Cytochrome b5-like Heme/Steroid binding domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X4C9_LEIDO

TriTrypDb:

LdBPK_311180.1 , LdCL_310018500 , LDHU3_31.1930

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

A0A3S7X4C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4C9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	73	75	PF00675	0.413
CLV_PCSK_KEX2_1	73	75	PF00082	0.429
DOC_MAPK_DCC_7	14	24	PF00069	0.485
DOC_USP7_MATH_1	109	113	PF00917	0.266
DOC_USP7_MATH_1	51	55	PF00917	0.551
LIG_14-3-3_CanoR_1	10	14	PF00244	0.524
LIG_14-3-3_CanoR_1	52	60	PF00244	0.434
LIG_Clathr_ClatBox_1	19	23	PF01394	0.504
LIG_FHA_1	112	118	PF00498	0.278
LIG_LIR_Apic_2	16	21	PF02991	0.547
LIG_LIR_Gen_1	93	104	PF02991	0.623
LIG_NRP_CendR_1	120	121	PF00754	0.594
LIG_PCNA_yPIPBox_3	27	40	PF02747	0.412
LIG_PTB_Apo_2	12	19	PF02174	0.500
LIG_PTB_Phospho_1	12	18	PF10480	0.500
LIG_SH2_GRB2like	39	42	PF00017	0.488
LIG_SH2_STAP1	96	100	PF00017	0.623
LIG_SH2_STAT3	39	42	PF00017	0.437
LIG_SH2_STAT5	18	21	PF00017	0.493
LIG_SH2_STAT5	39	42	PF00017	0.437
LIG_SH3_2	69	74	PF14604	0.610
LIG_SH3_3	66	72	PF00018	0.593
MOD_GlcNHglycan	111	114	PF01048	0.226
MOD_GlcNHglycan	78	81	PF01048	0.498
MOD_GSK3_1	76	83	PF00069	0.653
MOD_GSK3_1	9	16	PF00069	0.529
MOD_PIKK_1	42	48	PF00454	0.498
MOD_PKA_2	51	57	PF00069	0.434
MOD_PKA_2	9	15	PF00069	0.532
TRG_ENDOCYTIC_2	96	99	PF00928	0.596
TRG_ER_diArg_1	72	74	PF00400	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICI2	Leishmania donovani	28%	100%
A0A3Q8ILC3	Leishmania donovani	31%	100%
A0A3S7WPP2	Leishmania donovani	32%	100%
A4H4U1	Leishmania braziliensis	34%	100%
A4HJ97	Leishmania braziliensis	78%	100%
A4HJ98	Leishmania braziliensis	30%	100%
A4HJA2	Leishmania braziliensis	37%	100%
A4HT20	Leishmania infantum	32%	100%
A4I6P2	Leishmania infantum	100%	100%
A4I6P3	Leishmania infantum	28%	100%
E9ACS1	Leishmania major	36%	100%
E9AGY1	Leishmania infantum	31%	100%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q6E4	Leishmania major	34%	100%
Q4Q6E6	Leishmania major	28%	100%
Q4QIU6	Leishmania major	28%	100%