LeishMANIAdb
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Emp24/gp25L/p24 family/GOLD, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Emp24/gp25L/p24 family/GOLD, putative
Gene product:
emp24/gp25L/p24 family/GOLD, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X4D1_LEIDO
TriTrypDb:
LdBPK_311120.1 * , LdCL_310018000 , LDHU3_31.1850
Length:
325

Annotations

LeishMANIAdb annotations

Related to other eukaryotic COPII adaptors. Likely involved in ER to Golgi transport.. A Leishmaniid-specific subgroup of these proteins is missing the SigP (unclear topology and function). Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 4
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005783 endoplasmic reticulum 5 1
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 5 1
GO:0005794 Golgi apparatus 5 1
GO:0030134 COPII-coated ER to Golgi transport vesicle 8 1
GO:0030135 coated vesicle 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

A0A3S7X4D1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4D1

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 1
GO:0006996 organelle organization 4 1
GO:0007030 Golgi organization 5 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0016192 vesicle-mediated transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0048193 Golgi vesicle transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 119 121 PF00675 0.391
CLV_NRD_NRD_1 268 270 PF00675 0.410
CLV_NRD_NRD_1 3 5 PF00675 0.395
CLV_NRD_NRD_1 322 324 PF00675 0.424
CLV_NRD_NRD_1 56 58 PF00675 0.380
CLV_PCSK_KEX2_1 118 120 PF00082 0.403
CLV_PCSK_KEX2_1 3 5 PF00082 0.395
CLV_PCSK_KEX2_1 321 323 PF00082 0.451
CLV_PCSK_KEX2_1 56 58 PF00082 0.380
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.363
CLV_PCSK_PC1ET2_1 321 323 PF00082 0.354
CLV_PCSK_SKI1_1 120 124 PF00082 0.353
CLV_PCSK_SKI1_1 56 60 PF00082 0.380
CLV_PCSK_SKI1_1 95 99 PF00082 0.396
DEG_APCC_DBOX_1 119 127 PF00400 0.530
DOC_CYCLIN_RxL_1 211 221 PF00134 0.255
DOC_CYCLIN_yCln2_LP_2 40 46 PF00134 0.567
DOC_MAPK_FxFP_2 179 182 PF00069 0.210
DOC_MAPK_gen_1 116 126 PF00069 0.548
DOC_MAPK_gen_1 56 63 PF00069 0.577
DOC_MAPK_MEF2A_6 119 128 PF00069 0.604
DOC_MAPK_MEF2A_6 27 36 PF00069 0.571
DOC_MAPK_MEF2A_6 56 63 PF00069 0.577
DOC_PP1_RVXF_1 212 219 PF00149 0.275
DOC_PP1_RVXF_1 290 296 PF00149 0.378
DOC_PP2B_LxvP_1 101 104 PF13499 0.583
DOC_PP2B_LxvP_1 205 208 PF13499 0.224
DOC_PP2B_LxvP_1 50 53 PF13499 0.574
DOC_PP4_FxxP_1 179 182 PF00568 0.210
DOC_PP4_FxxP_1 38 41 PF00568 0.568
DOC_USP7_MATH_1 228 232 PF00917 0.215
DOC_USP7_MATH_1 66 70 PF00917 0.569
DOC_WW_Pin1_4 197 202 PF00397 0.210
DOC_WW_Pin1_4 82 87 PF00397 0.608
LIG_14-3-3_CanoR_1 17 26 PF00244 0.559
LIG_14-3-3_CanoR_1 3 11 PF00244 0.585
LIG_14-3-3_CanoR_1 62 70 PF00244 0.570
LIG_14-3-3_CterR_2 322 325 PF00244 0.571
LIG_BRCT_BRCA1_1 230 234 PF00533 0.210
LIG_BRCT_BRCA1_1 34 38 PF00533 0.570
LIG_EH1_1 156 164 PF00400 0.210
LIG_FHA_1 158 164 PF00498 0.334
LIG_FHA_1 188 194 PF00498 0.229
LIG_FHA_1 211 217 PF00498 0.250
LIG_FHA_1 241 247 PF00498 0.210
LIG_FHA_2 258 264 PF00498 0.210
LIG_LIR_Apic_2 178 182 PF02991 0.430
LIG_LIR_Apic_2 35 41 PF02991 0.571
LIG_LIR_Gen_1 260 268 PF02991 0.210
LIG_LIR_Nem_3 35 40 PF02991 0.572
LIG_MLH1_MIPbox_1 34 38 PF16413 0.570
LIG_Pex14_1 94 98 PF04695 0.588
LIG_Pex14_2 38 42 PF04695 0.569
LIG_PTB_Apo_2 173 180 PF02174 0.210
LIG_SH2_CRK 74 78 PF00017 0.598
LIG_SH2_GRB2like 174 177 PF00017 0.210
LIG_SH2_GRB2like 204 207 PF00017 0.237
LIG_SH2_STAT5 204 207 PF00017 0.210
LIG_SH3_3 101 107 PF00018 0.580
LIG_SUMO_SIM_anti_2 125 130 PF11976 0.231
LIG_SUMO_SIM_par_1 122 127 PF11976 0.526
LIG_SUMO_SIM_par_1 225 231 PF11976 0.210
LIG_SUMO_SIM_par_1 30 35 PF11976 0.569
LIG_UBA3_1 261 270 PF00899 0.210
LIG_WRC_WIRS_1 301 306 PF05994 0.341
LIG_WRC_WIRS_1 315 320 PF05994 0.480
LIG_WRC_WIRS_1 33 38 PF05994 0.570
LIG_WRPW_2 94 97 PF00400 0.588
MOD_CK1_1 21 27 PF00069 0.560
MOD_CK1_1 230 236 PF00069 0.210
MOD_CK1_1 5 11 PF00069 0.581
MOD_CK1_1 65 71 PF00069 0.571
MOD_CK2_1 257 263 PF00069 0.210
MOD_CK2_1 314 320 PF00069 0.213
MOD_GlcNHglycan 144 147 PF01048 0.355
MOD_GlcNHglycan 21 24 PF01048 0.364
MOD_GlcNHglycan 50 53 PF01048 0.374
MOD_GlcNHglycan 64 67 PF01048 0.356
MOD_GSK3_1 106 113 PF00069 0.609
MOD_GSK3_1 151 158 PF00069 0.321
MOD_GSK3_1 206 213 PF00069 0.336
MOD_GSK3_1 62 69 PF00069 0.569
MOD_GSK3_1 73 80 PF00069 0.591
MOD_NEK2_1 124 129 PF00069 0.436
MOD_NEK2_1 136 141 PF00069 0.314
MOD_NEK2_1 220 225 PF00069 0.427
MOD_NEK2_1 227 232 PF00069 0.340
MOD_NEK2_1 314 319 PF00069 0.213
MOD_NEK2_1 32 37 PF00069 0.571
MOD_NEK2_2 66 71 PF00069 0.573
MOD_PIKK_1 220 226 PF00454 0.210
MOD_PKA_2 187 193 PF00069 0.380
MOD_PKA_2 2 8 PF00069 0.592
MOD_PKA_2 77 83 PF00069 0.600
MOD_PKB_1 60 68 PF00069 0.570
MOD_Plk_2-3 155 161 PF00069 0.281
MOD_Plk_4 124 130 PF00069 0.424
MOD_Plk_4 222 228 PF00069 0.380
MOD_Plk_4 257 263 PF00069 0.210
MOD_Plk_4 300 306 PF00069 0.256
MOD_Plk_4 32 38 PF00069 0.570
MOD_ProDKin_1 197 203 PF00069 0.210
MOD_ProDKin_1 82 88 PF00069 0.608
MOD_SUMO_rev_2 249 258 PF00179 0.372
TRG_DiLeu_BaLyEn_6 54 59 PF01217 0.575
TRG_ENDOCYTIC_2 204 207 PF00928 0.210
TRG_ENDOCYTIC_2 74 77 PF00928 0.596
TRG_ER_diArg_1 183 186 PF00400 0.252
TRG_ER_diArg_1 56 58 PF00400 0.580
TRG_ER_diArg_1 59 62 PF00400 0.574
TRG_NLS_MonoExtN_4 116 122 PF00514 0.562
TRG_Pf-PMV_PEXEL_1 214 219 PF00026 0.419
TRG_Pf-PMV_PEXEL_1 237 241 PF00026 0.412
TRG_Pf-PMV_PEXEL_1 269 273 PF00026 0.410
TRG_Pf-PMV_PEXEL_1 283 287 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X4G7 Leishmania donovani 41% 100%
A4HJ91 Leishmania braziliensis 41% 100%
A4I6N5 Leishmania infantum 41% 100%
E9B1Q8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
Q4Q6F2 Leishmania major 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS