Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X4K1_LEIDO

TriTrypDb:

LdBPK_311500.1 , LdCL_310022100 , LDHU3_31.2600

Length:

1039

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.594
CLV_NRD_NRD_1	282	284	PF00675	0.611
CLV_NRD_NRD_1	291	293	PF00675	0.539
CLV_NRD_NRD_1	36	38	PF00675	0.639
CLV_NRD_NRD_1	51	53	PF00675	0.546
CLV_NRD_NRD_1	551	553	PF00675	0.589
CLV_NRD_NRD_1	7	9	PF00675	0.577
CLV_NRD_NRD_1	803	805	PF00675	0.705
CLV_NRD_NRD_1	840	842	PF00675	0.692
CLV_PCSK_FUR_1	280	284	PF00082	0.602
CLV_PCSK_FUR_1	288	292	PF00082	0.539
CLV_PCSK_KEX2_1	282	284	PF00082	0.611
CLV_PCSK_KEX2_1	290	292	PF00082	0.550
CLV_PCSK_KEX2_1	36	38	PF00082	0.639
CLV_PCSK_KEX2_1	51	53	PF00082	0.546
CLV_PCSK_KEX2_1	550	552	PF00082	0.597
CLV_PCSK_KEX2_1	7	9	PF00082	0.577
CLV_PCSK_KEX2_1	803	805	PF00082	0.705
CLV_PCSK_PC7_1	278	284	PF00082	0.622
CLV_PCSK_SKI1_1	101	105	PF00082	0.626
CLV_PCSK_SKI1_1	1033	1037	PF00082	0.541
CLV_PCSK_SKI1_1	168	172	PF00082	0.564
CLV_PCSK_SKI1_1	175	179	PF00082	0.547
CLV_PCSK_SKI1_1	306	310	PF00082	0.622
CLV_PCSK_SKI1_1	595	599	PF00082	0.723
CLV_PCSK_SKI1_1	821	825	PF00082	0.650
CLV_PCSK_SKI1_1	955	959	PF00082	0.630
CLV_Separin_Metazoa	818	822	PF03568	0.588
DEG_APCC_DBOX_1	282	290	PF00400	0.609
DEG_APCC_DBOX_1	335	343	PF00400	0.601
DEG_COP1_1	81	91	PF00400	0.681
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SIAH_1	745	753	PF03145	0.596
DEG_SPOP_SBC_1	658	662	PF00917	0.591
DOC_ANK_TNKS_1	830	837	PF00023	0.650
DOC_CYCLIN_RxL_1	97	107	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	718	724	PF00134	0.692
DOC_MAPK_MEF2A_6	124	131	PF00069	0.575
DOC_PP1_RVXF_1	875	882	PF00149	0.598
DOC_PP2B_LxvP_1	683	686	PF13499	0.666
DOC_PP4_FxxP_1	313	316	PF00568	0.604
DOC_PP4_FxxP_1	440	443	PF00568	0.608
DOC_PP4_FxxP_1	490	493	PF00568	0.633
DOC_PP4_FxxP_1	788	791	PF00568	0.675
DOC_PP4_FxxP_1	859	862	PF00568	0.569
DOC_PP4_FxxP_1	888	891	PF00568	0.655
DOC_USP7_MATH_1	139	143	PF00917	0.643
DOC_USP7_MATH_1	156	160	PF00917	0.586
DOC_USP7_MATH_1	222	226	PF00917	0.697
DOC_USP7_MATH_1	240	244	PF00917	0.554
DOC_USP7_MATH_1	417	421	PF00917	0.786
DOC_USP7_MATH_1	429	433	PF00917	0.700
DOC_USP7_MATH_1	50	54	PF00917	0.688
DOC_USP7_MATH_1	510	514	PF00917	0.721
DOC_USP7_MATH_1	539	543	PF00917	0.717
DOC_USP7_MATH_1	586	590	PF00917	0.629
DOC_USP7_MATH_1	614	618	PF00917	0.654
DOC_USP7_MATH_1	644	648	PF00917	0.707
DOC_USP7_MATH_1	658	662	PF00917	0.661
DOC_USP7_MATH_1	736	740	PF00917	0.609
DOC_USP7_MATH_1	791	795	PF00917	0.661
DOC_WW_Pin1_4	22	27	PF00397	0.756
DOC_WW_Pin1_4	267	272	PF00397	0.718
DOC_WW_Pin1_4	420	425	PF00397	0.706
DOC_WW_Pin1_4	45	50	PF00397	0.747
DOC_WW_Pin1_4	468	473	PF00397	0.763
DOC_WW_Pin1_4	640	645	PF00397	0.676
DOC_WW_Pin1_4	665	670	PF00397	0.668
DOC_WW_Pin1_4	68	73	PF00397	0.723
DOC_WW_Pin1_4	681	686	PF00397	0.669
DOC_WW_Pin1_4	739	744	PF00397	0.635
DOC_WW_Pin1_4	806	811	PF00397	0.680
DOC_WW_Pin1_4	830	835	PF00397	0.693
DOC_WW_Pin1_4	846	851	PF00397	0.729
DOC_WW_Pin1_4	89	94	PF00397	0.767
DOC_WW_Pin1_4	897	902	PF00397	0.657
DOC_WW_Pin1_4	962	967	PF00397	0.715
LIG_14-3-3_CanoR_1	291	300	PF00244	0.602
LIG_14-3-3_CanoR_1	51	57	PF00244	0.576
LIG_14-3-3_CanoR_1	550	559	PF00244	0.554
LIG_14-3-3_CanoR_1	576	580	PF00244	0.614
LIG_14-3-3_CanoR_1	793	799	PF00244	0.687
LIG_14-3-3_CanoR_1	852	862	PF00244	0.661
LIG_14-3-3_CanoR_1	896	901	PF00244	0.619
LIG_14-3-3_CanoR_1	979	985	PF00244	0.647
LIG_Actin_WH2_2	154	170	PF00022	0.617
LIG_Actin_WH2_2	710	725	PF00022	0.660
LIG_BRCT_BRCA1_1	153	157	PF00533	0.606
LIG_BRCT_BRCA1_1	766	770	PF00533	0.608
LIG_BRCT_BRCA1_1	855	859	PF00533	0.581
LIG_BRCT_BRCA1_1	899	903	PF00533	0.608
LIG_BRCT_BRCA1_1	916	920	PF00533	0.494
LIG_BRCT_BRCA1_2	916	922	PF00533	0.610
LIG_CtBP_PxDLS_1	669	673	PF00389	0.647
LIG_deltaCOP1_diTrp_1	878	888	PF00928	0.636
LIG_eIF4E_1	902	908	PF01652	0.611
LIG_FHA_1	1003	1009	PF00498	0.631
LIG_FHA_1	150	156	PF00498	0.567
LIG_FHA_1	203	209	PF00498	0.636
LIG_FHA_1	391	397	PF00498	0.529
LIG_FHA_1	4	10	PF00498	0.677
LIG_FHA_1	551	557	PF00498	0.573
LIG_FHA_1	631	637	PF00498	0.692
LIG_FHA_1	641	647	PF00498	0.588
LIG_FHA_1	98	104	PF00498	0.624
LIG_FHA_2	480	486	PF00498	0.612
LIG_FHA_2	69	75	PF00498	0.688
LIG_FHA_2	702	708	PF00498	0.639
LIG_FHA_2	780	786	PF00498	0.572
LIG_LIR_Apic_2	141	146	PF02991	0.667
LIG_LIR_Apic_2	19	23	PF02991	0.629
LIG_LIR_Apic_2	311	316	PF02991	0.591
LIG_LIR_Apic_2	439	443	PF02991	0.607
LIG_LIR_Apic_2	488	493	PF02991	0.641
LIG_LIR_Apic_2	785	791	PF02991	0.645
LIG_LIR_Apic_2	856	862	PF02991	0.573
LIG_LIR_Apic_2	899	905	PF02991	0.637
LIG_LIR_Gen_1	398	404	PF02991	0.603
LIG_LIR_Gen_1	474	481	PF02991	0.613
LIG_LIR_Gen_1	797	806	PF02991	0.651
LIG_LIR_Gen_1	81	89	PF02991	0.705
LIG_LIR_Nem_3	154	160	PF02991	0.664
LIG_LIR_Nem_3	398	403	PF02991	0.689
LIG_LIR_Nem_3	474	480	PF02991	0.616
LIG_LIR_Nem_3	797	801	PF02991	0.645
LIG_LIR_Nem_3	81	85	PF02991	0.705
LIG_LIR_Nem_3	878	884	PF02991	0.627
LIG_MLH1_MIPbox_1	899	903	PF16413	0.601
LIG_MYND_1	681	685	PF01753	0.649
LIG_NRP_CendR_1	1038	1039	PF00754	0.636
LIG_Pex14_2	309	313	PF04695	0.587
LIG_SH2_CRK	1010	1014	PF00017	0.623
LIG_SH2_CRK	562	566	PF00017	0.622
LIG_SH2_NCK_1	143	147	PF00017	0.671
LIG_SH2_PTP2	20	23	PF00017	0.679
LIG_SH2_SRC	20	23	PF00017	0.679
LIG_SH2_SRC	775	778	PF00017	0.565
LIG_SH2_STAP1	381	385	PF00017	0.593
LIG_SH2_STAT3	579	582	PF00017	0.668
LIG_SH2_STAT5	1018	1021	PF00017	0.697
LIG_SH2_STAT5	102	105	PF00017	0.669
LIG_SH2_STAT5	20	23	PF00017	0.679
LIG_SH2_STAT5	203	206	PF00017	0.637
LIG_SH2_STAT5	579	582	PF00017	0.626
LIG_SH2_STAT5	902	905	PF00017	0.628
LIG_SH3_1	20	26	PF00018	0.681
LIG_SH3_1	740	746	PF00018	0.635
LIG_SH3_3	20	26	PF00018	0.757
LIG_SH3_3	332	338	PF00018	0.637
LIG_SH3_3	740	746	PF00018	0.735
LIG_SH3_3	935	941	PF00018	0.682
LIG_SH3_CIN85_PxpxPR_1	331	336	PF14604	0.611
LIG_SUMO_SIM_anti_2	647	653	PF11976	0.561
LIG_SUMO_SIM_par_1	338	345	PF11976	0.648
LIG_SUMO_SIM_par_1	633	643	PF11976	0.690
LIG_SUMO_SIM_par_1	667	673	PF11976	0.648
LIG_TRAF2_1	257	260	PF00917	0.577
LIG_TRAF2_2	271	276	PF00917	0.671
LIG_TYR_ITIM	1008	1013	PF00017	0.565
LIG_WRC_WIRS_1	82	87	PF05994	0.646
MOD_CDC14_SPxK_1	48	51	PF00782	0.580
MOD_CDC14_SPxK_1	849	852	PF00782	0.583
MOD_CDK_SPK_2	739	744	PF00069	0.594
MOD_CDK_SPxK_1	45	51	PF00069	0.576
MOD_CDK_SPxK_1	846	852	PF00069	0.590
MOD_CDK_SPxxK_3	45	52	PF00069	0.710
MOD_CK1_1	107	113	PF00069	0.731
MOD_CK1_1	159	165	PF00069	0.652
MOD_CK1_1	207	213	PF00069	0.652
MOD_CK1_1	267	273	PF00069	0.729
MOD_CK1_1	345	351	PF00069	0.649
MOD_CK1_1	371	377	PF00069	0.617
MOD_CK1_1	409	415	PF00069	0.764
MOD_CK1_1	420	426	PF00069	0.713
MOD_CK1_1	445	451	PF00069	0.720
MOD_CK1_1	468	474	PF00069	0.620
MOD_CK1_1	544	550	PF00069	0.666
MOD_CK1_1	617	623	PF00069	0.745
MOD_CK1_1	647	653	PF00069	0.732
MOD_CK1_1	657	663	PF00069	0.620
MOD_CK1_1	668	674	PF00069	0.787
MOD_CK1_1	679	685	PF00069	0.644
MOD_CK1_1	694	700	PF00069	0.731
MOD_CK1_1	739	745	PF00069	0.727
MOD_CK1_1	794	800	PF00069	0.579
MOD_CK1_1	848	854	PF00069	0.691
MOD_CK1_1	975	981	PF00069	0.603
MOD_CK2_1	138	144	PF00069	0.713
MOD_CK2_1	50	56	PF00069	0.687
MOD_CK2_1	605	611	PF00069	0.772
MOD_CK2_1	68	74	PF00069	0.518
MOD_CK2_1	701	707	PF00069	0.590
MOD_CK2_1	713	719	PF00069	0.623
MOD_CK2_1	739	745	PF00069	0.727
MOD_CK2_1	779	785	PF00069	0.561
MOD_CK2_1	970	976	PF00069	0.746
MOD_CK2_1	992	998	PF00069	0.621
MOD_GlcNHglycan	109	112	PF01048	0.626
MOD_GlcNHglycan	146	149	PF01048	0.774
MOD_GlcNHglycan	212	215	PF01048	0.647
MOD_GlcNHglycan	234	238	PF01048	0.773
MOD_GlcNHglycan	259	264	PF01048	0.618
MOD_GlcNHglycan	26	29	PF01048	0.683
MOD_GlcNHglycan	319	322	PF01048	0.649
MOD_GlcNHglycan	344	347	PF01048	0.687
MOD_GlcNHglycan	371	374	PF01048	0.714
MOD_GlcNHglycan	40	43	PF01048	0.551
MOD_GlcNHglycan	414	418	PF01048	0.767
MOD_GlcNHglycan	460	465	PF01048	0.701
MOD_GlcNHglycan	524	528	PF01048	0.701
MOD_GlcNHglycan	543	546	PF01048	0.571
MOD_GlcNHglycan	587	591	PF01048	0.670
MOD_GlcNHglycan	616	619	PF01048	0.647
MOD_GlcNHglycan	656	659	PF01048	0.705
MOD_GlcNHglycan	678	681	PF01048	0.690
MOD_GlcNHglycan	686	689	PF01048	0.703
MOD_GlcNHglycan	793	796	PF01048	0.576
MOD_GlcNHglycan	972	975	PF01048	0.607
MOD_GSK3_1	103	110	PF00069	0.683
MOD_GSK3_1	135	142	PF00069	0.704
MOD_GSK3_1	338	345	PF00069	0.660
MOD_GSK3_1	368	375	PF00069	0.623
MOD_GSK3_1	38	45	PF00069	0.647
MOD_GSK3_1	406	413	PF00069	0.714
MOD_GSK3_1	438	445	PF00069	0.715
MOD_GSK3_1	479	486	PF00069	0.633
MOD_GSK3_1	498	505	PF00069	0.524
MOD_GSK3_1	540	547	PF00069	0.664
MOD_GSK3_1	605	612	PF00069	0.733
MOD_GSK3_1	613	620	PF00069	0.692
MOD_GSK3_1	640	647	PF00069	0.691
MOD_GSK3_1	654	661	PF00069	0.687
MOD_GSK3_1	664	671	PF00069	0.626
MOD_GSK3_1	779	786	PF00069	0.578
MOD_GSK3_1	853	860	PF00069	0.712
MOD_GSK3_1	914	921	PF00069	0.690
MOD_GSK3_1	932	939	PF00069	0.718
MOD_GSK3_1	962	969	PF00069	0.627
MOD_N-GLC_1	107	112	PF02516	0.531
MOD_N-GLC_1	139	144	PF02516	0.608
MOD_N-GLC_1	452	457	PF02516	0.642
MOD_N-GLC_1	604	609	PF02516	0.595
MOD_N-GLC_1	694	699	PF02516	0.610
MOD_NEK2_1	103	108	PF00069	0.682
MOD_NEK2_1	135	140	PF00069	0.688
MOD_NEK2_1	202	207	PF00069	0.714
MOD_NEK2_1	395	400	PF00069	0.575
MOD_NEK2_1	670	675	PF00069	0.701
MOD_NEK2_1	676	681	PF00069	0.654
MOD_NEK2_1	713	718	PF00069	0.615
MOD_NEK2_1	779	784	PF00069	0.608
MOD_NEK2_1	970	975	PF00069	0.633
MOD_PIKK_1	978	984	PF00454	0.599
MOD_PKA_1	550	556	PF00069	0.552
MOD_PKA_2	135	141	PF00069	0.632
MOD_PKA_2	50	56	PF00069	0.577
MOD_PKA_2	550	556	PF00069	0.573
MOD_PKA_2	575	581	PF00069	0.609
MOD_PKA_2	676	682	PF00069	0.644
MOD_PKA_2	978	984	PF00069	0.625
MOD_PKB_1	290	298	PF00069	0.602
MOD_PKB_1	550	558	PF00069	0.596
MOD_Plk_1	139	145	PF00069	0.608
MOD_Plk_1	452	458	PF00069	0.601
MOD_Plk_1	460	466	PF00069	0.541
MOD_Plk_1	498	504	PF00069	0.672
MOD_Plk_1	713	719	PF00069	0.701
MOD_Plk_1	80	86	PF00069	0.689
MOD_Plk_1	992	998	PF00069	0.572
MOD_Plk_4	127	133	PF00069	0.681
MOD_Plk_4	156	162	PF00069	0.652
MOD_Plk_4	16	22	PF00069	0.631
MOD_Plk_4	395	401	PF00069	0.573
MOD_Plk_4	498	504	PF00069	0.705
MOD_Plk_4	575	581	PF00069	0.609
MOD_Plk_4	644	650	PF00069	0.691
MOD_Plk_4	713	719	PF00069	0.659
MOD_Plk_4	915	921	PF00069	0.740
MOD_Plk_4	992	998	PF00069	0.572
MOD_ProDKin_1	22	28	PF00069	0.756
MOD_ProDKin_1	267	273	PF00069	0.718
MOD_ProDKin_1	420	426	PF00069	0.709
MOD_ProDKin_1	45	51	PF00069	0.749
MOD_ProDKin_1	468	474	PF00069	0.760
MOD_ProDKin_1	640	646	PF00069	0.676
MOD_ProDKin_1	665	671	PF00069	0.668
MOD_ProDKin_1	68	74	PF00069	0.722
MOD_ProDKin_1	681	687	PF00069	0.671
MOD_ProDKin_1	739	745	PF00069	0.635
MOD_ProDKin_1	806	812	PF00069	0.677
MOD_ProDKin_1	830	836	PF00069	0.695
MOD_ProDKin_1	846	852	PF00069	0.730
MOD_ProDKin_1	89	95	PF00069	0.763
MOD_ProDKin_1	897	903	PF00069	0.655
MOD_ProDKin_1	962	968	PF00069	0.711
TRG_DiLeu_BaEn_1	173	178	PF01217	0.633
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.667
TRG_ENDOCYTIC_2	1010	1013	PF00928	0.621
TRG_ENDOCYTIC_2	1018	1021	PF00928	0.474
TRG_ER_diArg_1	1037	1039	PF00400	0.674
TRG_ER_diArg_1	280	283	PF00400	0.600
TRG_ER_diArg_1	288	291	PF00400	0.559
TRG_ER_diArg_1	35	37	PF00400	0.638
TRG_ER_diArg_1	550	552	PF00400	0.658
TRG_ER_diArg_1	7	9	PF00400	0.577
TRG_ER_diArg_1	727	730	PF00400	0.765
TRG_ER_diArg_1	895	898	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJC9	Leishmania braziliensis	66%	100%
A4I6S5	Leishmania infantum	99%	100%
E9B1U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q6B5	Leishmania major	87%	100%