LeishMANIAdb
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CRAL/TRIO domain family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL/TRIO domain family protein
Gene product:
CRAL/TRIO domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X4R1_LEIDO
TriTrypDb:
LdBPK_312100.1 , LdCL_310029000 , LDHU3_31.3790
Length:
491

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 34
NetGPI no yes: 0, no: 34
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X4R1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4R1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 56 60 PF00656 0.551
CLV_NRD_NRD_1 299 301 PF00675 0.296
CLV_NRD_NRD_1 32 34 PF00675 0.440
CLV_PCSK_KEX2_1 34 36 PF00082 0.401
CLV_PCSK_KEX2_1 387 389 PF00082 0.310
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.431
CLV_PCSK_PC1ET2_1 387 389 PF00082 0.381
CLV_PCSK_SKI1_1 179 183 PF00082 0.310
CLV_PCSK_SKI1_1 23 27 PF00082 0.440
CLV_PCSK_SKI1_1 232 236 PF00082 0.333
CLV_PCSK_SKI1_1 250 254 PF00082 0.337
CLV_PCSK_SKI1_1 291 295 PF00082 0.382
CLV_PCSK_SKI1_1 387 391 PF00082 0.360
CLV_PCSK_SKI1_1 41 45 PF00082 0.341
CLV_Separin_Metazoa 30 34 PF03568 0.303
DOC_MAPK_gen_1 300 307 PF00069 0.360
DOC_MAPK_gen_1 85 94 PF00069 0.462
DOC_MAPK_HePTP_8 243 255 PF00069 0.294
DOC_MAPK_MEF2A_6 159 167 PF00069 0.326
DOC_MAPK_MEF2A_6 232 240 PF00069 0.358
DOC_MAPK_MEF2A_6 246 255 PF00069 0.441
DOC_MAPK_MEF2A_6 87 96 PF00069 0.441
DOC_PP4_FxxP_1 66 69 PF00568 0.286
DOC_USP7_MATH_1 3 7 PF00917 0.520
DOC_USP7_MATH_1 421 425 PF00917 0.599
DOC_USP7_MATH_1 443 447 PF00917 0.518
DOC_USP7_UBL2_3 246 250 PF12436 0.479
DOC_USP7_UBL2_3 346 350 PF12436 0.464
DOC_WW_Pin1_4 187 192 PF00397 0.296
DOC_WW_Pin1_4 276 281 PF00397 0.290
DOC_WW_Pin1_4 307 312 PF00397 0.358
DOC_WW_Pin1_4 441 446 PF00397 0.565
DOC_WW_Pin1_4 48 53 PF00397 0.537
DOC_WW_Pin1_4 65 70 PF00397 0.287
LIG_14-3-3_CanoR_1 141 149 PF00244 0.445
LIG_14-3-3_CanoR_1 388 393 PF00244 0.368
LIG_14-3-3_CanoR_1 85 90 PF00244 0.440
LIG_Actin_WH2_2 371 389 PF00022 0.312
LIG_Clathr_ClatBox_1 125 129 PF01394 0.247
LIG_deltaCOP1_diTrp_1 82 89 PF00928 0.466
LIG_eIF4E_1 73 79 PF01652 0.449
LIG_FHA_1 149 155 PF00498 0.485
LIG_FHA_1 188 194 PF00498 0.449
LIG_FHA_1 233 239 PF00498 0.309
LIG_FHA_1 24 30 PF00498 0.443
LIG_FHA_1 357 363 PF00498 0.648
LIG_FHA_1 373 379 PF00498 0.404
LIG_FHA_1 412 418 PF00498 0.402
LIG_FHA_1 425 431 PF00498 0.334
LIG_FHA_2 346 352 PF00498 0.719
LIG_FHA_2 451 457 PF00498 0.395
LIG_FHA_2 54 60 PF00498 0.619
LIG_LIR_Apic_2 413 418 PF02991 0.433
LIG_LIR_Apic_2 65 69 PF02991 0.286
LIG_LIR_Gen_1 397 405 PF02991 0.372
LIG_LIR_Gen_1 457 465 PF02991 0.438
LIG_LIR_Gen_1 88 96 PF02991 0.447
LIG_LIR_Nem_3 12 17 PF02991 0.618
LIG_LIR_Nem_3 147 152 PF02991 0.395
LIG_LIR_Nem_3 244 248 PF02991 0.354
