LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved (fragment)
Species:
Leishmania donovani
UniProt:
A0A3S7X4P2_LEIDO
TriTrypDb:
LdBPK_312130.1 * , LdCL_310029200 , LDHU3_31.3820
Length:
770

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A0A3S7X4P2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4P2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 177 181 PF00656 0.475
CLV_C14_Caspase3-7 239 243 PF00656 0.546
CLV_C14_Caspase3-7 544 548 PF00656 0.615
CLV_C14_Caspase3-7 560 564 PF00656 0.622
CLV_C14_Caspase3-7 613 617 PF00656 0.780
CLV_NRD_NRD_1 10 12 PF00675 0.765
CLV_NRD_NRD_1 412 414 PF00675 0.742
CLV_NRD_NRD_1 428 430 PF00675 0.777
CLV_NRD_NRD_1 566 568 PF00675 0.431
CLV_NRD_NRD_1 573 575 PF00675 0.272
CLV_NRD_NRD_1 579 581 PF00675 0.453
CLV_NRD_NRD_1 606 608 PF00675 0.443
CLV_NRD_NRD_1 63 65 PF00675 0.727
CLV_NRD_NRD_1 763 765 PF00675 0.512
CLV_NRD_NRD_1 98 100 PF00675 0.813
CLV_PCSK_FUR_1 425 429 PF00082 0.764
CLV_PCSK_FUR_1 61 65 PF00082 0.764
CLV_PCSK_KEX2_1 271 273 PF00082 0.850
CLV_PCSK_KEX2_1 412 414 PF00082 0.742
CLV_PCSK_KEX2_1 425 427 PF00082 0.719
CLV_PCSK_KEX2_1 428 430 PF00082 0.762
CLV_PCSK_KEX2_1 566 568 PF00082 0.431
CLV_PCSK_KEX2_1 572 574 PF00082 0.445
CLV_PCSK_KEX2_1 579 581 PF00082 0.453
CLV_PCSK_KEX2_1 63 65 PF00082 0.727
CLV_PCSK_KEX2_1 98 100 PF00082 0.813
CLV_PCSK_PC1ET2_1 271 273 PF00082 0.831
CLV_PCSK_PC7_1 59 65 PF00082 0.765
CLV_PCSK_SKI1_1 136 140 PF00082 0.750
CLV_PCSK_SKI1_1 366 370 PF00082 0.812
CLV_PCSK_SKI1_1 476 480 PF00082 0.640
CLV_PCSK_SKI1_1 566 570 PF00082 0.403
CLV_PCSK_SKI1_1 579 583 PF00082 0.442
CLV_PCSK_SKI1_1 81 85 PF00082 0.768
DEG_APCC_DBOX_1 159 167 PF00400 0.522
DEG_APCC_DBOX_1 237 245 PF00400 0.546
DEG_SCF_FBW7_1 378 385 PF00400 0.517
DEG_SPOP_SBC_1 109 113 PF00917 0.572
DOC_MAPK_gen_1 442 450 PF00069 0.464
DOC_PP1_RVXF_1 577 584 PF00149 0.646
DOC_PP1_RVXF_1 684 690 PF00149 0.696
DOC_PP2B_LxvP_1 502 505 PF13499 0.630
DOC_PP4_MxPP_1 650 653 PF00568 0.593
DOC_USP7_MATH_1 109 113 PF00917 0.572
DOC_USP7_MATH_1 236 240 PF00917 0.554
DOC_USP7_MATH_1 300 304 PF00917 0.470
DOC_USP7_MATH_1 306 310 PF00917 0.518
DOC_USP7_MATH_1 351 355 PF00917 0.480
DOC_USP7_MATH_1 414 418 PF00917 0.577
DOC_USP7_MATH_1 440 444 PF00917 0.555
DOC_USP7_MATH_1 486 490 PF00917 0.538
DOC_USP7_MATH_1 496 500 PF00917 0.588
DOC_USP7_MATH_1 614 618 PF00917 0.746
DOC_WW_Pin1_4 251 256 PF00397 0.535
DOC_WW_Pin1_4 378 383 PF00397 0.554
DOC_WW_Pin1_4 427 432 PF00397 0.569
DOC_WW_Pin1_4 484 489 PF00397 0.612
DOC_WW_Pin1_4 606 611 PF00397 0.781
DOC_WW_Pin1_4 734 739 PF00397 0.497
DOC_WW_Pin1_4 81 86 PF00397 0.647
LIG_14-3-3_CanoR_1 11 17 PF00244 0.536
LIG_14-3-3_CanoR_1 160 164 PF00244 0.456
LIG_14-3-3_CanoR_1 235 245 PF00244 0.535
LIG_14-3-3_CanoR_1 314 321 PF00244 0.561
LIG_14-3-3_CanoR_1 355 361 PF00244 0.574
LIG_14-3-3_CanoR_1 366 373 PF00244 0.493
LIG_14-3-3_CanoR_1 39 45 PF00244 0.584
LIG_14-3-3_CanoR_1 413 419 PF00244 0.542
LIG_14-3-3_CanoR_1 52 56 PF00244 0.480
LIG_14-3-3_CanoR_1 693 701 PF00244 0.693
LIG_Actin_WH2_2 156 174 PF00022 0.565
LIG_BIR_II_1 1 5 PF00653 0.585
LIG_BRCT_BRCA1_1 129 133 PF00533 0.587
LIG_Clathr_ClatBox_1 552 556 PF01394 0.676
LIG_deltaCOP1_diTrp_1 328 335 PF00928 0.546
LIG_eIF4E_1 707 713 PF01652 0.439
LIG_FHA_1 160 166 PF00498 0.553
LIG_FHA_1 280 286 PF00498 0.552
LIG_FHA_1 379 385 PF00498 0.490
LIG_FHA_1 392 398 PF00498 0.422
LIG_FHA_1 402 408 PF00498 0.569
LIG_FHA_1 677 683 PF00498 0.551
LIG_FHA_1 761 767 PF00498 0.564
LIG_FHA_1 82 88 PF00498 0.486
LIG_FHA_2 328 334 PF00498 0.546
LIG_FHA_2 406 412 PF00498 0.537
LIG_FHA_2 611 617 PF00498 0.830
LIG_GBD_Chelix_1 285 293 PF00786 0.786
LIG_KLC1_Yacidic_2 446 451 PF13176 0.459
LIG_LIR_Apic_2 489 495 PF02991 0.498
LIG_LIR_Gen_1 207 217 PF02991 0.534
LIG_LIR_Gen_1 282 292 PF02991 0.528
LIG_LIR_Gen_1 46 55 PF02991 0.480
LIG_LIR_Gen_1 463 472 PF02991 0.446
LIG_LIR_Gen_1 517 528 PF02991 0.411
LIG_LIR_Gen_1 699 709 PF02991 0.616
LIG_LIR_Gen_1 737 748 PF02991 0.334
LIG_LIR_Nem_3 180 185 PF02991 0.475
LIG_LIR_Nem_3 207 213 PF02991 0.518
LIG_LIR_Nem_3 282 287 PF02991 0.589
LIG_LIR_Nem_3 46 51 PF02991 0.479
LIG_LIR_Nem_3 463 467 PF02991 0.451
LIG_LIR_Nem_3 470 475 PF02991 0.421
LIG_LIR_Nem_3 517 523 PF02991 0.411
LIG_LIR_Nem_3 527 533 PF02991 0.411
LIG_LIR_Nem_3 697 703 PF02991 0.683
LIG_LIR_Nem_3 736 742 PF02991 0.418
LIG_LIR_Nem_3 754 759 PF02991 0.404
LIG_NRBOX 288 294 PF00104 0.526
LIG_PDZ_Class_2 765 770 PF00595 0.744
LIG_Pex14_1 331 335 PF04695 0.544
LIG_REV1ctd_RIR_1 14 23 PF16727 0.571
LIG_RPA_C_Fungi 568 580 PF08784 0.536
LIG_SH2_CRK 492 496 PF00017 0.634
LIG_SH2_CRK 530 534 PF00017 0.552
LIG_SH2_CRK 759 763 PF00017 0.431
LIG_SH2_NCK_1 492 496 PF00017 0.634
LIG_SH2_PTP2 284 287 PF00017 0.750
LIG_SH2_PTP2 707 710 PF00017 0.509
LIG_SH2_SRC 449 452 PF00017 0.560
LIG_SH2_SRC 767 770 PF00017 0.710
LIG_SH2_STAP1 131 135 PF00017 0.745
LIG_SH2_STAP1 245 249 PF00017 0.688
LIG_SH2_STAP1 683 687 PF00017 0.485
LIG_SH2_STAT3 477 480 PF00017 0.657
LIG_SH2_STAT5 284 287 PF00017 0.750
LIG_SH2_STAT5 388 391 PF00017 0.563
LIG_SH2_STAT5 449 452 PF00017 0.634
LIG_SH2_STAT5 460 463 PF00017 0.621
LIG_SH2_STAT5 50 53 PF00017 0.605
LIG_SH2_STAT5 532 535 PF00017 0.542
LIG_SH2_STAT5 683 686 PF00017 0.483
LIG_SH2_STAT5 707 710 PF00017 0.474
LIG_SH2_STAT5 761 764 PF00017 0.615
LIG_SH2_STAT5 767 770 PF00017 0.633
LIG_SH3_1 428 434 PF00018 0.722
LIG_SH3_3 187 193 PF00018 0.691
LIG_SH3_3 2 8 PF00018 0.580
LIG_SH3_3 24 30 PF00018 0.713
LIG_SH3_3 275 281 PF00018 0.754
LIG_SH3_3 387 393 PF00018 0.619
LIG_SH3_3 428 434 PF00018 0.780
LIG_SH3_3 485 491 PF00018 0.682
LIG_SH3_3 708 714 PF00018 0.509
LIG_SUMO_SIM_par_1 551 556 PF11976 0.591
LIG_TYR_ITIM 528 533 PF00017 0.391
MOD_CDC14_SPxK_1 609 612 PF00782 0.636
MOD_CDK_SPxK_1 606 612 PF00069 0.666
MOD_CDK_SPxxK_3 251 258 PF00069 0.678
MOD_CDK_SPxxK_3 487 494 PF00069 0.805
MOD_CDK_SPxxK_3 81 88 PF00069 0.724
MOD_CK1_1 110 116 PF00069 0.779
MOD_CK1_1 117 123 PF00069 0.850
MOD_CK1_1 15 21 PF00069 0.701
MOD_CK1_1 313 319 PF00069 0.591
MOD_CK1_1 358 364 PF00069 0.737
MOD_CK1_1 470 476 PF00069 0.687
MOD_CK1_1 482 488 PF00069 0.605
MOD_CK1_1 510 516 PF00069 0.474
MOD_CK1_1 606 612 PF00069 0.791
MOD_CK1_1 618 624 PF00069 0.604
MOD_CK1_1 692 698 PF00069 0.584
MOD_CK1_1 70 76 PF00069 0.822
MOD_CK2_1 314 320 PF00069 0.749
MOD_CK2_1 327 333 PF00069 0.518
MOD_GlcNHglycan 142 145 PF01048 0.734
MOD_GlcNHglycan 148 151 PF01048 0.643
MOD_GlcNHglycan 200 203 PF01048 0.773
MOD_GlcNHglycan 206 209 PF01048 0.655
MOD_GlcNHglycan 298 301 PF01048 0.595
MOD_GlcNHglycan 308 311 PF01048 0.648
MOD_GlcNHglycan 316 319 PF01048 0.688
MOD_GlcNHglycan 361 364 PF01048 0.607
MOD_GlcNHglycan 40 43 PF01048 0.807
MOD_GlcNHglycan 408 411 PF01048 0.668
MOD_GlcNHglycan 416 419 PF01048 0.667
MOD_GlcNHglycan 498 501 PF01048 0.718
MOD_GlcNHglycan 502 505 PF01048 0.713
MOD_GlcNHglycan 507 510 PF01048 0.698
MOD_GlcNHglycan 616 620 PF01048 0.712
MOD_GlcNHglycan 627 630 PF01048 0.699
MOD_GlcNHglycan 632 635 PF01048 0.628
MOD_GSK3_1 104 111 PF00069 0.794
MOD_GSK3_1 112 119 PF00069 0.851
MOD_GSK3_1 146 153 PF00069 0.725
MOD_GSK3_1 155 162 PF00069 0.765
MOD_GSK3_1 215 222 PF00069 0.613
MOD_GSK3_1 266 273 PF00069 0.719
MOD_GSK3_1 288 295 PF00069 0.699
MOD_GSK3_1 296 303 PF00069 0.501
MOD_GSK3_1 306 313 PF00069 0.619
MOD_GSK3_1 327 334 PF00069 0.576
MOD_GSK3_1 351 358 PF00069 0.681
MOD_GSK3_1 378 385 PF00069 0.636
MOD_GSK3_1 391 398 PF00069 0.504
MOD_GSK3_1 401 408 PF00069 0.637
MOD_GSK3_1 482 489 PF00069 0.704
MOD_GSK3_1 496 503 PF00069 0.728
MOD_GSK3_1 510 517 PF00069 0.325
MOD_GSK3_1 519 526 PF00069 0.414
MOD_GSK3_1 606 613 PF00069 0.793
MOD_GSK3_1 614 621 PF00069 0.699
MOD_GSK3_1 67 74 PF00069 0.753
MOD_GSK3_1 677 684 PF00069 0.478
MOD_GSK3_1 687 694 PF00069 0.550
MOD_GSK3_1 713 720 PF00069 0.285
MOD_GSK3_1 734 741 PF00069 0.538
MOD_GSK3_1 747 754 PF00069 0.407
MOD_LATS_1 106 112 PF00433 0.739
MOD_LATS_1 69 75 PF00433 0.788
MOD_N-GLC_1 12 17 PF02516 0.643
MOD_N-GLC_1 31 36 PF02516 0.508
MOD_N-GLC_1 677 682 PF02516 0.496
MOD_N-GLC_1 687 692 PF02516 0.530
MOD_N-GLC_1 733 738 PF02516 0.391
MOD_N-GLC_1 74 79 PF02516 0.782
MOD_N-GLC_1 81 86 PF02516 0.676
MOD_NEK2_1 215 220 PF00069 0.609
MOD_NEK2_1 292 297 PF00069 0.709
MOD_NEK2_1 335 340 PF00069 0.668
MOD_NEK2_1 383 388 PF00069 0.655
MOD_NEK2_1 405 410 PF00069 0.671
MOD_NEK2_1 467 472 PF00069 0.513
MOD_NEK2_1 507 512 PF00069 0.715
MOD_NEK2_1 51 56 PF00069 0.624
MOD_NEK2_1 515 520 PF00069 0.370
MOD_NEK2_1 523 528 PF00069 0.300
MOD_NEK2_1 603 608 PF00069 0.735
MOD_NEK2_1 681 686 PF00069 0.516
MOD_NEK2_1 689 694 PF00069 0.580
MOD_NEK2_2 155 160 PF00069 0.692
MOD_PIKK_1 150 156 PF00454 0.663
MOD_PIKK_1 366 372 PF00454 0.801
MOD_PIKK_1 476 482 PF00454 0.614
MOD_PKA_1 271 277 PF00069 0.752
MOD_PKA_2 107 113 PF00069 0.655
MOD_PKA_2 117 123 PF00069 0.518
MOD_PKA_2 159 165 PF00069 0.696
MOD_PKA_2 237 243 PF00069 0.677
MOD_PKA_2 271 277 PF00069 0.752
MOD_PKA_2 313 319 PF00069 0.707
MOD_PKA_2 38 44 PF00069 0.710
MOD_PKA_2 51 57 PF00069 0.601
MOD_PKA_2 593 599 PF00069 0.668
MOD_PKA_2 614 620 PF00069 0.692
MOD_PKA_2 62 68 PF00069 0.641
MOD_PKA_2 692 698 PF00069 0.625
MOD_PKA_2 70 76 PF00069 0.544
MOD_PKA_2 97 103 PF00069 0.773
MOD_PKB_1 474 482 PF00069 0.605
MOD_Plk_1 12 18 PF00069 0.649
MOD_Plk_1 127 133 PF00069 0.832
MOD_Plk_1 31 37 PF00069 0.624
MOD_Plk_1 327 333 PF00069 0.647
MOD_Plk_1 677 683 PF00069 0.491
MOD_Plk_2-3 542 548 PF00069 0.531
MOD_Plk_4 12 18 PF00069 0.649
MOD_Plk_4 288 294 PF00069 0.664
MOD_Plk_4 31 37 PF00069 0.624
MOD_Plk_4 383 389 PF00069 0.583
MOD_Plk_4 467 473 PF00069 0.547
MOD_Plk_4 510 516 PF00069 0.416
MOD_Plk_4 519 525 PF00069 0.325
MOD_Plk_4 533 539 PF00069 0.424
MOD_Plk_4 545 551 PF00069 0.465
MOD_Plk_4 639 645 PF00069 0.545
MOD_Plk_4 658 664 PF00069 0.540
MOD_Plk_4 677 683 PF00069 0.520
MOD_Plk_4 699 705 PF00069 0.439
MOD_Plk_4 713 719 PF00069 0.221
MOD_Plk_4 751 757 PF00069 0.437
MOD_ProDKin_1 251 257 PF00069 0.676
MOD_ProDKin_1 378 384 PF00069 0.703
MOD_ProDKin_1 427 433 PF00069 0.725
MOD_ProDKin_1 484 490 PF00069 0.784
MOD_ProDKin_1 606 612 PF00069 0.745
MOD_ProDKin_1 734 740 PF00069 0.621
MOD_ProDKin_1 81 87 PF00069 0.773
TRG_DiLeu_BaEn_1 288 293 PF01217 0.663
TRG_DiLeu_BaEn_4 247 253 PF01217 0.681
TRG_DiLeu_BaLyEn_6 379 384 PF01217 0.770
TRG_DiLeu_BaLyEn_6 548 553 PF01217 0.619
TRG_DiLeu_BaLyEn_6 577 582 PF01217 0.543
TRG_ENDOCYTIC_2 284 287 PF00928 0.669
TRG_ENDOCYTIC_2 530 533 PF00928 0.559
TRG_ENDOCYTIC_2 700 703 PF00928 0.502
TRG_ENDOCYTIC_2 707 710 PF00928 0.403
TRG_ENDOCYTIC_2 759 762 PF00928 0.431
TRG_ER_diArg_1 425 428 PF00400 0.730
TRG_ER_diArg_1 474 477 PF00400 0.613
TRG_ER_diArg_1 565 567 PF00400 0.544
TRG_ER_diArg_1 571 574 PF00400 0.531
TRG_ER_diArg_1 579 581 PF00400 0.560
TRG_ER_diArg_1 604 607 PF00400 0.520
TRG_ER_diArg_1 61 64 PF00400 0.678
TRG_ER_diArg_1 98 101 PF00400 0.788
TRG_Pf-PMV_PEXEL_1 258 263 PF00026 0.676
TRG_Pf-PMV_PEXEL_1 579 584 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZK3 Leptomonas seymouri 45% 100%
A4HJX2 Leishmania braziliensis 60% 100%
A4I6Y6 Leishmania infantum 99% 100%
E9B207 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q654 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS