1	406	412	PF00069	0.609
MOD_CK1_1	449	455	PF00069	0.673
MOD_CK1_1	76	82	PF00069	0.556
MOD_CK2_1	125	131	PF00069	0.632
MOD_CK2_1	144	150	PF00069	0.524
MOD_CK2_1	151	157	PF00069	0.646
MOD_CK2_1	204	210	PF00069	0.678
MOD_CK2_1	336	342	PF00069	0.675
MOD_CK2_1	415	421	PF00069	0.771
MOD_CK2_1	449	455	PF00069	0.673
MOD_CK2_1	76	82	PF00069	0.556
MOD_GlcNHglycan	157	160	PF01048	0.655
MOD_GlcNHglycan	198	201	PF01048	0.680
MOD_GlcNHglycan	214	217	PF01048	0.571
MOD_GlcNHglycan	235	238	PF01048	0.655
MOD_GlcNHglycan	278	281	PF01048	0.726
MOD_GlcNHglycan	304	307	PF01048	0.677
MOD_GlcNHglycan	314	317	PF01048	0.608
MOD_GlcNHglycan	347	350	PF01048	0.728
MOD_GlcNHglycan	351	354	PF01048	0.682
MOD_GlcNHglycan	389	392	PF01048	0.718
MOD_GlcNHglycan	397	400	PF01048	0.598
MOD_GlcNHglycan	486	489	PF01048	0.626
MOD_GSK3_1	125	132	PF00069	0.599
MOD_GSK3_1	144	151	PF00069	0.544
MOD_GSK3_1	155	162	PF00069	0.710
MOD_GSK3_1	166	173	PF00069	0.695
MOD_GSK3_1	198	205	PF00069	0.704
MOD_GSK3_1	227	234	PF00069	0.725
MOD_GSK3_1	281	288	PF00069	0.714
MOD_GSK3_1	289	296	PF00069	0.696
MOD_GSK3_1	300	307	PF00069	0.601
MOD_GSK3_1	308	315	PF00069	0.572
MOD_GSK3_1	324	331	PF00069	0.574
MOD_GSK3_1	337	344	PF00069	0.585
MOD_GSK3_1	345	352	PF00069	0.680
MOD_GSK3_1	380	387	PF00069	0.618
MOD_GSK3_1	400	407	PF00069	0.503
MOD_GSK3_1	480	487	PF00069	0.628
MOD_GSK3_1	76	83	PF00069	0.552
MOD_LATS_1	143	149	PF00433	0.627
MOD_LATS_1	168	174	PF00433	0.607
MOD_N-GLC_1	124	129	PF02516	0.604
MOD_N-GLC_1	203	208	PF02516	0.734
MOD_N-GLC_1	324	329	PF02516	0.601
MOD_N-GLC_1	80	85	PF02516	0.699
MOD_NEK2_1	129	134	PF00069	0.636
MOD_NEK2_1	144	149	PF00069	0.582
MOD_NEK2_1	202	207	PF00069	0.714
MOD_NEK2_1	326	331	PF00069	0.724
MOD_NEK2_1	408	413	PF00069	0.611
MOD_NEK2_1	479	484	PF00069	0.751
MOD_PIKK_1	151	157	PF00454	0.719
MOD_PIKK_1	330	336	PF00454	0.638
MOD_PIKK_1	408	414	PF00454	0.644
MOD_PK_1	28	34	PF00069	0.518
MOD_PKA_2	259	265	PF00069	0.679
MOD_PKA_2	289	295	PF00069	0.671
MOD_PKA_2	467	473	PF00069	0.705
MOD_PKA_2	9	15	PF00069	0.606
MOD_Plk_1	113	119	PF00069	0.673
MOD_Plk_1	181	187	PF00069	0.670
MOD_Plk_1	203	209	PF00069	0.694
MOD_Plk_1	324	330	PF00069	0.620
MOD_Plk_1	341	347	PF00069	0.639
MOD_Plk_1	73	79	PF00069	0.669
MOD_Plk_4	113	119	PF00069	0.670
MOD_Plk_4	125	131	PF00069	0.523
MOD_Plk_4	198	204	PF00069	0.723
MOD_Plk_4	28	34	PF00069	0.518
MOD_Plk_4	293	299	PF00069	0.643
MOD_Plk_4	384	390	PF00069	0.697
MOD_ProDKin_1	159	165	PF00069	0.704
MOD_ProDKin_1	243	249	PF00069	0.630
MOD_ProDKin_1	300	306	PF00069	0.700
MOD_ProDKin_1	353	359	PF00069	0.660
MOD_ProDKin_1	415	421	PF00069	0.618
MOD_SUMO_rev_2	147	154	PF00179	0.617
TRG_ENDOCYTIC_2	115	118	PF00928	0.617
TRG_ENDOCYTIC_2	4	7	PF00928	0.655
TRG_ER_diArg_1	18	21	PF00400	0.616
TRG_ER_diArg_1	23	26	PF00400	0.602
TRG_ER_diArg_1	300	302	PF00400	0.690
TRG_ER_diArg_1	471	473	PF00400	0.687
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJI6	Leishmania braziliensis	63%	100%
A4I6Y1	Leishmania infantum	99%	100%
E9B203	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q658	Leishmania major	90%	100%