CRAL/TRIO domain containing protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4P4_LEIDO

TriTrypDb:

LdBPK_312090.1 , LdCL_310028900 , LDHU3_31.3770

Length:

520

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 37
NetGPI	no	yes: 0, no: 37

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X4P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.543
CLV_NRD_NRD_1	144	146	PF00675	0.497
CLV_NRD_NRD_1	342	344	PF00675	0.412
CLV_NRD_NRD_1	373	375	PF00675	0.396
CLV_NRD_NRD_1	376	378	PF00675	0.477
CLV_NRD_NRD_1	379	381	PF00675	0.473
CLV_NRD_NRD_1	490	492	PF00675	0.409
CLV_NRD_NRD_1	75	77	PF00675	0.557
CLV_PCSK_FUR_1	374	378	PF00082	0.444
CLV_PCSK_FUR_1	488	492	PF00082	0.288
CLV_PCSK_KEX2_1	373	375	PF00082	0.389
CLV_PCSK_KEX2_1	376	378	PF00082	0.472
CLV_PCSK_KEX2_1	379	381	PF00082	0.473
CLV_PCSK_KEX2_1	490	492	PF00082	0.484
CLV_PCSK_KEX2_1	75	77	PF00082	0.551
CLV_PCSK_SKI1_1	174	178	PF00082	0.337
CLV_PCSK_SKI1_1	191	195	PF00082	0.302
CLV_PCSK_SKI1_1	236	240	PF00082	0.464
CLV_PCSK_SKI1_1	264	268	PF00082	0.369
CLV_PCSK_SKI1_1	284	288	PF00082	0.344
CLV_PCSK_SKI1_1	307	311	PF00082	0.421
CLV_PCSK_SKI1_1	314	318	PF00082	0.395
CLV_PCSK_SKI1_1	35	39	PF00082	0.461
CLV_Separin_Metazoa	188	192	PF03568	0.231
DOC_CYCLIN_yCln2_LP_2	54	57	PF00134	0.523
DOC_MAPK_gen_1	171	181	PF00069	0.338
DOC_MAPK_gen_1	29	36	PF00069	0.467
DOC_MAPK_HePTP_8	266	278	PF00069	0.279
DOC_MAPK_MEF2A_6	269	278	PF00069	0.462
DOC_PP1_RVXF_1	321	328	PF00149	0.316
DOC_PP1_RVXF_1	495	502	PF00149	0.351
DOC_PP2B_LxvP_1	54	57	PF13499	0.601
DOC_PP4_FxxP_1	438	441	PF00568	0.356
DOC_USP7_MATH_1	237	241	PF00917	0.384
DOC_USP7_MATH_1	469	473	PF00917	0.501
DOC_USP7_UBL2_3	284	288	PF12436	0.219
DOC_WW_Pin1_4	140	145	PF00397	0.330
DOC_WW_Pin1_4	299	304	PF00397	0.275
LIG_14-3-3_CanoR_1	129	136	PF00244	0.392
LIG_14-3-3_CanoR_1	449	455	PF00244	0.514
LIG_APCC_ABBA_1	276	281	PF00400	0.393
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BRCT_BRCA1_1	471	475	PF00533	0.594
LIG_deltaCOP1_diTrp_1	94	101	PF00928	0.494
LIG_FHA_1	131	137	PF00498	0.411
LIG_FHA_1	161	167	PF00498	0.490
LIG_FHA_1	17	23	PF00498	0.614
LIG_FHA_1	216	222	PF00498	0.428
LIG_FHA_1	395	401	PF00498	0.396
LIG_FHA_1	435	441	PF00498	0.362
LIG_FHA_1	85	91	PF00498	0.228
LIG_FHA_2	1	7	PF00498	0.667
LIG_FHA_2	240	246	PF00498	0.454
LIG_FHA_2	337	343	PF00498	0.426
LIG_FHA_2	449	455	PF00498	0.338
LIG_FHA_2	89	95	PF00498	0.221
LIG_Integrin_isoDGR_2	172	174	PF01839	0.198
LIG_LIR_Apic_2	436	441	PF02991	0.392
LIG_LIR_Gen_1	205	215	PF02991	0.386
LIG_LIR_Gen_1	397	404	PF02991	0.425
LIG_LIR_Gen_1	432	443	PF02991	0.447
LIG_LIR_Gen_1	49	57	PF02991	0.350
LIG_LIR_Nem_3	39	44	PF02991	0.467
LIG_LIR_Nem_3	397	402	PF02991	0.417
LIG_LIR_Nem_3	432	438	PF02991	0.391
LIG_LIR_Nem_3	49	54	PF02991	0.483
LIG_OCRL_FandH_1	493	505	PF00620	0.296
LIG_Pex14_2	122	126	PF04695	0.338
LIG_Pex14_2	435	439	PF04695	0.339
LIG_REV1ctd_RIR_1	284	290	PF16727	0.194
LIG_SH2_CRK	224	228	PF00017	0.371
LIG_SH2_CRK	308	312	PF00017	0.364
LIG_SH2_CRK	41	45	PF00017	0.452
LIG_SH2_PTP2	399	402	PF00017	0.495
LIG_SH2_SRC	345	348	PF00017	0.397
LIG_SH2_STAP1	308	312	PF00017	0.215
LIG_SH2_STAT3	367	370	PF00017	0.305
LIG_SH2_STAT5	345	348	PF00017	0.361
LIG_SH2_STAT5	399	402	PF00017	0.413
LIG_SH2_STAT5	461	464	PF00017	0.460
LIG_SH2_STAT5	51	54	PF00017	0.502
LIG_SH2_STAT5	85	88	PF00017	0.376
LIG_SH3_1	40	46	PF00018	0.308
LIG_SH3_2	369	374	PF14604	0.547
LIG_SH3_3	297	303	PF00018	0.370
LIG_SH3_3	366	372	PF00018	0.516
LIG_SH3_3	40	46	PF00018	0.450
LIG_SH3_3	71	77	PF00018	0.693
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.351
LIG_SUMO_SIM_anti_2	479	486	PF11976	0.405
LIG_SUMO_SIM_par_1	213	220	PF11976	0.248
LIG_TYR_ITIM	176	181	PF00017	0.391
LIG_TYR_ITIM	222	227	PF00017	0.282
LIG_TYR_ITIM	306	311	PF00017	0.444
LIG_UBA3_1	189	194	PF00899	0.399
LIG_UBA3_1	33	38	PF00899	0.529
LIG_WRC_WIRS_1	181	186	PF05994	0.190
LIG_WRC_WIRS_1	435	440	PF05994	0.413
MOD_CDC14_SPxK_1	143	146	PF00782	0.326
MOD_CDK_SPK_2	140	145	PF00069	0.330
MOD_CDK_SPxK_1	140	146	PF00069	0.319
MOD_CK1_1	326	332	PF00069	0.389
MOD_CK1_1	459	465	PF00069	0.446
MOD_CK1_1	88	94	PF00069	0.351
MOD_CK2_1	180	186	PF00069	0.431
MOD_CK2_1	213	219	PF00069	0.410
MOD_CK2_1	239	245	PF00069	0.395
MOD_CK2_1	448	454	PF00069	0.603
MOD_CK2_1	514	520	PF00069	0.727
MOD_CK2_1	88	94	PF00069	0.469
MOD_GlcNHglycan	233	236	PF01048	0.413
MOD_GlcNHglycan	328	331	PF01048	0.417
MOD_GlcNHglycan	364	367	PF01048	0.484
MOD_GlcNHglycan	386	390	PF01048	0.701
MOD_GlcNHglycan	445	448	PF01048	0.393
MOD_GlcNHglycan	58	61	PF01048	0.732
MOD_GlcNHglycan	62	65	PF01048	0.787
MOD_GSK3_1	16	23	PF00069	0.547
MOD_GSK3_1	195	202	PF00069	0.364
MOD_GSK3_1	213	220	PF00069	0.203
MOD_GSK3_1	326	333	PF00069	0.351
MOD_GSK3_1	378	385	PF00069	0.707
MOD_GSK3_1	394	401	PF00069	0.455
MOD_GSK3_1	457	464	PF00069	0.479
MOD_GSK3_1	56	63	PF00069	0.642
MOD_GSK3_1	7	14	PF00069	0.692
MOD_GSK3_1	84	91	PF00069	0.378
MOD_N-GLC_1	414	419	PF02516	0.283
MOD_NEK2_1	443	448	PF00069	0.379
MOD_NEK2_1	84	89	PF00069	0.495
MOD_NEK2_2	124	129	PF00069	0.354
MOD_PIKK_1	448	454	PF00454	0.476
MOD_PKA_1	323	329	PF00069	0.377
MOD_PKA_2	372	378	PF00069	0.640
MOD_PKA_2	448	454	PF00069	0.336
