Cold-shock DNA-binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

'Cold-shock' DNA-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4H1_LEIDO

TriTrypDb:

LdBPK_311360.1 , LdCL_310020500 , LDHU3_31.2230

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4H1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.650
CLV_C14_Caspase3-7	45	49	PF00656	0.447
CLV_NRD_NRD_1	237	239	PF00675	0.566
CLV_NRD_NRD_1	500	502	PF00675	0.546
CLV_PCSK_KEX2_1	340	342	PF00082	0.422
CLV_PCSK_KEX2_1	500	502	PF00082	0.546
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.422
DEG_COP1_1	269	280	PF00400	0.665
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DEG_SCF_FBW7_1	369	376	PF00400	0.543
DEG_SPOP_SBC_1	162	166	PF00917	0.762
DEG_SPOP_SBC_1	167	171	PF00917	0.690
DEG_SPOP_SBC_1	250	254	PF00917	0.653
DOC_MAPK_gen_1	238	245	PF00069	0.605
DOC_MAPK_gen_1	394	402	PF00069	0.499
DOC_MAPK_MEF2A_6	518	526	PF00069	0.536
DOC_PP1_RVXF_1	423	429	PF00149	0.495
DOC_PP2B_LxvP_1	281	284	PF13499	0.716
DOC_PP4_FxxP_1	307	310	PF00568	0.738
DOC_PP4_MxPP_1	259	262	PF00568	0.584
DOC_SPAK_OSR1_1	427	431	PF12202	0.495
DOC_USP7_MATH_1	250	254	PF00917	0.599
DOC_USP7_MATH_1	264	268	PF00917	0.644
DOC_USP7_MATH_1	284	288	PF00917	0.582
DOC_USP7_MATH_1	373	377	PF00917	0.599
DOC_USP7_MATH_1	492	496	PF00917	0.617
DOC_USP7_MATH_1	9	13	PF00917	0.537
DOC_WW_Pin1_4	109	114	PF00397	0.777
DOC_WW_Pin1_4	137	142	PF00397	0.743
DOC_WW_Pin1_4	191	196	PF00397	0.642
DOC_WW_Pin1_4	232	237	PF00397	0.647
DOC_WW_Pin1_4	369	374	PF00397	0.650
DOC_WW_Pin1_4	389	394	PF00397	0.410
DOC_WW_Pin1_4	395	400	PF00397	0.560
LIG_14-3-3_CanoR_1	319	325	PF00244	0.623
LIG_BRCT_BRCA1_1	303	307	PF00533	0.685
LIG_EVH1_1	314	318	PF00568	0.561
LIG_FHA_1	145	151	PF00498	0.633
LIG_FHA_1	162	168	PF00498	0.520
LIG_FHA_1	206	212	PF00498	0.565
LIG_FHA_1	229	235	PF00498	0.599
LIG_FHA_1	352	358	PF00498	0.419
LIG_FHA_1	379	385	PF00498	0.636
LIG_FHA_1	417	423	PF00498	0.538
LIG_FHA_2	384	390	PF00498	0.587
LIG_LIR_Apic_2	254	260	PF02991	0.699
LIG_LIR_Apic_2	304	310	PF02991	0.700
LIG_LIR_Apic_2	51	57	PF02991	0.617
LIG_LIR_Gen_1	529	535	PF02991	0.571
LIG_LIR_Nem_3	333	338	PF02991	0.415
LIG_LIR_Nem_3	415	420	PF02991	0.585
LIG_LIR_Nem_3	525	531	PF02991	0.530
LIG_LIR_Nem_3	68	73	PF02991	0.564
LIG_PCNA_PIPBox_1	328	337	PF02747	0.396
LIG_PCNA_yPIPBox_3	322	335	PF02747	0.452
LIG_SH2_CRK	257	261	PF00017	0.688
LIG_SH2_CRK	54	58	PF00017	0.715
LIG_SH2_CRK	6	10	PF00017	0.600
LIG_SH2_GRB2like	6	9	PF00017	0.656
LIG_SH2_NCK_1	257	261	PF00017	0.688
LIG_SH2_STAP1	528	532	PF00017	0.542
LIG_SH2_STAT5	280	283	PF00017	0.722
LIG_SH2_STAT5	54	57	PF00017	0.479
LIG_SH2_STAT5	69	72	PF00017	0.750
LIG_SH3_1	257	263	PF00018	0.678
LIG_SH3_2	317	322	PF14604	0.688
LIG_SH3_3	133	139	PF00018	0.596
LIG_SH3_3	192	198	PF00018	0.772
LIG_SH3_3	201	207	PF00018	0.575
LIG_SH3_3	211	217	PF00018	0.599
LIG_SH3_3	22	28	PF00018	0.633
LIG_SH3_3	257	263	PF00018	0.728
LIG_SH3_3	307	313	PF00018	0.735
LIG_SH3_3	314	320	PF00018	0.584
LIG_SH3_3	447	453	PF00018	0.569
LIG_SUMO_SIM_anti_2	443	448	PF11976	0.578
LIG_SUMO_SIM_par_1	41	48	PF11976	0.471
LIG_WRC_WIRS_1	286	291	PF05994	0.642
LIG_WW_3	316	320	PF00397	0.610
MOD_CDK_SPK_2	389	394	PF00069	0.593
MOD_CDK_SPxK_1	232	238	PF00069	0.548
MOD_CDK_SPxxK_3	232	239	PF00069	0.555
MOD_CK1_1	100	106	PF00069	0.712
MOD_CK1_1	144	150	PF00069	0.757
MOD_CK1_1	154	160	PF00069	0.775
MOD_CK1_1	163	169	PF00069	0.674
MOD_CK1_1	189	195	PF00069	0.740
MOD_CK1_1	205	211	PF00069	0.675
MOD_CK1_1	228	234	PF00069	0.490
MOD_CK1_1	246	252	PF00069	0.510
MOD_CK1_1	253	259	PF00069	0.643
MOD_CK1_1	267	273	PF00069	0.609
MOD_CK1_1	276	282	PF00069	0.622
MOD_CK1_1	302	308	PF00069	0.685
MOD_CK1_1	33	39	PF00069	0.683
MOD_CK1_1	459	465	PF00069	0.714
MOD_CK1_1	478	484	PF00069	0.570
MOD_CK1_1	78	84	PF00069	0.796
MOD_CK2_1	149	155	PF00069	0.748
MOD_CK2_1	383	389	PF00069	0.592
MOD_GlcNHglycan	102	105	PF01048	0.644
MOD_GlcNHglycan	147	150	PF01048	0.665
MOD_GlcNHglycan	173	176	PF01048	0.788
MOD_GlcNHglycan	208	211	PF01048	0.646
MOD_GlcNHglycan	247	251	PF01048	0.783
MOD_GlcNHglycan	272	275	PF01048	0.766
MOD_GlcNHglycan	301	304	PF01048	0.708
MOD_GlcNHglycan	33	36	PF01048	0.613
MOD_GlcNHglycan	459	462	PF01048	0.663
MOD_GlcNHglycan	78	81	PF01048	0.723
MOD_GSK3_1	137	144	PF00069	0.791
MOD_GSK3_1	145	152	PF00069	0.669
MOD_GSK3_1	156	163	PF00069	0.577
MOD_GSK3_1	167	174	PF00069	0.654
MOD_GSK3_1	177	184	PF00069	0.602
MOD_GSK3_1	186	193	PF00069	0.645
MOD_GSK3_1	202	209	PF00069	0.741
MOD_GSK3_1	228	235	PF00069	0.614
MOD_GSK3_1	245	252	PF00069	0.740
MOD_GSK3_1	264	271	PF00069	0.621
MOD_GSK3_1	272	279	PF00069	0.615
MOD_GSK3_1	295	302	PF00069	0.680
MOD_GSK3_1	351	358	PF00069	0.534
MOD_GSK3_1	361	368	PF00069	0.555
MOD_GSK3_1	369	376	PF00069	0.489
MOD_GSK3_1	379	386	PF00069	0.542
MOD_GSK3_1	4	11	PF00069	0.681
MOD_GSK3_1	456	463	PF00069	0.587
MOD_GSK3_1	65	72	PF00069	0.676
MOD_GSK3_1	78	85	PF00069	0.573
MOD_N-GLC_1	184	189	PF02516	0.680
MOD_N-GLC_1	377	382	PF02516	0.669
MOD_NEK2_1	160	165	PF00069	0.761
MOD_NEK2_1	188	193	PF00069	0.810
MOD_NEK2_1	200	205	PF00069	0.531
MOD_NEK2_1	225	230	PF00069	0.592
MOD_NEK2_1	297	302	PF00069	0.688
MOD_NEK2_1	30	35	PF00069	0.600
MOD_NEK2_1	351	356	PF00069	0.412
MOD_NEK2_1	377	382	PF00069	0.635
MOD_NEK2_1	457	462	PF00069	0.708
MOD_PIKK_1	264	270	PF00454	0.761
MOD_PIKK_1	33	39	PF00454	0.683
MOD_PIKK_1	461	467	PF00454	0.579
MOD_PIKK_1	480	486	PF00454	0.569
MOD_PKA_2	144	150	PF00069	0.765
MOD_PKA_2	75	81	PF00069	0.735
MOD_Plk_1	493	499	PF00069	0.546
MOD_Plk_1	60	66	PF00069	0.647
MOD_Plk_4	131	137	PF00069	0.685
MOD_Plk_4	276	282	PF00069	0.655
MOD_Plk_4	355	361	PF00069	0.443
MOD_Plk_4	65	71	PF00069	0.718
MOD_ProDKin_1	109	115	PF00069	0.780
MOD_ProDKin_1	137	143	PF00069	0.745
MOD_ProDKin_1	191	197	PF00069	0.641
MOD_ProDKin_1	232	238	PF00069	0.651
MOD_ProDKin_1	369	375	PF00069	0.650
MOD_ProDKin_1	389	395	PF00069	0.400
MOD_SUMO_for_1	58	61	PF00179	0.635
TRG_DiLeu_BaLyEn_6	519	524	PF01217	0.559
TRG_ENDOCYTIC_2	335	338	PF00928	0.405
TRG_ENDOCYTIC_2	531	534	PF00928	0.508
TRG_ER_diArg_1	425	428	PF00400	0.495
TRG_ER_diArg_1	500	502	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P654	Leptomonas seymouri	37%	97%
A4HJB7	Leishmania braziliensis	61%	98%
A4I6R0	Leishmania infantum	99%	100%
E9B1T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q6C9	Leishmania major	88%	100%