Triplex capsid protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4H0_LEIDO

TriTrypDb:

LdBPK_311550.1 , LdCL_310022600 , LDHU3_31.2730

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.665
CLV_C14_Caspase3-7	544	548	PF00656	0.798
CLV_NRD_NRD_1	174	176	PF00675	0.621
CLV_NRD_NRD_1	447	449	PF00675	0.417
CLV_NRD_NRD_1	614	616	PF00675	0.518
CLV_NRD_NRD_1	636	638	PF00675	0.662
CLV_PCSK_KEX2_1	174	176	PF00082	0.627
CLV_PCSK_KEX2_1	447	449	PF00082	0.417
CLV_PCSK_KEX2_1	614	616	PF00082	0.572
CLV_PCSK_SKI1_1	115	119	PF00082	0.460
CLV_PCSK_SKI1_1	196	200	PF00082	0.468
CLV_PCSK_SKI1_1	295	299	PF00082	0.565
CLV_PCSK_SKI1_1	376	380	PF00082	0.510
CLV_PCSK_SKI1_1	584	588	PF00082	0.623
CLV_PCSK_SKI1_1	85	89	PF00082	0.520
DEG_APCC_DBOX_1	114	122	PF00400	0.454
DEG_COP1_1	3	13	PF00400	0.492
DEG_SCF_FBW7_1	414	421	PF00400	0.531
DOC_CDC14_PxL_1	215	223	PF14671	0.571
DOC_CKS1_1	35	40	PF01111	0.558
DOC_CYCLIN_RxL_1	80	91	PF00134	0.544
DOC_MAPK_DCC_7	229	237	PF00069	0.422
DOC_MAPK_DCC_7	711	719	PF00069	0.602
DOC_MAPK_gen_1	174	181	PF00069	0.562
DOC_MAPK_gen_1	447	454	PF00069	0.402
DOC_MAPK_MEF2A_6	165	173	PF00069	0.674
DOC_MAPK_MEF2A_6	229	237	PF00069	0.451
DOC_MAPK_MEF2A_6	711	719	PF00069	0.762
DOC_PP2B_LxvP_1	249	252	PF13499	0.619
DOC_PP4_FxxP_1	15	18	PF00568	0.543
DOC_PP4_FxxP_1	35	38	PF00568	0.487
DOC_PP4_FxxP_1	454	457	PF00568	0.639
DOC_PP4_FxxP_1	628	631	PF00568	0.639
DOC_PP4_FxxP_1	699	702	PF00568	0.677
DOC_PP4_MxPP_1	685	688	PF00568	0.610
DOC_USP7_MATH_1	132	136	PF00917	0.531
DOC_USP7_MATH_1	139	143	PF00917	0.588
DOC_USP7_MATH_1	252	256	PF00917	0.643
DOC_USP7_MATH_1	355	359	PF00917	0.610
DOC_USP7_MATH_1	377	381	PF00917	0.488
DOC_USP7_MATH_1	465	469	PF00917	0.736
DOC_USP7_MATH_1	537	541	PF00917	0.823
DOC_USP7_MATH_1	598	602	PF00917	0.527
DOC_USP7_MATH_1	702	706	PF00917	0.735
DOC_USP7_MATH_1	852	856	PF00917	0.741
DOC_USP7_MATH_1	884	888	PF00917	0.749
DOC_USP7_UBL2_3	707	711	PF12436	0.746
DOC_WW_Pin1_4	137	142	PF00397	0.604
DOC_WW_Pin1_4	34	39	PF00397	0.434
DOC_WW_Pin1_4	414	419	PF00397	0.670
DOC_WW_Pin1_4	463	468	PF00397	0.744
DOC_WW_Pin1_4	535	540	PF00397	0.742
DOC_WW_Pin1_4	680	685	PF00397	0.760
DOC_WW_Pin1_4	720	725	PF00397	0.732
DOC_WW_Pin1_4	803	808	PF00397	0.742
DOC_WW_Pin1_4	829	834	PF00397	0.736
DOC_WW_Pin1_4	886	891	PF00397	0.714
DOC_WW_Pin1_4	923	928	PF00397	0.704
LIG_14-3-3_CanoR_1	143	153	PF00244	0.545
LIG_14-3-3_CanoR_1	376	384	PF00244	0.514
LIG_14-3-3_CanoR_1	405	409	PF00244	0.621
LIG_14-3-3_CanoR_1	89	97	PF00244	0.584
LIG_BIR_III_2	549	553	PF00653	0.570
LIG_BRCT_BRCA1_1	221	225	PF00533	0.417
LIG_BRCT_BRCA1_1	253	257	PF00533	0.490
LIG_EVH1_1	740	744	PF00568	0.797
LIG_FHA_1	126	132	PF00498	0.559
LIG_FHA_1	157	163	PF00498	0.504
LIG_FHA_1	365	371	PF00498	0.487
LIG_FHA_1	373	379	PF00498	0.480
LIG_FHA_1	397	403	PF00498	0.543
LIG_FHA_1	415	421	PF00498	0.475
LIG_FHA_1	435	441	PF00498	0.706
LIG_FHA_1	485	491	PF00498	0.663
LIG_FHA_1	498	504	PF00498	0.549
LIG_FHA_1	858	864	PF00498	0.740
LIG_FHA_1	887	893	PF00498	0.765
LIG_FHA_2	399	405	PF00498	0.548
LIG_FHA_2	542	548	PF00498	0.683
LIG_FHA_2	585	591	PF00498	0.635
LIG_Integrin_RGD_1	448	450	PF01839	0.458
LIG_LIR_Apic_2	12	18	PF02991	0.615
LIG_LIR_Apic_2	32	38	PF02991	0.500
LIG_LIR_Apic_2	453	458	PF02991	0.642
LIG_LIR_Apic_2	48	53	PF02991	0.493
LIG_LIR_Gen_1	147	156	PF02991	0.482
LIG_LIR_Gen_1	222	233	PF02991	0.548
LIG_LIR_Gen_1	333	343	PF02991	0.608
LIG_LIR_Gen_1	902	910	PF02991	0.714
LIG_LIR_Nem_3	147	152	PF02991	0.442
LIG_LIR_Nem_3	222	228	PF02991	0.515
LIG_LIR_Nem_3	333	338	PF02991	0.643
LIG_LIR_Nem_3	619	625	PF02991	0.518
LIG_LIR_Nem_3	772	777	PF02991	0.718
LIG_LIR_Nem_3	794	798	PF02991	0.717
LIG_LIR_Nem_3	899	903	PF02991	0.712
LIG_MYND_1	684	688	PF01753	0.749
LIG_MYND_1	827	831	PF01753	0.693
LIG_PCNA_PIPBox_1	277	286	PF02747	0.471
LIG_PCNA_yPIPBox_3	99	113	PF02747	0.573
LIG_SH2_CRK	58	62	PF00017	0.636
LIG_SH2_CRK	622	626	PF00017	0.459
LIG_SH2_NCK_1	335	339	PF00017	0.702
LIG_SH2_NCK_1	50	54	PF00017	0.488
LIG_SH2_NCK_1	595	599	PF00017	0.597
LIG_SH2_PTP2	455	458	PF00017	0.611
LIG_SH2_PTP2	903	906	PF00017	0.695
LIG_SH2_SRC	455	458	PF00017	0.664
LIG_SH2_SRC	595	598	PF00017	0.600
LIG_SH2_STAP1	335	339	PF00017	0.660
LIG_SH2_STAT3	205	208	PF00017	0.458
LIG_SH2_STAT5	130	133	PF00017	0.538
LIG_SH2_STAT5	203	206	PF00017	0.452
LIG_SH2_STAT5	258	261	PF00017	0.486
LIG_SH2_STAT5	262	265	PF00017	0.477
LIG_SH2_STAT5	272	275	PF00017	0.517
LIG_SH2_STAT5	284	287	PF00017	0.438
LIG_SH2_STAT5	335	338	PF00017	0.696
LIG_SH2_STAT5	34	37	PF00017	0.530
LIG_SH2_STAT5	368	371	PF00017	0.526
LIG_SH2_STAT5	373	376	PF00017	0.503
LIG_SH2_STAT5	392	395	PF00017	0.425
LIG_SH2_STAT5	455	458	PF00017	0.672
LIG_SH2_STAT5	50	53	PF00017	0.290
LIG_SH2_STAT5	609	612	PF00017	0.458
LIG_SH2_STAT5	730	733	PF00017	0.688
LIG_SH2_STAT5	793	796	PF00017	0.775
LIG_SH2_STAT5	888	891	PF00017	0.719
LIG_SH2_STAT5	903	906	PF00017	0.695
LIG_SH3_2	11	16	PF14604	0.525
LIG_SH3_2	169	174	PF14604	0.579
LIG_SH3_3	133	139	PF00018	0.571
LIG_SH3_3	160	166	PF00018	0.665
LIG_SH3_3	213	219	PF00018	0.417
LIG_SH3_3	35	41	PF00018	0.566
LIG_SH3_3	681	687	PF00018	0.715
LIG_SH3_3	735	741	PF00018	0.775
LIG_SH3_3	8	14	PF00018	0.486
LIG_SH3_3	824	830	PF00018	0.767
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.465
LIG_SUMO_SIM_anti_2	397	404	PF11976	0.505
LIG_SUMO_SIM_par_1	397	404	PF11976	0.520
LIG_SUMO_SIM_par_1	715	720	PF11976	0.798
LIG_SxIP_EBH_1	225	239	PF03271	0.427
LIG_WRC_WIRS_1	284	289	PF05994	0.479
LIG_WRC_WIRS_1	451	456	PF05994	0.499
LIG_WRC_WIRS_1	792	797	PF05994	0.775
LIG_WRC_WIRS_1	937	942	PF05994	0.580
LIG_WW_1	743	746	PF00397	0.810
LIG_WW_2	827	830	PF00397	0.691
MOD_CDC14_SPxK_1	140	143	PF00782	0.647
MOD_CDK_SPxK_1	137	143	PF00069	0.620
MOD_CK1_1	333	339	PF00069	0.633
MOD_CK1_1	382	388	PF00069	0.536
MOD_CK1_1	398	404	PF00069	0.537
MOD_CK1_1	459	465	PF00069	0.681
MOD_CK1_1	497	503	PF00069	0.714
MOD_CK1_1	505	511	PF00069	0.728
MOD_CK1_1	541	547	PF00069	0.790
MOD_CK1_1	700	706	PF00069	0.751
MOD_CK1_1	720	726	PF00069	0.580
MOD_CK1_1	733	739	PF00069	0.599
MOD_CK1_1	749	755	PF00069	0.761
MOD_CK1_1	803	809	PF00069	0.794
MOD_CK1_1	857	863	PF00069	0.656
MOD_CK1_1	899	905	PF00069	0.640
MOD_CK2_1	475	481	PF00069	0.683
MOD_CK2_1	485	491	PF00069	0.558
MOD_GlcNHglycan	146	149	PF01048	0.540
MOD_GlcNHglycan	187	190	PF01048	0.454
MOD_GlcNHglycan	19	22	PF01048	0.449
MOD_GlcNHglycan	221	224	PF01048	0.424
MOD_GlcNHglycan	357	360	PF01048	0.686
MOD_GlcNHglycan	437	440	PF01048	0.578
MOD_GlcNHglycan	5	8	PF01048	0.462
MOD_GlcNHglycan	507	510	PF01048	0.711
MOD_GlcNHglycan	515	518	PF01048	0.740
MOD_GlcNHglycan	529	534	PF01048	0.566
MOD_GlcNHglycan	540	543	PF01048	0.544
MOD_GlcNHglycan	643	646	PF01048	0.719
MOD_GlcNHglycan	66	69	PF01048	0.641
MOD_GlcNHglycan	667	670	PF01048	0.760
MOD_GlcNHglycan	719	722	PF01048	0.732
MOD_GlcNHglycan	735	738	PF01048	0.626
MOD_GlcNHglycan	751	754	PF01048	0.746
MOD_GlcNHglycan	877	880	PF01048	0.727
MOD_GlcNHglycan	918	921	PF01048	0.675
MOD_GSK3_1	219	226	PF00069	0.470
MOD_GSK3_1	326	333	PF00069	0.656
MOD_GSK3_1	355	362	PF00069	0.629
MOD_GSK3_1	372	379	PF00069	0.508
MOD_GSK3_1	412	419	PF00069	0.628
MOD_GSK3_1	456	463	PF00069	0.623
MOD_GSK3_1	465	472	PF00069	0.650
MOD_GSK3_1	494	501	PF00069	0.751
MOD_GSK3_1	505	512	PF00069	0.593
MOD_GSK3_1	525	532	PF00069	0.710
MOD_GSK3_1	537	544	PF00069	0.742
MOD_GSK3_1	567	574	PF00069	0.493
MOD_GSK3_1	64	71	PF00069	0.646
MOD_GSK3_1	769	776	PF00069	0.676
MOD_GSK3_1	796	803	PF00069	0.646
MOD_GSK3_1	848	855	PF00069	0.771
MOD_GSK3_1	884	891	PF00069	0.709
MOD_GSK3_1	912	919	PF00069	0.663
MOD_GSK3_1	923	930	PF00069	0.738
MOD_N-GLC_1	192	197	PF02516	0.493
MOD_N-GLC_1	382	387	PF02516	0.607
MOD_N-GLC_1	498	503	PF02516	0.767
MOD_NEK2_1	221	226	PF00069	0.451
MOD_NEK2_1	469	474	PF00069	0.764
MOD_NEK2_1	484	489	PF00069	0.576
MOD_NEK2_1	503	508	PF00069	0.554
MOD_NEK2_1	567	572	PF00069	0.494
MOD_NEK2_1	717	722	PF00069	0.644
MOD_NEK2_1	761	766	PF00069	0.688
MOD_NEK2_1	773	778	PF00069	0.480
MOD_NEK2_1	875	880	PF00069	0.695
MOD_NEK2_1	88	93	PF00069	0.486
MOD_NEK2_1	913	918	PF00069	0.764
MOD_NEK2_1	95	100	PF00069	0.426
MOD_NEK2_2	223	228	PF00069	0.539
MOD_NMyristoyl	1	7	PF02799	0.463
MOD_PIKK_1	697	703	PF00454	0.748
MOD_PIKK_1	747	753	PF00454	0.714
MOD_PIKK_1	796	802	PF00454	0.687
MOD_PIKK_1	852	858	PF00454	0.718
MOD_PKA_1	556	562	PF00069	0.562
MOD_PKA_2	404	410	PF00069	0.620
MOD_PKA_2	460	466	PF00069	0.696
MOD_PKA_2	632	638	PF00069	0.644
MOD_PKA_2	88	94	PF00069	0.584
MOD_Plk_1	192	198	PF00069	0.490
MOD_Plk_1	396	402	PF00069	0.541
MOD_Plk_1	498	504	PF00069	0.665
MOD_Plk_1	68	74	PF00069	0.567
MOD_Plk_2-3	404	410	PF00069	0.620
MOD_Plk_4	158	164	PF00069	0.541
MOD_Plk_4	330	336	PF00069	0.666
MOD_Plk_4	398	404	PF00069	0.495
MOD_Plk_4	450	456	PF00069	0.525
MOD_Plk_4	499	505	PF00069	0.647
MOD_Plk_4	567	573	PF00069	0.445
MOD_Plk_4	604	610	PF00069	0.510
MOD_Plk_4	769	775	PF00069	0.719
MOD_Plk_4	791	797	PF00069	0.774
MOD_Plk_4	899	905	PF00069	0.719
MOD_ProDKin_1	137	143	PF00069	0.614
MOD_ProDKin_1	34	40	PF00069	0.432
MOD_ProDKin_1	414	420	PF00069	0.664
MOD_ProDKin_1	463	469	PF00069	0.749
MOD_ProDKin_1	535	541	PF00069	0.740
MOD_ProDKin_1	680	686	PF00069	0.761
MOD_ProDKin_1	720	726	PF00069	0.729
MOD_ProDKin_1	803	809	PF00069	0.740
MOD_ProDKin_1	829	835	PF00069	0.738
MOD_ProDKin_1	886	892	PF00069	0.713
MOD_ProDKin_1	923	929	PF00069	0.706
MOD_SUMO_for_1	290	293	PF00179	0.506
MOD_SUMO_rev_2	574	583	PF00179	0.465
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.626
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.555
TRG_ENDOCYTIC_2	284	287	PF00928	0.523
TRG_ENDOCYTIC_2	335	338	PF00928	0.634
TRG_ENDOCYTIC_2	622	625	PF00928	0.461
TRG_ENDOCYTIC_2	793	796	PF00928	0.775
TRG_ENDOCYTIC_2	903	906	PF00928	0.579
TRG_ER_diArg_1	112	115	PF00400	0.563
TRG_ER_diArg_1	173	175	PF00400	0.593
TRG_ER_diArg_1	446	448	PF00400	0.409
TRG_ER_diArg_1	613	615	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBS8	Leptomonas seymouri	42%	100%
A0A422NZA5	Trypanosoma rangeli	31%	100%
A4HJD3	Leishmania braziliensis	71%	99%
A4I6T0	Leishmania infantum	98%	100%
E9B1V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q6B0	Leishmania major	91%	100%