Nucleosome assembly protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4M4_LEIDO

TriTrypDb:

LdBPK_311770.1 , LdCL_310025000 , LDHU3_31.3050

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0000785	chromatin	2	1

Expansion

Sequence features

A0A3S7X4M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4M4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	12
GO:0006334	nucleosome assembly	7	12
GO:0006338	chromatin remodeling	5	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0034728	nucleosome organization	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0065004	protein-DNA complex assembly	6	12
GO:0071824	protein-DNA complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.723
CLV_C14_Caspase3-7	347	351	PF00656	0.829
CLV_NRD_NRD_1	40	42	PF00675	0.345
CLV_NRD_NRD_1	80	82	PF00675	0.411
CLV_PCSK_KEX2_1	39	41	PF00082	0.387
CLV_PCSK_SKI1_1	119	123	PF00082	0.372
CLV_PCSK_SKI1_1	169	173	PF00082	0.343
CLV_PCSK_SKI1_1	192	196	PF00082	0.443
CLV_PCSK_SKI1_1	240	244	PF00082	0.348
CLV_PCSK_SKI1_1	315	319	PF00082	0.389
CLV_PCSK_SKI1_1	89	93	PF00082	0.358
DEG_APCC_DBOX_1	168	176	PF00400	0.559
DOC_ANK_TNKS_1	179	186	PF00023	0.598
DOC_MAPK_gen_1	167	175	PF00069	0.569
DOC_MAPK_gen_1	236	246	PF00069	0.570
DOC_MAPK_gen_1	252	261	PF00069	0.477
DOC_MAPK_MEF2A_6	239	246	PF00069	0.591
DOC_PP1_RVXF_1	117	124	PF00149	0.598
DOC_PP1_RVXF_1	190	196	PF00149	0.589
DOC_PP4_FxxP_1	123	126	PF00568	0.626
DOC_PP4_FxxP_1	274	277	PF00568	0.551
DOC_USP7_MATH_1	140	144	PF00917	0.611
DOC_USP7_MATH_1	159	163	PF00917	0.626
DOC_USP7_MATH_1	20	24	PF00917	0.727
DOC_USP7_MATH_1	267	271	PF00917	0.634
DOC_USP7_MATH_1	363	367	PF00917	0.825
DOC_USP7_UBL2_3	118	122	PF12436	0.606
DOC_USP7_UBL2_3	236	240	PF12436	0.555
DOC_USP7_UBL2_3	250	254	PF12436	0.504
DOC_WW_Pin1_4	138	143	PF00397	0.613
DOC_WW_Pin1_4	195	200	PF00397	0.609
DOC_WW_Pin1_4	273	278	PF00397	0.634
DOC_WW_Pin1_4	377	382	PF00397	0.795
LIG_14-3-3_CanoR_1	98	108	PF00244	0.644
LIG_BIR_III_2	113	117	PF00653	0.653
LIG_CaM_IQ_9	42	58	PF13499	0.634
LIG_eIF4E_1	43	49	PF01652	0.559
LIG_FHA_1	224	230	PF00498	0.627
LIG_FHA_1	241	247	PF00498	0.452
LIG_FHA_1	307	313	PF00498	0.627
LIG_FHA_2	104	110	PF00498	0.548
LIG_FHA_2	11	17	PF00498	0.828
LIG_FHA_2	163	169	PF00498	0.549
LIG_FHA_2	174	180	PF00498	0.550
LIG_FHA_2	212	218	PF00498	0.595
LIG_FHA_2	326	332	PF00498	0.667
LIG_FHA_2	33	39	PF00498	0.575
LIG_FHA_2	90	96	PF00498	0.557
LIG_LIR_Gen_1	269	280	PF02991	0.551
LIG_LIR_Nem_3	269	275	PF02991	0.541
LIG_LIR_Nem_3	366	371	PF02991	0.781
LIG_LIR_Nem_3	51	55	PF02991	0.573
LIG_NRBOX	44	50	PF00104	0.559
LIG_PCNA_PIPBox_1	46	55	PF02747	0.653
LIG_PCNA_yPIPBox_3	39	53	PF02747	0.547
LIG_Pex14_2	271	275	PF04695	0.548
LIG_SH2_STAT3	43	46	PF00017	0.634
LIG_SH2_STAT5	202	205	PF00017	0.551
LIG_SH2_STAT5	320	323	PF00017	0.549
LIG_SH3_2	105	110	PF14604	0.653
LIG_SH3_3	102	108	PF00018	0.653
LIG_SH3_3	274	280	PF00018	0.636
LIG_SUMO_SIM_anti_2	26	33	PF11976	0.658
LIG_SUMO_SIM_par_1	26	33	PF11976	0.629
LIG_TRAF2_1	396	399	PF00917	0.841
LIG_TRAF2_1	92	95	PF00917	0.573
MOD_CDK_SPxxK_3	377	384	PF00069	0.799
MOD_CK1_1	15	21	PF00069	0.784
MOD_CK1_1	162	168	PF00069	0.537
