HEAT repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4Q0_LEIDO

TriTrypDb:

LdBPK_312340.1 , LdCL_310031400 , LDHU3_31.4170

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4Q0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0000774	adenyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0036094	small molecule binding	2	1
GO:0060590	ATPase regulator activity	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.551
CLV_C14_Caspase3-7	316	320	PF00656	0.367
CLV_NRD_NRD_1	359	361	PF00675	0.299
CLV_NRD_NRD_1	71	73	PF00675	0.467
CLV_PCSK_KEX2_1	71	73	PF00082	0.467
CLV_PCSK_KEX2_1	91	93	PF00082	0.371
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.403
CLV_PCSK_SKI1_1	360	364	PF00082	0.330
CLV_PCSK_SKI1_1	365	369	PF00082	0.325
CLV_PCSK_SKI1_1	417	421	PF00082	0.448
CLV_PCSK_SKI1_1	80	84	PF00082	0.473
CLV_PCSK_SKI1_1	91	95	PF00082	0.405
DEG_APCC_DBOX_1	79	87	PF00400	0.538
DOC_ANK_TNKS_1	439	446	PF00023	0.466
DOC_CYCLIN_RxL_1	91	101	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.427
DOC_MAPK_gen_1	91	98	PF00069	0.452
DOC_PP1_RVXF_1	363	370	PF00149	0.356
DOC_PP1_RVXF_1	449	455	PF00149	0.392
DOC_PP1_RVXF_1	92	99	PF00149	0.435
DOC_USP7_MATH_1	161	165	PF00917	0.590
DOC_USP7_MATH_1	167	171	PF00917	0.629
DOC_USP7_MATH_1	173	177	PF00917	0.664
DOC_USP7_MATH_1	44	48	PF00917	0.691
DOC_USP7_MATH_1	82	86	PF00917	0.480
DOC_WW_Pin1_4	289	294	PF00397	0.383
DOC_WW_Pin1_4	328	333	PF00397	0.529
DOC_WW_Pin1_4	412	417	PF00397	0.441
DOC_WW_Pin1_4	85	90	PF00397	0.496
LIG_14-3-3_CanoR_1	312	318	PF00244	0.373
LIG_14-3-3_CanoR_1	360	369	PF00244	0.348
LIG_14-3-3_CterR_2	460	462	PF00244	0.417
LIG_APCC_ABBA_1	197	202	PF00400	0.349
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_Clathr_ClatBox_1	97	101	PF01394	0.435
LIG_deltaCOP1_diTrp_1	129	137	PF00928	0.383
LIG_FHA_1	299	305	PF00498	0.432
LIG_FHA_1	312	318	PF00498	0.371
LIG_FHA_1	329	335	PF00498	0.706
LIG_FHA_1	357	363	PF00498	0.303
LIG_FHA_2	314	320	PF00498	0.441
LIG_FHA_2	340	346	PF00498	0.513
LIG_Integrin_RGD_1	179	181	PF01839	0.602
LIG_LIR_Gen_1	136	143	PF02991	0.360
LIG_LIR_Gen_1	201	211	PF02991	0.388
LIG_LIR_Gen_1	75	84	PF02991	0.547
LIG_LIR_Nem_3	201	206	PF02991	0.390
LIG_LIR_Nem_3	349	355	PF02991	0.470
LIG_LIR_Nem_3	75	79	PF02991	0.540
LIG_NRBOX	272	278	PF00104	0.370
LIG_Pex14_1	133	137	PF04695	0.362
LIG_PTAP_UEV_1	30	35	PF05743	0.630
LIG_SH2_CRK	352	356	PF00017	0.437
LIG_SH2_STAT5	372	375	PF00017	0.328
LIG_SH3_3	28	34	PF00018	0.676
LIG_SH3_3	83	89	PF00018	0.475
LIG_SUMO_SIM_anti_2	301	309	PF11976	0.494
LIG_SUMO_SIM_par_1	331	336	PF11976	0.472
LIG_TRAF2_1	120	123	PF00917	0.356
LIG_TRAF2_1	344	347	PF00917	0.521
LIG_TRAF2_1	379	382	PF00917	0.555
MOD_CDC14_SPxK_1	88	91	PF00782	0.438
MOD_CDK_SPK_2	412	417	PF00069	0.418
MOD_CDK_SPxK_1	85	91	PF00069	0.469
MOD_CDK_SPxxK_3	85	92	PF00069	0.462
MOD_CK1_1	2	8	PF00069	0.536
MOD_CK1_1	292	298	PF00069	0.453
MOD_CK1_1	393	399	PF00069	0.459
MOD_CK1_1	40	46	PF00069	0.615
MOD_CK1_1	47	53	PF00069	0.569
MOD_CK1_1	85	91	PF00069	0.469
MOD_CK2_1	317	323	PF00069	0.518
MOD_CK2_1	341	347	PF00069	0.707
MOD_CK2_1	376	382	PF00069	0.543
MOD_GlcNHglycan	166	170	PF01048	0.597
MOD_GlcNHglycan	194	197	PF01048	0.418
MOD_GlcNHglycan	209	212	PF01048	0.435
MOD_GlcNHglycan	24	27	PF01048	0.497
MOD_GlcNHglycan	301	304	PF01048	0.554
MOD_GlcNHglycan	31	34	PF01048	0.647
MOD_GlcNHglycan	392	395	PF01048	0.471
MOD_GlcNHglycan	4	7	PF01048	0.567
MOD_GlcNHglycan	49	52	PF01048	0.613
MOD_GlcNHglycan	80	83	PF01048	0.477
MOD_GSK3_1	161	168	PF00069	0.575
MOD_GSK3_1	288	295	PF00069	0.560
MOD_GSK3_1	313	320	PF00069	0.474
MOD_GSK3_1	333	340	PF00069	0.530
MOD_GSK3_1	356	363	PF00069	0.318
MOD_GSK3_1	372	379	PF00069	0.457
MOD_GSK3_1	40	47	PF00069	0.620
MOD_GSK3_1	78	85	PF00069	0.469
MOD_N-GLC_1	101	106	PF02516	0.499
MOD_N-GLC_1	34	39	PF02516	0.708
MOD_N-GLC_2	13	15	PF02516	0.458
MOD_NEK2_1	159	164	PF00069	0.531
MOD_NEK2_1	298	303	PF00069	0.520
MOD_NEK2_1	311	316	PF00069	0.312
MOD_NEK2_1	355	360	PF00069	0.404
MOD_NEK2_1	373	378	PF00069	0.438
MOD_PIKK_1	433	439	PF00454	0.430
MOD_PKA_1	360	366	PF00069	0.275
MOD_PKA_2	288	294	PF00069	0.336
MOD_PKA_2	29	35	PF00069	0.562
MOD_PKA_2	311	317	PF00069	0.544
MOD_PKA_2	40	46	PF00069	0.688
MOD_Plk_2-3	341	347	PF00069	0.451
MOD_Plk_4	269	275	PF00069	0.366
MOD_Plk_4	292	298	PF00069	0.388
MOD_Plk_4	317	323	PF00069	0.409
MOD_ProDKin_1	289	295	PF00069	0.377
MOD_ProDKin_1	328	334	PF00069	0.518
MOD_ProDKin_1	412	418	PF00069	0.439
MOD_ProDKin_1	85	91	PF00069	0.493
MOD_SUMO_rev_2	101	109	PF00179	0.506
TRG_DiLeu_BaEn_3	122	128	PF01217	0.395
TRG_DiLeu_BaEn_4	381	387	PF01217	0.356
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.387
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.359
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.369
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.439
TRG_ENDOCYTIC_2	352	355	PF00928	0.445
TRG_ENDOCYTIC_2	76	79	PF00928	0.542
TRG_NES_CRM1_1	236	250	PF08389	0.518
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXH6	Leptomonas seymouri	47%	100%
A4HJL0	Leishmania braziliensis	65%	100%
A4I710	Leishmania infantum	99%	100%
E9B228	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q634	Leishmania major	87%	100%
V5BA98	Trypanosoma cruzi	28%	100%