LIG_LIR_Nem_3 262 267 PF02991 0.364
LIG_LIR_Nem_3 397 403 PF02991 0.338
LIG_LIR_Nem_3 409 415 PF02991 0.371
LIG_LIR_Nem_3 457 463 PF02991 0.448
LIG_LIR_Nem_3 65 70 PF02991 0.468
LIG_LYPXL_SIV_4 286 294 PF13949 0.319
LIG_LYPXL_yS_3 14 17 PF13949 0.373
LIG_MAD2 123 131 PF02301 0.243
LIG_OCRL_FandH_1 470 482 PF00620 0.290
LIG_PCNA_PIPBox_1 195 204 PF02747 0.266
LIG_PCNA_PIPBox_1 257 266 PF02747 0.196
LIG_Pex14_2 412 416 PF04695 0.325
LIG_Pex14_2 460 464 PF04695 0.221
LIG_PTB_Apo_2 69 76 PF02174 0.245
LIG_PTB_Phospho_1 69 75 PF10480 0.245
LIG_SH2_CRK 287 291 PF00017 0.367
LIG_SH2_CRK 36 40 PF00017 0.459
LIG_SH2_CRK 49 53 PF00017 0.541
LIG_SH2_GRB2like 166 169 PF00017 0.446
LIG_SH2_SRC 341 344 PF00017 0.456
LIG_SH2_STAT5 149 152 PF00017 0.341
LIG_SH2_STAT5 166 169 PF00017 0.278
LIG_SH2_STAT5 322 325 PF00017 0.382
LIG_SH2_STAT5 326 329 PF00017 0.378
LIG_SH2_STAT5 415 418 PF00017 0.389
LIG_SH2_STAT5 438 441 PF00017 0.498
LIG_SH2_STAT5 452 455 PF00017 0.338
LIG_SH2_STAT5 73 76 PF00017 0.365
LIG_SH3_3 128 134 PF00018 0.480
LIG_SH3_3 169 175 PF00018 0.223
LIG_SH3_3 274 280 PF00018 0.361
LIG_SUMO_SIM_anti_2 26 33 PF11976 0.243
LIG_SUMO_SIM_par_1 124 129 PF11976 0.236
LIG_SUMO_SIM_par_1 233 239 PF11976 0.352
LIG_SUMO_SIM_par_1 273 279 PF11976 0.210
LIG_TRAF2_1 19 22 PF00917 0.392
LIG_TRAF2_1 382 385 PF00917 0.464
LIG_TYR_ITIM 164 169 PF00017 0.369
LIG_TYR_ITIM 243 248 PF00017 0.399
LIG_UBA3_1 125 130 PF00899 0.247
LIG_UBA3_1 177 182 PF00899 0.403
LIG_UBA3_1 28 34 PF00899 0.521
LIG_UBA3_1 459 467 PF00899 0.235
LIG_WRC_WIRS_1 149 154 PF05994 0.196
LIG_WRC_WIRS_1 63 68 PF05994 0.516
MOD_CDC14_SPxK_1 68 71 PF00782 0.260
MOD_CDK_SPxK_1 65 71 PF00069 0.278
MOD_CK1_1 357 363 PF00069 0.644
MOD_CK1_1 424 430 PF00069 0.472
MOD_CK1_1 441 447 PF00069 0.483
MOD_CK1_1 469 475 PF00069 0.390
MOD_CK2_1 103 109 PF00069 0.273
MOD_CK2_1 168 174 PF00069 0.434
MOD_CK2_1 345 351 PF00069 0.547
MOD_CK2_1 430 436 PF00069 0.458
MOD_CK2_1 441 447 PF00069 0.381
MOD_CK2_1 48 54 PF00069 0.485
MOD_CK2_1 94 100 PF00069 0.301
MOD_GlcNHglycan 111 114 PF01048 0.452
MOD_GlcNHglycan 142 145 PF01048 0.366
MOD_GlcNHglycan 232 235 PF01048 0.196
MOD_GlcNHglycan 351 354 PF01048 0.675
MOD_GlcNHglycan 363 366 PF01048 0.647
MOD_GlcNHglycan 403 406 PF01048 0.449
MOD_GSK3_1 345 352 PF00069 0.629
MOD_GSK3_1 357 364 PF00069 0.602
MOD_GSK3_1 372 379 PF00069 0.461
MOD_GSK3_1 421 428 PF00069 0.398
MOD_GSK3_1 446 453 PF00069 0.384
MOD_GSK3_1 481 488 PF00069 0.410
MOD_N-GLC_2 72 74 PF02516 0.238
MOD_NEK2_1 230 235 PF00069 0.356
MOD_NEK2_1 256 261 PF00069 0.339
MOD_NEK2_1 349 354 PF00069 0.582
MOD_NEK2_1 425 430 PF00069 0.585
MOD_NEK2_1 481 486 PF00069 0.469
MOD_NEK2_1 53 58 PF00069 0.419
MOD_NEK2_1 92 97 PF00069 0.347
MOD_NEK2_2 62 67 PF00069 0.316
MOD_PK_1 394 400 PF00069 0.261
