Biotin/lipoate protein ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

biotin/lipoate protein ligase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4E1_LEIDO

TriTrypDb:

LdBPK_311070.1 , LdCL_310017300 , LDHU3_31.1790

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X4E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4E1

PDB structure(s): 6jhu_A , 7dbs_A

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	4	10
GO:0016874	ligase activity	2	12
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	10
GO:0018271	biotin-protein ligase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.424
CLV_PCSK_KEX2_1	223	225	PF00082	0.486
CLV_PCSK_KEX2_1	91	93	PF00082	0.424
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.535
CLV_PCSK_SKI1_1	163	167	PF00082	0.561
CLV_PCSK_SKI1_1	217	221	PF00082	0.513
CLV_PCSK_SKI1_1	92	96	PF00082	0.423
DEG_APCC_DBOX_1	91	99	PF00400	0.614
DOC_MAPK_DCC_7	75	84	PF00069	0.561
DOC_MAPK_gen_1	91	97	PF00069	0.616
DOC_MAPK_MEF2A_6	75	84	PF00069	0.534
DOC_MAPK_RevD_3	79	92	PF00069	0.606
DOC_PP4_FxxP_1	63	66	PF00568	0.487
DOC_USP7_MATH_1	105	109	PF00917	0.622
DOC_USP7_UBL2_3	213	217	PF12436	0.483
DOC_WW_Pin1_4	178	183	PF00397	0.482
DOC_WW_Pin1_4	196	201	PF00397	0.491
DOC_WW_Pin1_4	51	56	PF00397	0.535
LIG_14-3-3_CanoR_1	102	109	PF00244	0.474
LIG_14-3-3_CanoR_1	248	254	PF00244	0.588
LIG_14-3-3_CanoR_1	26	34	PF00244	0.599
LIG_14-3-3_CanoR_1	50	55	PF00244	0.566
LIG_CtBP_PxDLS_1	231	235	PF00389	0.543
LIG_FHA_1	16	22	PF00498	0.535
LIG_FHA_1	60	66	PF00498	0.512
LIG_FHA_2	133	139	PF00498	0.547
LIG_FHA_2	179	185	PF00498	0.581
LIG_FHA_2	196	202	PF00498	0.475
LIG_LIR_Apic_2	51	55	PF02991	0.598
LIG_LIR_Apic_2	62	66	PF02991	0.617
LIG_LIR_Gen_1	209	219	PF02991	0.554
LIG_LIR_Nem_3	140	146	PF02991	0.555
LIG_LIR_Nem_3	209	214	PF02991	0.562
LIG_LIR_Nem_3	241	245	PF02991	0.430
LIG_PDZ_Class_2	258	263	PF00595	0.490
LIG_Pex14_1	190	194	PF04695	0.370
LIG_SH2_CRK	222	226	PF00017	0.375
LIG_SH2_STAT5	143	146	PF00017	0.577
LIG_SH3_3	77	83	PF00018	0.475
LIG_WRC_WIRS_1	208	213	PF05994	0.501
LIG_WRC_WIRS_1	60	65	PF05994	0.487
MOD_CDK_SPK_2	178	183	PF00069	0.360
MOD_CDK_SPK_2	51	56	PF00069	0.529
MOD_CK1_1	238	244	PF00069	0.575
MOD_CK2_1	132	138	PF00069	0.510
MOD_CK2_1	195	201	PF00069	0.550
MOD_CK2_1	203	209	PF00069	0.456
MOD_GlcNHglycan	103	106	PF01048	0.349
MOD_GlcNHglycan	255	260	PF01048	0.482
MOD_GSK3_1	101	108	PF00069	0.614
MOD_GSK3_1	196	203	PF00069	0.555
MOD_GSK3_1	21	28	PF00069	0.645
MOD_GSK3_1	44	51	PF00069	0.580
MOD_NEK2_1	215	220	PF00069	0.445
MOD_NEK2_1	25	30	PF00069	0.625
MOD_NEK2_1	59	64	PF00069	0.510
MOD_PKA_2	101	107	PF00069	0.474
MOD_PKA_2	203	209	PF00069	0.537
MOD_PKA_2	247	253	PF00069	0.413
MOD_PKA_2	25	31	PF00069	0.514
MOD_PKA_2	44	50	PF00069	0.510
MOD_Plk_1	163	169	PF00069	0.561
MOD_Plk_1	215	221	PF00069	0.433
MOD_Plk_1	232	238	PF00069	0.522
MOD_Plk_4	132	138	PF00069	0.527
MOD_Plk_4	163	169	PF00069	0.584
MOD_Plk_4	203	209	PF00069	0.528
MOD_ProDKin_1	178	184	PF00069	0.482
MOD_ProDKin_1	196	202	PF00069	0.486
MOD_ProDKin_1	51	57	PF00069	0.535
MOD_SUMO_for_1	74	77	PF00179	0.612
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.606
TRG_ENDOCYTIC_2	143	146	PF00928	0.577
TRG_ENDOCYTIC_2	222	225	PF00928	0.359
TRG_ENDOCYTIC_2	60	63	PF00928	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUD5	Leptomonas seymouri	72%	100%
A0A0S4JE29	Bodo saltans	34%	85%
A0A1X0P3B0	Trypanosomatidae	52%	100%
A0A3R7NY08	Trypanosoma rangeli	48%	100%
A4HJ88	Leishmania braziliensis	85%	100%
A4I6N1	Leishmania infantum	98%	100%
D0A8L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B1Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P46363	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	87%
Q4Q6F6	Leishmania major	93%	100%
Q59014	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	32%	100%
V5DNJ4	Trypanosoma cruzi	50%	100%