Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4M7_LEIDO

TriTrypDb:

LdBPK_311990.1 , LdCL_310027700 , LDHU3_31.3560

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X4M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4M7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.522
CLV_NRD_NRD_1	195	197	PF00675	0.526
CLV_NRD_NRD_1	282	284	PF00675	0.572
CLV_NRD_NRD_1	315	317	PF00675	0.562
CLV_NRD_NRD_1	36	38	PF00675	0.556
CLV_NRD_NRD_1	500	502	PF00675	0.598
CLV_PCSK_FUR_1	129	133	PF00082	0.526
CLV_PCSK_FUR_1	313	317	PF00082	0.565
CLV_PCSK_KEX2_1	131	133	PF00082	0.505
CLV_PCSK_KEX2_1	195	197	PF00082	0.526
CLV_PCSK_KEX2_1	281	283	PF00082	0.645
CLV_PCSK_KEX2_1	315	317	PF00082	0.562
CLV_PCSK_KEX2_1	36	38	PF00082	0.560
CLV_PCSK_PC7_1	127	133	PF00082	0.529
CLV_PCSK_SKI1_1	226	230	PF00082	0.567
CLV_PCSK_SKI1_1	344	348	PF00082	0.480
DOC_CYCLIN_yCln2_LP_2	545	551	PF00134	0.802
DOC_MAPK_MEF2A_6	200	207	PF00069	0.695
DOC_PP2B_LxvP_1	31	34	PF13499	0.670
DOC_PP4_FxxP_1	549	552	PF00568	0.825
DOC_USP7_MATH_1	16	20	PF00917	0.397
DOC_USP7_MATH_1	222	226	PF00917	0.718
DOC_USP7_MATH_1	233	237	PF00917	0.785
DOC_USP7_MATH_1	248	252	PF00917	0.728
DOC_USP7_MATH_1	292	296	PF00917	0.800
DOC_USP7_MATH_1	483	487	PF00917	0.720
DOC_USP7_MATH_1	559	563	PF00917	0.795
DOC_USP7_MATH_1	71	75	PF00917	0.794
DOC_WW_Pin1_4	110	115	PF00397	0.736
DOC_WW_Pin1_4	180	185	PF00397	0.711
DOC_WW_Pin1_4	199	204	PF00397	0.751
DOC_WW_Pin1_4	244	249	PF00397	0.772
DOC_WW_Pin1_4	260	265	PF00397	0.770
DOC_WW_Pin1_4	283	288	PF00397	0.846
DOC_WW_Pin1_4	294	299	PF00397	0.724
DOC_WW_Pin1_4	356	361	PF00397	0.830
DOC_WW_Pin1_4	376	381	PF00397	0.580
DOC_WW_Pin1_4	394	399	PF00397	0.671
DOC_WW_Pin1_4	410	415	PF00397	0.623
DOC_WW_Pin1_4	450	455	PF00397	0.739
DOC_WW_Pin1_4	468	473	PF00397	0.720
DOC_WW_Pin1_4	496	501	PF00397	0.799
DOC_WW_Pin1_4	532	537	PF00397	0.761
DOC_WW_Pin1_4	544	549	PF00397	0.765
LIG_14-3-3_CanoR_1	195	203	PF00244	0.723
LIG_14-3-3_CanoR_1	206	212	PF00244	0.643
LIG_14-3-3_CanoR_1	390	398	PF00244	0.797
LIG_14-3-3_CanoR_1	403	411	PF00244	0.668
LIG_14-3-3_CanoR_1	447	452	PF00244	0.735
LIG_14-3-3_CanoR_1	540	548	PF00244	0.827
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_BIR_III_4	291	295	PF00653	0.781
LIG_BRCT_BRCA1_1	182	186	PF00533	0.703
LIG_BRCT_BRCA1_1	239	243	PF00533	0.764
LIG_BRCT_BRCA1_1	322	326	PF00533	0.758
LIG_BRCT_BRCA1_1	378	382	PF00533	0.763
LIG_FHA_1	200	206	PF00498	0.729
LIG_FHA_1	359	365	PF00498	0.784
LIG_FHA_1	376	382	PF00498	0.738
LIG_FHA_2	165	171	PF00498	0.686
LIG_FHA_2	286	292	PF00498	0.796
LIG_FHA_2	320	326	PF00498	0.760
LIG_FHA_2	44	50	PF00498	0.788
LIG_Integrin_RGD_1	65	67	PF01839	0.582
LIG_LIR_Apic_2	547	552	PF02991	0.823
LIG_LIR_Gen_1	25	34	PF02991	0.643
LIG_LIR_Gen_1	323	331	PF02991	0.760
LIG_LIR_Nem_3	151	155	PF02991	0.647
LIG_LIR_Nem_3	25	31	PF02991	0.629
LIG_LIR_Nem_3	323	329	PF02991	0.760
LIG_LIR_Nem_3	439	443	PF02991	0.760
LIG_LIR_Nem_3	462	467	PF02991	0.767
LIG_LYPXL_yS_3	464	467	PF13949	0.767
LIG_MYND_1	496	500	PF01753	0.723
LIG_REV1ctd_RIR_1	277	286	PF16727	0.782
LIG_SH2_CRK	28	32	PF00017	0.644
LIG_SH2_NCK_1	219	223	PF00017	0.680
LIG_SH2_NCK_1	39	43	PF00017	0.719
LIG_SH2_SRC	39	42	PF00017	0.752
LIG_SH2_STAP1	415	419	PF00017	0.778
LIG_SH3_3	108	114	PF00018	0.699
LIG_SH3_3	242	248	PF00018	0.754
LIG_SH3_3	332	338	PF00018	0.695
LIG_SH3_3	448	454	PF00018	0.783
LIG_SH3_3	490	496	PF00018	0.760
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.328
LIG_SUMO_SIM_par_1	13	19	PF11976	0.316
LIG_SUMO_SIM_par_1	164	170	PF11976	0.764
LIG_SUMO_SIM_par_1	2	9	PF11976	0.390
LIG_TRAF2_1	167	170	PF00917	0.685
LIG_TRAF2_1	46	49	PF00917	0.756
LIG_WRC_WIRS_1	305	310	PF05994	0.696
LIG_WRC_WIRS_1	531	536	PF05994	0.826
MOD_CDC14_SPxK_1	286	289	PF00782	0.847
MOD_CDC14_SPxK_1	499	502	PF00782	0.795
MOD_CDK_SPK_2	496	501	PF00069	0.789
MOD_CDK_SPxK_1	283	289	PF00069	0.847
MOD_CDK_SPxK_1	496	502	PF00069	0.790
MOD_CDK_SPxxK_3	199	206	PF00069	0.767
MOD_CDK_SPxxK_3	356	363	PF00069	0.747
MOD_CK1_1	220	226	PF00069	0.742
MOD_CK1_1	237	243	PF00069	0.725
MOD_CK1_1	268	274	PF00069	0.747
MOD_CK1_1	307	313	PF00069	0.818
MOD_CK1_1	356	362	PF00069	0.830
MOD_CK1_1	392	398	PF00069	0.829
MOD_CK1_1	439	445	PF00069	0.746
MOD_CK1_1	450	456	PF00069	0.741
MOD_CK1_1	471	477	PF00069	0.780
MOD_CK1_1	486	492	PF00069	0.778
MOD_CK1_1	535	541	PF00069	0.766
MOD_CK1_1	547	553	PF00069	0.750
MOD_CK1_1	562	568	PF00069	0.836
MOD_CK2_1	164	170	PF00069	0.691
MOD_CK2_1	43	49	PF00069	0.808
MOD_Cter_Amidation	193	196	PF01082	0.523
MOD_DYRK1A_RPxSP_1	110	114	PF00069	0.718
MOD_DYRK1A_RPxSP_1	244	248	PF00069	0.755
MOD_GlcNHglycan	222	225	PF01048	0.515
MOD_GlcNHglycan	250	253	PF01048	0.572
MOD_GlcNHglycan	260	263	PF01048	0.572
MOD_GlcNHglycan	270	273	PF01048	0.591
MOD_GlcNHglycan	28	31	PF01048	0.478
MOD_GlcNHglycan	309	312	PF01048	0.593
MOD_GlcNHglycan	391	394	PF01048	0.527
MOD_GlcNHglycan	473	476	PF01048	0.559
MOD_GlcNHglycan	485	488	PF01048	0.523
MOD_GlcNHglycan	49	53	PF01048	0.556
MOD_GlcNHglycan	513	516	PF01048	0.624
MOD_GlcNHglycan	519	522	PF01048	0.471
MOD_GlcNHglycan	542	545	PF01048	0.599
MOD_GlcNHglycan	561	564	PF01048	0.579
MOD_GlcNHglycan	73	76	PF01048	0.589
MOD_GSK3_1	195	202	PF00069	0.703
MOD_GSK3_1	22	29	PF00069	0.588
MOD_GSK3_1	233	240	PF00069	0.800
MOD_GSK3_1	244	251	PF00069	0.694
MOD_GSK3_1	292	299	PF00069	0.800
MOD_GSK3_1	371	378	PF00069	0.797
MOD_GSK3_1	385	392	PF00069	0.683
MOD_GSK3_1	403	410	PF00069	0.598
MOD_GSK3_1	442	449	PF00069	0.747
MOD_GSK3_1	467	474	PF00069	0.782
MOD_GSK3_1	530	537	PF00069	0.754
MOD_GSK3_1	540	547	PF00069	0.755
MOD_GSK3_1	551	558	PF00069	0.770
MOD_GSK3_1	561	568	PF00069	0.671
MOD_N-GLC_1	436	441	PF02516	0.561
MOD_NEK2_1	15	20	PF00069	0.296
MOD_NEK2_1	207	212	PF00069	0.694
MOD_NEK2_1	217	222	PF00069	0.699
MOD_NEK2_1	375	380	PF00069	0.815
MOD_NEK2_1	436	441	PF00069	0.763
MOD_NEK2_1	467	472	PF00069	0.790
MOD_NEK2_1	6	11	PF00069	0.413
MOD_NEK2_2	239	244	PF00069	0.839
MOD_PIKK_1	296	302	PF00454	0.793
MOD_PIKK_1	76	82	PF00454	0.829
MOD_PK_1	447	453	PF00069	0.735
MOD_PKA_1	195	201	PF00069	0.727
MOD_PKA_2	194	200	PF00069	0.728
MOD_PKA_2	205	211	PF00069	0.700
MOD_PKA_2	389	395	PF00069	0.783
MOD_PKA_2	446	452	PF00069	0.666
MOD_PKA_2	539	545	PF00069	0.827
MOD_PKA_2	76	82	PF00069	0.774
MOD_Plk_1	234	240	PF00069	0.828
MOD_Plk_1	327	333	PF00069	0.764
MOD_Plk_1	415	421	PF00069	0.825
MOD_Plk_1	436	442	PF00069	0.815
MOD_Plk_1	48	54	PF00069	0.757
MOD_Plk_2-3	320	326	PF00069	0.760
MOD_Plk_2-3	43	49	PF00069	0.722
MOD_Plk_4	16	22	PF00069	0.427
MOD_Plk_4	207	213	PF00069	0.701
MOD_ProDKin_1	110	116	PF00069	0.732
MOD_ProDKin_1	180	186	PF00069	0.714
MOD_ProDKin_1	199	205	PF00069	0.750
MOD_ProDKin_1	244	250	PF00069	0.770
MOD_ProDKin_1	260	266	PF00069	0.770
MOD_ProDKin_1	283	289	PF00069	0.847
MOD_ProDKin_1	294	300	PF00069	0.724
MOD_ProDKin_1	356	362	PF00069	0.829
MOD_ProDKin_1	376	382	PF00069	0.582
MOD_ProDKin_1	394	400	PF00069	0.670
MOD_ProDKin_1	410	416	PF00069	0.624
MOD_ProDKin_1	450	456	PF00069	0.741
MOD_ProDKin_1	468	474	PF00069	0.721
MOD_ProDKin_1	496	502	PF00069	0.800
MOD_ProDKin_1	532	538	PF00069	0.760
MOD_ProDKin_1	544	550	PF00069	0.765
MOD_SUMO_for_1	348	351	PF00179	0.774
TRG_DiLeu_BaEn_4	169	175	PF01217	0.755
TRG_ENDOCYTIC_2	102	105	PF00928	0.814
TRG_ENDOCYTIC_2	28	31	PF00928	0.639
TRG_ENDOCYTIC_2	464	467	PF00928	0.767
TRG_ER_diArg_1	127	130	PF00400	0.735
TRG_ER_diArg_1	135	138	PF00400	0.703
TRG_ER_diArg_1	280	283	PF00400	0.766
TRG_ER_diArg_1	312	315	PF00400	0.846
TRG_ER_diArg_1	36	38	PF00400	0.757
TRG_NLS_MonoExtC_3	282	287	PF00514	0.789
TRG_NLS_MonoExtN_4	281	287	PF00514	0.789
TRG_Pf-PMV_PEXEL_1	36	41	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM8	Leptomonas seymouri	44%	77%
A4HJH7	Leishmania braziliensis	65%	100%
A4I6X0	Leishmania infantum	100%	100%
E9B1Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q667	Leishmania major	90%	100%