MOD_PKA_2 132 138 PF00069 0.495
MOD_PKA_2 140 146 PF00069 0.376
MOD_Plk_1 376 382 PF00069 0.478
MOD_Plk_4 232 238 PF00069 0.333
MOD_Plk_4 259 265 PF00069 0.425
MOD_Plk_4 394 400 PF00069 0.383
MOD_Plk_4 411 417 PF00069 0.417
MOD_Plk_4 430 436 PF00069 0.484
MOD_Plk_4 466 472 PF00069 0.367
MOD_Plk_4 62 68 PF00069 0.529
MOD_ProDKin_1 187 193 PF00069 0.296
MOD_ProDKin_1 276 282 PF00069 0.290
MOD_ProDKin_1 307 313 PF00069 0.358
MOD_ProDKin_1 441 447 PF00069 0.569
MOD_ProDKin_1 48 54 PF00069 0.552
MOD_ProDKin_1 65 71 PF00069 0.284
MOD_SUMO_for_1 222 225 PF00179 0.196
TRG_DiLeu_BaEn_1 24 29 PF01217 0.376
TRG_ENDOCYTIC_2 14 17 PF00928 0.598
TRG_ENDOCYTIC_2 149 152 PF00928 0.380
TRG_ENDOCYTIC_2 166 169 PF00928 0.340
TRG_ENDOCYTIC_2 212 215 PF00928 0.372
TRG_ENDOCYTIC_2 245 248 PF00928 0.372
TRG_ENDOCYTIC_2 287 290 PF00928 0.376
TRG_ENDOCYTIC_2 36 39 PF00928 0.467
TRG_ENDOCYTIC_2 75 78 PF00928 0.334
TRG_ER_diArg_1 32 35 PF00400 0.381

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6D4 Leptomonas seymouri 38% 94%
A0A0N0P991 Leptomonas seymouri 29% 100%
A0A0N0P9K9 Leptomonas seymouri 25% 100%
A0A0N1I2J8 Leptomonas seymouri 42% 100%
A0A0N1PCS4 Leptomonas seymouri 50% 100%
A0A0S4J7N0 Bodo saltans 24% 100%
A0A0S4KJL3 Bodo saltans 28% 100%
A0A1X0NUH5 Trypanosomatidae 26% 84%
A0A1X0NUJ5 Trypanosomatidae 26% 100%
A0A3Q8ICN0 Leishmania donovani 51% 100%
A0A3Q8IGQ2 Leishmania donovani 32% 97%
A0A3R7MUL5 Trypanosoma rangeli 25% 89%
A0A3S7X4P4 Leishmania donovani 41% 100%
A0A422P1E3 Trypanosoma rangeli 27% 100%
A4HJI7 Leishmania braziliensis 41% 100%
A4HJI8 Leishmania braziliensis 76% 100%
A4HJI9 Leishmania braziliensis 51% 100%
A4HKB3 Leishmania braziliensis 32% 99%
A4HKB4 Leishmania braziliensis 24% 100%
A4I6Y2 Leishmania infantum 41% 100%
A4I6Y3 Leishmania infantum 99% 100%
A4I6Y4 Leishmania infantum 51% 98%
A4I7U3 Leishmania infantum 32% 97%
B5MCN3 Homo sapiens 21% 100%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B205 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B206 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 98%
E9B2Q1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 98%
O17907 Caenorhabditis elegans 23% 100%
O76054 Homo sapiens 22% 100%
P58875 Bos taurus 21% 100%
Q03606 Caenorhabditis elegans 23% 68%
Q0V9N0 Xenopus tropicalis 23% 69%
Q16KN5 Aedes aegypti 23% 76%
Q4Q5F6 Leishmania major 33% 98%
Q4Q655 Leishmania major 49% 100%
Q4Q656 Leishmania major 93% 100%
Q4Q657 Leishmania major 41% 100%
Q8R0F9 Mus musculus 21% 100%
Q92503 Homo sapiens 22% 69%
Q99J08 Mus musculus 21% 100%
Q99MS0 Rattus norvegicus 21% 100%
Q9UDX3 Homo sapiens 23% 100%
Q9VMD6 Drosophila melanogaster 23% 75%
V5BL84 Trypanosoma cruzi 26% 100%
V5BQT0 Trypanosoma cruzi 25% 89%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS