Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4N0_LEIDO

TriTrypDb:

LdBPK_311760.1 , LdCL_310024800 , LDHU3_31.3020

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4N0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.501
CLV_NRD_NRD_1	249	251	PF00675	0.677
CLV_NRD_NRD_1	402	404	PF00675	0.701
CLV_PCSK_FUR_1	399	403	PF00082	0.672
CLV_PCSK_KEX2_1	249	251	PF00082	0.677
CLV_PCSK_KEX2_1	401	403	PF00082	0.710
CLV_PCSK_SKI1_1	109	113	PF00082	0.473
CLV_PCSK_SKI1_1	130	134	PF00082	0.484
CLV_PCSK_SKI1_1	210	214	PF00082	0.502
CLV_PCSK_SKI1_1	374	378	PF00082	0.530
DEG_MDM2_SWIB_1	295	302	PF02201	0.519
DEG_Nend_UBRbox_1	1	4	PF02207	0.733
DEG_SCF_FBW7_2	71	78	PF00400	0.561
DOC_CKS1_1	101	106	PF01111	0.630
DOC_CKS1_1	285	290	PF01111	0.602
DOC_CKS1_1	72	77	PF01111	0.689
DOC_CYCLIN_yCln2_LP_2	69	72	PF00134	0.674
DOC_MAPK_gen_1	109	119	PF00069	0.527
DOC_MAPK_gen_1	205	215	PF00069	0.472
DOC_MAPK_MEF2A_6	110	119	PF00069	0.520
DOC_MAPK_NFAT4_5	112	120	PF00069	0.453
DOC_PP2B_LxvP_1	121	124	PF13499	0.521
DOC_PP2B_LxvP_1	69	72	PF13499	0.674
DOC_USP7_MATH_1	197	201	PF00917	0.587
DOC_USP7_MATH_1	228	232	PF00917	0.712
DOC_USP7_MATH_1	291	295	PF00917	0.584
DOC_USP7_MATH_1	344	348	PF00917	0.684
DOC_USP7_MATH_1	358	362	PF00917	0.524
DOC_USP7_MATH_1	391	395	PF00917	0.740
DOC_USP7_MATH_1	8	12	PF00917	0.691
DOC_WW_Pin1_4	100	105	PF00397	0.549
DOC_WW_Pin1_4	238	243	PF00397	0.694
DOC_WW_Pin1_4	254	259	PF00397	0.351
DOC_WW_Pin1_4	284	289	PF00397	0.649
DOC_WW_Pin1_4	348	353	PF00397	0.713
DOC_WW_Pin1_4	71	76	PF00397	0.677
LIG_14-3-3_CanoR_1	109	119	PF00244	0.470
LIG_14-3-3_CanoR_1	2	7	PF00244	0.691
LIG_14-3-3_CanoR_1	274	279	PF00244	0.599
LIG_14-3-3_CanoR_1	43	47	PF00244	0.592
LIG_14-3-3_CanoR_1	60	70	PF00244	0.680
LIG_Actin_RPEL_3	102	121	PF02755	0.583
LIG_BRCT_BRCA1_1	250	254	PF00533	0.681
LIG_CaM_NSCaTE_8	129	136	PF13499	0.420
LIG_deltaCOP1_diTrp_1	297	304	PF00928	0.472
LIG_FHA_1	180	186	PF00498	0.540
LIG_FHA_1	22	28	PF00498	0.715
LIG_FHA_1	287	293	PF00498	0.668
LIG_FHA_1	393	399	PF00498	0.783
LIG_FHA_1	408	414	PF00498	0.532
LIG_FHA_2	101	107	PF00498	0.663
LIG_GSK3_LRP6_1	71	76	PF00069	0.602
LIG_LIR_Gen_1	113	124	PF02991	0.542
LIG_LIR_Gen_1	294	303	PF02991	0.497
LIG_LIR_Nem_3	113	119	PF02991	0.510
LIG_LIR_Nem_3	294	298	PF02991	0.523
LIG_LIR_Nem_3	33	39	PF02991	0.740
LIG_LYPXL_yS_3	36	39	PF13949	0.665
LIG_MYND_1	100	104	PF01753	0.624
LIG_MYND_1	18	22	PF01753	0.671
LIG_NRBOX	263	269	PF00104	0.420
LIG_Pex14_2	295	299	PF04695	0.529
LIG_PTAP_UEV_1	31	36	PF05743	0.655
LIG_SH2_CRK	223	227	PF00017	0.574
LIG_SH2_CRK	310	314	PF00017	0.520
LIG_SH2_CRK	357	361	PF00017	0.636
LIG_SH2_NCK_1	159	163	PF00017	0.539
LIG_SH2_NCK_1	223	227	PF00017	0.574
LIG_SH2_NCK_1	357	361	PF00017	0.636
LIG_SH2_SRC	223	226	PF00017	0.571
LIG_SH2_STAT3	98	101	PF00017	0.675
LIG_SH2_STAT5	369	372	PF00017	0.438
