RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4F6_LEIDO

TriTrypDb:

LdBPK_311030.1 , LdCL_310016900 , LDHU3_31.1730

Length:

901

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4F6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.597
CLV_C14_Caspase3-7	27	31	PF00656	0.617
CLV_C14_Caspase3-7	307	311	PF00656	0.359
CLV_C14_Caspase3-7	551	555	PF00656	0.576
CLV_MEL_PAP_1	507	513	PF00089	0.499
CLV_NRD_NRD_1	161	163	PF00675	0.495
CLV_NRD_NRD_1	254	256	PF00675	0.260
CLV_NRD_NRD_1	404	406	PF00675	0.595
CLV_NRD_NRD_1	483	485	PF00675	0.560
CLV_NRD_NRD_1	768	770	PF00675	0.417
CLV_PCSK_FUR_1	854	858	PF00082	0.442
CLV_PCSK_KEX2_1	254	256	PF00082	0.260
CLV_PCSK_KEX2_1	305	307	PF00082	0.378
CLV_PCSK_KEX2_1	483	485	PF00082	0.561
CLV_PCSK_KEX2_1	641	643	PF00082	0.411
CLV_PCSK_KEX2_1	768	770	PF00082	0.417
CLV_PCSK_KEX2_1	856	858	PF00082	0.400
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.378
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.372
CLV_PCSK_PC1ET2_1	856	858	PF00082	0.400
CLV_PCSK_SKI1_1	135	139	PF00082	0.526
CLV_PCSK_SKI1_1	563	567	PF00082	0.440
CLV_PCSK_SKI1_1	775	779	PF00082	0.375
CLV_PCSK_SKI1_1	808	812	PF00082	0.388
CLV_PCSK_SKI1_1	857	861	PF00082	0.401
CLV_PCSK_SKI1_1	864	868	PF00082	0.391
DEG_APCC_DBOX_1	774	782	PF00400	0.362
DEG_SPOP_SBC_1	756	760	PF00917	0.501
DOC_CYCLIN_RxL_1	195	205	PF00134	0.290
DOC_CYCLIN_yClb5_NLxxxL_5	639	648	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	519	522	PF00134	0.588
DOC_MAPK_gen_1	254	260	PF00069	0.460
DOC_MAPK_gen_1	854	861	PF00069	0.411
DOC_MAPK_MEF2A_6	775	784	PF00069	0.361
DOC_PP1_RVXF_1	855	862	PF00149	0.420
DOC_PP2B_LxvP_1	126	129	PF13499	0.559
DOC_PP2B_LxvP_1	519	522	PF13499	0.592
DOC_PP4_FxxP_1	518	521	PF00568	0.636
DOC_PP4_FxxP_1	717	720	PF00568	0.549
DOC_USP7_MATH_1	187	191	PF00917	0.428
DOC_USP7_MATH_1	213	217	PF00917	0.466
DOC_USP7_MATH_1	311	315	PF00917	0.429
DOC_USP7_MATH_1	529	533	PF00917	0.540
DOC_USP7_MATH_1	609	613	PF00917	0.508
DOC_USP7_MATH_1	745	749	PF00917	0.655
DOC_USP7_MATH_1	756	760	PF00917	0.456
DOC_USP7_MATH_1	82	86	PF00917	0.587
DOC_USP7_MATH_1	840	844	PF00917	0.524
DOC_USP7_MATH_1	93	97	PF00917	0.518
DOC_USP7_UBL2_3	172	176	PF12436	0.446
DOC_WW_Pin1_4	103	108	PF00397	0.579
DOC_WW_Pin1_4	120	125	PF00397	0.521
DOC_WW_Pin1_4	15	20	PF00397	0.581
DOC_WW_Pin1_4	329	334	PF00397	0.594
DOC_WW_Pin1_4	336	341	PF00397	0.566
DOC_WW_Pin1_4	351	356	PF00397	0.513
DOC_WW_Pin1_4	362	367	PF00397	0.574
DOC_WW_Pin1_4	392	397	PF00397	0.616
DOC_WW_Pin1_4	438	443	PF00397	0.564
DOC_WW_Pin1_4	445	450	PF00397	0.547
DOC_WW_Pin1_4	467	472	PF00397	0.599
DOC_WW_Pin1_4	5	10	PF00397	0.546
DOC_WW_Pin1_4	54	59	PF00397	0.553
LIG_14-3-3_CanoR_1	622	629	PF00244	0.370
LIG_14-3-3_CanoR_1	642	651	PF00244	0.362
LIG_14-3-3_CanoR_1	864	873	PF00244	0.351
LIG_BH_BH3_1	496	512	PF00452	0.503
LIG_BIR_III_2	287	291	PF00653	0.425
LIG_BIR_III_2	646	650	PF00653	0.400
LIG_BIR_III_4	585	589	PF00653	0.325
LIG_eIF4E_1	776	782	PF01652	0.359
LIG_EVH1_1	126	130	PF00568	0.560
LIG_FHA_1	187	193	PF00498	0.442
LIG_FHA_1	194	200	PF00498	0.400
LIG_FHA_1	392	398	PF00498	0.559
LIG_FHA_1	419	425	PF00498	0.647
LIG_FHA_1	614	620	PF00498	0.459
LIG_FHA_2	305	311	PF00498	0.502
LIG_FHA_2	528	534	PF00498	0.545
LIG_FHA_2	551	557	PF00498	0.437
LIG_FHA_2	866	872	PF00498	0.387
LIG_IBAR_NPY_1	148	150	PF08397	0.531
LIG_LIR_Apic_2	151	155	PF02991	0.544
LIG_LIR_Apic_2	391	396	PF02991	0.571
LIG_LIR_Apic_2	517	521	PF02991	0.610
LIG_LIR_Gen_1	113	119	PF02991	0.580
LIG_LIR_Gen_1	220	226	PF02991	0.488
LIG_LIR_Gen_1	33	42	PF02991	0.598
LIG_LIR_Gen_1	450	461	PF02991	0.581
LIG_LIR_Gen_1	884	892	PF02991	0.358
LIG_LIR_Nem_3	113	117	PF02991	0.577
LIG_LIR_Nem_3	170	174	PF02991	0.444
LIG_LIR_Nem_3	220	224	PF02991	0.488
LIG_LIR_Nem_3	313	318	PF02991	0.414
LIG_LIR_Nem_3	33	37	PF02991	0.581
LIG_LIR_Nem_3	450	456	PF02991	0.661
LIG_LIR_Nem_3	692	698	PF02991	0.583
LIG_LIR_Nem_3	713	717	PF02991	0.554
LIG_LIR_Nem_3	770	776	PF02991	0.408
LIG_LIR_Nem_3	78	83	PF02991	0.607
LIG_LIR_Nem_3	860	865	PF02991	0.349
LIG_LIR_Nem_3	884	890	PF02991	0.404
LIG_MYND_1	124	128	PF01753	0.563
LIG_NRBOX	592	598	PF00104	0.373
LIG_PAM2_1	351	363	PF00658	0.589
LIG_PCNA_yPIPBox_3	272	285	PF02747	0.424
LIG_Pex14_1	236	240	PF04695	0.488
LIG_Pex14_2	862	866	PF04695	0.382
LIG_SH2_CRK	114	118	PF00017	0.619
LIG_SH2_CRK	152	156	PF00017	0.545
LIG_SH2_GRB2like	315	318	PF00017	0.415
LIG_SH2_NCK_1	800	804	PF00017	0.363
LIG_SH2_SRC	372	375	PF00017	0.545
LIG_SH2_SRC	41	44	PF00017	0.561
LIG_SH2_STAP1	32	36	PF00017	0.571
LIG_SH2_STAP1	800	804	PF00017	0.355
LIG_SH2_STAT5	150	153	PF00017	0.556
LIG_SH2_STAT5	159	162	PF00017	0.511
LIG_SH2_STAT5	221	224	PF00017	0.488
LIG_SH2_STAT5	372	375	PF00017	0.579
LIG_SH2_STAT5	4	7	PF00017	0.572
LIG_SH2_STAT5	41	44	PF00017	0.596
LIG_SH2_STAT5	776	779	PF00017	0.374
LIG_SH3_1	52	58	PF00018	0.555
LIG_SH3_3	121	127	PF00018	0.587
LIG_SH3_3	261	267	PF00018	0.597
LIG_SH3_3	344	350	PF00018	0.590
LIG_SH3_3	393	399	PF00018	0.517
LIG_SH3_3	468	474	PF00018	0.637
LIG_SH3_3	52	58	PF00018	0.555
LIG_SH3_3	523	529	PF00018	0.513
LIG_SH3_5	155	159	PF00018	0.528
LIG_SH3_5	449	453	PF00018	0.574
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.339
LIG_SUMO_SIM_par_1	592	598	PF11976	0.339
LIG_TRAF2_1	175	178	PF00917	0.444
LIG_TRAF2_1	787	790	PF00917	0.406
LIG_TRFH_1	518	522	PF08558	0.609
LIG_UBA3_1	297	305	PF00899	0.395
LIG_UBA3_1	632	641	PF00899	0.313
LIG_WRC_WIRS_1	453	458	PF05994	0.583
LIG_WW_2	124	127	PF00397	0.565
MOD_CDK_SPK_2	15	20	PF00069	0.544
MOD_CDK_SPK_2	54	59	PF00069	0.553
MOD_CDK_SPxxK_3	351	358	PF00069	0.592
MOD_CDK_SPxxK_3	5	12	PF00069	0.548
MOD_CK1_1	106	112	PF00069	0.727
MOD_CK1_1	3	9	PF00069	0.559
MOD_CK1_1	413	419	PF00069	0.641
MOD_CK1_1	422	428	PF00069	0.754
MOD_CK1_1	467	473	PF00069	0.599
MOD_CK1_1	487	493	PF00069	0.481
MOD_CK1_1	505	511	PF00069	0.741
MOD_CK1_1	757	763	PF00069	0.481
MOD_CK2_1	253	259	PF00069	0.290
MOD_CK2_1	589	595	PF00069	0.389
MOD_CK2_1	719	725	PF00069	0.641
MOD_CK2_1	727	733	PF00069	0.636
MOD_CK2_1	756	762	PF00069	0.484
MOD_CK2_1	784	790	PF00069	0.363
MOD_CK2_1	865	871	PF00069	0.340
MOD_GlcNHglycan	255	258	PF01048	0.290
MOD_GlcNHglycan	274	277	PF01048	0.397
MOD_GlcNHglycan	334	337	PF01048	0.597
MOD_GlcNHglycan	380	383	PF01048	0.798
MOD_GlcNHglycan	415	418	PF01048	0.647
MOD_GlcNHglycan	421	424	PF01048	0.701
MOD_GlcNHglycan	43	46	PF01048	0.572
MOD_GlcNHglycan	462	465	PF01048	0.661
MOD_GlcNHglycan	487	490	PF01048	0.627
MOD_GlcNHglycan	512	515	PF01048	0.641
MOD_GlcNHglycan	550	553	PF01048	0.576
MOD_GlcNHglycan	611	614	PF01048	0.522
MOD_GlcNHglycan	675	678	PF01048	0.534
MOD_GlcNHglycan	743	746	PF01048	0.767
MOD_GlcNHglycan	759	762	PF01048	0.443
MOD_GlcNHglycan	797	800	PF01048	0.412
MOD_GlcNHglycan	814	817	PF01048	0.512
MOD_GlcNHglycan	850	853	PF01048	0.738
MOD_GlcNHglycan	89	92	PF01048	0.586
MOD_GSK3_1	106	113	PF00069	0.532
MOD_GSK3_1	202	209	PF00069	0.290
MOD_GSK3_1	26	33	PF00069	0.565
MOD_GSK3_1	332	339	PF00069	0.619
MOD_GSK3_1	378	385	PF00069	0.571
MOD_GSK3_1	406	413	PF00069	0.682
MOD_GSK3_1	415	422	PF00069	0.617
MOD_GSK3_1	434	441	PF00069	0.559
MOD_GSK3_1	443	450	PF00069	0.646
MOD_GSK3_1	451	458	PF00069	0.570
MOD_GSK3_1	460	467	PF00069	0.565
MOD_GSK3_1	546	553	PF00069	0.460
MOD_GSK3_1	609	616	PF00069	0.544
MOD_GSK3_1	679	686	PF00069	0.558
MOD_GSK3_1	741	748	PF00069	0.642
MOD_GSK3_1	752	759	PF00069	0.563
MOD_GSK3_1	848	855	PF00069	0.680
MOD_N-GLC_1	120	125	PF02516	0.619
MOD_N-GLC_1	228	233	PF02516	0.290
MOD_N-GLC_1	476	481	PF02516	0.554
MOD_N-GLC_1	642	647	PF02516	0.361
MOD_N-GLC_1	689	694	PF02516	0.536
MOD_N-GLC_1	840	845	PF02516	0.511
MOD_N-GLC_2	830	832	PF02516	0.397
MOD_NEK2_1	138	143	PF00069	0.650
MOD_NEK2_1	193	198	PF00069	0.377
MOD_NEK2_1	243	248	PF00069	0.290
MOD_NEK2_1	253	258	PF00069	0.290
MOD_NEK2_1	334	339	PF00069	0.576
MOD_NEK2_1	47	52	PF00069	0.546
MOD_NEK2_1	546	551	PF00069	0.598
MOD_NEK2_1	576	581	PF00069	0.391
MOD_NEK2_1	666	671	PF00069	0.426
MOD_NEK2_1	689	694	PF00069	0.579
MOD_NEK2_1	822	827	PF00069	0.477
MOD_NEK2_2	586	591	PF00069	0.325
MOD_PIKK_1	447	453	PF00454	0.563
MOD_PIKK_1	576	582	PF00454	0.411
MOD_PIKK_1	621	627	PF00454	0.380
MOD_PIKK_1	666	672	PF00454	0.433
MOD_PIKK_1	93	99	PF00454	0.615
MOD_PKA_2	253	259	PF00069	0.290
MOD_PKA_2	621	627	PF00069	0.382
MOD_PKB_1	561	569	PF00069	0.395
MOD_Plk_1	451	457	PF00069	0.580
MOD_Plk_1	47	53	PF00069	0.576
MOD_Plk_1	476	482	PF00069	0.544
MOD_Plk_1	563	569	PF00069	0.393
MOD_Plk_1	857	863	PF00069	0.391
MOD_Plk_2-3	110	116	PF00069	0.601
MOD_Plk_2-3	30	36	PF00069	0.604
MOD_Plk_4	202	208	PF00069	0.290
MOD_Plk_4	311	317	PF00069	0.396
MOD_Plk_4	502	508	PF00069	0.539
MOD_Plk_4	700	706	PF00069	0.583
MOD_Plk_4	719	725	PF00069	0.574
MOD_ProDKin_1	103	109	PF00069	0.577
MOD_ProDKin_1	120	126	PF00069	0.522
MOD_ProDKin_1	15	21	PF00069	0.583
MOD_ProDKin_1	329	335	PF00069	0.596
MOD_ProDKin_1	336	342	PF00069	0.567
MOD_ProDKin_1	351	357	PF00069	0.513
MOD_ProDKin_1	362	368	PF00069	0.576
MOD_ProDKin_1	392	398	PF00069	0.616
MOD_ProDKin_1	438	444	PF00069	0.565
MOD_ProDKin_1	445	451	PF00069	0.548
MOD_ProDKin_1	467	473	PF00069	0.600
MOD_ProDKin_1	5	11	PF00069	0.546
MOD_ProDKin_1	54	60	PF00069	0.552
MOD_SUMO_for_1	175	178	PF00179	0.444
MOD_SUMO_rev_2	735	745	PF00179	0.599
TRG_DiLeu_BaEn_1	178	183	PF01217	0.438
TRG_DiLeu_BaEn_1	762	767	PF01217	0.413
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.575
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.557
TRG_DiLeu_BaLyEn_6	624	629	PF01217	0.323
TRG_ENDOCYTIC_2	114	117	PF00928	0.579
TRG_ENDOCYTIC_2	221	224	PF00928	0.329
TRG_ENDOCYTIC_2	238	241	PF00928	0.329
TRG_ENDOCYTIC_2	315	318	PF00928	0.415
TRG_ENDOCYTIC_2	453	456	PF00928	0.667
TRG_ENDOCYTIC_2	584	587	PF00928	0.350
TRG_ENDOCYTIC_2	714	717	PF00928	0.557
TRG_ENDOCYTIC_2	836	839	PF00928	0.489
TRG_ER_diArg_1	179	182	PF00400	0.438
TRG_ER_diArg_1	222	225	PF00400	0.329
TRG_ER_diArg_1	253	255	PF00400	0.290
TRG_ER_diArg_1	767	769	PF00400	0.387
TRG_NES_CRM1_1	585	598	PF08389	0.376
TRG_NES_CRM1_1	646	660	PF08389	0.378
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P425	Leptomonas seymouri	56%	98%
A0A3Q8IET1	Leishmania donovani	32%	100%
A4HJ83	Leishmania braziliensis	80%	99%
A4I6M7	Leishmania infantum	99%	100%
A4I6M8	Leishmania infantum	31%	100%
E9B1Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6G0	Leishmania major	92%	100%