Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4F1_LEIDO

TriTrypDb:

LdBPK_311450.1 , LdCL_310021400 , LDHU3_31.2350

Length:

1157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4F1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1137	1141	PF00656	0.650
CLV_C14_Caspase3-7	220	224	PF00656	0.649
CLV_C14_Caspase3-7	465	469	PF00656	0.619
CLV_C14_Caspase3-7	53	57	PF00656	0.670
CLV_C14_Caspase3-7	703	707	PF00656	0.736
CLV_NRD_NRD_1	1085	1087	PF00675	0.596
CLV_NRD_NRD_1	118	120	PF00675	0.614
CLV_NRD_NRD_1	187	189	PF00675	0.728
CLV_NRD_NRD_1	19	21	PF00675	0.590
CLV_NRD_NRD_1	260	262	PF00675	0.622
CLV_NRD_NRD_1	30	32	PF00675	0.526
CLV_NRD_NRD_1	328	330	PF00675	0.739
CLV_NRD_NRD_1	370	372	PF00675	0.603
CLV_NRD_NRD_1	377	379	PF00675	0.544
CLV_NRD_NRD_1	82	84	PF00675	0.644
CLV_NRD_NRD_1	841	843	PF00675	0.685
CLV_NRD_NRD_1	847	849	PF00675	0.681
CLV_NRD_NRD_1	985	987	PF00675	0.726
CLV_PCSK_FUR_1	845	849	PF00082	0.711
CLV_PCSK_KEX2_1	187	189	PF00082	0.740
CLV_PCSK_KEX2_1	260	262	PF00082	0.622
CLV_PCSK_KEX2_1	29	31	PF00082	0.679
CLV_PCSK_KEX2_1	328	330	PF00082	0.739
CLV_PCSK_KEX2_1	370	372	PF00082	0.603
CLV_PCSK_KEX2_1	377	379	PF00082	0.544
CLV_PCSK_KEX2_1	82	84	PF00082	0.644
CLV_PCSK_KEX2_1	841	843	PF00082	0.685
CLV_PCSK_KEX2_1	847	849	PF00082	0.681
CLV_PCSK_KEX2_1	963	965	PF00082	0.732
CLV_PCSK_KEX2_1	985	987	PF00082	0.726
CLV_PCSK_PC1ET2_1	963	965	PF00082	0.732
CLV_PCSK_PC7_1	26	32	PF00082	0.623
CLV_PCSK_SKI1_1	1091	1095	PF00082	0.726
CLV_PCSK_SKI1_1	314	318	PF00082	0.602
CLV_PCSK_SKI1_1	847	851	PF00082	0.703
CLV_PCSK_SKI1_1	889	893	PF00082	0.594
DEG_APCC_DBOX_1	846	854	PF00400	0.657
DOC_AGCK_PIF_2	722	727	PF00069	0.637
DOC_CDC14_PxL_1	347	355	PF14671	0.579
DOC_CKS1_1	966	971	PF01111	0.664
DOC_CYCLIN_RxL_1	842	855	PF00134	0.649
DOC_MAPK_FxFP_2	207	210	PF00069	0.673
DOC_MAPK_gen_1	26	36	PF00069	0.667
DOC_MAPK_gen_1	370	381	PF00069	0.605
DOC_MAPK_gen_1	841	851	PF00069	0.687
DOC_MAPK_MEF2A_6	845	853	PF00069	0.708
DOC_PP1_RVXF_1	1144	1150	PF00149	0.668
DOC_PP1_RVXF_1	406	412	PF00149	0.635
DOC_PP2B_LxvP_1	1071	1074	PF13499	0.690
DOC_PP2B_LxvP_1	272	275	PF13499	0.835
DOC_PP4_FxxP_1	207	210	PF00568	0.673
DOC_PP4_FxxP_1	271	274	PF00568	0.712
DOC_PP4_FxxP_1	46	49	PF00568	0.726
DOC_PP4_FxxP_1	564	567	PF00568	0.652
DOC_PP4_MxPP_1	635	638	PF00568	0.571
DOC_USP7_MATH_1	1054	1058	PF00917	0.559
DOC_USP7_MATH_1	144	148	PF00917	0.544
DOC_USP7_MATH_1	175	179	PF00917	0.749
DOC_USP7_MATH_1	210	214	PF00917	0.641
DOC_USP7_MATH_1	236	240	PF00917	0.672
DOC_USP7_MATH_1	244	248	PF00917	0.545
DOC_USP7_MATH_1	275	279	PF00917	0.661
DOC_USP7_MATH_1	337	341	PF00917	0.599
DOC_USP7_MATH_1	393	397	PF00917	0.486
DOC_USP7_MATH_1	440	444	PF00917	0.715
DOC_USP7_MATH_1	450	454	PF00917	0.652
DOC_USP7_MATH_1	480	484	PF00917	0.680
DOC_USP7_MATH_1	489	493	PF00917	0.618
DOC_USP7_MATH_1	591	595	PF00917	0.727
DOC_USP7_MATH_1	60	64	PF00917	0.669
DOC_USP7_MATH_1	611	615	PF00917	0.639
DOC_USP7_MATH_1	645	649	PF00917	0.717
DOC_USP7_MATH_1	659	663	PF00917	0.594
DOC_USP7_MATH_1	690	694	PF00917	0.667
DOC_USP7_MATH_1	709	713	PF00917	0.682
DOC_USP7_MATH_1	776	780	PF00917	0.793
DOC_USP7_MATH_1	825	829	PF00917	0.644
DOC_USP7_MATH_1	864	868	PF00917	0.727
DOC_USP7_MATH_1	921	925	PF00917	0.669
DOC_USP7_MATH_1	936	940	PF00917	0.537
DOC_USP7_MATH_1	942	946	PF00917	0.662
DOC_WW_Pin1_4	1	6	PF00397	0.685
DOC_WW_Pin1_4	1050	1055	PF00397	0.574
DOC_WW_Pin1_4	198	203	PF00397	0.667
DOC_WW_Pin1_4	411	416	PF00397	0.642
DOC_WW_Pin1_4	56	61	PF00397	0.698
DOC_WW_Pin1_4	646	651	PF00397	0.640
DOC_WW_Pin1_4	672	677	PF00397	0.684
DOC_WW_Pin1_4	686	691	PF00397	0.556
DOC_WW_Pin1_4	711	716	PF00397	0.628
DOC_WW_Pin1_4	965	970	PF00397	0.716
LIG_14-3-3_CanoR_1	188	198	PF00244	0.679
LIG_14-3-3_CanoR_1	342	350	PF00244	0.593
LIG_14-3-3_CanoR_1	588	596	PF00244	0.648
LIG_14-3-3_CanoR_1	671	676	PF00244	0.720
LIG_14-3-3_CanoR_1	841	845	PF00244	0.690
LIG_14-3-3_CanoR_1	848	854	PF00244	0.652
LIG_Actin_WH2_2	343	359	PF00022	0.578
LIG_BIR_III_2	93	97	PF00653	0.652
LIG_BIR_III_4	1140	1144	PF00653	0.660
LIG_BRCT_BRCA1_1	238	242	PF00533	0.623
LIG_BRCT_BRCA1_1	339	343	PF00533	0.593
LIG_BRCT_BRCA1_1	351	355	PF00533	0.442
LIG_BRCT_BRCA1_1	906	910	PF00533	0.705
LIG_BRCT_BRCA1_1	939	943	PF00533	0.671
LIG_BRCT_BRCA1_1	97	101	PF00533	0.631
LIG_CaM_IQ_9	363	379	PF13499	0.603
LIG_FHA_1	209	215	PF00498	0.712
LIG_FHA_1	367	373	PF00498	0.607
LIG_FHA_1	414	420	PF00498	0.601
LIG_FHA_1	505	511	PF00498	0.661
LIG_FHA_1	514	520	PF00498	0.485
LIG_FHA_1	733	739	PF00498	0.716
LIG_FHA_1	784	790	PF00498	0.686
LIG_FHA_1	904	910	PF00498	0.573
LIG_FHA_2	1007	1013	PF00498	0.651
LIG_FHA_2	154	160	PF00498	0.615
LIG_FHA_2	288	294	PF00498	0.711
LIG_FHA_2	51	57	PF00498	0.661
LIG_FHA_2	528	534	PF00498	0.665
LIG_FHA_2	778	784	PF00498	0.575
LIG_FHA_2	966	972	PF00498	0.711
LIG_GBD_Chelix_1	394	402	PF00786	0.571
LIG_LIR_Apic_2	269	274	PF02991	0.706
LIG_LIR_Apic_2	562	567	PF02991	0.657
LIG_LIR_Gen_1	247	256	PF02991	0.600
LIG_LIR_Gen_1	296	303	PF02991	0.594
LIG_LIR_Gen_1	340	351	PF02991	0.590
LIG_LIR_Gen_1	40	49	PF02991	0.602
LIG_LIR_Gen_1	404	413	PF02991	0.576
LIG_LIR_Nem_3	1040	1044	PF02991	0.689
LIG_LIR_Nem_3	1150	1154	PF02991	0.638
LIG_LIR_Nem_3	121	126	PF02991	0.592
LIG_LIR_Nem_3	132	138	PF02991	0.551
LIG_LIR_Nem_3	247	251	PF02991	0.604
LIG_LIR_Nem_3	296	300	PF02991	0.598
LIG_LIR_Nem_3	340	346	PF02991	0.705
LIG_LIR_Nem_3	40	46	PF02991	0.595
LIG_LIR_Nem_3	404	409	PF02991	0.564
LIG_LYPXL_yS_3	135	138	PF13949	0.571
LIG_Pex14_1	618	622	PF04695	0.693
LIG_Pex14_2	317	321	PF04695	0.574
LIG_PTB_Apo_2	964	971	PF02174	0.718
LIG_PTB_Phospho_1	964	970	PF10480	0.720
LIG_Rb_LxCxE_1	358	369	PF01857	0.552
LIG_SH2_GRB2like	859	862	PF00017	0.705
LIG_SH2_GRB2like	965	968	PF00017	0.722
LIG_SH2_NCK_1	297	301	PF00017	0.586
LIG_SH2_SRC	859	862	PF00017	0.657
LIG_SH2_SRC	970	973	PF00017	0.708
LIG_SH2_STAP1	142	146	PF00017	0.606
LIG_SH2_STAP1	297	301	PF00017	0.586
LIG_SH2_STAP1	575	579	PF00017	0.730
LIG_SH2_STAT3	164	167	PF00017	0.617
LIG_SH2_STAT3	323	326	PF00017	0.552
LIG_SH2_STAT5	117	120	PF00017	0.611
LIG_SH2_STAT5	13	16	PF00017	0.571
LIG_SH2_STAT5	323	326	PF00017	0.631
LIG_SH2_STAT5	605	608	PF00017	0.691
LIG_SH2_STAT5	627	630	PF00017	0.690
LIG_SH2_STAT5	723	726	PF00017	0.708
LIG_SH2_STAT5	734	737	PF00017	0.640
LIG_SH2_STAT5	85	88	PF00017	0.682
LIG_SH2_STAT5	932	935	PF00017	0.604
LIG_SH2_STAT5	965	968	PF00017	0.674
LIG_SH3_2	658	663	PF14604	0.731
LIG_SH3_3	1090	1096	PF00018	0.712
LIG_SH3_3	1118	1124	PF00018	0.818
LIG_SH3_3	238	244	PF00018	0.645
LIG_SH3_3	330	336	PF00018	0.624
LIG_SH3_3	412	418	PF00018	0.596
LIG_SH3_3	521	527	PF00018	0.657
LIG_SH3_3	631	637	PF00018	0.666
LIG_SH3_3	644	650	PF00018	0.644
LIG_SH3_3	655	661	PF00018	0.659
LIG_SH3_3	950	956	PF00018	0.718
LIG_SH3_3	963	969	PF00018	0.588
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.648
LIG_SUMO_SIM_par_1	849	855	PF11976	0.703
LIG_TRAF2_1	555	558	PF00917	0.637
LIG_TRAF2_1	581	584	PF00917	0.600
LIG_TRAF2_2	637	642	PF00917	0.594
LIG_TYR_ITIM	133	138	PF00017	0.578
LIG_UBA3_1	36	42	PF00899	0.653
LIG_WRC_WIRS_1	138	143	PF05994	0.564
LIG_WW_2	336	339	PF00397	0.598
LIG_WW_3	216	220	PF00397	0.660
MOD_CDC14_SPxK_1	4	7	PF00782	0.565
MOD_CDK_SPxK_1	1	7	PF00069	0.610
MOD_CK1_1	122	128	PF00069	0.702
MOD_CK1_1	267	273	PF00069	0.698
MOD_CK1_1	453	459	PF00069	0.651
MOD_CK1_1	51	57	PF00069	0.688
MOD_CK1_1	648	654	PF00069	0.705
MOD_CK1_1	65	71	PF00069	0.717
MOD_CK1_1	675	681	PF00069	0.711
MOD_CK1_1	686	692	PF00069	0.602
MOD_CK1_1	74	80	PF00069	0.662
MOD_CK1_1	799	805	PF00069	0.713
MOD_CK1_1	812	818	PF00069	0.597
MOD_CK1_1	827	833	PF00069	0.550
