Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4E6_LEIDO

TriTrypDb:

LdBPK_311020.1 , LdCL_310016800 , LDHU3_31.1700

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.696
CLV_C14_Caspase3-7	236	240	PF00656	0.708
CLV_C14_Caspase3-7	822	826	PF00656	0.787
CLV_C14_Caspase3-7	864	868	PF00656	0.670
CLV_C14_Caspase3-7	915	919	PF00656	0.704
CLV_NRD_NRD_1	144	146	PF00675	0.708
CLV_NRD_NRD_1	222	224	PF00675	0.602
CLV_NRD_NRD_1	275	277	PF00675	0.714
CLV_NRD_NRD_1	290	292	PF00675	0.415
CLV_NRD_NRD_1	329	331	PF00675	0.725
CLV_NRD_NRD_1	505	507	PF00675	0.470
CLV_NRD_NRD_1	52	54	PF00675	0.690
CLV_NRD_NRD_1	528	530	PF00675	0.503
CLV_NRD_NRD_1	787	789	PF00675	0.499
CLV_PCSK_KEX2_1	144	146	PF00082	0.708
CLV_PCSK_KEX2_1	222	224	PF00082	0.602
CLV_PCSK_KEX2_1	275	277	PF00082	0.672
CLV_PCSK_KEX2_1	286	288	PF00082	0.434
CLV_PCSK_KEX2_1	290	292	PF00082	0.427
CLV_PCSK_KEX2_1	299	301	PF00082	0.497
CLV_PCSK_KEX2_1	329	331	PF00082	0.725
CLV_PCSK_KEX2_1	505	507	PF00082	0.470
CLV_PCSK_KEX2_1	52	54	PF00082	0.735
CLV_PCSK_KEX2_1	528	530	PF00082	0.503
CLV_PCSK_KEX2_1	66	68	PF00082	0.603
CLV_PCSK_KEX2_1	78	80	PF00082	0.596
CLV_PCSK_KEX2_1	787	789	PF00082	0.507
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.487
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.514
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.700
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.596
CLV_PCSK_PC7_1	524	530	PF00082	0.509
CLV_PCSK_SKI1_1	213	217	PF00082	0.554
CLV_PCSK_SKI1_1	395	399	PF00082	0.776
CLV_PCSK_SKI1_1	44	48	PF00082	0.784
CLV_PCSK_SKI1_1	472	476	PF00082	0.612
CLV_PCSK_SKI1_1	488	492	PF00082	0.439
CLV_PCSK_SKI1_1	499	503	PF00082	0.528
CLV_PCSK_SKI1_1	556	560	PF00082	0.551
CLV_PCSK_SKI1_1	619	623	PF00082	0.464
CLV_PCSK_SKI1_1	721	725	PF00082	0.493
CLV_PCSK_SKI1_1	788	792	PF00082	0.501
DEG_APCC_DBOX_1	66	74	PF00400	0.627
DEG_Kelch_Keap1_1	916	921	PF01344	0.517
DEG_MDM2_SWIB_1	614	621	PF02201	0.528
DEG_SPOP_SBC_1	355	359	PF00917	0.588
DEG_SPOP_SBC_1	730	734	PF00917	0.752
DOC_CDC14_PxL_1	536	544	PF14671	0.399
DOC_CDC14_PxL_1	639	647	PF14671	0.669
DOC_CKS1_1	226	231	PF01111	0.604
DOC_CKS1_1	47	52	PF01111	0.652
DOC_CKS1_1	702	707	PF01111	0.442
DOC_CYCLIN_RxL_1	483	493	PF00134	0.510
DOC_CYCLIN_RxL_1	552	563	PF00134	0.520
DOC_CYCLIN_RxL_1	613	624	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	723	726	PF00134	0.479
DOC_MAPK_gen_1	66	75	PF00069	0.695
