LeishMANIAdb
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Mannosyltransferase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mannosyltransferase-like protein
Gene product:
mannosyltransferase-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X4M2_LEIDO
TriTrypDb:
LdBPK_311920.1 * , LdCL_310026900 , LDHU3_31.3440
Length:
966

Annotations

LeishMANIAdb annotations

A complex and fast-evolving family of glycosyltransferases. Their structural innovations and expansion is in accordance with a role in interactions with the environment. Despite the short hydrophobic segment, the N-terminal signal-like stretch is likely to be a signal-anchor as wil all Golgi-resident glycosyltransferases, not a secretory signal. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 13
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A0A3S7X4M2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4M2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0016740 transferase activity 2 15
GO:0016757 glycosyltransferase activity 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 387 391 PF00656 0.479
CLV_NRD_NRD_1 371 373 PF00675 0.643
CLV_NRD_NRD_1 401 403 PF00675 0.635
CLV_NRD_NRD_1 504 506 PF00675 0.649
CLV_NRD_NRD_1 633 635 PF00675 0.673
CLV_NRD_NRD_1 680 682 PF00675 0.616
CLV_NRD_NRD_1 69 71 PF00675 0.596
CLV_NRD_NRD_1 746 748 PF00675 0.544
CLV_NRD_NRD_1 783 785 PF00675 0.549
CLV_NRD_NRD_1 929 931 PF00675 0.500
CLV_NRD_NRD_1 933 935 PF00675 0.482
CLV_PCSK_KEX2_1 371 373 PF00082 0.674
CLV_PCSK_KEX2_1 401 403 PF00082 0.644
CLV_PCSK_KEX2_1 503 505 PF00082 0.655
CLV_PCSK_KEX2_1 632 634 PF00082 0.640
CLV_PCSK_KEX2_1 680 682 PF00082 0.584
CLV_PCSK_KEX2_1 783 785 PF00082 0.549
CLV_PCSK_KEX2_1 929 931 PF00082 0.482
CLV_PCSK_KEX2_1 933 935 PF00082 0.461
CLV_PCSK_PC1ET2_1 632 634 PF00082 0.688
CLV_PCSK_PC7_1 929 935 PF00082 0.512
CLV_PCSK_SKI1_1 178 182 PF00082 0.661
CLV_PCSK_SKI1_1 218 222 PF00082 0.714
CLV_PCSK_SKI1_1 305 309 PF00082 0.693
CLV_PCSK_SKI1_1 33 37 PF00082 0.555
CLV_PCSK_SKI1_1 481 485 PF00082 0.705
CLV_PCSK_SKI1_1 592 596 PF00082 0.672
CLV_PCSK_SKI1_1 614 618 PF00082 0.631
CLV_PCSK_SKI1_1 735 739 PF00082 0.550
CLV_Separin_Metazoa 916 920 PF03568 0.306
DEG_Nend_Nbox_1 1 3 PF02207 0.727
DEG_SCF_FBW7_1 201 206 PF00400 0.502
DOC_ANK_TNKS_1 882 889 PF00023 0.341
DOC_CYCLIN_yClb5_NLxxxL_5 127 136 PF00134 0.414
DOC_CYCLIN_yCln2_LP_2 108 114 PF00134 0.418
DOC_CYCLIN_yCln2_LP_2 238 244 PF00134 0.422
DOC_MAPK_gen_1 41 49 PF00069 0.663
DOC_MAPK_gen_1 610 619 PF00069 0.405
DOC_MAPK_gen_1 747 754 PF00069 0.346
