Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X4R2_LEIDO

TriTrypDb:

LdBPK_312150.1 , LdCL_310029500 , LDHU3_31.3840

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4R2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.665
CLV_NRD_NRD_1	166	168	PF00675	0.653
CLV_NRD_NRD_1	180	182	PF00675	0.708
CLV_NRD_NRD_1	203	205	PF00675	0.711
CLV_NRD_NRD_1	206	208	PF00675	0.730
CLV_NRD_NRD_1	265	267	PF00675	0.656
CLV_NRD_NRD_1	314	316	PF00675	0.774
CLV_NRD_NRD_1	330	332	PF00675	0.552
CLV_NRD_NRD_1	347	349	PF00675	0.544
CLV_NRD_NRD_1	385	387	PF00675	0.570
CLV_NRD_NRD_1	9	11	PF00675	0.663
CLV_PCSK_FUR_1	204	208	PF00082	0.727
CLV_PCSK_KEX2_1	166	168	PF00082	0.653
CLV_PCSK_KEX2_1	180	182	PF00082	0.646
CLV_PCSK_KEX2_1	202	204	PF00082	0.704
CLV_PCSK_KEX2_1	206	208	PF00082	0.717
CLV_PCSK_KEX2_1	265	267	PF00082	0.656
CLV_PCSK_KEX2_1	314	316	PF00082	0.786
CLV_PCSK_KEX2_1	330	332	PF00082	0.556
CLV_PCSK_KEX2_1	347	349	PF00082	0.544
CLV_PCSK_KEX2_1	385	387	PF00082	0.570
CLV_PCSK_KEX2_1	9	11	PF00082	0.663
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.609
CLV_PCSK_PC7_1	198	204	PF00082	0.572
CLV_PCSK_PC7_1	343	349	PF00082	0.616
CLV_PCSK_SKI1_1	198	202	PF00082	0.601
CLV_PCSK_SKI1_1	210	214	PF00082	0.554
CLV_PCSK_SKI1_1	228	232	PF00082	0.576
CLV_PCSK_SKI1_1	249	253	PF00082	0.556
DEG_COP1_1	356	365	PF00400	0.669
DOC_CKS1_1	76	81	PF01111	0.668
DOC_MAPK_gen_1	314	322	PF00069	0.664
DOC_MAPK_gen_1	6	16	PF00069	0.614
DOC_MAPK_MEF2A_6	315	324	PF00069	0.663
DOC_MAPK_RevD_3	189	204	PF00069	0.622
DOC_PP4_FxxP_1	366	369	PF00568	0.603
DOC_PP4_MxPP_1	133	136	PF00568	0.516
DOC_USP7_MATH_1	103	107	PF00917	0.609
DOC_USP7_MATH_1	115	119	PF00917	0.735
DOC_USP7_MATH_1	137	141	PF00917	0.616
DOC_USP7_MATH_1	211	215	PF00917	0.633
DOC_USP7_MATH_1	341	345	PF00917	0.620
DOC_USP7_MATH_1	361	365	PF00917	0.572
DOC_USP7_UBL2_3	307	311	PF12436	0.684
DOC_WW_Pin1_4	1	6	PF00397	0.644
DOC_WW_Pin1_4	17	22	PF00397	0.698
DOC_WW_Pin1_4	184	189	PF00397	0.652
DOC_WW_Pin1_4	228	233	PF00397	0.647
DOC_WW_Pin1_4	25	30	PF00397	0.694
DOC_WW_Pin1_4	255	260	PF00397	0.603
DOC_WW_Pin1_4	331	336	PF00397	0.562
DOC_WW_Pin1_4	35	40	PF00397	0.594
DOC_WW_Pin1_4	355	360	PF00397	0.666
DOC_WW_Pin1_4	71	76	PF00397	0.642
LIG_14-3-3_CanoR_1	171	177	PF00244	0.619
LIG_14-3-3_CanoR_1	241	248	PF00244	0.580
LIG_14-3-3_CanoR_1	314	323	PF00244	0.661
