LeishMANIAdb
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Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine Rich repeat, putative
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7X4D3_LEIDO
TriTrypDb:
LdBPK_311250.1 , LdCL_310019200 , LDHU3_31.2030
Length:
897

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7

Expansion

Sequence features

A0A3S7X4D3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4D3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 179 183 PF00656 0.452
CLV_C14_Caspase3-7 221 225 PF00656 0.478
CLV_C14_Caspase3-7 617 621 PF00656 0.495
CLV_C14_Caspase3-7 712 716 PF00656 0.548
CLV_C14_Caspase3-7 772 776 PF00656 0.553
CLV_NRD_NRD_1 185 187 PF00675 0.576
CLV_NRD_NRD_1 653 655 PF00675 0.588
CLV_NRD_NRD_1 719 721 PF00675 0.572
CLV_NRD_NRD_1 730 732 PF00675 0.625
CLV_NRD_NRD_1 889 891 PF00675 0.448
CLV_PCSK_KEX2_1 185 187 PF00082 0.576
CLV_PCSK_KEX2_1 633 635 PF00082 0.396
CLV_PCSK_KEX2_1 653 655 PF00082 0.458
CLV_PCSK_KEX2_1 719 721 PF00082 0.556
CLV_PCSK_PC1ET2_1 633 635 PF00082 0.396
CLV_PCSK_SKI1_1 112 116 PF00082 0.562
CLV_PCSK_SKI1_1 159 163 PF00082 0.481
CLV_PCSK_SKI1_1 210 214 PF00082 0.491
CLV_PCSK_SKI1_1 270 274 PF00082 0.458
CLV_PCSK_SKI1_1 531 535 PF00082 0.563
CLV_PCSK_SKI1_1 580 584 PF00082 0.408
CLV_PCSK_SKI1_1 673 677 PF00082 0.635
CLV_PCSK_SKI1_1 795 799 PF00082 0.394
DEG_APCC_DBOX_1 568 576 PF00400 0.424
DEG_APCC_DBOX_1 603 611 PF00400 0.483
DEG_APCC_DBOX_1 794 802 PF00400 0.440
DEG_MDM2_SWIB_1 48 56 PF02201 0.422
DEG_Nend_UBRbox_2 1 3 PF02207 0.612
DEG_SCF_FBW7_2 662 669 PF00400 0.565
DEG_SCF_FBW7_2 744 750 PF00400 0.391
DEG_SPOP_SBC_1 310 314 PF00917 0.490
DOC_CKS1_1 235 240 PF01111 0.552
DOC_CKS1_1 33 38 PF01111 0.658
DOC_CKS1_1 361 366 PF01111 0.567
DOC_CKS1_1 435 440 PF01111 0.538
DOC_CKS1_1 744 749 PF01111 0.479
DOC_CYCLIN_RxL_1 153 165 PF00134 0.414
DOC_MAPK_DCC_7 569 577 PF00069 0.428
DOC_MAPK_gen_1 479 486 PF00069 0.472
DOC_MAPK_gen_1 719 726 PF00069 0.559
DOC_MAPK_MEF2A_6 339 348 PF00069 0.566
DOC_MAPK_MEF2A_6 569 577 PF00069 0.428
DOC_PP2B_LxvP_1 88 91 PF13499 0.581
DOC_PP4_FxxP_1 184 187 PF00568 0.427
DOC_PP4_FxxP_1 235 238 PF00568 0.533
DOC_PP4_FxxP_1 72 75 PF00568 0.456
DOC_SPAK_OSR1_1 524 528 PF12202 0.348
DOC_USP7_MATH_1 140 144 PF00917 0.478
DOC_USP7_MATH_1 218 222 PF00917 0.348
DOC_USP7_MATH_1 278 282 PF00917 0.500
