Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4H9_LEIDO

TriTrypDb:

LdBPK_311720.1 , LdCL_310024400 , LDHU3_31.2970

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4H9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.693
CLV_C14_Caspase3-7	654	658	PF00656	0.547
CLV_NRD_NRD_1	138	140	PF00675	0.739
CLV_NRD_NRD_1	168	170	PF00675	0.695
CLV_NRD_NRD_1	196	198	PF00675	0.624
CLV_NRD_NRD_1	227	229	PF00675	0.538
CLV_NRD_NRD_1	304	306	PF00675	0.617
CLV_PCSK_KEX2_1	138	140	PF00082	0.765
CLV_PCSK_KEX2_1	159	161	PF00082	0.649
CLV_PCSK_KEX2_1	170	172	PF00082	0.639
CLV_PCSK_KEX2_1	196	198	PF00082	0.661
CLV_PCSK_KEX2_1	226	228	PF00082	0.552
CLV_PCSK_KEX2_1	304	306	PF00082	0.662
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.649
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.639
CLV_PCSK_PC7_1	155	161	PF00082	0.580
CLV_PCSK_SKI1_1	197	201	PF00082	0.635
CLV_PCSK_SKI1_1	495	499	PF00082	0.388
CLV_PCSK_SKI1_1	547	551	PF00082	0.528
CLV_PCSK_SKI1_1	585	589	PF00082	0.623
CLV_PCSK_SKI1_1	634	638	PF00082	0.502
CLV_PCSK_SKI1_1	69	73	PF00082	0.808
DEG_SCF_TRCP1_1	379	385	PF00400	0.426
DEG_SPOP_SBC_1	125	129	PF00917	0.675
DEG_SPOP_SBC_1	356	360	PF00917	0.582
DOC_ANK_TNKS_1	557	564	PF00023	0.689
DOC_CKS1_1	351	356	PF01111	0.677
DOC_CYCLIN_RxL_1	276	290	PF00134	0.571
DOC_CYCLIN_RxL_1	544	554	PF00134	0.557
DOC_MAPK_gen_1	226	232	PF00069	0.547
DOC_MAPK_gen_1	425	434	PF00069	0.595
DOC_MAPK_gen_1	66	75	PF00069	0.791
DOC_MAPK_MEF2A_6	212	221	PF00069	0.584
DOC_PP1_RVXF_1	235	242	PF00149	0.490
DOC_PP1_RVXF_1	545	552	PF00149	0.562
DOC_PP4_FxxP_1	550	553	PF00568	0.567
DOC_USP7_MATH_1	120	124	PF00917	0.714
DOC_USP7_MATH_1	126	130	PF00917	0.764
DOC_USP7_MATH_1	146	150	PF00917	0.547
DOC_USP7_MATH_1	163	167	PF00917	0.601
DOC_USP7_MATH_1	189	193	PF00917	0.718
DOC_USP7_MATH_1	356	360	PF00917	0.516
DOC_USP7_MATH_1	39	43	PF00917	0.765
DOC_USP7_MATH_1	399	403	PF00917	0.565
DOC_USP7_MATH_1	412	416	PF00917	0.689
DOC_USP7_MATH_1	533	537	PF00917	0.442
DOC_USP7_MATH_1	651	655	PF00917	0.605
DOC_USP7_MATH_1	92	96	PF00917	0.712
DOC_USP7_UBL2_3	242	246	PF12436	0.533
DOC_WW_Pin1_4	128	133	PF00397	0.746
DOC_WW_Pin1_4	159	164	PF00397	0.684
DOC_WW_Pin1_4	261	266	PF00397	0.498
DOC_WW_Pin1_4	35	40	PF00397	0.668
DOC_WW_Pin1_4	350	355	PF00397	0.620
DOC_WW_Pin1_4	360	365	PF00397	0.539
DOC_WW_Pin1_4	382	387	PF00397	0.535
DOC_WW_Pin1_4	414	419	PF00397	0.764
DOC_WW_Pin1_4	448	453	PF00397	0.451