LIG_14-3-3_CanoR_1	33	38	PF00244	0.650
LIG_14-3-3_CanoR_1	9	15	PF00244	0.677
LIG_14-3-3_CanoR_1	90	95	PF00244	0.635
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_2	185	189	PF00653	0.643
LIG_BIR_III_4	56	60	PF00653	0.551
LIG_BRCT_BRCA1_1	137	141	PF00533	0.668
LIG_BRCT_BRCA1_1	257	261	PF00533	0.640
LIG_CtBP_PxDLS_1	188	192	PF00389	0.640
LIG_DLG_GKlike_1	90	98	PF00625	0.657
LIG_FHA_1	11	17	PF00498	0.693
LIG_FHA_1	225	231	PF00498	0.639
LIG_FHA_1	26	32	PF00498	0.664
LIG_FHA_1	315	321	PF00498	0.663
LIG_FHA_1	40	46	PF00498	0.541
LIG_FHA_1	89	95	PF00498	0.666
LIG_FHA_2	314	320	PF00498	0.663
LIG_Integrin_RGD_1	338	340	PF01839	0.689
LIG_IRF3_LxIS_1	320	325	PF10401	0.667
LIG_LIR_Apic_2	364	369	PF02991	0.608
LIG_LIR_Gen_1	288	295	PF02991	0.646
LIG_LIR_Nem_3	138	144	PF02991	0.675
LIG_LIR_Nem_3	288	294	PF02991	0.644
LIG_LIR_Nem_3	373	378	PF02991	0.602
LIG_SH2_STAP1	88	92	PF00017	0.640
LIG_SH2_STAT5	109	112	PF00017	0.558
LIG_SH2_STAT5	293	296	PF00017	0.745
LIG_SH3_3	131	137	PF00018	0.637
LIG_SH3_3	139	145	PF00018	0.601
LIG_SH3_3	157	163	PF00018	0.549
LIG_SH3_3	229	235	PF00018	0.603
LIG_SH3_3	317	323	PF00018	0.632
LIG_SH3_3	346	352	PF00018	0.629
LIG_SUMO_SIM_anti_2	376	384	PF11976	0.616
LIG_SUMO_SIM_par_1	376	384	PF11976	0.616
LIG_TRAF2_1	316	319	PF00917	0.629
LIG_WRC_WIRS_1	248	253	PF05994	0.641
MOD_CDK_SPK_2	1	6	PF00069	0.644
MOD_CDK_SPK_2	228	233	PF00069	0.608
MOD_CDK_SPK_2	331	336	PF00069	0.541
MOD_CDK_SPxxK_3	331	338	PF00069	0.545
MOD_CK1_1	151	157	PF00069	0.539
MOD_CK1_1	158	164	PF00069	0.594
MOD_CK1_1	165	171	PF00069	0.553
MOD_CK1_1	172	178	PF00069	0.530
MOD_CK1_1	187	193	PF00069	0.644
MOD_CK1_1	214	220	PF00069	0.632
MOD_CK1_1	222	228	PF00069	0.582
MOD_CK1_1	250	256	PF00069	0.618
MOD_CK1_1	325	331	PF00069	0.678
MOD_CK1_1	364	370	PF00069	0.620
MOD_CK1_1	40	46	PF00069	0.606
MOD_CK1_1	86	92	PF00069	0.642
MOD_CK1_1	93	99	PF00069	0.565
MOD_CK2_1	17	23	PF00069	0.628
MOD_CK2_1	231	237	PF00069	0.645
MOD_CK2_1	313	319	PF00069	0.658
MOD_CK2_1	93	99	PF00069	0.614
MOD_DYRK1A_RPxSP_1	331	335	PF00069	0.536
MOD_DYRK1A_RPxSP_1	35	39	PF00069	0.604
MOD_GlcNHglycan	105	108	PF01048	0.630
MOD_GlcNHglycan	137	140	PF01048	0.570
MOD_GlcNHglycan	213	216	PF01048	0.672
MOD_GlcNHglycan	253	256	PF01048	0.661
MOD_GlcNHglycan	261	264	PF01048	0.659
MOD_GlcNHglycan	307	310	PF01048	0.647
MOD_GlcNHglycan	324	327	PF01048	0.529
