Aminopeptidase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aminopeptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4Q1_LEIDO

TriTrypDb:

LdBPK_312330.1 , LdCL_310031300 , LDHU3_31.4160

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X4Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4Q1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043171	peptide catabolic process	4	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004177	aminopeptidase activity	5	10
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0008238	exopeptidase activity	4	10
GO:0008270	zinc ion binding	6	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0008235	metalloexopeptidase activity	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0070006	metalloaminopeptidase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.617
CLV_NRD_NRD_1	152	154	PF00675	0.673
CLV_NRD_NRD_1	159	161	PF00675	0.622
CLV_NRD_NRD_1	287	289	PF00675	0.447
CLV_NRD_NRD_1	371	373	PF00675	0.528
CLV_NRD_NRD_1	43	45	PF00675	0.491
CLV_NRD_NRD_1	79	81	PF00675	0.506
CLV_PCSK_FUR_1	41	45	PF00082	0.555
CLV_PCSK_FUR_1	77	81	PF00082	0.545
CLV_PCSK_KEX2_1	152	154	PF00082	0.705
CLV_PCSK_KEX2_1	371	373	PF00082	0.528
CLV_PCSK_KEX2_1	43	45	PF00082	0.491
CLV_PCSK_KEX2_1	556	558	PF00082	0.362
CLV_PCSK_KEX2_1	79	81	PF00082	0.539
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.743
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.364
CLV_PCSK_PC7_1	367	373	PF00082	0.501
CLV_PCSK_SKI1_1	101	105	PF00082	0.538
CLV_PCSK_SKI1_1	189	193	PF00082	0.396
CLV_PCSK_SKI1_1	250	254	PF00082	0.360
CLV_PCSK_SKI1_1	277	281	PF00082	0.473
CLV_PCSK_SKI1_1	375	379	PF00082	0.561
CLV_PCSK_SKI1_1	541	545	PF00082	0.313
CLV_PCSK_SKI1_1	553	557	PF00082	0.329
CLV_PCSK_SKI1_1	85	89	PF00082	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DEG_SPOP_SBC_1	323	327	PF00917	0.689
DEG_SPOP_SBC_1	517	521	PF00917	0.433
DEG_SPOP_SBC_1	522	526	PF00917	0.368
DOC_CYCLIN_RxL_1	380	390	PF00134	0.494
DOC_MAPK_MEF2A_6	572	581	PF00069	0.396
DOC_PP1_RVXF_1	187	194	PF00149	0.401
DOC_PP1_RVXF_1	260	266	PF00149	0.410
DOC_PP2B_PxIxI_1	581	587	PF00149	0.490
DOC_PP4_FxxP_1	19	22	PF00568	0.465
DOC_PP4_FxxP_1	253	256	PF00568	0.335
DOC_PP4_FxxP_1	399	402	PF00568	0.335
DOC_USP7_MATH_1	142	146	PF00917	0.719
DOC_USP7_MATH_1	172	176	PF00917	0.733
DOC_USP7_MATH_1	509	513	PF00917	0.382
DOC_USP7_MATH_1	517	521	PF00917	0.360
DOC_USP7_MATH_1	522	526	PF00917	0.343
DOC_USP7_MATH_1	57	61	PF00917	0.713