DOC_MAPK_gen_1 770 777 PF00069 0.410
DOC_MAPK_MEF2A_6 41 49 PF00069 0.696
DOC_MAPK_MEF2A_6 436 445 PF00069 0.516
DOC_MAPK_MEF2A_6 634 643 PF00069 0.439
DOC_PP1_RVXF_1 733 740 PF00149 0.387
DOC_PP2B_LxvP_1 108 111 PF13499 0.462
DOC_PP2B_LxvP_1 238 241 PF13499 0.454
DOC_PP2B_PxIxI_1 816 822 PF00149 0.352
DOC_PP4_FxxP_1 541 544 PF00568 0.416
DOC_PP4_FxxP_1 628 631 PF00568 0.396
DOC_PP4_FxxP_1 841 844 PF00568 0.272
DOC_PP4_FxxP_1 882 885 PF00568 0.316
DOC_USP7_MATH_1 167 171 PF00917 0.467
DOC_USP7_MATH_1 203 207 PF00917 0.524
DOC_USP7_MATH_1 23 27 PF00917 0.675
DOC_USP7_MATH_1 475 479 PF00917 0.543
DOC_USP7_MATH_1 602 606 PF00917 0.509
DOC_USP7_MATH_1 710 714 PF00917 0.393
DOC_USP7_MATH_1 907 911 PF00917 0.277
DOC_USP7_MATH_2 76 82 PF00917 0.415
DOC_WW_Pin1_4 199 204 PF00397 0.588
DOC_WW_Pin1_4 27 32 PF00397 0.786
DOC_WW_Pin1_4 597 602 PF00397 0.516
DOC_WW_Pin1_4 682 687 PF00397 0.414
DOC_WW_Pin1_4 783 788 PF00397 0.437
DOC_WW_Pin1_4 890 895 PF00397 0.336
LIG_14-3-3_CanoR_1 146 156 PF00244 0.469
LIG_14-3-3_CanoR_1 178 186 PF00244 0.398
LIG_14-3-3_CanoR_1 235 239 PF00244 0.456
LIG_14-3-3_CanoR_1 280 286 PF00244 0.599
LIG_14-3-3_CanoR_1 33 38 PF00244 0.796
LIG_14-3-3_CanoR_1 338 344 PF00244 0.534
LIG_14-3-3_CanoR_1 382 386 PF00244 0.489
LIG_14-3-3_CanoR_1 481 487 PF00244 0.538
LIG_14-3-3_CanoR_1 489 498 PF00244 0.474
LIG_14-3-3_CanoR_1 536 544 PF00244 0.479
LIG_14-3-3_CanoR_1 573 577 PF00244 0.473
LIG_14-3-3_CanoR_1 633 641 PF00244 0.318
LIG_14-3-3_CanoR_1 724 733 PF00244 0.424
LIG_14-3-3_CanoR_1 772 776 PF00244 0.402
LIG_BIR_III_4 405 409 PF00653 0.487
LIG_deltaCOP1_diTrp_1 666 675 PF00928 0.302
LIG_deltaCOP1_diTrp_1 868 875 PF00928 0.322
LIG_FHA_1 122 128 PF00498 0.498
LIG_FHA_1 247 253 PF00498 0.456
LIG_FHA_1 295 301 PF00498 0.508
LIG_FHA_1 368 374 PF00498 0.504
LIG_FHA_1 522 528 PF00498 0.506
LIG_FHA_1 771 777 PF00498 0.403
LIG_FHA_1 821 827 PF00498 0.322
LIG_FHA_1 912 918 PF00498 0.299
LIG_FHA_2 246 252 PF00498 0.488
LIG_FHA_2 290 296 PF00498 0.544
LIG_FHA_2 338 344 PF00498 0.534
LIG_FHA_2 661 667 PF00498 0.411
LIG_FHA_2 668 674 PF00498 0.392
LIG_FHA_2 726 732 PF00498 0.430
LIG_FHA_2 843 849 PF00498 0.272
LIG_LIR_Apic_2 329 335 PF02991 0.558
LIG_LIR_Apic_2 539 544 PF02991 0.472
LIG_LIR_Apic_2 839 844 PF02991 0.273
LIG_LIR_Apic_2 848 853 PF02991 0.273
LIG_LIR_Apic_2 867 872 PF02991 0.272
LIG_LIR_Apic_2 879 885 PF02991 0.254
LIG_LIR_Gen_1 123 133 PF02991 0.531
LIG_LIR_Gen_1 267 276 PF02991 0.423
LIG_LIR_Gen_1 384 392 PF02991 0.494
LIG_LIR_Gen_1 493 501 PF02991 0.504
LIG_LIR_Gen_1 593 602 PF02991 0.493
LIG_LIR_Gen_1 64 73 PF02991 0.474
LIG_LIR_Gen_1 673 679 PF02991 0.366
LIG_LIR_Nem_3 123 129 PF02991 0.490
LIG_LIR_Nem_3 267 272 PF02991 0.427
LIG_LIR_Nem_3 384 388 PF02991 0.491
LIG_LIR_Nem_3 493 498 PF02991 0.471
LIG_LIR_Nem_3 593 598 PF02991 0.477
LIG_LIR_Nem_3 64 69 PF02991 0.394
LIG_LIR_Nem_3 673 678 PF02991 0.313
LIG_LIR_Nem_3 815 819 PF02991 0.303
LIG_LYPXL_yS_3 816 819 PF13949 0.346
LIG_NRBOX 128 134 PF00104 0.444
LIG_PCNA_yPIPBox_3 480 492 PF02747 0.537
LIG_Pex14_2 738 742 PF04695 0.343
LIG_Pex14_2 797 801 PF04695 0.450
LIG_PTAP_UEV_1 762 767 PF05743 0.392
LIG_REV1ctd_RIR_1 604 614 PF16727 0.470
LIG_SH2_CRK 404 408 PF00017 0.487
LIG_SH2_CRK 495 499 PF00017 0.539
LIG_SH2_CRK 588 592 PF00017 0.485
LIG_SH2_GRB2like 835 838 PF00017 0.355
LIG_SH2_NCK_1 283 287 PF00017 0.557
LIG_SH2_NCK_1 376 380 PF00017 0.489
LIG_SH2_NCK_1 404 408 PF00017 0.487
LIG_SH2_NCK_1 495 499 PF00017 0.473
LIG_SH2_NCK_1 701 705 PF00017 0.431
LIG_SH2_NCK_1 835 839 PF00017 0.355
LIG_SH2_PTP2 126 129 PF00017 0.403
LIG_SH2_PTP2 555 558 PF00017 0.410
LIG_SH2_SRC 701 704 PF00017 0.429
LIG_SH2_SRC 835 838 PF00017 0.355
LIG_SH2_SRC 900 903 PF00017 0.359
LIG_SH2_STAT3 706 709 PF00017 0.438
LIG_SH2_STAT5 126 129 PF00017 0.403
LIG_SH2_STAT5 283 286 PF00017 0.573
LIG_SH2_STAT5 368 371 PF00017 0.464
LIG_SH2_STAT5 555 558 PF00017 0.351
LIG_SH2_STAT5 642 645 PF00017 0.345
LIG_SH2_STAT5 736 739 PF00017 0.389
LIG_SH2_STAT5 920 923 PF00017 0.268
LIG_SH3_1 70 76 PF00018 0.404
LIG_SH3_2 28 33 PF14604 0.598
LIG_SH3_2 45 50 PF14604 0.574
LIG_SH3_3 238 244 PF00018 0.430
LIG_SH3_3 25 31 PF00018 0.619
LIG_SH3_3 361 367 PF00018 0.578
LIG_SH3_3 42 48 PF00018 0.620
LIG_SH3_3 503 509 PF00018 0.526
LIG_SH3_3 595 601 PF00018 0.462
LIG_SH3_3 70 76 PF00018 0.448
LIG_SH3_3 760 766 PF00018 0.313
LIG_SH3_3 891 897 PF00018 0.315
LIG_SH3_3 919 925 PF00018 0.299
LIG_SUMO_SIM_anti_2 104 110 PF11976 0.343
LIG_SUMO_SIM_anti_2 234 240 PF11976 0.464
LIG_SUMO_SIM_anti_2 247 255 PF11976 0.498
LIG_SUMO_SIM_par_1 57 62 PF11976 0.374
LIG_SUMO_SIM_par_1 773 779 PF11976 0.391
LIG_SUMO_SIM_par_1 818 823 PF11976 0.328
LIG_SUMO_SIM_par_1 862 868 PF11976 0.304
LIG_TRAF2_1 384 387 PF00917 0.524
LIG_TRAF2_1 728 731 PF00917 0.411
LIG_TYR_ITIM 586 591 PF00017 0.598
LIG_TYR_ITSM 491 498 PF00017 0.547
LIG_UBA3_1 65 71 PF00899 0.561
LIG_WRC_WIRS_1 272 277 PF05994 0.645
LIG_WRC_WIRS_1 739 744 PF05994 0.418
LIG_WW_3 335 339 PF00397 0.608
MOD_CDC14_SPxK_1 30 33 PF00782 0.506
MOD_CDC14_SPxK_1 685 688 PF00782 0.530
MOD_CDK_SPxK_1 27 33 PF00069 0.509
MOD_CDK_SPxK_1 682 688 PF00069 0.513
MOD_CK1_1 120 126 PF00069 0.622
MOD_CK1_1 374 380 PF00069 0.621
MOD_CK1_1 496 502 PF00069 0.716
MOD_CK1_1 517 523 PF00069 0.630
MOD_CK1_1 596 602 PF00069 0.595
MOD_CK1_1 648 654 PF00069 0.390
MOD_CK1_1 717 723 PF00069 0.457
MOD_CK1_1 764 770 PF00069 0.374
MOD_CK1_1 790 796 PF00069 0.492
MOD_CK1_1 893 899 PF00069 0.408
MOD_CK2_1 15 21 PF00069 0.819
MOD_CK2_1 245 251 PF00069 0.654
MOD_CK2_1 289 295 PF00069 0.787
MOD_CK2_1 337 343 PF00069 0.694
MOD_CK2_1 381 387 PF00069 0.670
MOD_CK2_1 643 649 PF00069 0.416
MOD_CK2_1 723 729 PF00069 0.517
MOD_CK2_1 78 84 PF00069 0.676
MOD_CK2_1 824 830 PF00069 0.473
MOD_CK2_1 842 848 PF00069 0.188
MOD_CMANNOS 207 210 PF00535 0.481
MOD_CMANNOS 452 455 PF00535 0.563
MOD_Cter_Amidation 931 934 PF01082 0.314
MOD_GlcNHglycan 119 122 PF01048 0.614
MOD_GlcNHglycan 12 15 PF01048 0.583
MOD_GlcNHglycan 149 152 PF01048 0.693
MOD_GlcNHglycan 16 20 PF01048 0.588
MOD_GlcNHglycan 163 166 PF01048 0.408
MOD_GlcNHglycan 187 190 PF01048 0.660
MOD_GlcNHglycan 328 331 PF01048 0.685
MOD_GlcNHglycan 373 376 PF01048 0.603
MOD_GlcNHglycan 519 522 PF01048 0.662
MOD_GlcNHglycan 540 544 PF01048 0.602
MOD_GlcNHglycan 578 581 PF01048 0.631
MOD_GlcNHglycan 763 766 PF01048 0.583
MOD_GlcNHglycan 825 829 PF01048 0.383
MOD_GSK3_1 117 124 PF00069 0.654
MOD_GSK3_1 199 206 PF00069 0.644
MOD_GSK3_1 23 30 PF00069 0.623
MOD_GSK3_1 367 374 PF00069 0.635
MOD_GSK3_1 517 524 PF00069 0.713
MOD_GSK3_1 572 579 PF00069 0.603
MOD_GSK3_1 593 600 PF00069 0.707
MOD_GSK3_1 61 68 PF00069 0.219
MOD_GSK3_1 710 717 PF00069 0.447
MOD_GSK3_1 74 81 PF00069 0.485
MOD_GSK3_1 783 790 PF00069 0.498
MOD_GSK3_1 820 827 PF00069 0.470
MOD_GSK3_1 907 914 PF00069 0.349
MOD_N-GLC_1 104 109 PF02516 0.588
MOD_N-GLC_1 121 126 PF02516 0.556
MOD_NEK2_1 276 281 PF00069 0.694
MOD_NEK2_1 303 308 PF00069 0.656
MOD_NEK2_1 594 599 PF00069 0.574
MOD_NEK2_1 65 70 PF00069 0.573
MOD_NEK2_1 674 679 PF00069 0.404
MOD_NEK2_1 738 743 PF00069 0.433
MOD_NEK2_1 797 802 PF00069 0.516
MOD_NEK2_1 956 961 PF00069 0.554
MOD_NEK2_2 439 444 PF00069 0.489
MOD_NEK2_2 602 607 PF00069 0.570
MOD_OFUCOSY 715 721 PF10250 0.446
MOD_PIKK_1 305 311 PF00454 0.633
MOD_PIKK_1 764 770 PF00454 0.390
MOD_PIKK_1 91 97 PF00454 0.551
MOD_PK_1 714 720 PF00069 0.412
MOD_PKA_1 371 377 PF00069 0.658
MOD_PKA_1 632 638 PF00069 0.382
MOD_PKA_2 234 240 PF00069 0.636
MOD_PKA_2 337 343 PF00069 0.694
MOD_PKA_2 371 377 PF00069 0.630
MOD_PKA_2 381 387 PF00069 0.576
MOD_PKA_2 40 46 PF00069 0.714
MOD_PKA_2 572 578 PF00069 0.636
MOD_PKA_2 632 638 PF00069 0.382
MOD_PKA_2 723 729 PF00069 0.565
MOD_PKA_2 771 777 PF00069 0.503