DOC_MAPK_gen_1	78	84	PF00069	0.539
DOC_MAPK_MEF2A_6	69	77	PF00069	0.580
DOC_PP1_RVXF_1	497	503	PF00149	0.606
DOC_PP1_SILK_1	446	451	PF00149	0.595
DOC_PP2B_LxvP_1	723	726	PF13499	0.479
DOC_USP7_MATH_1	183	187	PF00917	0.639
DOC_USP7_MATH_1	263	267	PF00917	0.650
DOC_USP7_MATH_1	317	321	PF00917	0.679
DOC_USP7_MATH_1	364	368	PF00917	0.570
DOC_USP7_MATH_1	408	412	PF00917	0.601
DOC_USP7_MATH_1	465	469	PF00917	0.715
DOC_USP7_MATH_1	568	572	PF00917	0.353
DOC_USP7_MATH_1	652	656	PF00917	0.659
DOC_USP7_MATH_1	728	732	PF00917	0.691
DOC_USP7_MATH_1	794	798	PF00917	0.496
DOC_USP7_MATH_1	847	851	PF00917	0.710
DOC_USP7_UBL2_3	295	299	PF12436	0.591
DOC_USP7_UBL2_3	62	66	PF12436	0.720
DOC_WW_Pin1_4	157	162	PF00397	0.766
DOC_WW_Pin1_4	225	230	PF00397	0.706
DOC_WW_Pin1_4	231	236	PF00397	0.717
DOC_WW_Pin1_4	318	323	PF00397	0.591
DOC_WW_Pin1_4	349	354	PF00397	0.605
DOC_WW_Pin1_4	46	51	PF00397	0.618
DOC_WW_Pin1_4	467	472	PF00397	0.621
DOC_WW_Pin1_4	701	706	PF00397	0.376
DOC_WW_Pin1_4	726	731	PF00397	0.674
LIG_14-3-3_CanoR_1	144	149	PF00244	0.707
LIG_14-3-3_CanoR_1	182	192	PF00244	0.544
LIG_14-3-3_CanoR_1	452	461	PF00244	0.727
LIG_14-3-3_CanoR_1	567	577	PF00244	0.430
LIG_14-3-3_CanoR_1	681	687	PF00244	0.377
LIG_14-3-3_CanoR_1	69	74	PF00244	0.636
LIG_14-3-3_CanoR_1	81	85	PF00244	0.561
LIG_Actin_WH2_2	353	371	PF00022	0.758
LIG_Actin_WH2_2	879	895	PF00022	0.625
LIG_CSL_BTD_1	232	235	PF09270	0.669
LIG_deltaCOP1_diTrp_1	615	622	PF00928	0.447
LIG_deltaCOP1_diTrp_1	693	698	PF00928	0.399
LIG_eIF4E_1	496	502	PF01652	0.604
LIG_EVH1_1	724	728	PF00568	0.648
LIG_FHA_1	103	109	PF00498	0.777
LIG_FHA_1	226	232	PF00498	0.605
LIG_FHA_1	242	248	PF00498	0.581
LIG_FHA_1	350	356	PF00498	0.659
LIG_FHA_1	370	376	PF00498	0.520
LIG_FHA_1	41	47	PF00498	0.614
LIG_FHA_1	456	462	PF00498	0.670
LIG_FHA_1	70	76	PF00498	0.581
LIG_FHA_1	702	708	PF00498	0.377
LIG_FHA_1	934	940	PF00498	0.672
LIG_FHA_2	133	139	PF00498	0.714
LIG_FHA_2	234	240	PF00498	0.707
LIG_FHA_2	545	551	PF00498	0.576
LIG_FHA_2	818	824	PF00498	0.746
LIG_FHA_2	920	926	PF00498	0.789
LIG_GSK3_LRP6_1	726	732	PF00069	0.618
LIG_LIR_Apic_2	376	380	PF02991	0.611
LIG_LIR_Gen_1	306	315	PF02991	0.509
LIG_LIR_Gen_1	611	622	PF02991	0.499
LIG_LIR_Gen_1	636	645	PF02991	0.692
LIG_LIR_Gen_1	83	92	PF02991	0.526
LIG_LIR_Gen_1	945	951	PF02991	0.564
LIG_LIR_Nem_3	306	311	PF02991	0.495
LIG_LIR_Nem_3	611	617	PF02991	0.469
LIG_LIR_Nem_3	620	625	PF02991	0.420
