LeishMANIAdb
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Surface membrane protein gp46-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface membrane protein gp46-like protein
Gene product:
surface membrane protein gp46-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X4J4_LEIDO
TriTrypDb:
LdBPK_311490.1 , LdCL_310022000 , LDHU3_31.2590
Length:
303

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 34, no: 8
NetGPI no yes: 0, no: 42
Cellular components
Term Name Level Count
GO:0005929 cilium 4 43
GO:0042995 cell projection 2 43
GO:0043226 organelle 2 43
GO:0043227 membrane-bounded organelle 3 43
GO:0110165 cellular anatomical entity 1 43
GO:0120025 plasma membrane bounded cell projection 3 43
GO:0016020 membrane 2 7

Expansion

Sequence features

A0A3S7X4J4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4J4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 237 241 PF00656 0.515
CLV_NRD_NRD_1 215 217 PF00675 0.556
CLV_NRD_NRD_1 230 232 PF00675 0.459
CLV_NRD_NRD_1 50 52 PF00675 0.485
CLV_NRD_NRD_1 7 9 PF00675 0.686
CLV_PCSK_KEX2_1 215 217 PF00082 0.552
CLV_PCSK_KEX2_1 7 9 PF00082 0.686
CLV_PCSK_SKI1_1 107 111 PF00082 0.254
CLV_PCSK_SKI1_1 15 19 PF00082 0.610
CLV_PCSK_SKI1_1 159 163 PF00082 0.480
CLV_PCSK_SKI1_1 183 187 PF00082 0.480
CLV_PCSK_SKI1_1 51 55 PF00082 0.449
DEG_APCC_DBOX_1 14 22 PF00400 0.626
DOC_CYCLIN_yClb5_NLxxxL_5 190 199 PF00134 0.266
DOC_CYCLIN_yClb5_NLxxxL_5 238 247 PF00134 0.465
DOC_MAPK_gen_1 13 21 PF00069 0.651
DOC_MAPK_gen_1 231 238 PF00069 0.486
DOC_MAPK_MEF2A_6 15 23 PF00069 0.586
DOC_USP7_MATH_1 293 297 PF00917 0.485
DOC_USP7_MATH_1 98 102 PF00917 0.332
DOC_USP7_MATH_2 248 254 PF00917 0.480
DOC_USP7_UBL2_3 120 124 PF12436 0.337
DOC_WW_Pin1_4 27 32 PF00397 0.633
DOC_WW_Pin1_4 34 39 PF00397 0.551
LIG_14-3-3_CanoR_1 183 188 PF00244 0.395
LIG_14-3-3_CanoR_1 231 238 PF00244 0.495
LIG_APCC_ABBA_1 85 90 PF00400 0.282
LIG_BIR_III_2 59 63 PF00653 0.510
LIG_BRCT_BRCA1_1 276 280 PF00533 0.322
LIG_BRCT_BRCA1_1 68 72 PF00533 0.553
LIG_FHA_1 146 152 PF00498 0.368
LIG_FHA_1 170 176 PF00498 0.355
LIG_FHA_1 194 200 PF00498 0.364
LIG_FHA_1 218 224 PF00498 0.419
LIG_FHA_1 22 28 PF00498 0.605
LIG_FHA_1 242 248 PF00498 0.419
LIG_FHA_2 133 139 PF00498 0.491
LIG_FHA_2 172 178 PF00498 0.497
LIG_FHA_2 208 214 PF00498 0.461
LIG_FHA_2 235 241 PF00498 0.445
LIG_GBD_Chelix_1 19 27 PF00786 0.424
LIG_KLC1_Yacidic_2 86 90 PF13176 0.263
LIG_LIR_Gen_1 138 147 PF02991 0.450
LIG_LIR_Gen_1 154 161 PF02991 0.358
LIG_LIR_Gen_1 177 185 PF02991 0.398
LIG_LIR_Gen_1 186 195 PF02991 0.324
LIG_LIR_Gen_1 40 48 PF02991 0.454
LIG_LIR_Nem_3 130 134 PF02991 0.424
LIG_LIR_Nem_3 160 166 PF02991 0.390
LIG_LIR_Nem_3 177 182 PF02991 0.323
LIG_LIR_Nem_3 186 190 PF02991 0.326
LIG_LIR_Nem_3 226 230 PF02991 0.411
LIG_LIR_Nem_3 36 42 PF02991 0.489
LIG_NRBOX 24 30 PF00104 0.541
LIG_Pex14_1 163 167 PF04695 0.265
LIG_Pex14_2 53 57 PF04695 0.307
LIG_SH2_CRK 108 112 PF00017 0.213
LIG_SH2_CRK 42 46 PF00017 0.404
LIG_SH2_GRB2like 143 146 PF00017 0.410
LIG_SH2_NCK_1 108 112 PF00017 0.180
LIG_SH2_NCK_1 42 46 PF00017 0.559
LIG_SH2_STAP1 143 147 PF00017 0.284
LIG_SH2_STAT3 282 285 PF00017 0.251
LIG_SH2_STAT5 139 142 PF00017 0.429
LIG_SH2_STAT5 88 91 PF00017 0.580
LIG_SH3_3 92 98 PF00018 0.553
LIG_SUMO_SIM_par_1 19 24 PF11976 0.600
LIG_TYR_ITSM 38 45 PF00017 0.310
MOD_CDC14_SPxK_1 30 33 PF00782 0.389
MOD_CDK_SPxK_1 27 33 PF00069 0.390
MOD_CK1_1 130 136 PF00069 0.388
MOD_CK1_1 141 147 PF00069 0.393
MOD_CK1_1 202 208 PF00069 0.379
MOD_CK1_1 234 240 PF00069 0.374
MOD_CK1_1 253 259 PF00069 0.339
MOD_CK1_1 274 280 PF00069 0.412
MOD_CK1_1 37 43 PF00069 0.508
MOD_CK1_1 78 84 PF00069 0.435
MOD_CK2_1 132 138 PF00069 0.471
MOD_CK2_1 171 177 PF00069 0.492
MOD_CK2_1 207 213 PF00069 0.534
MOD_GlcNHglycan 101 104 PF01048 0.474
MOD_GlcNHglycan 159 162 PF01048 0.395
MOD_GlcNHglycan 204 207 PF01048 0.425
MOD_GlcNHglycan 252 255 PF01048 0.439
MOD_GlcNHglycan 42 45 PF01048 0.495
MOD_GSK3_1 110 117 PF00069 0.381
MOD_GSK3_1 119 126 PF00069 0.454
MOD_GSK3_1 141 148 PF00069 0.387
MOD_GSK3_1 195 202 PF00069 0.445
MOD_GSK3_1 219 226 PF00069 0.401
MOD_GSK3_1 232 239 PF00069 0.451
MOD_GSK3_1 75 82 PF00069 0.410
MOD_N-GLC_1 114 119 PF02516 0.494
MOD_N-GLC_1 193 198 PF02516 0.387
MOD_N-GLC_1 241 246 PF02516 0.431
MOD_N-GLC_2 266 268 PF02516 0.289
MOD_N-GLC_2 299 301 PF02516 0.534
MOD_NEK2_1 110 115 PF00069 0.335
MOD_NEK2_1 123 128 PF00069 0.303
MOD_NEK2_1 147 152 PF00069 0.338
MOD_NEK2_1 171 176 PF00069 0.353
MOD_NEK2_1 195 200 PF00069 0.395
MOD_NEK2_1 219 224 PF00069 0.345
MOD_NEK2_2 119 124 PF00069 0.360
MOD_PK_1 232 238 PF00069 0.302
MOD_PK_1 66 72 PF00069 0.291
MOD_PKA_1 231 237 PF00069 0.466
MOD_PKB_1 181 189 PF00069 0.224
MOD_Plk_1 114 120 PF00069 0.527
MOD_Plk_1 286 292 PF00069 0.444
MOD_Plk_4 207 213 PF00069 0.403
MOD_Plk_4 253 259 PF00069 0.439
MOD_Plk_4 271 277 PF00069 0.498
MOD_Plk_4 286 292 PF00069 0.447
MOD_ProDKin_1 27 33 PF00069 0.636
MOD_ProDKin_1 34 40 PF00069 0.550
TRG_DiLeu_BaLyEn_6 59 64 PF01217 0.318
TRG_ENDOCYTIC_2 108 111 PF00928 0.474
TRG_ENDOCYTIC_2 139 142 PF00928 0.484
TRG_ENDOCYTIC_2 42 45 PF00928 0.410
TRG_ER_diArg_1 181 184 PF00400 0.438
TRG_ER_diArg_1 6 8 PF00400 0.691

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P227 Leptomonas seymouri 34% 97%
A0A0N0P276 Leptomonas seymouri 27% 98%
A0A0N0P2L4 Leptomonas seymouri 31% 100%
A0A0N0P4M2 Leptomonas seymouri 26% 100%
A0A0N1HY53 Leptomonas seymouri 35% 100%
A0A0S4IIK7 Bodo saltans 27% 73%
A0A0S4IQP4 Bodo saltans 37% 77%
A0A0S4IR61 Bodo saltans 29% 75%
A0A0S4IVH1 Bodo saltans 28% 100%
A0A0S4IVN7 Bodo saltans 37% 79%
A0A0S4IY39 Bodo saltans 27% 94%
A0A0S4IZC7 Bodo saltans 33% 74%
A0A0S4J1A6 Bodo saltans 33% 70%
A0A0S4J353 Bodo saltans 25% 100%
A0A0S4J805 Bodo saltans 30% 100%
A0A0S4JB29 Bodo saltans 26% 100%
A0A0S4JEK1 Bodo saltans 24% 74%
A0A0S4JEZ2 Bodo saltans 29% 95%
A0A0S4JMF9 Bodo saltans 32% 76%
A0A0S4JS11 Bodo saltans 31% 95%
A0A0S4JS89 Bodo saltans 31% 68%
A0A0S4JU20 Bodo saltans 26% 100%
A0A0S4KHE4 Bodo saltans 33% 82%
A0A0S4KL26 Bodo saltans 25% 83%
A0A0S4KMV2 Bodo saltans 30% 77%
A0A1X0NKN8 Trypanosomatidae 26% 100%
A0A3Q8I9A6 Leishmania donovani 33% 100%
A0A3Q8I9D0 Leishmania donovani 35% 100%
A0A3Q8IFC2 Leishmania donovani 33% 69%
A0A3Q8IIJ9 Leishmania donovani 100% 100%
A0A3S5H6D6 Leishmania donovani 26% 100%
A0A3S7WPB2 Leishmania donovani 25% 100%
A4H4G6 Leishmania braziliensis 25% 99%
A4H5P0 Leishmania braziliensis 28% 100%
A4HBX3 Leishmania braziliensis 35% 67%
A4HJC8 Leishmania braziliensis 69% 100%
A4HJX1 Leishmania braziliensis 34% 69%
A4HTX9 Leishmania infantum 25% 100%
A4HVB0 Leishmania infantum 33% 100%
A4I6S2 Leishmania infantum 29% 69%
A4I6S4 Leishmania infantum 99% 100%
E8NHG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 68%
E8NHP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9ACQ0 Leishmania major 25% 100%
E9AG65 Leishmania infantum 25% 100%
E9AGG5 Leishmania infantum 33% 100%
E9AGH0 Leishmania infantum 34% 100%
E9AKM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AMQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B1U3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 67%
E9B1U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 72%
E9B1U6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
P35334 Phaseolus vulgaris 25% 89%
P58822 Phaseolus vulgaris 25% 89%
P58823 Phaseolus vulgaris 25% 89%
Q25331 Leishmania major 31% 100%
Q4PSE6 Arabidopsis thaliana 26% 70%
Q4Q6B6 Leishmania major 91% 100%
Q4Q6B7 Leishmania major 90% 100%
Q4QC79 Leishmania major 37% 66%
Q4QGJ4 Leishmania major 31% 100%
Q4QGJ7 Leishmania major 31% 100%
Q4QGK6 Leishmania major 31% 100%
Q4QGL4 Leishmania major 35% 100%
Q4QHW6 Leishmania major 26% 100%
Q8GT95 Oryza sativa subsp. japonica 26% 91%
Q8W3M4 Arabidopsis thaliana 27% 75%
Q9M5J8 Arabidopsis thaliana 30% 92%
Q9M5J9 Arabidopsis thaliana 27% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS