AP2 domain transcription factor AP2X-11

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubercidin resistance protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4Q2_LEIDO

TriTrypDb:

LdBPK_312050.1 , LdCL_310028500 , LDHU3_31.3710

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X4Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4Q2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.720
CLV_C14_Caspase3-7	253	257	PF00656	0.672
CLV_C14_Caspase3-7	412	416	PF00656	0.737
CLV_NRD_NRD_1	277	279	PF00675	0.550
CLV_NRD_NRD_1	476	478	PF00675	0.571
CLV_PCSK_KEX2_1	476	478	PF00082	0.571
CLV_PCSK_SKI1_1	12	16	PF00082	0.553
CLV_PCSK_SKI1_1	481	485	PF00082	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.780
DEG_SCF_FBW7_1	319	324	PF00400	0.713
DEG_SPOP_SBC_1	308	312	PF00917	0.788
DEG_SPOP_SBC_1	455	459	PF00917	0.674
DEG_SPOP_SBC_1	81	85	PF00917	0.731
DOC_CKS1_1	144	149	PF01111	0.785
DOC_CKS1_1	540	545	PF01111	0.773
DOC_PP4_FxxP_1	575	578	PF00568	0.721
DOC_USP7_MATH_1	108	112	PF00917	0.712
DOC_USP7_MATH_1	178	182	PF00917	0.800
DOC_USP7_MATH_1	246	250	PF00917	0.663
DOC_USP7_MATH_1	307	311	PF00917	0.773
DOC_USP7_MATH_1	321	325	PF00917	0.679
DOC_USP7_MATH_1	367	371	PF00917	0.753
DOC_USP7_MATH_1	589	593	PF00917	0.412
DOC_USP7_MATH_1	80	84	PF00917	0.847
DOC_WW_Pin1_4	119	124	PF00397	0.696
DOC_WW_Pin1_4	134	139	PF00397	0.711
DOC_WW_Pin1_4	143	148	PF00397	0.733
DOC_WW_Pin1_4	216	221	PF00397	0.750
DOC_WW_Pin1_4	29	34	PF00397	0.763
DOC_WW_Pin1_4	303	308	PF00397	0.813
DOC_WW_Pin1_4	310	315	PF00397	0.761
DOC_WW_Pin1_4	317	322	PF00397	0.692
DOC_WW_Pin1_4	371	376	PF00397	0.773
DOC_WW_Pin1_4	460	465	PF00397	0.766
DOC_WW_Pin1_4	487	492	PF00397	0.731
DOC_WW_Pin1_4	494	499	PF00397	0.733
DOC_WW_Pin1_4	539	544	PF00397	0.777
LIG_14-3-3_CanoR_1	143	147	PF00244	0.762
LIG_14-3-3_CanoR_1	234	244	PF00244	0.736
LIG_Actin_WH2_2	407	422	PF00022	0.677
LIG_deltaCOP1_diTrp_1	232	240	PF00928	0.809
LIG_DLG_GKlike_1	534	542	PF00625	0.725
LIG_FHA_1	314	320	PF00498	0.784
LIG_FHA_1	329	335	PF00498	0.674
LIG_FHA_1	351	357	PF00498	0.817
LIG_FHA_1	406	412	PF00498	0.740
LIG_FHA_1	469	475	PF00498	0.671
LIG_FHA_1	488	494	PF00498	0.673
LIG_FHA_2	224	230	PF00498	0.684
LIG_FHA_2	318	324	PF00498	0.786
LIG_FHA_2	410	416	PF00498	0.774
LIG_FHA_2	446	452	PF00498	0.735
LIG_LIR_Apic_2	462	468	PF02991	0.700
LIG_LIR_Apic_2	509	514	PF02991	0.716
LIG_LIR_Gen_1	592	602	PF02991	0.299
LIG_LIR_Gen_1	93	103	PF02991	0.792
LIG_LIR_Nem_3	28	34	PF02991	0.674
LIG_LIR_Nem_3	569	575	PF02991	0.736
LIG_LIR_Nem_3	592	597	PF02991	0.299
LIG_LIR_Nem_3	93	98	PF02991	0.825
LIG_MYND_1	149	153	PF01753	0.687
LIG_NRBOX	226	232	PF00104	0.726
LIG_Pex14_2	590	594	PF04695	0.299
LIG_REV1ctd_RIR_1	357	366	PF16727	0.777
LIG_SH2_CRK	95	99	PF00017	0.750
LIG_SH2_NCK_1	465	469	PF00017	0.683
LIG_SH2_STAP1	95	99	PF00017	0.750
LIG_SH3_3	18	24	PF00018	0.731
LIG_SH3_3	27	33	PF00018	0.674
LIG_SH3_3	369	375	PF00018	0.779
LIG_SH3_3	540	546	PF00018	0.772
LIG_SH3_CIN85_PxpxPR_1	138	143	PF14604	0.684
LIG_SUMO_SIM_par_1	330	335	PF11976	0.718
LIG_SUMO_SIM_par_1	490	497	PF11976	0.698
LIG_TRAF2_1	226	229	PF00917	0.629
LIG_TRAF2_1	533	536	PF00917	0.677
LIG_TRAF2_1	567	570	PF00917	0.689
LIG_WRC_WIRS_1	356	361	PF05994	0.692
MOD_CDK_SPK_2	539	544	PF00069	0.777
MOD_CDK_SPxxK_3	143	150	PF00069	0.751
MOD_CK1_1	10	16	PF00069	0.753
MOD_CK1_1	111	117	PF00069	0.733
MOD_CK1_1	122	128	PF00069	0.752
MOD_CK1_1	155	161	PF00069	0.748
MOD_CK1_1	206	212	PF00069	0.803
MOD_CK1_1	235	241	PF00069	0.659
MOD_CK1_1	249	255	PF00069	0.667
MOD_CK1_1	284	290	PF00069	0.782
MOD_CK1_1	310	316	PF00069	0.776
MOD_CK1_1	340	346	PF00069	0.786
MOD_CK1_1	365	371	PF00069	0.751
MOD_CK1_1	463	469	PF00069	0.758
MOD_CK1_1	487	493	PF00069	0.705
MOD_CK1_1	518	524	PF00069	0.814
MOD_CK1_1	539	545	PF00069	0.741
MOD_CK1_1	55	61	PF00069	0.773
MOD_CK1_1	85	91	PF00069	0.819
MOD_CK1_1	93	99	PF00069	0.726
MOD_CK2_1	223	229	PF00069	0.670
MOD_CK2_1	288	294	PF00069	0.761
MOD_CK2_1	317	323	PF00069	0.789
MOD_CK2_1	348	354	PF00069	0.782
MOD_CK2_1	393	399	PF00069	0.767
MOD_CK2_1	44	50	PF00069	0.732
MOD_CK2_1	445	451	PF00069	0.740
MOD_CK2_1	530	536	PF00069	0.676
MOD_CK2_1	98	104	PF00069	0.741
MOD_GlcNHglycan	138	141	PF01048	0.496
MOD_GlcNHglycan	154	157	PF01048	0.473
MOD_GlcNHglycan	180	183	PF01048	0.606
MOD_GlcNHglycan	189	192	PF01048	0.518
MOD_GlcNHglycan	206	209	PF01048	0.561
MOD_GlcNHglycan	237	240	PF01048	0.558
MOD_GlcNHglycan	346	349	PF01048	0.638
MOD_GlcNHglycan	365	368	PF01048	0.550
MOD_GlcNHglycan	427	430	PF01048	0.603
MOD_GlcNHglycan	481	484	PF01048	0.479
MOD_GlcNHglycan	486	489	PF01048	0.450
MOD_GlcNHglycan	515	518	PF01048	0.594
MOD_GlcNHglycan	524	527	PF01048	0.470
MOD_GlcNHglycan	57	60	PF01048	0.632
MOD_GlcNHglycan	591	594	PF01048	0.468
MOD_GlcNHglycan	9	12	PF01048	0.521
MOD_GSK3_1	192	199	PF00069	0.765
MOD_GSK3_1	25	32	PF00069	0.705
MOD_GSK3_1	284	291	PF00069	0.789
MOD_GSK3_1	303	310	PF00069	0.773
MOD_GSK3_1	313	320	PF00069	0.730
MOD_GSK3_1	328	335	PF00069	0.697
MOD_GSK3_1	340	347	PF00069	0.761
MOD_GSK3_1	358	365	PF00069	0.793
MOD_GSK3_1	367	374	PF00069	0.717
MOD_GSK3_1	38	45	PF00069	0.716
MOD_GSK3_1	405	412	PF00069	0.740
MOD_GSK3_1	435	442	PF00069	0.827
MOD_GSK3_1	455	462	PF00069	0.687
MOD_GSK3_1	515	522	PF00069	0.790
MOD_GSK3_1	530	537	PF00069	0.681
MOD_GSK3_1	81	88	PF00069	0.766
MOD_GSK3_1	90	97	PF00069	0.678
MOD_LATS_1	532	538	PF00433	0.722
MOD_N-GLC_1	518	523	PF02516	0.521
MOD_N-GLC_1	65	70	PF02516	0.544
MOD_N-GLC_1	7	12	PF02516	0.487
MOD_NEK2_1	439	444	PF00069	0.741
MOD_NEK2_1	44	49	PF00069	0.732
MOD_NEK2_1	445	450	PF00069	0.716
MOD_NEK2_1	493	498	PF00069	0.753
MOD_NEK2_1	94	99	PF00069	0.748
MOD_PIKK_1	206	212	PF00454	0.756
MOD_PIKK_1	284	290	PF00454	0.770
MOD_PIKK_1	337	343	PF00454	0.729
MOD_PIKK_1	348	354	PF00454	0.733
MOD_PIKK_1	382	388	PF00454	0.746
MOD_PIKK_1	400	406	PF00454	0.744
MOD_PIKK_1	52	58	PF00454	0.734
MOD_PIKK_1	536	542	PF00454	0.744
MOD_PK_1	82	88	PF00069	0.678
MOD_PKA_2	142	148	PF00069	0.758
MOD_PKA_2	81	87	PF00069	0.682
MOD_Plk_1	255	261	PF00069	0.738
MOD_Plk_1	518	524	PF00069	0.736
MOD_Plk_1	534	540	PF00069	0.762
MOD_Plk_1	90	96	PF00069	0.739
MOD_Plk_4	355	361	PF00069	0.765
MOD_Plk_4	409	415	PF00069	0.821
MOD_Plk_4	82	88	PF00069	0.757
MOD_Plk_4	90	96	PF00069	0.677
MOD_ProDKin_1	119	125	PF00069	0.697
MOD_ProDKin_1	134	140	PF00069	0.710
MOD_ProDKin_1	143	149	PF00069	0.733
MOD_ProDKin_1	216	222	PF00069	0.748
MOD_ProDKin_1	29	35	PF00069	0.763
MOD_ProDKin_1	303	309	PF00069	0.815
MOD_ProDKin_1	310	316	PF00069	0.761
MOD_ProDKin_1	317	323	PF00069	0.693
MOD_ProDKin_1	371	377	PF00069	0.775
MOD_ProDKin_1	460	466	PF00069	0.765
MOD_ProDKin_1	487	493	PF00069	0.730
MOD_ProDKin_1	494	500	PF00069	0.732
MOD_ProDKin_1	539	545	PF00069	0.775
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.741
TRG_ENDOCYTIC_2	572	575	PF00928	0.728
TRG_ENDOCYTIC_2	95	98	PF00928	0.829
TRG_ER_diArg_1	476	478	PF00400	0.673
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJI3	Leishmania braziliensis	56%	99%
A4I732	Leishmania infantum	100%	100%
E9B200	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q661	Leishmania major	89%	100%