MOD_CK1_1	852	858	PF00069	0.754
MOD_CK1_1	875	881	PF00069	0.743
MOD_CK1_1	895	901	PF00069	0.584
MOD_CK2_1	1050	1056	PF00069	0.627
MOD_CK2_1	1150	1156	PF00069	0.618
MOD_CK2_1	144	150	PF00069	0.616
MOD_CK2_1	287	293	PF00069	0.678
MOD_CK2_1	303	309	PF00069	0.599
MOD_CK2_1	527	533	PF00069	0.664
MOD_CK2_1	552	558	PF00069	0.687
MOD_CK2_1	763	769	PF00069	0.731
MOD_CK2_1	932	938	PF00069	0.680
MOD_CK2_1	965	971	PF00069	0.683
MOD_Cter_Amidation	839	842	PF01082	0.613
MOD_DYRK1A_RPxSP_1	646	650	PF00069	0.624
MOD_GlcNHglycan	1056	1059	PF01048	0.672
MOD_GlcNHglycan	225	228	PF01048	0.768
MOD_GlcNHglycan	266	269	PF01048	0.686
MOD_GlcNHglycan	277	280	PF01048	0.581
MOD_GlcNHglycan	305	308	PF01048	0.600
MOD_GlcNHglycan	430	433	PF01048	0.738
MOD_GlcNHglycan	442	445	PF01048	0.738
MOD_GlcNHglycan	453	456	PF01048	0.663
MOD_GlcNHglycan	478	481	PF01048	0.702
MOD_GlcNHglycan	482	485	PF01048	0.690
MOD_GlcNHglycan	499	502	PF01048	0.598
MOD_GlcNHglycan	50	53	PF01048	0.621
MOD_GlcNHglycan	553	557	PF01048	0.736
MOD_GlcNHglycan	62	65	PF01048	0.738
MOD_GlcNHglycan	711	714	PF01048	0.705
MOD_GlcNHglycan	786	789	PF01048	0.781
MOD_GlcNHglycan	798	801	PF01048	0.600
MOD_GlcNHglycan	817	820	PF01048	0.540
MOD_GlcNHglycan	838	841	PF01048	0.676
MOD_GlcNHglycan	866	869	PF01048	0.755
MOD_GlcNHglycan	872	875	PF01048	0.778
MOD_GlcNHglycan	897	900	PF01048	0.728
MOD_GlcNHglycan	923	926	PF01048	0.702
MOD_GlcNHglycan	934	937	PF01048	0.589
MOD_GlcNHglycan	938	942	PF01048	0.549
MOD_GlcNHglycan	948	951	PF01048	0.628
MOD_GSK3_1	1018	1025	PF00069	0.654
MOD_GSK3_1	1050	1057	PF00069	0.634
MOD_GSK3_1	337	344	PF00069	0.595
MOD_GSK3_1	462	469	PF00069	0.592
MOD_GSK3_1	476	483	PF00069	0.664
MOD_GSK3_1	490	497	PF00069	0.670
MOD_GSK3_1	50	57	PF00069	0.707
MOD_GSK3_1	513	520	PF00069	0.699
MOD_GSK3_1	58	65	PF00069	0.651
MOD_GSK3_1	587	594	PF00069	0.702
MOD_GSK3_1	648	655	PF00069	0.673
MOD_GSK3_1	661	668	PF00069	0.655
MOD_GSK3_1	67	74	PF00069	0.821
MOD_GSK3_1	671	678	PF00069	0.637
MOD_GSK3_1	686	693	PF00069	0.552
MOD_GSK3_1	792	799	PF00069	0.712
MOD_GSK3_1	805	812	PF00069	0.594
MOD_GSK3_1	821	828	PF00069	0.558
MOD_GSK3_1	836	843	PF00069	0.559
MOD_GSK3_1	932	939	PF00069	0.673
MOD_GSK3_1	942	949	PF00069	0.621
MOD_GSK3_1	985	992	PF00069	0.807
MOD_N-GLC_1	889	894	PF02516	0.593
MOD_N-GLC_1	910	915	PF02516	0.589
MOD_N-GLC_1	926	931	PF02516	0.607
MOD_N-GLC_2	231	233	PF02516	0.787
MOD_NEK2_1	1112	1117	PF00069	0.675
MOD_NEK2_1	366	371	PF00069	0.677
MOD_NEK2_1	462	467	PF00069	0.662
MOD_NEK2_1	598	603	PF00069	0.752
MOD_NEK2_1	677	682	PF00069	0.711
MOD_NEK2_1	849	854	PF00069	0.701
MOD_NEK2_2	144	149	PF00069	0.548
MOD_NEK2_2	504	509	PF00069	0.664
MOD_NEK2_2	840	845	PF00069	0.627
MOD_NMyristoyl	1	7	PF02799	0.779
MOD_PIKK_1	1073	1079	PF00454	0.630
MOD_PIKK_1	1105	1111	PF00454	0.664
MOD_PIKK_1	111	117	PF00454	0.683
MOD_PIKK_1	190	196	PF00454	0.644
MOD_PIKK_1	661	667	PF00454	0.733
MOD_PIKK_1	72	78	PF00454	0.634
MOD_PIKK_1	799	805	PF00454	0.713
MOD_PK_1	573	579	PF00069	0.726
MOD_PKA_1	119	125	PF00069	0.600
MOD_PKA_1	190	196	PF00069	0.663
MOD_PKA_1	985	991	PF00069	0.727
MOD_PKA_2	341	347	PF00069	0.620
MOD_PKA_2	587	593	PF00069	0.624
MOD_PKA_2	645	651	PF00069	0.687
MOD_PKA_2	65	71	PF00069	0.705
MOD_PKA_2	78	84	PF00069	0.610
MOD_PKA_2	813	819	PF00069	0.731
MOD_PKA_2	840	846	PF00069	0.668
MOD_PKA_2	985	991	PF00069	0.727
MOD_Plk_1	32	38	PF00069	0.652
MOD_Plk_1	573	579	PF00069	0.835
MOD_Plk_1	892	898	PF00069	0.632
MOD_Plk_2-3	1150	1156	PF00069	0.618
MOD_Plk_2-3	790	796	PF00069	0.659
MOD_Plk_4	137	143	PF00069	0.641
MOD_Plk_4	236	242	PF00069	0.712
MOD_Plk_4	244	250	PF00069	0.648
MOD_Plk_4	267	273	PF00069	0.819
MOD_Plk_4	32	38	PF00069	0.652
MOD_Plk_4	527	533	PF00069	0.664
MOD_ProDKin_1	1	7	PF00069	0.677
MOD_ProDKin_1	1050	1056	PF00069	0.578
MOD_ProDKin_1	198	204	PF00069	0.666
MOD_ProDKin_1	411	417	PF00069	0.641
MOD_ProDKin_1	56	62	PF00069	0.700
MOD_ProDKin_1	646	652	PF00069	0.634
MOD_ProDKin_1	672	678	PF00069	0.684
MOD_ProDKin_1	686	692	PF00069	0.557
MOD_ProDKin_1	711	717	PF00069	0.623
MOD_ProDKin_1	965	971	PF00069	0.713
MOD_SUMO_rev_2	1137	1145	PF00179	0.608
TRG_DiLeu_BaEn_1	458	463	PF01217	0.653
TRG_DiLeu_BaEn_2	297	303	PF01217	0.588
TRG_DiLeu_BaEn_2	396	402	PF01217	0.578
TRG_ENDOCYTIC_2	1044	1047	PF00928	0.574
TRG_ENDOCYTIC_2	135	138	PF00928	0.650
TRG_ENDOCYTIC_2	297	300	PF00928	0.596
TRG_ER_diArg_1	259	261	PF00400	0.602
TRG_ER_diArg_1	29	31	PF00400	0.679
TRG_ER_diArg_1	359	362	PF00400	0.592
TRG_ER_diArg_1	370	372	PF00400	0.490
TRG_ER_diArg_1	376	378	PF00400	0.436
TRG_ER_diArg_1	844	847	PF00400	0.703
TRG_ER_diArg_1	985	987	PF00400	0.726
TRG_NLS_MonoCore_2	19	24	PF00514	0.530
TRG_NLS_MonoExtN_4	20	25	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	1098	1102	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	1152	1156	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	985	989	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJC4	Leishmania braziliensis	74%	99%
A4I6R9	Leishmania infantum	100%	100%
E9B1U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6C0	Leishmania major	92%	100%