MOD_Plk_1	117	123	PF00069	0.423
MOD_Plk_1	406	412	PF00069	0.395
MOD_Plk_4	217	223	PF00069	0.403
MOD_Plk_4	255	261	PF00069	0.346
MOD_Plk_4	301	307	PF00069	0.329
MOD_Plk_4	336	342	PF00069	0.315
MOD_Plk_4	434	440	PF00069	0.396
MOD_Plk_4	47	53	PF00069	0.302
MOD_Plk_4	85	91	PF00069	0.385
MOD_ProDKin_1	140	146	PF00069	0.335
MOD_ProDKin_1	299	305	PF00069	0.275
MOD_SUMO_rev_2	338	346	PF00179	0.288
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.552
TRG_ENDOCYTIC_2	178	181	PF00928	0.358
TRG_ENDOCYTIC_2	224	227	PF00928	0.371
TRG_ENDOCYTIC_2	308	311	PF00928	0.379
TRG_ENDOCYTIC_2	399	402	PF00928	0.396
TRG_ENDOCYTIC_2	41	44	PF00928	0.463
TRG_ENDOCYTIC_2	51	54	PF00928	0.450
TRG_ER_diArg_1	372	374	PF00400	0.384
TRG_ER_diArg_1	376	379	PF00400	0.491
TRG_ER_diArg_1	487	490	PF00400	0.529
TRG_ER_diArg_1	74	76	PF00400	0.604
TRG_NES_CRM1_1	205	219	PF08389	0.215
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	44%	99%
A0A0N0P991	Leptomonas seymouri	26%	100%
A0A0N0P992	Leptomonas seymouri	22%	68%
A0A0N0P9K9	Leptomonas seymouri	28%	100%
A0A0N1I2J8	Leptomonas seymouri	35%	100%
A0A0N1PCS4	Leptomonas seymouri	36%	100%
A0A0S4J7N0	Bodo saltans	26%	100%
A0A0S4KJL3	Bodo saltans	30%	100%
A0A1X0NUH5	Trypanosomatidae	22%	89%
A0A1X0NUJ5	Trypanosomatidae	27%	100%
A0A3Q8ICN0	Leishmania donovani	39%	100%
A0A3Q8IGQ2	Leishmania donovani	28%	100%
A0A3R7MUL5	Trypanosoma rangeli	25%	94%
A0A3S5H7R8	Leishmania donovani	25%	68%
A0A3S7X4R1	Leishmania donovani	41%	100%
A0A422P1E3	Trypanosoma rangeli	28%	100%
A4HJI7	Leishmania braziliensis	67%	99%
A4HJI8	Leishmania braziliensis	41%	100%
A4HJI9	Leishmania braziliensis	38%	96%
A4HKB3	Leishmania braziliensis	29%	100%
A4HKB4	Leishmania braziliensis	27%	100%
A4HKB5	Leishmania braziliensis	22%	68%
A4I6Y2	Leishmania infantum	99%	100%
A4I6Y3	Leishmania infantum	41%	99%
A4I6Y4	Leishmania infantum	39%	100%
A4I7U3	Leishmania infantum	28%	100%
A4I7U4	Leishmania infantum	25%	68%
A8Y5H7	Mus musculus	21%	73%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B2Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	68%
O43304	Homo sapiens	22%	75%
O76054	Homo sapiens	22%	100%
P58875	Bos taurus	22%	100%
Q03606	Caenorhabditis elegans	21%	72%
Q0V9N0	Xenopus tropicalis	22%	74%
Q4Q5F5	Leishmania major	24%	68%
Q4Q5F6	Leishmania major	28%	100%
Q4Q655	Leishmania major	39%	100%
Q4Q656	Leishmania major	40%	99%
Q4Q657	Leishmania major	88%	99%
Q92503	Homo sapiens	22%	73%
Q99J08	Mus musculus	22%	100%
Q99MS0	Rattus norvegicus	22%	100%
Q9UDX3	Homo sapiens	21%	100%
V5BL84	Trypanosoma cruzi	27%	100%
V5BQT0	Trypanosoma cruzi	24%	94%