Microtubule-binding stalk of dynein motor, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding stalk of dynein motor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X4D8_LEIDO

TriTrypDb:

LdBPK_311280.1 , LdCL_310019700 , LDHU3_31.2100

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005875	microtubule associated complex	2	11
GO:0030286	dynein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:1902494	catalytic complex	2	11
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X4D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4D8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035721	intraciliary retrograde transport	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008569	minus-end-directed microtubule motor activity	3	11
GO:0045505	dynein intermediate chain binding	3	11
GO:0051959	dynein light intermediate chain binding	3	11
GO:0140657	ATP-dependent activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.467
CLV_C14_Caspase3-7	462	466	PF00656	0.622
CLV_NRD_NRD_1	10	12	PF00675	0.696
CLV_NRD_NRD_1	229	231	PF00675	0.327
CLV_NRD_NRD_1	283	285	PF00675	0.275
CLV_NRD_NRD_1	297	299	PF00675	0.551
CLV_PCSK_FUR_1	295	299	PF00082	0.551
CLV_PCSK_FUR_1	310	314	PF00082	0.456
CLV_PCSK_KEX2_1	105	107	PF00082	0.461
CLV_PCSK_KEX2_1	213	215	PF00082	0.294
CLV_PCSK_KEX2_1	228	230	PF00082	0.311
CLV_PCSK_KEX2_1	297	299	PF00082	0.564
CLV_PCSK_KEX2_1	312	314	PF00082	0.658
CLV_PCSK_KEX2_1	544	546	PF00082	0.544
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.538
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.294
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.658
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.544
CLV_PCSK_PC7_1	209	215	PF00082	0.331
CLV_PCSK_SKI1_1	105	109	PF00082	0.432
CLV_PCSK_SKI1_1	126	130	PF00082	0.459
CLV_PCSK_SKI1_1	182	186	PF00082	0.324
CLV_PCSK_SKI1_1	209	213	PF00082	0.326
CLV_PCSK_SKI1_1	392	396	PF00082	0.545
CLV_PCSK_SKI1_1	422	426	PF00082	0.505
CLV_PCSK_SKI1_1	428	432	PF00082	0.508
CLV_PCSK_SKI1_1	453	457	PF00082	0.613
CLV_PCSK_SKI1_1	467	471	PF00082	0.553
DEG_APCC_DBOX_1	208	216	PF00400	0.482
DOC_CYCLIN_yClb5_NLxxxL_5	441	449	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	505	511	PF00134	0.511
DOC_PP1_RVXF_1	193	200	PF00149	0.478
DOC_USP7_MATH_1	340	344	PF00917	0.778
DOC_USP7_MATH_1	528	532	PF00917	0.585
DOC_USP7_UBL2_3	285	289	PF12436	0.477
DOC_USP7_UBL2_3	437	441	PF12436	0.505
DOC_USP7_UBL2_3	533	537	PF12436	0.678
DOC_WW_Pin1_4	12	17	PF00397	0.597
DOC_WW_Pin1_4	315	320	PF00397	0.642
DOC_WW_Pin1_4	332	337	PF00397	0.687
DOC_WW_Pin1_4	347	352	PF00397	0.808
DOC_WW_Pin1_4	361	366	PF00397	0.649
DOC_WW_Pin1_4	411	416	PF00397	0.532
DOC_WW_Pin1_4	6	11	PF00397	0.645
LIG_14-3-3_CanoR_1	207	212	PF00244	0.495
LIG_14-3-3_CanoR_1	240	247	PF00244	0.503
LIG_14-3-3_CanoR_1	341	349	PF00244	0.735
LIG_14-3-3_CanoR_1	41	45	PF00244	0.425
LIG_Actin_WH2_2	406	424	PF00022	0.578
LIG_APCC_ABBAyCdc20_2	428	434	PF00400	0.458
LIG_Clathr_ClatBox_1	47	51	PF01394	0.472
LIG_CSL_BTD_1	348	351	PF09270	0.571
LIG_FHA_1	15	21	PF00498	0.721
LIG_FHA_1	498	504	PF00498	0.705
LIG_FHA_1	601	607	PF00498	0.440
LIG_FHA_2	189	195	PF00498	0.531
LIG_FHA_2	240	246	PF00498	0.449
LIG_Integrin_isoDGR_2	614	616	PF01839	0.492
LIG_LIR_Apic_2	173	177	PF02991	0.469
LIG_LIR_Gen_1	196	206	PF02991	0.453
LIG_LIR_Nem_3	165	171	PF02991	0.451
LIG_LIR_Nem_3	196	202	PF02991	0.453
LIG_PTB_Apo_2	235	242	PF02174	0.449
LIG_SH2_GRB2like	327	330	PF00017	0.510
LIG_SH2_NCK_1	379	383	PF00017	0.522
LIG_SH2_NCK_1	403	407	PF00017	0.485
LIG_SH2_PTP2	174	177	PF00017	0.531
LIG_SH2_SRC	327	330	PF00017	0.471
LIG_SH2_SRC	403	406	PF00017	0.441
LIG_SH2_STAP1	142	146	PF00017	0.502
LIG_SH2_STAT5	174	177	PF00017	0.531
LIG_SH2_STAT5	201	204	PF00017	0.542
LIG_SH2_STAT5	235	238	PF00017	0.453
LIG_SH2_STAT5	327	330	PF00017	0.510
LIG_SH2_STAT5	52	55	PF00017	0.480
LIG_SH2_STAT5	622	625	PF00017	0.634
LIG_SH3_1	366	372	PF00018	0.644
LIG_SH3_2	13	18	PF14604	0.683
LIG_SH3_3	172	178	PF00018	0.492
LIG_SH3_3	366	372	PF00018	0.644
LIG_SH3_3	506	512	PF00018	0.599
LIG_SH3_3	7	13	PF00018	0.694
LIG_SH3_4	537	544	PF00018	0.624
LIG_SH3_CIN85_PxpxPR_1	336	341	PF14604	0.595
LIG_SUMO_SIM_par_1	188	194	PF11976	0.464
LIG_SUMO_SIM_par_1	408	414	PF11976	0.666
LIG_TRAF2_1	117	120	PF00917	0.565
LIG_TRAF2_1	156	159	PF00917	0.482
LIG_TRFH_1	235	239	PF08558	0.451
LIG_UBA3_1	525	533	PF00899	0.496
LIG_UBA3_1	584	590	PF00899	0.526
MOD_CDC14_SPxK_1	15	18	PF00782	0.691
MOD_CDC14_SPxK_1	9	12	PF00782	0.713
MOD_CDK_SPK_2	336	341	PF00069	0.717
MOD_CDK_SPK_2	347	352	PF00069	0.762
MOD_CDK_SPK_2	361	366	PF00069	0.550
MOD_CDK_SPK_2	6	11	PF00069	0.699
MOD_CDK_SPxK_1	6	12	PF00069	0.725
MOD_CDK_SPxxK_3	361	368	PF00069	0.674
MOD_CK1_1	14	20	PF00069	0.700
MOD_CK1_1	224	230	PF00069	0.417
MOD_CK1_1	23	29	PF00069	0.679
MOD_CK2_1	188	194	PF00069	0.495
MOD_CK2_1	528	534	PF00069	0.735
MOD_Cter_Amidation	542	545	PF01082	0.626
MOD_GlcNHglycan	343	346	PF01048	0.750
MOD_GlcNHglycan	83	86	PF01048	0.582
MOD_GSK3_1	19	26	PF00069	0.634
MOD_GSK3_1	217	224	PF00069	0.565
MOD_GSK3_1	239	246	PF00069	0.557
MOD_GSK3_1	328	335	PF00069	0.691
MOD_GSK3_1	336	343	PF00069	0.789
MOD_GSK3_1	377	384	PF00069	0.586
MOD_GSK3_1	405	412	PF00069	0.555
MOD_GSK3_1	596	603	PF00069	0.521
MOD_N-GLC_1	124	129	PF02516	0.471
MOD_N-GLC_1	328	333	PF02516	0.617
MOD_N-GLC_1	565	570	PF02516	0.570
MOD_N-GLC_1	596	601	PF02516	0.477
MOD_NEK2_1	124	129	PF00069	0.480
MOD_NEK2_1	188	193	PF00069	0.541
MOD_NEK2_1	247	252	PF00069	0.436
MOD_NEK2_1	290	295	PF00069	0.512
MOD_NEK2_1	395	400	PF00069	0.476
MOD_NEK2_1	456	461	PF00069	0.559
MOD_NEK2_1	497	502	PF00069	0.653
MOD_NEK2_1	565	570	PF00069	0.576
MOD_PIKK_1	217	223	PF00454	0.542
MOD_PK_1	33	39	PF00069	0.488
MOD_PKA_1	11	17	PF00069	0.719
MOD_PKA_2	239	245	PF00069	0.503
MOD_PKA_2	340	346	PF00069	0.651
MOD_PKA_2	40	46	PF00069	0.415
MOD_Plk_1	124	130	PF00069	0.472
MOD_Plk_1	193	199	PF00069	0.536
MOD_Plk_1	290	296	PF00069	0.562
MOD_Plk_1	306	312	PF00069	0.616
MOD_Plk_4	26	32	PF00069	0.641
MOD_Plk_4	381	387	PF00069	0.673
MOD_Plk_4	395	401	PF00069	0.441
MOD_Plk_4	406	412	PF00069	0.575
MOD_Plk_4	600	606	PF00069	0.436
MOD_ProDKin_1	315	321	PF00069	0.648
MOD_ProDKin_1	332	338	PF00069	0.687
MOD_ProDKin_1	347	353	PF00069	0.808
MOD_ProDKin_1	361	367	PF00069	0.644
MOD_ProDKin_1	411	417	PF00069	0.527
MOD_ProDKin_1	6	12	PF00069	0.645
MOD_SUMO_for_1	304	307	PF00179	0.356
MOD_SUMO_rev_2	155	163	PF00179	0.556
MOD_SUMO_rev_2	277	287	PF00179	0.469
MOD_SUMO_rev_2	389	394	PF00179	0.491
MOD_SUMO_rev_2	434	442	PF00179	0.553
MOD_SUMO_rev_2	459	469	PF00179	0.620
MOD_SUMO_rev_2	481	490	PF00179	0.545
MOD_SUMO_rev_2	530	538	PF00179	0.596
TRG_DiLeu_BaEn_1	521	526	PF01217	0.507
TRG_DiLeu_BaEn_2	599	605	PF01217	0.432
TRG_DiLeu_BaEn_4	119	125	PF01217	0.586
TRG_ER_diArg_1	206	209	PF00400	0.504
TRG_ER_diArg_1	228	230	PF00400	0.578
TRG_ER_diArg_1	294	297	PF00400	0.577
TRG_ER_diArg_1	365	368	PF00400	0.666
TRG_NES_CRM1_1	179	194	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.221
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ8	Leptomonas seymouri	25%	67%
A0A0N1PDQ0	Leptomonas seymouri	56%	100%
A0A1X0NQ11	Trypanosomatidae	36%	74%
A0A422NZ91	Trypanosoma rangeli	35%	77%
A4HJA9	Leishmania braziliensis	72%	99%
A4I6Q2	Leishmania infantum	100%	100%
E9B1S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q6D7	Leishmania major	92%	100%
V5DGE3	Trypanosoma cruzi	35%	78%