MOD_GlcNHglycan	349	352	PF01048	0.569
MOD_GlcNHglycan	359	362	PF01048	0.597
MOD_GlcNHglycan	375	378	PF01048	0.505
MOD_GlcNHglycan	42	45	PF01048	0.651
MOD_GSK3_1	151	158	PF00069	0.628
MOD_GSK3_1	161	168	PF00069	0.559
MOD_GSK3_1	211	218	PF00069	0.733
MOD_GSK3_1	224	231	PF00069	0.691
MOD_GSK3_1	247	254	PF00069	0.622
MOD_GSK3_1	25	32	PF00069	0.611
MOD_GSK3_1	255	262	PF00069	0.581
MOD_GSK3_1	299	306	PF00069	0.724
MOD_GSK3_1	325	332	PF00069	0.646
MOD_GSK3_1	33	40	PF00069	0.616
MOD_GSK3_1	339	346	PF00069	0.573
MOD_GSK3_1	357	364	PF00069	0.549
MOD_GSK3_1	71	78	PF00069	0.655
MOD_GSK3_1	86	93	PF00069	0.639
MOD_GSK3_1	94	101	PF00069	0.721
MOD_LATS_1	8	14	PF00433	0.586
MOD_N-GLC_1	148	153	PF02516	0.611
MOD_NEK2_1	155	160	PF00069	0.639
MOD_NEK2_1	247	252	PF00069	0.636
MOD_PIKK_1	240	246	PF00454	0.582
MOD_PIKK_1	314	320	PF00454	0.631
MOD_PIKK_1	37	43	PF00454	0.582
MOD_PK_1	219	225	PF00069	0.652
MOD_PK_1	33	39	PF00069	0.622
MOD_PKA_1	166	172	PF00069	0.659
MOD_PKA_1	206	212	PF00069	0.625
MOD_PKA_1	265	271	PF00069	0.655
MOD_PKA_1	314	320	PF00069	0.661
MOD_PKA_1	347	353	PF00069	0.609
MOD_PKA_2	115	121	PF00069	0.644
MOD_PKA_2	165	171	PF00069	0.654
MOD_PKA_2	206	212	PF00069	0.760
MOD_PKA_2	215	221	PF00069	0.636
MOD_PKA_2	240	246	PF00069	0.628
MOD_PKA_2	265	271	PF00069	0.678
MOD_PKA_2	313	319	PF00069	0.658
MOD_PKA_2	329	335	PF00069	0.516
MOD_PKA_2	347	353	PF00069	0.532
MOD_PKB_1	204	212	PF00069	0.623
MOD_Plk_1	287	293	PF00069	0.647
MOD_Plk_1	299	305	PF00069	0.559
MOD_Plk_1	98	104	PF00069	0.562
MOD_Plk_4	151	157	PF00069	0.683
MOD_Plk_4	192	198	PF00069	0.658
MOD_Plk_4	247	253	PF00069	0.644
MOD_Plk_4	361	367	PF00069	0.661
MOD_ProDKin_1	1	7	PF00069	0.642
MOD_ProDKin_1	17	23	PF00069	0.696
MOD_ProDKin_1	184	190	PF00069	0.652
MOD_ProDKin_1	228	234	PF00069	0.645
MOD_ProDKin_1	25	31	PF00069	0.698
MOD_ProDKin_1	255	261	PF00069	0.606
MOD_ProDKin_1	331	337	PF00069	0.564
MOD_ProDKin_1	35	41	PF00069	0.593
MOD_ProDKin_1	355	361	PF00069	0.664
MOD_ProDKin_1	71	77	PF00069	0.645
TRG_ENDOCYTIC_2	248	251	PF00928	0.630
TRG_ER_diArg_1	206	208	PF00400	0.759
TRG_ER_diArg_1	313	315	PF00400	0.725
TRG_ER_diArg_1	329	331	PF00400	0.536
TRG_ER_diArg_1	347	349	PF00400	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I6Y8	Leishmania infantum	99%	100%
E9B209	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4Q652	Leishmania major	83%	99%