MOD_PKA_2 790 796 PF00069 0.377
MOD_PKA_2 877 883 PF00069 0.431
MOD_Plk_1 104 110 PF00069 0.577
MOD_Plk_1 246 252 PF00069 0.632
MOD_Plk_1 521 527 PF00069 0.583
MOD_Plk_1 770 776 PF00069 0.488
MOD_Plk_1 78 84 PF00069 0.542
MOD_Plk_2-3 421 427 PF00069 0.687
MOD_Plk_2-3 74 80 PF00069 0.505
MOD_Plk_4 104 110 PF00069 0.485
MOD_Plk_4 168 174 PF00069 0.529
MOD_Plk_4 234 240 PF00069 0.627
MOD_Plk_4 271 277 PF00069 0.668
MOD_Plk_4 318 324 PF00069 0.524
MOD_Plk_4 493 499 PF00069 0.668
MOD_Plk_4 602 608 PF00069 0.659
MOD_Plk_4 61 67 PF00069 0.329
MOD_Plk_4 674 680 PF00069 0.468
MOD_Plk_4 771 777 PF00069 0.426
MOD_Plk_4 790 796 PF00069 0.524
MOD_Plk_4 956 962 PF00069 0.472
MOD_ProDKin_1 199 205 PF00069 0.756
MOD_ProDKin_1 27 33 PF00069 0.758
MOD_ProDKin_1 597 603 PF00069 0.652
MOD_ProDKin_1 682 688 PF00069 0.513
MOD_ProDKin_1 783 789 PF00069 0.528
MOD_ProDKin_1 890 896 PF00069 0.405
MOD_SUMO_for_1 742 745 PF00179 0.356
TRG_DiLeu_BaEn_1 295 300 PF01217 0.648
TRG_DiLeu_BaEn_1 771 776 PF01217 0.508
TRG_DiLeu_BaLyEn_6 108 113 PF01217 0.513
TRG_ENDOCYTIC_2 126 129 PF00928 0.632
TRG_ENDOCYTIC_2 404 407 PF00928 0.618
TRG_ENDOCYTIC_2 495 498 PF00928 0.699
TRG_ENDOCYTIC_2 588 591 PF00928 0.600
TRG_ENDOCYTIC_2 736 739 PF00928 0.507
TRG_ENDOCYTIC_2 816 819 PF00928 0.419
TRG_ER_diArg_1 258 261 PF00400 0.644
TRG_ER_diArg_1 371 373 PF00400 0.531
TRG_ER_diArg_1 401 403 PF00400 0.608
TRG_ER_diArg_1 503 505 PF00400 0.579
TRG_ER_diArg_1 510 513 PF00400 0.537
TRG_ER_diArg_1 611 614 PF00400 0.586
TRG_ER_diArg_1 661 664 PF00400 0.511
TRG_ER_diArg_1 679 681 PF00400 0.401
TRG_ER_diArg_1 783 785 PF00400 0.404
TRG_ER_diArg_1 929 931 PF00400 0.324
TRG_ER_diArg_1 933 936 PF00400 0.296
TRG_NLS_MonoExtC_3 631 637 PF00514 0.479
TRG_NLS_MonoExtN_4 629 636 PF00514 0.466
TRG_Pf-PMV_PEXEL_1 230 234 PF00026 0.637
TRG_Pf-PMV_PEXEL_1 557 561 PF00026 0.486
TRG_Pf-PMV_PEXEL_1 70 74 PF00026 0.592
TRG_Pf-PMV_PEXEL_1 941 945 PF00026 0.501

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NJI2 Trypanosomatidae 36% 100%
A0A1X0NR25 Trypanosomatidae 31% 93%
A0A3R7NS98 Trypanosoma rangeli 31% 96%
A0A3R7RH60 Trypanosoma rangeli 40% 100%
A0A3S7X4P3 Leishmania donovani 100% 100%
A4HJG8 Leishmania braziliensis 71% 99%
A4I6X8 Leishmania infantum 100% 100%
E9B1Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B1Y6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9B1Y7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q674 Leishmania major 94% 100%
Q4Q675 Leishmania major 94% 100%
V5BEQ4 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS