TLC domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sphingosine N-acyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4J5_LEIDO

TriTrypDb:

LdBPK_311800.1 , LdCL_310025300 , LDHU3_31.3110

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X4J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4J5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	14
GO:0006643	membrane lipid metabolic process	4	14
GO:0006665	sphingolipid metabolic process	4	14
GO:0006672	ceramide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0008610	lipid biosynthetic process	4	14
GO:0009058	biosynthetic process	2	14
GO:0009987	cellular process	1	14
GO:0030148	sphingolipid biosynthetic process	5	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044255	cellular lipid metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0046467	membrane lipid biosynthetic process	4	14
GO:0046513	ceramide biosynthetic process	5	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016410	N-acyltransferase activity	5	14
GO:0016740	transferase activity	2	14
GO:0016746	acyltransferase activity	3	14
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	14
GO:0050291	sphingosine N-acyltransferase activity	6	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	246	252	PF00089	0.561
CLV_NRD_NRD_1	137	139	PF00675	0.353
CLV_NRD_NRD_1	281	283	PF00675	0.297
CLV_NRD_NRD_1	284	286	PF00675	0.290
CLV_NRD_NRD_1	298	300	PF00675	0.264
CLV_NRD_NRD_1	35	37	PF00675	0.736
CLV_NRD_NRD_1	453	455	PF00675	0.583
CLV_NRD_NRD_1	458	460	PF00675	0.580
CLV_PCSK_FUR_1	282	286	PF00082	0.221
CLV_PCSK_KEX2_1	221	223	PF00082	0.267
CLV_PCSK_KEX2_1	281	283	PF00082	0.305
CLV_PCSK_KEX2_1	284	286	PF00082	0.306
CLV_PCSK_KEX2_1	35	37	PF00082	0.736
CLV_PCSK_KEX2_1	453	455	PF00082	0.585
CLV_PCSK_KEX2_1	458	460	PF00082	0.582
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.284
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.537
CLV_PCSK_PC7_1	454	460	PF00082	0.539
CLV_PCSK_SKI1_1	140	144	PF00082	0.380
CLV_PCSK_SKI1_1	218	222	PF00082	0.340
CLV_PCSK_SKI1_1	300	304	PF00082	0.310
CLV_PCSK_SKI1_1	408	412	PF00082	0.539
DOC_ANK_TNKS_1	10	17	PF00023	0.440
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.361
DOC_MAPK_gen_1	136	144	PF00069	0.539
DOC_MAPK_MEF2A_6	143	152	PF00069	0.508
DOC_PP2B_LxvP_1	183	186	PF13499	0.354
DOC_PP2B_LxvP_1	25	28	PF13499	0.491
DOC_PP4_FxxP_1	171	174	PF00568	0.275
DOC_SPAK_OSR1_1	104	108	PF12202	0.636
DOC_USP7_MATH_1	18	22	PF00917	0.462
DOC_USP7_MATH_1	431	435	PF00917	0.772
DOC_USP7_MATH_1	436	440	PF00917	0.739
DOC_USP7_UBL2_3	139	143	PF12436	0.611
DOC_USP7_UBL2_3	296	300	PF12436	0.573
DOC_WW_Pin1_4	131	136	PF00397	0.679
DOC_WW_Pin1_4	14	19	PF00397	0.455
DOC_WW_Pin1_4	340	345	PF00397	0.354
LIG_14-3-3_CanoR_1	128	134	PF00244	0.691
LIG_14-3-3_CanoR_1	299	303	PF00244	0.549
LIG_14-3-3_CanoR_1	305	313	PF00244	0.530
LIG_14-3-3_CanoR_1	35	39	PF00244	0.508
LIG_14-3-3_CanoR_1	4	12	PF00244	0.455
LIG_14-3-3_CanoR_1	42	46	PF00244	0.442
LIG_Actin_WH2_2	373	391	PF00022	0.578
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_BRCT_BRCA1_1	156	160	PF00533	0.330
LIG_Clathr_ClatBox_1	213	217	PF01394	0.451
LIG_EH1_1	230	238	PF00400	0.374
LIG_FHA_1	232	238	PF00498	0.315
LIG_FHA_1	7	13	PF00498	0.480
LIG_GBD_Chelix_1	356	364	PF00786	0.376
LIG_LIR_Gen_1	100	109	PF02991	0.607
LIG_LIR_Gen_1	17	27	PF02991	0.426
LIG_LIR_Gen_1	44	55	PF02991	0.410
LIG_LIR_Nem_3	100	105	PF02991	0.629
LIG_LIR_Nem_3	157	163	PF02991	0.348
LIG_LIR_Nem_3	167	173	PF02991	0.244
LIG_LIR_Nem_3	17	22	PF02991	0.403
LIG_LIR_Nem_3	223	228	PF02991	0.471
LIG_LIR_Nem_3	247	253	PF02991	0.274
LIG_LIR_Nem_3	321	327	PF02991	0.323
LIG_LIR_Nem_3	44	50	PF02991	0.370
LIG_LIR_Nem_3	52	57	PF02991	0.350
LIG_LYPXL_S_1	81	85	PF13949	0.391
LIG_LYPXL_yS_3	82	85	PF13949	0.391
LIG_NRBOX	355	361	PF00104	0.318
LIG_Pex14_1	149	153	PF04695	0.343
LIG_Pex14_1	354	358	PF04695	0.421
LIG_Pex14_2	320	324	PF04695	0.318
LIG_REV1ctd_RIR_1	322	332	PF16727	0.346
LIG_SH2_CRK	108	112	PF00017	0.590
LIG_SH2_CRK	19	23	PF00017	0.431
LIG_SH2_CRK	330	334	PF00017	0.468
LIG_SH2_NCK_1	189	193	PF00017	0.361
LIG_SH2_STAP1	19	23	PF00017	0.454
LIG_SH2_STAT3	162	165	PF00017	0.330
LIG_SH2_STAT3	273	276	PF00017	0.561
LIG_SH2_STAT5	154	157	PF00017	0.328
LIG_SH2_STAT5	163	166	PF00017	0.302
LIG_SH2_STAT5	206	209	PF00017	0.321
LIG_SH2_STAT5	253	256	PF00017	0.324
LIG_SH2_STAT5	26	29	PF00017	0.495
LIG_SH2_STAT5	273	276	PF00017	0.338
LIG_SH2_STAT5	330	333	PF00017	0.420
LIG_SH2_STAT5	96	99	PF00017	0.580
LIG_SH3_3	185	191	PF00018	0.268
LIG_SH3_3	77	83	PF00018	0.391
LIG_SUMO_SIM_anti_2	234	242	PF11976	0.345
LIG_SUMO_SIM_anti_2	74	79	PF11976	0.322
LIG_SUMO_SIM_par_1	234	242	PF11976	0.345
LIG_SUMO_SIM_par_1	261	268	PF11976	0.354
LIG_SUMO_SIM_par_1	373	379	PF11976	0.411
LIG_TRAF2_1	191	194	PF00917	0.352
LIG_TRAF2_1	418	421	PF00917	0.778
LIG_TYR_ITIM	80	85	PF00017	0.443
LIG_UBA3_1	213	221	PF00899	0.468
MOD_CDK_SPK_2	131	136	PF00069	0.679
MOD_CDK_SPK_2	340	345	PF00069	0.318
MOD_CDK_SPxxK_3	131	138	PF00069	0.615
MOD_CDK_SPxxK_3	340	347	PF00069	0.354
MOD_CK1_1	309	315	PF00069	0.488
MOD_CK1_1	34	40	PF00069	0.473
MOD_CK1_1	439	445	PF00069	0.779
MOD_CK1_1	6	12	PF00069	0.477
MOD_CK2_1	18	24	PF00069	0.435
MOD_CK2_1	390	396	PF00069	0.677
MOD_CK2_1	406	412	PF00069	0.698
MOD_GlcNHglycan	124	127	PF01048	0.515
MOD_GlcNHglycan	5	8	PF01048	0.557
MOD_GlcNHglycan	51	54	PF01048	0.638
MOD_GlcNHglycan	68	71	PF01048	0.561
MOD_GSK3_1	110	117	PF00069	0.639
MOD_GSK3_1	14	21	PF00069	0.451
MOD_GSK3_1	263	270	PF00069	0.424
MOD_GSK3_1	336	343	PF00069	0.380
MOD_GSK3_1	37	44	PF00069	0.476
MOD_GSK3_1	396	403	PF00069	0.710
MOD_GSK3_1	406	413	PF00069	0.701
MOD_GSK3_1	436	443	PF00069	0.773
MOD_GSK3_1	444	451	PF00069	0.780
MOD_GSK3_1	45	52	PF00069	0.431
MOD_LATS_1	406	412	PF00433	0.716
MOD_N-GLC_1	31	36	PF02516	0.667
MOD_N-GLC_1	448	453	PF02516	0.565
MOD_N-GLC_1	45	50	PF02516	0.530
MOD_N-GLC_2	314	316	PF02516	0.421
MOD_NEK2_1	148	153	PF00069	0.417
MOD_NEK2_1	155	160	PF00069	0.417
MOD_NEK2_1	265	270	PF00069	0.330
MOD_NEK2_1	378	383	PF00069	0.594
MOD_NEK2_1	410	415	PF00069	0.733
MOD_NEK2_1	440	445	PF00069	0.774
MOD_NEK2_1	73	78	PF00069	0.250
MOD_NEK2_2	336	341	PF00069	0.329
MOD_PIKK_1	448	454	PF00454	0.738
MOD_PKA_1	284	290	PF00069	0.421
MOD_PKA_1	453	459	PF00069	0.796
MOD_PKA_2	284	290	PF00069	0.551
MOD_PKA_2	292	298	PF00069	0.529
MOD_PKA_2	3	9	PF00069	0.497
MOD_PKA_2	34	40	PF00069	0.519
MOD_PKA_2	41	47	PF00069	0.455
MOD_PKA_2	431	437	PF00069	0.709
MOD_PKA_2	453	459	PF00069	0.796
MOD_PKB_1	282	290	PF00069	0.491
MOD_Plk_1	177	183	PF00069	0.361
MOD_Plk_1	309	315	PF00069	0.466
MOD_Plk_1	73	79	PF00069	0.285
MOD_Plk_2-3	390	396	PF00069	0.625
MOD_Plk_4	148	154	PF00069	0.374
MOD_Plk_4	209	215	PF00069	0.360
MOD_Plk_4	232	238	PF00069	0.401
MOD_Plk_4	298	304	PF00069	0.513
MOD_Plk_4	73	79	PF00069	0.300
MOD_ProDKin_1	131	137	PF00069	0.672
MOD_ProDKin_1	14	20	PF00069	0.458
MOD_ProDKin_1	340	346	PF00069	0.354
MOD_SUMO_rev_2	420	425	PF00179	0.786
TRG_ENDOCYTIC_2	108	111	PF00928	0.537
TRG_ENDOCYTIC_2	19	22	PF00928	0.405
TRG_ENDOCYTIC_2	253	256	PF00928	0.318
TRG_ENDOCYTIC_2	370	373	PF00928	0.403
TRG_ENDOCYTIC_2	82	85	PF00928	0.446
TRG_ENDOCYTIC_2	86	89	PF00928	0.430
TRG_ER_diArg_1	135	138	PF00400	0.667
TRG_NLS_MonoExtN_4	135	142	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N8	Leptomonas seymouri	64%	100%
A0A0S4JEY3	Bodo saltans	32%	100%
A0A0S4JIF9	Bodo saltans	34%	100%
A0A1X0NPU5	Trypanosomatidae	46%	100%
A0A1X0NPY1	Trypanosomatidae	47%	100%
A0A422MNN3	Trypanosoma rangeli	46%	100%
A4HJG0	Leishmania braziliensis	70%	100%
A4I6V5	Leishmania infantum	99%	100%
C9ZMC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZWR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B1X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q684	Leishmania major	95%	100%