LIG_LIR_Nem_3	636	642	PF02991	0.459
LIG_LIR_Nem_3	763	769	PF02991	0.695
LIG_LIR_Nem_3	83	88	PF02991	0.517
LIG_LIR_Nem_3	945	950	PF02991	0.559
LIG_Pex14_1	618	622	PF04695	0.447
LIG_Pex14_1	695	699	PF04695	0.377
LIG_Pex14_2	614	618	PF04695	0.442
LIG_Pex14_2	942	946	PF04695	0.559
LIG_SH2_CRK	390	394	PF00017	0.740
LIG_SH2_CRK	445	449	PF00017	0.738
LIG_SH2_NCK_1	377	381	PF00017	0.607
LIG_SH2_PTP2	537	540	PF00017	0.385
LIG_SH2_SRC	537	540	PF00017	0.520
LIG_SH2_SRC	95	98	PF00017	0.719
LIG_SH2_STAP1	146	150	PF00017	0.706
LIG_SH2_STAT5	106	109	PF00017	0.716
LIG_SH2_STAT5	390	393	PF00017	0.631
LIG_SH2_STAT5	489	492	PF00017	0.493
LIG_SH2_STAT5	496	499	PF00017	0.411
LIG_SH2_STAT5	537	540	PF00017	0.385
LIG_SH2_STAT5	628	631	PF00017	0.667
LIG_SH2_STAT5	702	705	PF00017	0.410
LIG_SH2_STAT5	766	769	PF00017	0.541
LIG_SH3_3	107	113	PF00018	0.641
LIG_SH3_3	223	229	PF00018	0.601
LIG_SH3_3	240	246	PF00018	0.725
LIG_SH3_3	70	76	PF00018	0.710
LIG_SH3_3	722	728	PF00018	0.530
LIG_SH3_3	753	759	PF00018	0.638
LIG_SH3_3	91	97	PF00018	0.592
LIG_SH3_4	893	900	PF00018	0.663
LIG_SUMO_SIM_par_1	105	112	PF11976	0.779
LIG_SUMO_SIM_par_1	910	916	PF11976	0.606
LIG_TRAF2_1	279	282	PF00917	0.494
LIG_TRAF2_1	321	324	PF00917	0.692
LIG_TRAF2_1	712	715	PF00917	0.602
LIG_TYR_ITIM	443	448	PF00017	0.734
LIG_TYR_ITIM	533	538	PF00017	0.517
MOD_CDK_SPK_2	467	472	PF00069	0.577
MOD_CDK_SPxK_1	46	52	PF00069	0.616
MOD_CDK_SPxxK_3	157	164	PF00069	0.705
MOD_CDK_SPxxK_3	46	53	PF00069	0.597
MOD_CK1_1	30	36	PF00069	0.775
MOD_CK1_1	358	364	PF00069	0.631
MOD_CK1_1	416	422	PF00069	0.677
MOD_CK1_1	5	11	PF00069	0.700
MOD_CK1_1	584	590	PF00069	0.653
MOD_CK1_1	65	71	PF00069	0.584
MOD_CK1_1	655	661	PF00069	0.675
MOD_CK1_1	729	735	PF00069	0.687
MOD_CK1_1	828	834	PF00069	0.745
MOD_CK1_1	83	89	PF00069	0.580
MOD_CK1_1	919	925	PF00069	0.747
MOD_CK1_1	945	951	PF00069	0.699
MOD_CK2_1	132	138	PF00069	0.725
MOD_CK2_1	148	154	PF00069	0.557
MOD_CK2_1	184	190	PF00069	0.633
MOD_CK2_1	276	282	PF00069	0.579
MOD_CK2_1	317	323	PF00069	0.759
MOD_CK2_1	364	370	PF00069	0.747
MOD_CK2_1	544	550	PF00069	0.529
MOD_CK2_1	577	583	PF00069	0.475
MOD_CK2_1	641	647	PF00069	0.602
MOD_CK2_1	709	715	PF00069	0.466
MOD_CK2_1	817	823	PF00069	0.779
MOD_CK2_1	945	951	PF00069	0.570
MOD_CMANNOS	695	698	PF00535	0.379
MOD_Cter_Amidation	327	330	PF01082	0.625
MOD_DYRK1A_RPxSP_1	157	161	PF00069	0.672
MOD_DYRK1A_RPxSP_1	225	229	PF00069	0.567
MOD_GlcNHglycan	260	263	PF01048	0.695
MOD_GlcNHglycan	29	32	PF01048	0.747
MOD_GlcNHglycan	313	316	PF01048	0.572
MOD_GlcNHglycan	460	464	PF01048	0.632
MOD_GlcNHglycan	562	565	PF01048	0.430
MOD_GlcNHglycan	588	591	PF01048	0.695
MOD_GlcNHglycan	592	595	PF01048	0.678
MOD_GlcNHglycan	655	658	PF01048	0.711
MOD_GlcNHglycan	659	662	PF01048	0.665
MOD_GlcNHglycan	686	689	PF01048	0.386
MOD_GlcNHglycan	7	10	PF01048	0.704
MOD_GlcNHglycan	711	714	PF01048	0.524
MOD_GlcNHglycan	808	811	PF01048	0.616
MOD_GlcNHglycan	825	828	PF01048	0.577
MOD_GlcNHglycan	867	870	PF01048	0.708
MOD_GlcNHglycan	873	877	PF01048	0.614
MOD_GlcNHglycan	918	921	PF01048	0.527
MOD_GSK3_1	144	151	PF00069	0.735
MOD_GSK3_1	227	234	PF00069	0.634
MOD_GSK3_1	258	265	PF00069	0.691
MOD_GSK3_1	354	361	PF00069	0.583
MOD_GSK3_1	369	376	PF00069	0.583
MOD_GSK3_1	415	422	PF00069	0.657
MOD_GSK3_1	451	458	PF00069	0.679
MOD_GSK3_1	573	580	PF00069	0.586
MOD_GSK3_1	586	593	PF00069	0.524
MOD_GSK3_1	637	644	PF00069	0.585
MOD_GSK3_1	65	72	PF00069	0.676
MOD_GSK3_1	652	659	PF00069	0.664
MOD_GSK3_1	668	675	PF00069	0.381
MOD_GSK3_1	726	733	PF00069	0.695
MOD_GSK3_1	815	822	PF00069	0.683
MOD_GSK3_1	823	830	PF00069	0.759
MOD_GSK3_1	831	838	PF00069	0.677
MOD_GSK3_1	865	872	PF00069	0.641
MOD_N-GLC_1	183	188	PF02516	0.725
MOD_N-GLC_1	239	244	PF02516	0.644
MOD_N-GLC_1	27	32	PF02516	0.763
MOD_N-GLC_1	422	427	PF02516	0.714
MOD_N-GLC_1	452	457	PF02516	0.565
MOD_NEK2_1	241	246	PF00069	0.718
MOD_NEK2_1	29	34	PF00069	0.661
MOD_NEK2_1	311	316	PF00069	0.632
MOD_NEK2_1	341	346	PF00069	0.636
MOD_NEK2_1	444	449	PF00069	0.582
MOD_NEK2_1	490	495	PF00069	0.487
MOD_NEK2_1	554	559	PF00069	0.409
MOD_NEK2_1	573	578	PF00069	0.474
MOD_NEK2_1	769	774	PF00069	0.496
MOD_NEK2_1	865	870	PF00069	0.760
MOD_NEK2_1	942	947	PF00069	0.553
MOD_NEK2_2	364	369	PF00069	0.744
MOD_PIKK_1	369	375	PF00454	0.766
MOD_PIKK_1	388	394	PF00454	0.488
MOD_PIKK_1	423	429	PF00454	0.773
MOD_PIKK_1	478	484	PF00454	0.731
MOD_PIKK_1	56	62	PF00454	0.709
MOD_PIKK_1	581	587	PF00454	0.607
MOD_PIKK_1	744	750	PF00454	0.708
MOD_PK_1	144	150	PF00069	0.727
MOD_PK_1	613	619	PF00069	0.402
MOD_PK_1	800	806	PF00069	0.563
MOD_PKA_1	144	150	PF00069	0.672
MOD_PKA_2	144	150	PF00069	0.751
MOD_PKA_2	328	334	PF00069	0.713
MOD_PKA_2	419	425	PF00069	0.636
MOD_PKA_2	451	457	PF00069	0.622
MOD_PKA_2	682	688	PF00069	0.437
MOD_PKA_2	80	86	PF00069	0.499
MOD_PKA_2	812	818	PF00069	0.679
MOD_PKB_1	225	233	PF00069	0.626
MOD_PKB_1	450	458	PF00069	0.565
MOD_PKB_1	67	75	PF00069	0.590
MOD_Plk_1	173	179	PF00069	0.609
MOD_Plk_1	239	245	PF00069	0.635
MOD_Plk_1	554	560	PF00069	0.550
MOD_Plk_1	795	801	PF00069	0.468
MOD_Plk_1	887	893	PF00069	0.701
MOD_Plk_4	102	108	PF00069	0.681
MOD_Plk_4	173	179	PF00069	0.744
MOD_Plk_4	227	233	PF00069	0.756
MOD_Plk_4	379	385	PF00069	0.594
MOD_Plk_4	444	450	PF00069	0.660
MOD_Plk_4	613	619	PF00069	0.448
MOD_Plk_4	668	674	PF00069	0.490
MOD_Plk_4	80	86	PF00069	0.562
MOD_Plk_4	887	893	PF00069	0.627
MOD_Plk_4	942	948	PF00069	0.690
MOD_ProDKin_1	157	163	PF00069	0.762
MOD_ProDKin_1	225	231	PF00069	0.708
MOD_ProDKin_1	318	324	PF00069	0.593
MOD_ProDKin_1	349	355	PF00069	0.606
MOD_ProDKin_1	46	52	PF00069	0.619
MOD_ProDKin_1	467	473	PF00069	0.620
MOD_ProDKin_1	701	707	PF00069	0.374
MOD_ProDKin_1	726	732	PF00069	0.685
MOD_SUMO_for_1	298	301	PF00179	0.440
MOD_SUMO_rev_2	301	307	PF00179	0.525
MOD_SUMO_rev_2	620	627	PF00179	0.456
MOD_SUMO_rev_2	63	68	PF00179	0.629
MOD_SUMO_rev_2	785	792	PF00179	0.457
TRG_DiLeu_BaEn_1	861	866	PF01217	0.761
TRG_DiLeu_BaEn_1	873	878	PF01217	0.495
TRG_DiLeu_BaEn_1	887	892	PF01217	0.572
TRG_DiLeu_BaEn_4	887	893	PF01217	0.572
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.572
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.734
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.681
TRG_ENDOCYTIC_2	390	393	PF00928	0.723
TRG_ENDOCYTIC_2	445	448	PF00928	0.737
TRG_ENDOCYTIC_2	535	538	PF00928	0.387
TRG_ENDOCYTIC_2	628	631	PF00928	0.650
TRG_ENDOCYTIC_2	700	703	PF00928	0.540
TRG_ENDOCYTIC_2	766	769	PF00928	0.541
TRG_ER_diArg_1	144	146	PF00400	0.680
TRG_ER_diArg_1	222	225	PF00400	0.596
TRG_ER_diArg_1	275	277	PF00400	0.739
TRG_ER_diArg_1	449	452	PF00400	0.750
TRG_ER_diArg_1	51	53	PF00400	0.697
TRG_ER_diArg_1	528	530	PF00400	0.503
TRG_ER_diArg_1	67	70	PF00400	0.553
TRG_ER_diArg_1	786	788	PF00400	0.503
TRG_NES_CRM1_1	620	635	PF08389	0.485
TRG_NLS_Bipartite_1	275	289	PF00514	0.606
TRG_NLS_Bipartite_1	52	70	PF00514	0.597
TRG_NLS_MonoExtN_4	394	399	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	499	504	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	619	624	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC02	Leptomonas seymouri	43%	97%
A4HJ82	Leishmania braziliensis	62%	98%
A4I6M6	Leishmania infantum	99%	100%
E9B1P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q6G1	Leishmania major	86%	100%