LIG_SH3_3	219	225	PF00018	0.527
LIG_SH3_3	236	242	PF00018	0.674
LIG_SH3_3	26	32	PF00018	0.720
LIG_SH3_3	282	288	PF00018	0.608
LIG_SH3_3	69	75	PF00018	0.688
LIG_SUMO_SIM_anti_2	319	326	PF11976	0.454
LIG_SUMO_SIM_par_1	229	237	PF11976	0.595
LIG_TRAF2_1	242	245	PF00917	0.766
LIG_TYR_ITIM	355	360	PF00017	0.686
LIG_UBA3_1	264	270	PF00899	0.453
LIG_WRC_WIRS_1	292	297	PF05994	0.594
MOD_CK1_1	176	182	PF00069	0.549
MOD_CK1_1	200	206	PF00069	0.504
MOD_CK1_1	248	254	PF00069	0.668
MOD_CK1_1	277	283	PF00069	0.688
MOD_CK1_1	347	353	PF00069	0.679
MOD_CK1_1	392	398	PF00069	0.764
MOD_CK1_1	45	51	PF00069	0.651
MOD_CK2_1	238	244	PF00069	0.711
MOD_GlcNHglycan	11	14	PF01048	0.729
MOD_GlcNHglycan	147	150	PF01048	0.482
MOD_GlcNHglycan	199	202	PF01048	0.556
MOD_GlcNHglycan	226	229	PF01048	0.709
MOD_GlcNHglycan	32	35	PF01048	0.739
MOD_GlcNHglycan	347	350	PF01048	0.705
MOD_GlcNHglycan	387	390	PF01048	0.659
MOD_GlcNHglycan	82	85	PF01048	0.624
MOD_GSK3_1	172	179	PF00069	0.558
MOD_GSK3_1	192	199	PF00069	0.630
MOD_GSK3_1	224	231	PF00069	0.633
MOD_GSK3_1	234	241	PF00069	0.643
MOD_GSK3_1	244	251	PF00069	0.646
MOD_GSK3_1	274	281	PF00069	0.557
MOD_GSK3_1	344	351	PF00069	0.650
MOD_GSK3_1	385	392	PF00069	0.701
MOD_GSK3_1	9	16	PF00069	0.732
MOD_NEK2_1	1	6	PF00069	0.652
MOD_NEK2_1	119	124	PF00069	0.427
MOD_NEK2_2	23	28	PF00069	0.720
MOD_NEK2_2	291	296	PF00069	0.627
MOD_PIKK_1	286	292	PF00454	0.645
MOD_PIKK_1	327	333	PF00454	0.635
MOD_PIKK_1	358	364	PF00454	0.599
MOD_PIKK_1	45	51	PF00454	0.655
MOD_PK_1	274	280	PF00069	0.455
MOD_PKA_2	1	7	PF00069	0.767
MOD_PKA_2	248	254	PF00069	0.725
MOD_PKA_2	30	36	PF00069	0.733
MOD_PKA_2	42	48	PF00069	0.598
MOD_PKA_2	8	14	PF00069	0.707
MOD_PKB_1	7	15	PF00069	0.690
MOD_Plk_1	228	234	PF00069	0.699
MOD_Plk_1	77	83	PF00069	0.649
MOD_Plk_4	228	234	PF00069	0.547
MOD_Plk_4	23	29	PF00069	0.715
MOD_Plk_4	42	48	PF00069	0.519
MOD_ProDKin_1	100	106	PF00069	0.540
MOD_ProDKin_1	238	244	PF00069	0.693
MOD_ProDKin_1	254	260	PF00069	0.340
MOD_ProDKin_1	284	290	PF00069	0.647
MOD_ProDKin_1	348	354	PF00069	0.712
MOD_ProDKin_1	71	77	PF00069	0.676
MOD_SUMO_rev_2	105	111	PF00179	0.418
MOD_SUMO_rev_2	126	132	PF00179	0.449
MOD_SUMO_rev_2	87	95	PF00179	0.748
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.546
TRG_ENDOCYTIC_2	310	313	PF00928	0.407
TRG_ENDOCYTIC_2	357	360	PF00928	0.648
TRG_ENDOCYTIC_2	36	39	PF00928	0.665
TRG_ER_diArg_1	401	403	PF00400	0.769
TRG_ER_diArg_1	6	9	PF00400	0.724
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T2	Leptomonas seymouri	48%	100%
A0A1X0NVH2	Trypanosomatidae	28%	100%
A0A3R7MTX4	Trypanosoma rangeli	28%	100%
A4HJF6	Leishmania braziliensis	71%	99%
A4I6V1	Leishmania infantum	98%	100%
D0A7B7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B1X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q688	Leishmania major	93%	100%
V5C1D3	Trypanosoma cruzi	30%	100%