Pentamidine resistance protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p-glycoprotein e (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X4H7_LEIDO

TriTrypDb:

LdBPK_311290.1 , LdBPK_340690.1 , LdCL_310019800 , LDHU3_23.0280

Length:

1680

Annotations

LeishMANIAdb annotations

An ABC transporter related to genes in fungi and other microbes. . Exact number of TM segments unclear.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	28
GO:0043226	organelle	2	1
GO:0043229	intracellular organelle	3	1
GO:0110165	cellular anatomical entity	1	28

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Expansion

Sequence features

A0A3S7X4H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0009987	cellular process	1	5
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	5

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	28
GO:0003824	catalytic activity	1	8
GO:0005215	transporter activity	1	28
GO:0005488	binding	1	28
GO:0005524	ATP binding	5	28
GO:0015399	primary active transmembrane transporter activity	4	28
GO:0016787	hydrolase activity	2	8
GO:0017076	purine nucleotide binding	4	28
GO:0022804	active transmembrane transporter activity	3	28
GO:0022857	transmembrane transporter activity	2	28

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1171	1175	PF00656	0.470
CLV_C14_Caspase3-7	1336	1340	PF00656	0.197
CLV_C14_Caspase3-7	1403	1407	PF00656	0.444
CLV_C14_Caspase3-7	143	147	PF00656	0.493
CLV_C14_Caspase3-7	690	694	PF00656	0.523
CLV_C14_Caspase3-7	801	805	PF00656	0.471
CLV_C14_Caspase3-7	836	840	PF00656	0.486
CLV_C14_Caspase3-7	911	915	PF00656	0.514
CLV_MEL_PAP_1	133	139	PF00089	0.267
CLV_NRD_NRD_1	1132	1134	PF00675	0.283

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGL0	Leptomonas seymouri	35%	100%
A0A0S4IYC2	Bodo saltans	35%	100%
A0A0S4J4A2	Bodo saltans	26%	100%
A0A0S4JH64	Bodo saltans	30%	100%
A0A0S4JM70	Bodo saltans	33%	94%
A0A1X0NHR8	Trypanosomatidae	40%	100%
A0A1X0NPP4	Trypanosomatidae	37%	97%
A0A1X0PAJ0	Trypanosomatidae	25%	100%
A0A3Q8IAV7	Leishmania donovani	40%	96%
A0A3Q8IEG0	Leishmania donovani	40%	95%

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