Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X4E5_LEIDO

TriTrypDb:

LdBPK_311200.1 , LdCL_310018700 , LDHU3_31.1960

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X4E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4E5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.625
CLV_C14_Caspase3-7	41	45	PF00656	0.558
CLV_PCSK_KEX2_1	160	162	PF00082	0.717
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.717
CLV_PCSK_SKI1_1	107	111	PF00082	0.453
CLV_PCSK_SKI1_1	40	44	PF00082	0.502
CLV_PCSK_SKI1_1	8	12	PF00082	0.453
DEG_SCF_FBW7_1	108	114	PF00400	0.652
DOC_CKS1_1	108	113	PF01111	0.651
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.427
DOC_MAPK_gen_1	130	137	PF00069	0.475
DOC_MAPK_MEF2A_6	130	137	PF00069	0.486
DOC_PP2B_LxvP_1	133	136	PF13499	0.427
DOC_USP7_MATH_1	111	115	PF00917	0.739
DOC_USP7_MATH_1	128	132	PF00917	0.683
DOC_USP7_MATH_1	28	32	PF00917	0.676
DOC_USP7_MATH_1	49	53	PF00917	0.654
DOC_WW_Pin1_4	100	105	PF00397	0.754
DOC_WW_Pin1_4	107	112	PF00397	0.626
DOC_WW_Pin1_4	77	82	PF00397	0.791
DOC_WW_Pin1_4	93	98	PF00397	0.781
LIG_APCC_ABBA_1	34	39	PF00400	0.663
LIG_BRCT_BRCA1_1	130	134	PF00533	0.655
LIG_FHA_1	101	107	PF00498	0.770
LIG_FHA_1	108	114	PF00498	0.601
LIG_FHA_2	122	128	PF00498	0.756
LIG_LIR_Apic_2	15	19	PF02991	0.646
LIG_LIR_Gen_1	152	159	PF02991	0.578
LIG_LIR_Nem_3	131	137	PF02991	0.475
LIG_LIR_Nem_3	152	158	PF02991	0.545
LIG_NRP_CendR_1	160	162	PF00754	0.767
LIG_REV1ctd_RIR_1	7	16	PF16727	0.650
LIG_SH2_PTP2	155	158	PF00017	0.487
LIG_SH2_SRC	16	19	PF00017	0.650
LIG_SH2_STAT5	155	158	PF00017	0.512
LIG_SH2_STAT5	16	19	PF00017	0.650
LIG_SH2_STAT5	22	25	PF00017	0.633
LIG_SH2_STAT5	37	40	PF00017	0.555
LIG_SH3_3	153	159	PF00018	0.615
LIG_SH3_3	75	81	PF00018	0.784
LIG_TRAF2_1	81	84	PF00917	0.815
LIG_TYR_ITIM	153	158	PF00017	0.672
MOD_CDK_SPxxK_3	100	107	PF00069	0.662
MOD_CK1_1	126	132	PF00069	0.789
MOD_CK2_1	121	127	PF00069	0.823
MOD_GlcNHglycan	149	152	PF01048	0.305
MOD_GSK3_1	107	114	PF00069	0.742
MOD_GSK3_1	117	124	PF00069	0.785
MOD_GSK3_1	73	80	PF00069	0.776
MOD_NEK2_1	147	152	PF00069	0.497
MOD_Plk_1	49	55	PF00069	0.711
MOD_Plk_4	12	18	PF00069	0.668
MOD_Plk_4	149	155	PF00069	0.336
MOD_ProDKin_1	100	106	PF00069	0.750
MOD_ProDKin_1	107	113	PF00069	0.624
MOD_ProDKin_1	77	83	PF00069	0.794
MOD_ProDKin_1	93	99	PF00069	0.782
TRG_ENDOCYTIC_2	155	158	PF00928	0.562
TRG_ENDOCYTIC_2	7	10	PF00928	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJ99	Leishmania braziliensis	68%	100%
A4I6P4	Leishmania infantum	100%	100%
E9B1R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	97%
Q4Q6E5	Leishmania major	89%	100%