DOC_USP7_MATH_1 326 330 PF00917 0.623
DOC_USP7_MATH_1 553 557 PF00917 0.445
DOC_USP7_MATH_1 675 679 PF00917 0.604
DOC_USP7_MATH_1 699 703 PF00917 0.653
DOC_USP7_MATH_1 763 767 PF00917 0.413
DOC_USP7_MATH_2 659 665 PF00917 0.638
DOC_WW_Pin1_4 234 239 PF00397 0.539
DOC_WW_Pin1_4 32 37 PF00397 0.615
DOC_WW_Pin1_4 357 362 PF00397 0.575
DOC_WW_Pin1_4 434 439 PF00397 0.619
DOC_WW_Pin1_4 445 450 PF00397 0.547
DOC_WW_Pin1_4 452 457 PF00397 0.503
DOC_WW_Pin1_4 501 506 PF00397 0.435
DOC_WW_Pin1_4 536 541 PF00397 0.526
DOC_WW_Pin1_4 662 667 PF00397 0.569
DOC_WW_Pin1_4 680 685 PF00397 0.528
DOC_WW_Pin1_4 740 745 PF00397 0.564
DOC_WW_Pin1_4 759 764 PF00397 0.315
LIG_14-3-3_CanoR_1 109 115 PF00244 0.625
LIG_14-3-3_CanoR_1 297 307 PF00244 0.380
LIG_14-3-3_CanoR_1 365 370 PF00244 0.651
LIG_14-3-3_CanoR_1 45 49 PF00244 0.537
LIG_14-3-3_CanoR_1 531 537 PF00244 0.461
LIG_14-3-3_CanoR_1 653 659 PF00244 0.535
LIG_14-3-3_CanoR_1 671 679 PF00244 0.517
LIG_14-3-3_CanoR_1 719 724 PF00244 0.552
LIG_14-3-3_CanoR_1 731 735 PF00244 0.590
LIG_14-3-3_CanoR_1 8 12 PF00244 0.603
LIG_14-3-3_CterR_2 895 897 PF00244 0.514
LIG_Actin_WH2_2 53 69 PF00022 0.530
LIG_APCC_ABBA_1 547 552 PF00400 0.433
LIG_BRCT_BRCA1_1 166 170 PF00533 0.456
LIG_BRCT_BRCA1_1 291 295 PF00533 0.389
LIG_CaM_IQ_9 605 621 PF13499 0.452
LIG_Clathr_ClatBox_1 533 537 PF01394 0.434
LIG_Clathr_ClatBox_1 838 842 PF01394 0.394
LIG_EH_1 119 123 PF12763 0.561
LIG_EH_1 845 849 PF12763 0.426
LIG_eIF4E_1 249 255 PF01652 0.399
LIG_eIF4E_1 803 809 PF01652 0.475
LIG_FAT_LD_1 151 159 PF03623 0.408
LIG_FHA_1 229 235 PF00498 0.544
LIG_FHA_1 33 39 PF00498 0.746
LIG_FHA_1 339 345 PF00498 0.612
LIG_FHA_1 446 452 PF00498 0.623
LIG_FHA_1 563 569 PF00498 0.495
LIG_FHA_1 779 785 PF00498 0.493
LIG_FHA_1 83 89 PF00498 0.550
LIG_FHA_1 834 840 PF00498 0.405
LIG_FHA_1 850 856 PF00498 0.307
LIG_FHA_1 866 872 PF00498 0.338
LIG_FHA_2 177 183 PF00498 0.444
LIG_FHA_2 240 246 PF00498 0.511
LIG_FHA_2 435 441 PF00498 0.558
LIG_FHA_2 615 621 PF00498 0.500
LIG_FHA_2 92 98 PF00498 0.451
LIG_GBD_Chelix_1 150 158 PF00786 0.433
LIG_GBD_Chelix_1 250 258 PF00786 0.460
LIG_LIR_Apic_2 182 187 PF02991 0.419
LIG_LIR_Apic_2 69 75 PF02991 0.521
LIG_LIR_Gen_1 146 155 PF02991 0.457
LIG_LIR_Gen_1 164 173 PF02991 0.311
LIG_LIR_Gen_1 383 393 PF02991 0.625
LIG_LIR_Gen_1 47 56 PF02991 0.426
LIG_LIR_Gen_1 586 593 PF02991 0.397
LIG_LIR_Gen_1 594 605 PF02991 0.401
LIG_LIR_Gen_1 646 652 PF02991 0.511
LIG_LIR_Gen_1 777 784 PF02991 0.487
LIG_LIR_Nem_3 146 150 PF02991 0.469
LIG_LIR_Nem_3 164 169 PF02991 0.339
LIG_LIR_Nem_3 172 176 PF02991 0.333
LIG_LIR_Nem_3 383 388 PF02991 0.628
LIG_LIR_Nem_3 47 51 PF02991 0.428
LIG_LIR_Nem_3 503 509 PF02991 0.425
LIG_LIR_Nem_3 594 600 PF02991 0.447
LIG_LIR_Nem_3 646 650 PF02991 0.501
LIG_LIR_Nem_3 683 689 PF02991 0.459
LIG_LIR_Nem_3 777 782 PF02991 0.458
LIG_LIR_Nem_3 785 791 PF02991 0.391
LIG_LIR_Nem_3 842 848 PF02991 0.389
LIG_LIR_Nem_3 852 856 PF02991 0.388
LIG_LYPXL_yS_3 506 509 PF13949 0.415
LIG_MLH1_MIPbox_1 166 170 PF16413 0.456
LIG_NRBOX 128 134 PF00104 0.417
LIG_PCNA_yPIPBox_3 413 426 PF02747 0.526
LIG_PCNA_yPIPBox_3 512 526 PF02747 0.346
LIG_Pex14_2 169 173 PF04695 0.371
LIG_Pex14_2 271 275 PF04695 0.439
LIG_Pex14_2 48 52 PF04695 0.419
LIG_PTB_Apo_2 847 854 PF02174 0.432
LIG_Rb_LxCxE_1 858 879 PF01857 0.482
LIG_SH2_NCK_1 647 651 PF00017 0.519
LIG_SH2_PTP2 788 791 PF00017 0.434
LIG_SH2_STAP1 166 170 PF00017 0.456
LIG_SH2_STAP1 196 200 PF00017 0.484
LIG_SH2_STAP1 696 700 PF00017 0.507
LIG_SH2_STAT3 108 111 PF00017 0.562
LIG_SH2_STAT3 557 560 PF00017 0.403
LIG_SH2_STAT5 249 252 PF00017 0.519
LIG_SH2_STAT5 303 306 PF00017 0.399
LIG_SH2_STAT5 362 365 PF00017 0.570
LIG_SH2_STAT5 778 781 PF00017 0.468
LIG_SH2_STAT5 788 791 PF00017 0.397
LIG_SH3_2 573 578 PF14604 0.391
LIG_SH3_3 28 34 PF00018 0.691
LIG_SH3_3 358 364 PF00018 0.732
LIG_SH3_3 432 438 PF00018 0.575
LIG_SH3_3 570 576 PF00018 0.401
LIG_SH3_3 741 747 PF00018 0.501
LIG_SUMO_SIM_anti_2 127 134 PF11976 0.431
LIG_SUMO_SIM_par_1 208 216 PF11976 0.429
LIG_SUMO_SIM_par_1 341 349 PF11976 0.632
LIG_SUMO_SIM_par_1 532 539 PF11976 0.535
LIG_SUMO_SIM_par_1 563 571 PF11976 0.430
LIG_SUMO_SIM_par_1 780 786 PF11976 0.386
LIG_SUMO_SIM_par_1 806 812 PF11976 0.403
LIG_TRAF2_1 143 146 PF00917 0.513
LIG_TRAF2_1 649 652 PF00917 0.586
LIG_TYR_ITIM 645 650 PF00017 0.472
LIG_WRC_WIRS_1 11 16 PF05994 0.646
LIG_WRC_WIRS_1 170 175 PF05994 0.375
LIG_WRC_WIRS_1 181 186 PF05994 0.463
MOD_CDK_SPK_2 360 365 PF00069 0.567
MOD_CDK_SPK_2 662 667 PF00069 0.569
MOD_CDK_SPxxK_3 452 459 PF00069 0.546
MOD_CDK_SPxxK_3 536 543 PF00069 0.509
MOD_CDK_SPxxK_3 680 687 PF00069 0.480
MOD_CK1_1 100 106 PF00069 0.416
MOD_CK1_1 206 212 PF00069 0.355
MOD_CK1_1 298 304 PF00069 0.383
MOD_CK1_1 335 341 PF00069 0.642
MOD_CK1_1 360 366 PF00069 0.653
MOD_CK1_1 535 541 PF00069 0.426
MOD_CK1_1 680 686 PF00069 0.581
MOD_CK1_1 710 716 PF00069 0.620
MOD_CK1_1 730 736 PF00069 0.496
MOD_CK1_1 743 749 PF00069 0.404
MOD_CK1_1 878 884 PF00069 0.421
MOD_CK2_1 100 106 PF00069 0.410
MOD_CK2_1 140 146 PF00069 0.453
MOD_CK2_1 239 245 PF00069 0.532
MOD_CK2_1 299 305 PF00069 0.380
MOD_CK2_1 317 323 PF00069 0.572
MOD_CK2_1 730 736 PF00069 0.656
MOD_GlcNHglycan 166 169 PF01048 0.385
MOD_GlcNHglycan 251 254 PF01048 0.477
MOD_GlcNHglycan 307 310 PF01048 0.426
MOD_GlcNHglycan 323 327 PF01048 0.579
MOD_GlcNHglycan 588 591 PF01048 0.422
MOD_GlcNHglycan 673 676 PF01048 0.556
MOD_GlcNHglycan 770 774 PF01048 0.454
MOD_GlcNHglycan 878 881 PF01048 0.443
MOD_GSK3_1 153 160 PF00069 0.491
MOD_GSK3_1 176 183 PF00069 0.441
MOD_GSK3_1 206 213 PF00069 0.406
MOD_GSK3_1 224 231 PF00069 0.464
MOD_GSK3_1 249 256 PF00069 0.447
MOD_GSK3_1 278 285 PF00069 0.434
MOD_GSK3_1 295 302 PF00069 0.394
MOD_GSK3_1 305 312 PF00069 0.427
MOD_GSK3_1 322 329 PF00069 0.610
MOD_GSK3_1 331 338 PF00069 0.571
MOD_GSK3_1 340 347 PF00069 0.521
MOD_GSK3_1 532 539 PF00069 0.446
MOD_GSK3_1 620 627 PF00069 0.427
MOD_GSK3_1 657 664 PF00069 0.695
MOD_GSK3_1 671 678 PF00069 0.656
MOD_GSK3_1 705 712 PF00069 0.605
MOD_GSK3_1 759 766 PF00069 0.630
MOD_GSK3_1 778 785 PF00069 0.327
MOD_GSK3_1 817 824 PF00069 0.402
MOD_GSK3_1 871 878 PF00069 0.467
MOD_GSK3_1 91 98 PF00069 0.453
MOD_N-GLC_1 228 233 PF02516 0.564
MOD_N-GLC_1 239 244 PF02516 0.423
MOD_N-GLC_1 680 685 PF02516 0.508
MOD_N-GLC_1 849 854 PF02516 0.414
MOD_NEK2_1 161 166 PF00069 0.440
MOD_NEK2_1 169 174 PF00069 0.337
MOD_NEK2_1 180 185 PF00069 0.352
MOD_NEK2_1 295 300 PF00069 0.474
MOD_NEK2_1 332 337 PF00069 0.616
MOD_NEK2_1 373 378 PF00069 0.642
MOD_NEK2_1 583 588 PF00069 0.358
MOD_NEK2_1 66 71 PF00069 0.464
MOD_NEK2_1 689 694 PF00069 0.637
MOD_NEK2_1 7 12 PF00069 0.613
MOD_NEK2_1 706 711 PF00069 0.508
MOD_NEK2_1 727 732 PF00069 0.638
MOD_NEK2_1 782 787 PF00069 0.407
MOD_NEK2_1 841 846 PF00069 0.371
MOD_NEK2_1 875 880 PF00069 0.348
MOD_NEK2_2 157 162 PF00069 0.427
MOD_PIKK_1 107 113 PF00454 0.570
MOD_PIKK_1 38 44 PF00454 0.530
MOD_PIKK_1 493 499 PF00454 0.459
MOD_PIKK_1 652 658 PF00454 0.625
MOD_PK_1 365 371 PF00069 0.625
MOD_PK_1 719 725 PF00069 0.543
MOD_PKA_1 719 725 PF00069 0.516
MOD_PKA_2 296 302 PF00069 0.471
MOD_PKA_2 427 433 PF00069 0.654
MOD_PKA_2 44 50 PF00069 0.540
MOD_PKA_2 520 526 PF00069 0.410
MOD_PKA_2 568 574 PF00069 0.456
MOD_PKA_2 652 658 PF00069 0.538
MOD_PKA_2 66 72 PF00069 0.483
MOD_PKA_2 7 13 PF00069 0.675
MOD_PKA_2 718 724 PF00069 0.634
MOD_PKA_2 730 736 PF00069 0.554
MOD_Plk_1 228 234 PF00069 0.555
MOD_Plk_1 289 295 PF00069 0.448
MOD_Plk_1 562 568 PF00069 0.464
MOD_Plk_1 841 847 PF00069 0.390
MOD_Plk_1 849 855 PF00069 0.408
MOD_Plk_2-3 620 626 PF00069 0.390
MOD_Plk_2-3 817 823 PF00069 0.437
MOD_Plk_4 125 131 PF00069 0.623
MOD_Plk_4 176 182 PF00069 0.398
MOD_Plk_4 2 8 PF00069 0.601
MOD_Plk_4 299 305 PF00069 0.369
MOD_Plk_4 373 379 PF00069 0.527
MOD_Plk_4 44 50 PF00069 0.502
MOD_Plk_4 470 476 PF00069 0.412
MOD_Plk_4 583 589 PF00069 0.500
MOD_Plk_4 66 72 PF00069 0.494
MOD_Plk_4 719 725 PF00069 0.539
MOD_Plk_4 763 769 PF00069 0.513
MOD_Plk_4 865 871 PF00069 0.383
MOD_ProDKin_1 234 240 PF00069 0.545
MOD_ProDKin_1 32 38 PF00069 0.605
MOD_ProDKin_1 357 363 PF00069 0.574
MOD_ProDKin_1 434 440 PF00069 0.619
MOD_ProDKin_1 445 451 PF00069 0.549
MOD_ProDKin_1 452 458 PF00069 0.502
MOD_ProDKin_1 501 507 PF00069 0.437
MOD_ProDKin_1 536 542 PF00069 0.513
MOD_ProDKin_1 662 668 PF00069 0.564
MOD_ProDKin_1 680 686 PF00069 0.529
MOD_ProDKin_1 740 746 PF00069 0.550
MOD_ProDKin_1 759 765 PF00069 0.321
MOD_SUMO_for_1 666 669 PF00179 0.554
MOD_SUMO_rev_2 202 212 PF00179 0.473
MOD_SUMO_rev_2 347 353 PF00179 0.618
TRG_AP2beta_CARGO_1 594 604 PF09066 0.476
TRG_DiLeu_BaEn_1 2 7 PF01217 0.551
TRG_DiLeu_BaEn_3 290 296 PF01217 0.406
TRG_DiLeu_BaEn_3 399 405 PF01217 0.483
TRG_DiLeu_LyEn_5 529 534 PF01217 0.427
TRG_ENDOCYTIC_2 166 169 PF00928 0.461
TRG_ENDOCYTIC_2 506 509 PF00928 0.415
TRG_ENDOCYTIC_2 588 591 PF00928 0.468
TRG_ENDOCYTIC_2 647 650 PF00928 0.516
TRG_ENDOCYTIC_2 788 791 PF00928 0.434
TRG_ENDOCYTIC_2 845 848 PF00928 0.471
TRG_ER_diArg_1 184 186 PF00400 0.560
TRG_ER_diArg_1 401 404 PF00400 0.484
TRG_ER_diArg_1 577 580 PF00400 0.417
TRG_ER_diArg_1 718 720 PF00400 0.572
TRG_Pf-PMV_PEXEL_1 403 408 PF00026 0.524
TRG_Pf-PMV_PEXEL_1 559 563 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5A0 Leptomonas seymouri 32% 95%
A4HJA6 Leishmania braziliensis 64% 100%
A4I6P9 Leishmania infantum 99% 100%
E9B1S1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q6E0 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS