Cilia- and flagella-associated protein 300

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4498), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4F5_LEIDO

TriTrypDb:

LdBPK_311100.1 , LdCL_310017800 , LDHU3_31.1830

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005856	cytoskeleton	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7X4F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4F5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.627
CLV_C14_Caspase3-7	21	25	PF00656	0.618
CLV_NRD_NRD_1	296	298	PF00675	0.309
CLV_PCSK_KEX2_1	182	184	PF00082	0.527
CLV_PCSK_KEX2_1	296	298	PF00082	0.311
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.578
CLV_PCSK_PC7_1	292	298	PF00082	0.233
CLV_PCSK_SKI1_1	102	106	PF00082	0.377
CLV_PCSK_SKI1_1	134	138	PF00082	0.542
CLV_PCSK_SKI1_1	157	161	PF00082	0.597
CLV_PCSK_SKI1_1	199	203	PF00082	0.392
CLV_PCSK_SKI1_1	251	255	PF00082	0.327
CLV_PCSK_SKI1_1	29	33	PF00082	0.532
CLV_PCSK_SKI1_1	297	301	PF00082	0.372
CLV_Separin_Metazoa	144	148	PF03568	0.519
DEG_APCC_DBOX_1	156	164	PF00400	0.577
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DOC_MAPK_gen_1	296	304	PF00069	0.433
DOC_PP4_FxxP_1	105	108	PF00568	0.511
DOC_USP7_MATH_1	14	18	PF00917	0.705
DOC_USP7_MATH_1	27	31	PF00917	0.352
DOC_USP7_MATH_1	7	11	PF00917	0.641
DOC_USP7_MATH_1	70	74	PF00917	0.677
DOC_USP7_MATH_1	83	87	PF00917	0.463
DOC_USP7_MATH_2	53	59	PF00917	0.590
DOC_WW_Pin1_4	68	73	PF00397	0.743
LIG_14-3-3_CanoR_1	134	143	PF00244	0.546
LIG_14-3-3_CanoR_1	297	303	PF00244	0.483
LIG_Actin_WH2_2	148	163	PF00022	0.538
LIG_APCC_ABBA_1	187	192	PF00400	0.633
LIG_BIR_III_2	24	28	PF00653	0.566
LIG_FHA_1	371	377	PF00498	0.532
LIG_FHA_2	139	145	PF00498	0.441
LIG_FHA_2	165	171	PF00498	0.642
LIG_FHA_2	227	233	PF00498	0.679
LIG_FHA_2	306	312	PF00498	0.507
LIG_LIR_Apic_2	103	108	PF02991	0.500
LIG_LIR_Apic_2	47	53	PF02991	0.458
LIG_LIR_Gen_1	137	146	PF02991	0.446
LIG_LIR_Gen_1	261	272	PF02991	0.476
LIG_LIR_Gen_1	326	337	PF02991	0.589
LIG_LIR_Nem_3	130	136	PF02991	0.409
LIG_LIR_Nem_3	137	143	PF02991	0.431
LIG_LIR_Nem_3	26	31	PF02991	0.574
LIG_LIR_Nem_3	261	267	PF02991	0.493
LIG_LIR_Nem_3	293	298	PF02991	0.568
LIG_LIR_Nem_3	326	332	PF02991	0.546
LIG_LIR_Nem_3	335	341	PF02991	0.518
LIG_SH2_CRK	28	32	PF00017	0.553
LIG_SH2_CRK	295	299	PF00017	0.487
LIG_SH2_CRK	329	333	PF00017	0.580
LIG_SH2_CRK	338	342	PF00017	0.474
LIG_SH2_CRK	362	366	PF00017	0.476
LIG_SH2_CRK	50	54	PF00017	0.531
LIG_SH2_PTP2	364	367	PF00017	0.476
LIG_SH2_SRC	287	290	PF00017	0.500
LIG_SH2_STAT5	176	179	PF00017	0.523
LIG_SH2_STAT5	287	290	PF00017	0.487
LIG_SH2_STAT5	362	365	PF00017	0.476
LIG_SH3_3	66	72	PF00018	0.754
LIG_TRAF2_1	258	261	PF00917	0.580
LIG_TRAF2_1	308	311	PF00917	0.565
LIG_TRAF2_1	318	321	PF00917	0.536
LIG_TYR_ITIM	327	332	PF00017	0.462
LIG_TYR_ITIM	360	365	PF00017	0.487
LIG_WRC_WIRS_1	56	61	PF05994	0.660
MOD_CK1_1	370	376	PF00069	0.551
MOD_CK1_1	71	77	PF00069	0.681
MOD_CK2_1	138	144	PF00069	0.447
MOD_CK2_1	20	26	PF00069	0.592
MOD_CK2_1	221	227	PF00069	0.690
MOD_CK2_1	255	261	PF00069	0.530
MOD_CK2_1	305	311	PF00069	0.559
MOD_CK2_1	55	61	PF00069	0.667
MOD_GlcNHglycan	10	13	PF01048	0.706
MOD_GlcNHglycan	15	19	PF01048	0.702
MOD_GlcNHglycan	240	243	PF01048	0.581
MOD_GlcNHglycan	273	276	PF01048	0.393
MOD_GlcNHglycan	323	326	PF01048	0.371
MOD_GlcNHglycan	64	67	PF01048	0.669
MOD_GlcNHglycan	85	88	PF01048	0.577
MOD_GSK3_1	134	141	PF00069	0.537
MOD_GSK3_1	14	21	PF00069	0.619
MOD_GSK3_1	222	229	PF00069	0.704
MOD_GSK3_1	51	58	PF00069	0.614
MOD_N-GLC_2	361	363	PF02516	0.276
MOD_NEK2_1	100	105	PF00069	0.368
MOD_NEK2_1	236	241	PF00069	0.704
MOD_NEK2_1	298	303	PF00069	0.546
MOD_NEK2_2	27	32	PF00069	0.388
MOD_NEK2_2	344	349	PF00069	0.562
MOD_PKA_2	138	144	PF00069	0.544
MOD_PKB_1	49	57	PF00069	0.567
MOD_Plk_2-3	164	170	PF00069	0.685
MOD_Plk_2-3	192	198	PF00069	0.570
MOD_Plk_2-3	228	234	PF00069	0.722
MOD_Plk_2-3	55	61	PF00069	0.657
MOD_Plk_4	121	127	PF00069	0.715
MOD_Plk_4	27	33	PF00069	0.506
MOD_Plk_4	333	339	PF00069	0.510
MOD_Plk_4	344	350	PF00069	0.484
MOD_Plk_4	372	378	PF00069	0.565
MOD_ProDKin_1	68	74	PF00069	0.743
MOD_SUMO_for_1	213	216	PF00179	0.535
TRG_ENDOCYTIC_2	264	267	PF00928	0.476
TRG_ENDOCYTIC_2	28	31	PF00928	0.560
TRG_ENDOCYTIC_2	295	298	PF00928	0.489
TRG_ENDOCYTIC_2	329	332	PF00928	0.562
TRG_ENDOCYTIC_2	338	341	PF00928	0.562
TRG_ENDOCYTIC_2	362	365	PF00928	0.476
TRG_ER_diArg_1	295	297	PF00400	0.518
TRG_NES_CRM1_1	293	306	PF08389	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P369	Leptomonas seymouri	51%	100%
A0A0S4JGK6	Bodo saltans	29%	100%
A0A1X0NJZ3	Trypanosomatidae	31%	97%
A0A422NQV4	Trypanosoma rangeli	39%	100%
A4HJ90	Leishmania braziliensis	79%	100%
A4I6N4	Leishmania infantum	99%	100%
C9ZM71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B1Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q6F3	Leishmania major	93%	100%
V5DGC7	Trypanosoma cruzi	39%	96%