DOC_WW_Pin1_4	48	53	PF00397	0.835
DOC_WW_Pin1_4	486	491	PF00397	0.511
DOC_WW_Pin1_4	88	93	PF00397	0.764
LIG_14-3-3_CanoR_1	10	17	PF00244	0.699
LIG_14-3-3_CanoR_1	124	132	PF00244	0.730
LIG_14-3-3_CanoR_1	138	147	PF00244	0.602
LIG_14-3-3_CanoR_1	35	39	PF00244	0.784
LIG_14-3-3_CanoR_1	644	652	PF00244	0.572
LIG_Actin_WH2_2	542	560	PF00022	0.591
LIG_APCC_ABBA_1	219	224	PF00400	0.663
LIG_APCC_ABBA_1	661	666	PF00400	0.503
LIG_BIR_III_4	413	417	PF00653	0.662
LIG_BRCT_BRCA1_1	547	551	PF00533	0.547
LIG_Clathr_ClatBox_1	431	435	PF01394	0.531
LIG_FHA_1	100	106	PF00498	0.799
LIG_FHA_1	132	138	PF00498	0.800
LIG_FHA_1	205	211	PF00498	0.627
LIG_FHA_1	383	389	PF00498	0.491
LIG_FHA_1	427	433	PF00498	0.324
LIG_FHA_1	496	502	PF00498	0.501
LIG_FHA_1	520	526	PF00498	0.420
LIG_FHA_1	594	600	PF00498	0.374
LIG_FHA_1	612	618	PF00498	0.419
LIG_FHA_2	288	294	PF00498	0.418
LIG_FHA_2	408	414	PF00498	0.696
LIG_FHA_2	449	455	PF00498	0.452
LIG_FHA_2	480	486	PF00498	0.483
LIG_LIR_Apic_2	548	553	PF02991	0.557
LIG_LIR_Gen_1	289	299	PF02991	0.404
LIG_LIR_Gen_1	459	466	PF02991	0.520
LIG_LIR_Gen_1	596	605	PF02991	0.426
LIG_LIR_Gen_1	607	618	PF02991	0.385
LIG_LIR_LC3C_4	216	221	PF02991	0.621
LIG_LIR_Nem_3	289	294	PF02991	0.406
LIG_LIR_Nem_3	368	374	PF02991	0.407
LIG_LIR_Nem_3	459	463	PF02991	0.419
LIG_LIR_Nem_3	541	546	PF02991	0.398
LIG_LIR_Nem_3	607	613	PF02991	0.481
LIG_MLH1_MIPbox_1	547	551	PF16413	0.561
LIG_MYND_3	673	677	PF01753	0.722
LIG_NRBOX	631	637	PF00104	0.442
LIG_SH2_CRK	374	378	PF00017	0.546
LIG_SH2_CRK	493	497	PF00017	0.407
LIG_SH2_CRK	546	550	PF00017	0.407
LIG_SH2_NCK_1	291	295	PF00017	0.419
LIG_SH2_PTP2	460	463	PF00017	0.367
LIG_SH2_SRC	215	218	PF00017	0.616
LIG_SH2_SRC	291	294	PF00017	0.414
LIG_SH2_STAP1	291	295	PF00017	0.391
LIG_SH2_STAP1	493	497	PF00017	0.407
LIG_SH2_STAP1	506	510	PF00017	0.439
LIG_SH2_STAT5	156	159	PF00017	0.597
LIG_SH2_STAT5	164	167	PF00017	0.659
LIG_SH2_STAT5	33	36	PF00017	0.760
LIG_SH2_STAT5	376	379	PF00017	0.555
LIG_SH2_STAT5	391	394	PF00017	0.353
LIG_SH2_STAT5	455	458	PF00017	0.389
LIG_SH2_STAT5	460	463	PF00017	0.367
LIG_SH2_STAT5	506	509	PF00017	0.575
LIG_SH2_STAT5	524	527	PF00017	0.288
LIG_SH2_STAT5	610	613	PF00017	0.543
LIG_SH2_STAT5	76	79	PF00017	0.612
LIG_SH3_2	553	558	PF14604	0.688
LIG_SH3_3	25	31	PF00018	0.553
LIG_SH3_3	358	364	PF00018	0.535
LIG_SH3_3	550	556	PF00018	0.616
LIG_SH3_3	86	92	PF00018	0.735
LIG_Sin3_3	509	516	PF02671	0.516