DOC_USP7_UBL2_3	154	158	PF12436	0.636
DOC_WW_Pin1_4	299	304	PF00397	0.422
DOC_WW_Pin1_4	518	523	PF00397	0.406
DOC_WW_Pin1_4	601	606	PF00397	0.576
LIG_14-3-3_CanoR_1	214	219	PF00244	0.396
LIG_14-3-3_CanoR_1	375	384	PF00244	0.495
LIG_14-3-3_CanoR_1	535	543	PF00244	0.396
LIG_APCC_ABBA_1	199	204	PF00400	0.524
LIG_Clathr_ClatBox_1	190	194	PF01394	0.498
LIG_deltaCOP1_diTrp_1	185	193	PF00928	0.494
LIG_FHA_1	12	18	PF00498	0.414
LIG_FHA_1	207	213	PF00498	0.288
LIG_FHA_1	233	239	PF00498	0.463
LIG_FHA_1	35	41	PF00498	0.471
LIG_FHA_1	354	360	PF00498	0.585
LIG_FHA_1	376	382	PF00498	0.521
LIG_FHA_1	453	459	PF00498	0.443
LIG_FHA_1	524	530	PF00498	0.390
LIG_FHA_2	172	178	PF00498	0.771
LIG_FHA_2	240	246	PF00498	0.335
LIG_FHA_2	279	285	PF00498	0.447
LIG_FHA_2	513	519	PF00498	0.355
LIG_LIR_Gen_1	313	321	PF02991	0.506
LIG_LIR_Gen_1	360	369	PF02991	0.487
LIG_LIR_Gen_1	70	76	PF02991	0.559
LIG_LIR_Nem_3	274	279	PF02991	0.365
LIG_LIR_Nem_3	313	317	PF02991	0.462
LIG_LIR_Nem_3	360	364	PF02991	0.512
LIG_LIR_Nem_3	70	75	PF02991	0.530
LIG_NRBOX	410	416	PF00104	0.479
LIG_PDZ_Class_1	616	621	PF00595	0.608
LIG_Pex14_2	244	248	PF04695	0.479
LIG_SH2_CRK	361	365	PF00017	0.525
LIG_SH2_NCK_1	361	365	PF00017	0.518
LIG_SH2_SRC	438	441	PF00017	0.396
LIG_SH2_SRC	548	551	PF00017	0.447
LIG_SH2_STAP1	72	76	PF00017	0.550
LIG_SH2_STAT5	310	313	PF00017	0.365
LIG_SH2_STAT5	361	364	PF00017	0.525
LIG_SH2_STAT5	421	424	PF00017	0.354
LIG_SH2_STAT5	607	610	PF00017	0.404
LIG_SH3_3	253	259	PF00018	0.378
LIG_SH3_3	300	306	PF00018	0.340
LIG_SH3_3	337	343	PF00018	0.468
LIG_SH3_3	414	420	PF00018	0.373
LIG_SH3_3	474	480	PF00018	0.252
LIG_SH3_3	576	582	PF00018	0.523
LIG_SH3_3	599	605	PF00018	0.575
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.563
LIG_SUMO_SIM_anti_2	409	415	PF11976	0.346
LIG_SUMO_SIM_par_1	104	110	PF11976	0.424
LIG_SUMO_SIM_par_1	128	133	PF11976	0.554
LIG_TRAF2_1	585	588	PF00917	0.541
LIG_TRFH_1	361	365	PF08558	0.439
LIG_TYR_ITIM	359	364	PF00017	0.446
LIG_WRC_WIRS_1	215	220	PF05994	0.447
LIG_WRC_WIRS_1	311	316	PF05994	0.459
MOD_CK1_1	117	123	PF00069	0.610
MOD_CK1_1	141	147	PF00069	0.749
MOD_CK1_1	175	181	PF00069	0.678
MOD_CK1_1	20	26	PF00069	0.565
MOD_CK1_1	275	281	PF00069	0.340
MOD_CK1_1	351	357	PF00069	0.601
MOD_CK1_1	511	517	PF00069	0.434
MOD_CK1_1	521	527	PF00069	0.330
MOD_CK1_1	60	66	PF00069	0.685
MOD_CK2_1	239	245	PF00069	0.335
MOD_CK2_1	278	284	PF00069	0.447
MOD_CK2_1	420	426	PF00069	0.319
MOD_CK2_1	512	518	PF00069	0.476
MOD_Cter_Amidation	286	289	PF01082	0.447
MOD_Cter_Amidation	440	443	PF01082	0.432
MOD_GlcNHglycan	116	119	PF01048	0.564
MOD_GlcNHglycan	140	143	PF01048	0.650
MOD_GlcNHglycan	146	149	PF01048	0.690
MOD_GlcNHglycan	2	6	PF01048	0.614
MOD_GlcNHglycan	23	26	PF01048	0.518
MOD_GlcNHglycan	31	34	PF01048	0.419
MOD_GlcNHglycan	326	329	PF01048	0.689
MOD_GlcNHglycan	350	353	PF01048	0.608
MOD_GlcNHglycan	422	425	PF01048	0.319
MOD_GlcNHglycan	450	453	PF01048	0.362
MOD_GlcNHglycan	510	514	PF01048	0.357
MOD_GlcNHglycan	52	55	PF01048	0.718
MOD_GlcNHglycan	531	534	PF01048	0.495
MOD_GlcNHglycan	587	591	PF01048	0.406
MOD_GlcNHglycan	618	621	PF01048	0.609
MOD_GSK3_1	138	145	PF00069	0.702
MOD_GSK3_1	17	24	PF00069	0.542
MOD_GSK3_1	171	178	PF00069	0.702
MOD_GSK3_1	228	235	PF00069	0.420
MOD_GSK3_1	271	278	PF00069	0.355
MOD_GSK3_1	322	329	PF00069	0.696
MOD_GSK3_1	353	360	PF00069	0.597
MOD_GSK3_1	448	455	PF00069	0.378
MOD_GSK3_1	508	515	PF00069	0.326
MOD_GSK3_1	517	524	PF00069	0.335
MOD_GSK3_1	525	532	PF00069	0.179
MOD_GSK3_1	56	63	PF00069	0.701
MOD_N-GLC_1	357	362	PF02516	0.527
MOD_NEK2_1	17	22	PF00069	0.455
MOD_NEK2_1	359	364	PF00069	0.558
MOD_NEK2_1	495	500	PF00069	0.490
MOD_NEK2_1	543	548	PF00069	0.487
MOD_PIKK_1	206	212	PF00454	0.396
MOD_PK_1	128	134	PF00069	0.551
MOD_PKA_1	153	159	PF00069	0.687
MOD_PKA_2	20	26	PF00069	0.520
MOD_PKA_2	385	391	PF00069	0.479
MOD_PKA_2	47	53	PF00069	0.621
MOD_PKA_2	534	540	PF00069	0.444
MOD_Plk_1	142	148	PF00069	0.539
MOD_Plk_1	357	363	PF00069	0.483
MOD_Plk_2-3	67	73	PF00069	0.596
MOD_Plk_4	35	41	PF00069	0.521
MOD_Plk_4	359	365	PF00069	0.511
MOD_Plk_4	427	433	PF00069	0.392
MOD_Plk_4	495	501	PF00069	0.495
MOD_ProDKin_1	299	305	PF00069	0.422
MOD_ProDKin_1	518	524	PF00069	0.406
MOD_ProDKin_1	601	607	PF00069	0.577
MOD_SUMO_for_1	321	324	PF00179	0.567
TRG_DiLeu_BaEn_1	459	464	PF01217	0.387
TRG_DiLeu_BaEn_2	70	76	PF01217	0.557
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.428
TRG_DiLeu_LyEn_5	236	241	PF01217	0.479
TRG_ENDOCYTIC_2	361	364	PF00928	0.479
TRG_ENDOCYTIC_2	72	75	PF00928	0.555
TRG_ER_diArg_1	42	44	PF00400	0.480
TRG_ER_diArg_1	76	79	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC92	Leptomonas seymouri	57%	100%
A0A1X0NRQ5	Trypanosomatidae	38%	100%
A0A422N3Z8	Trypanosoma rangeli	35%	100%
A4HJK9	Leishmania braziliensis	75%	99%
A4I709	Leishmania infantum	100%	100%
C9ZWP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9B227	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q635	Leishmania major	92%	100%
V5AMB1	Trypanosoma cruzi	35%	100%