Nucleosome assembly protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4M4_LEIDO

TriTrypDb:

LdBPK_311770.1 , LdCL_310025000 , LDHU3_31.3050

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S7X4M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4M4

Function

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Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	12
GO:0006334	nucleosome assembly	7	12
GO:0006338	chromatin remodeling	5	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0034728	nucleosome organization	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0065004	protein-DNA complex assembly	6	12

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Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.723
CLV_C14_Caspase3-7	347	351	PF00656	0.829
CLV_NRD_NRD_1	40	42	PF00675	0.345
CLV_NRD_NRD_1	80	82	PF00675	0.411
CLV_PCSK_KEX2_1	39	41	PF00082	0.387
CLV_PCSK_SKI1_1	119	123	PF00082	0.372
CLV_PCSK_SKI1_1	169	173	PF00082	0.343
CLV_PCSK_SKI1_1	192	196	PF00082	0.443
CLV_PCSK_SKI1_1	240	244	PF00082	0.348
CLV_PCSK_SKI1_1	315	319	PF00082	0.389

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J2	Leptomonas seymouri	32%	100%
A0A0N1IJI7	Leptomonas seymouri	68%	99%
A0A0S4J1L1	Bodo saltans	41%	98%
A0A1X0NTY9	Trypanosomatidae	42%	93%
A0A3Q8IA70	Leishmania donovani	31%	100%
A0A3R7KHX6	Trypanosoma rangeli	42%	93%
A0A3R7KRI5	Trypanosoma rangeli	29%	100%
A4HA02	Leishmania braziliensis	34%	100%
A4HJF7	Leishmania braziliensis	84%	100%
A4HY66	Leishmania infantum	31%	100%

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