MOD_CK2_1	152	158	PF00069	0.627
MOD_CK2_1	173	179	PF00069	0.651
MOD_CK2_1	18	24	PF00069	0.773
MOD_CK2_1	195	201	PF00069	0.594
MOD_CK2_1	32	38	PF00069	0.459
MOD_CK2_1	325	331	PF00069	0.610
MOD_CK2_1	338	344	PF00069	0.756
MOD_CK2_1	348	354	PF00069	0.795
MOD_CK2_1	89	95	PF00069	0.548
MOD_GlcNHglycan	132	135	PF01048	0.427
MOD_GlcNHglycan	142	145	PF01048	0.388
MOD_GSK3_1	15	22	PF00069	0.797
MOD_GSK3_1	99	106	PF00069	0.541
MOD_N-GLC_1	204	209	PF02516	0.409
MOD_N-GLC_1	240	245	PF02516	0.359
MOD_N-GLC_2	68	70	PF02516	0.453
MOD_NEK2_1	149	154	PF00069	0.548
MOD_NEK2_1	242	247	PF00069	0.653
MOD_NEK2_2	267	272	PF00069	0.634
MOD_PIKK_1	306	312	PF00454	0.653
MOD_PKA_2	223	229	PF00069	0.646
MOD_Plk_1	204	210	PF00069	0.609
MOD_Plk_1	240	246	PF00069	0.559
MOD_Plk_1	32	38	PF00069	0.561
MOD_Plk_2-3	211	217	PF00069	0.599
MOD_Plk_2-3	346	352	PF00069	0.817
MOD_Plk_4	159	165	PF00069	0.550
MOD_Plk_4	267	273	PF00069	0.548
MOD_ProDKin_1	138	144	PF00069	0.613
MOD_ProDKin_1	195	201	PF00069	0.609
MOD_ProDKin_1	273	279	PF00069	0.634
MOD_ProDKin_1	377	383	PF00069	0.795
TRG_ENDOCYTIC_2	52	55	PF00928	0.548
TRG_ER_diArg_1	372	375	PF00400	0.838
TRG_ER_diArg_1	39	41	PF00400	0.466
TRG_ER_diArg_1	55	58	PF00400	0.514
TRG_NES_CRM1_1	26	38	PF08389	0.557
TRG_NLS_Bipartite_1	239	253	PF00514	0.634
TRG_NLS_MonoExtN_4	247	253	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J2	Leptomonas seymouri	32%	100%
A0A0N1IJI7	Leptomonas seymouri	68%	99%
A0A0S4J1L1	Bodo saltans	41%	98%
A0A1X0NTY9	Trypanosomatidae	42%	93%
A0A3Q8IA70	Leishmania donovani	31%	100%
A0A3R7KHX6	Trypanosoma rangeli	42%	93%
A0A3R7KRI5	Trypanosoma rangeli	29%	100%
A4HA02	Leishmania braziliensis	34%	100%
A4HJF7	Leishmania braziliensis	84%	100%
A4HY66	Leishmania infantum	31%	100%
A4I6V2	Leishmania infantum	100%	100%
A6H767	Bos taurus	33%	100%
B8AW64	Oryza sativa subsp. indica	33%	100%
B8B2R4	Oryza sativa subsp. indica	34%	100%
C9ZXT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
D0A0I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B1X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O59797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P25293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	97%
P28656	Mus musculus	33%	100%
P55209	Homo sapiens	33%	100%
P78920	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q28EB4	Xenopus tropicalis	33%	100%
Q2TA40	Bos taurus	32%	100%
Q4Q687	Leishmania major	93%	100%
Q4QDH7	Leishmania major	30%	100%
Q4U0Y4	Xenopus laevis	32%	100%
Q53WK4	Oryza sativa subsp. japonica	32%	100%
Q55ED1	Dictyostelium discoideum	28%	100%
Q5AAI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	93%
Q5R4D4	Pongo abelii	33%	100%
Q5U2Z3	Rattus norvegicus	33%	100%
Q5VND6	Oryza sativa subsp. japonica	34%	100%
Q70Z16	Nicotiana tabacum	32%	100%
Q70Z17	Nicotiana tabacum	35%	100%
Q70Z18	Nicotiana tabacum	35%	100%
Q70Z19	Nicotiana tabacum	31%	100%
Q78ZA7	Mus musculus	34%	100%
Q7ZY81	Xenopus laevis	34%	100%
Q94K07	Arabidopsis thaliana	35%	100%
Q99733	Homo sapiens	32%	100%
Q9SZI2	Arabidopsis thaliana	35%	100%
Q9Z2G8	Rattus norvegicus	33%	100%
Q9ZUP3	Arabidopsis thaliana	34%	100%
V5BUC1	Trypanosoma cruzi	43%	89%
V5BX23	Trypanosoma cruzi	25%	100%