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.552
LIG_SUMO_SIM_par_1	429	435	PF11976	0.552
LIG_TRAF2_1	482	485	PF00917	0.647
LIG_TRFH_1	448	452	PF08558	0.435
LIG_UBA3_1	631	637	PF00899	0.479
LIG_WRC_WIRS_1	594	599	PF05994	0.515
MOD_CDC14_SPxK_1	38	41	PF00782	0.650
MOD_CDK_SPK_2	128	133	PF00069	0.758
MOD_CDK_SPK_2	382	387	PF00069	0.535
MOD_CDK_SPxK_1	35	41	PF00069	0.650
MOD_CDK_SPxxK_3	128	135	PF00069	0.737
MOD_CDK_SPxxK_3	261	268	PF00069	0.495
MOD_CK1_1	100	106	PF00069	0.717
MOD_CK1_1	127	133	PF00069	0.803
MOD_CK1_1	149	155	PF00069	0.620
MOD_CK1_1	261	267	PF00069	0.499
MOD_CK1_1	316	322	PF00069	0.714
MOD_CK1_1	355	361	PF00069	0.536
MOD_CK1_1	402	408	PF00069	0.619
MOD_CK1_1	581	587	PF00069	0.655
MOD_CK1_1	593	599	PF00069	0.419
MOD_CK1_1	65	71	PF00069	0.791
MOD_CK2_1	110	116	PF00069	0.684
MOD_CK2_1	261	267	PF00069	0.469
MOD_CK2_1	448	454	PF00069	0.452
MOD_CK2_1	479	485	PF00069	0.476
MOD_DYRK1A_RPxSP_1	35	39	PF00069	0.604
MOD_GlcNHglycan	107	110	PF01048	0.787
MOD_GlcNHglycan	11	14	PF01048	0.666
MOD_GlcNHglycan	118	121	PF01048	0.649
MOD_GlcNHglycan	149	152	PF01048	0.634
MOD_GlcNHglycan	187	190	PF01048	0.674
MOD_GlcNHglycan	319	322	PF01048	0.674
MOD_GlcNHglycan	324	327	PF01048	0.713
MOD_GlcNHglycan	342	345	PF01048	0.609
MOD_GlcNHglycan	354	357	PF01048	0.619
MOD_GlcNHglycan	379	382	PF01048	0.450
MOD_GlcNHglycan	413	417	PF01048	0.748
MOD_GlcNHglycan	559	562	PF01048	0.773
MOD_GlcNHglycan	580	583	PF01048	0.698
MOD_GlcNHglycan	585	588	PF01048	0.605
MOD_GlcNHglycan	653	656	PF01048	0.590
MOD_GlcNHglycan	69	72	PF01048	0.717
MOD_GSK3_1	110	117	PF00069	0.784
MOD_GSK3_1	120	127	PF00069	0.750
MOD_GSK3_1	159	166	PF00069	0.656
MOD_GSK3_1	185	192	PF00069	0.652
MOD_GSK3_1	31	38	PF00069	0.792
MOD_GSK3_1	313	320	PF00069	0.633
MOD_GSK3_1	336	343	PF00069	0.665
MOD_GSK3_1	352	359	PF00069	0.474
MOD_GSK3_1	408	415	PF00069	0.710
MOD_GSK3_1	475	482	PF00069	0.441
MOD_GSK3_1	581	588	PF00069	0.648
MOD_GSK3_1	604	611	PF00069	0.559
MOD_GSK3_1	88	95	PF00069	0.734
MOD_LATS_1	136	142	PF00433	0.707
MOD_N-GLC_2	332	334	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.725
MOD_NEK2_1	317	322	PF00069	0.684
MOD_NEK2_1	340	345	PF00069	0.666
MOD_NEK2_1	377	382	PF00069	0.508
MOD_NEK2_1	545	550	PF00069	0.423
MOD_NEK2_1	67	72	PF00069	0.714
MOD_NEK2_2	164	169	PF00069	0.636
MOD_PIKK_1	604	610	PF00454	0.534
MOD_PKA_1	138	144	PF00069	0.705
MOD_PKA_2	114	120	PF00069	0.735
MOD_PKA_2	138	144	PF00069	0.702
MOD_PKA_2	174	180	PF00069	0.718
MOD_PKA_2	34	40	PF00069	0.805
MOD_PKA_2	426	432	PF00069	0.607
MOD_PKA_2	475	481	PF00069	0.432
MOD_PKA_2	533	539	PF00069	0.443
MOD_PKA_2	557	563	PF00069	0.746
MOD_PKA_2	578	584	PF00069	0.677
MOD_PKA_2	9	15	PF00069	0.705
MOD_PKB_1	122	130	PF00069	0.637
MOD_PKB_1	285	293	PF00069	0.421
MOD_Plk_1	453	459	PF00069	0.396
MOD_Plk_1	611	617	PF00069	0.579
MOD_Plk_1	97	103	PF00069	0.714
MOD_Plk_2-3	206	212	PF00069	0.637
MOD_Plk_4	100	106	PF00069	0.763
MOD_Plk_4	149	155	PF00069	0.636
MOD_Plk_4	18	24	PF00069	0.663
MOD_Plk_4	268	274	PF00069	0.543
MOD_Plk_4	294	300	PF00069	0.518
MOD_Plk_4	336	342	PF00069	0.613
MOD_Plk_4	357	363	PF00069	0.537
MOD_Plk_4	437	443	PF00069	0.394
MOD_Plk_4	456	462	PF00069	0.370
MOD_Plk_4	520	526	PF00069	0.499
MOD_Plk_4	538	544	PF00069	0.302
MOD_Plk_4	590	596	PF00069	0.573
MOD_Plk_4	611	617	PF00069	0.527
MOD_ProDKin_1	128	134	PF00069	0.747
MOD_ProDKin_1	159	165	PF00069	0.677
MOD_ProDKin_1	261	267	PF00069	0.499
MOD_ProDKin_1	35	41	PF00069	0.670
MOD_ProDKin_1	350	356	PF00069	0.612
MOD_ProDKin_1	360	366	PF00069	0.530
MOD_ProDKin_1	382	388	PF00069	0.530
MOD_ProDKin_1	414	420	PF00069	0.762
MOD_ProDKin_1	448	454	PF00069	0.452
MOD_ProDKin_1	48	54	PF00069	0.834
MOD_ProDKin_1	486	492	PF00069	0.503
MOD_ProDKin_1	88	94	PF00069	0.764
MOD_SUMO_rev_2	654	661	PF00179	0.634
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.390
TRG_ENDOCYTIC_2	248	251	PF00928	0.420
TRG_ENDOCYTIC_2	291	294	PF00928	0.395
TRG_ENDOCYTIC_2	374	377	PF00928	0.420
TRG_ENDOCYTIC_2	460	463	PF00928	0.367
TRG_ENDOCYTIC_2	493	496	PF00928	0.410
TRG_ENDOCYTIC_2	546	549	PF00928	0.413
TRG_ENDOCYTIC_2	610	613	PF00928	0.439
TRG_ER_diArg_1	122	125	PF00400	0.677
TRG_ER_diArg_1	132	135	PF00400	0.694
TRG_ER_diArg_1	137	139	PF00400	0.663
TRG_ER_diArg_1	168	171	PF00400	0.672
TRG_ER_diArg_1	226	228	PF00400	0.575
TRG_ER_diArg_1	284	287	PF00400	0.432
TRG_ER_diArg_1	303	305	PF00400	0.623
TRG_NLS_Bipartite_1	159	173	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ1	Leptomonas seymouri	65%	100%
A0A1X0NQ51	Trypanosomatidae	43%	100%
A0A3R7LJ81	Trypanosoma rangeli	44%	100%
A4HJF2	Leishmania braziliensis	80%	99%
A4I6U7	Leishmania infantum	99%	100%
C9ZMB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B1X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q692	Leishmania major	94%	100%
V5B8N6	Trypanosoma cruzi	41%	100%