Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X4D3_LEIDO

TriTrypDb:

LdBPK_311250.1 , LdCL_310019200 , LDHU3_31.2030

Length:

897

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

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Expansion

Sequence features

A0A3S7X4D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4D3

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.452
CLV_C14_Caspase3-7	221	225	PF00656	0.478
CLV_C14_Caspase3-7	617	621	PF00656	0.495
CLV_C14_Caspase3-7	712	716	PF00656	0.548
CLV_C14_Caspase3-7	772	776	PF00656	0.553
CLV_NRD_NRD_1	185	187	PF00675	0.576
CLV_NRD_NRD_1	653	655	PF00675	0.588
CLV_NRD_NRD_1	719	721	PF00675	0.572
CLV_NRD_NRD_1	730	732	PF00675	0.625
CLV_NRD_NRD_1	889	891	PF00675	0.448

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A0	Leptomonas seymouri	32%	95%
A4HJA6	Leishmania braziliensis	64%	100%
A4I6P9	Leishmania infantum	99%	100%
E9B1S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q6E0	Leishmania major	85%	100%

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