LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania donovani
UniProt:
A0A3S7X4B7_LEIDO
TriTrypDb:
LdCL_310017500 , LDHU3_31.1810
Length:
638

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 3
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4B7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4B7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 249 253 PF00656 0.609
CLV_C14_Caspase3-7 458 462 PF00656 0.600
CLV_C14_Caspase3-7 5 9 PF00656 0.673
CLV_C14_Caspase3-7 555 559 PF00656 0.671
CLV_NRD_NRD_1 174 176 PF00675 0.677
CLV_NRD_NRD_1 204 206 PF00675 0.564
CLV_NRD_NRD_1 511 513 PF00675 0.673
CLV_NRD_NRD_1 556 558 PF00675 0.812
CLV_NRD_NRD_1 568 570 PF00675 0.673
CLV_NRD_NRD_1 613 615 PF00675 0.668
CLV_PCSK_KEX2_1 173 175 PF00082 0.695
CLV_PCSK_KEX2_1 204 206 PF00082 0.555
CLV_PCSK_KEX2_1 556 558 PF00082 0.798
CLV_PCSK_SKI1_1 102 106 PF00082 0.622
CLV_PCSK_SKI1_1 152 156 PF00082 0.569
CLV_PCSK_SKI1_1 325 329 PF00082 0.664
CLV_PCSK_SKI1_1 406 410 PF00082 0.651
CLV_PCSK_SKI1_1 513 517 PF00082 0.663
CLV_PCSK_SKI1_1 629 633 PF00082 0.612
DEG_COP1_1 410 418 PF00400 0.668
DEG_Nend_UBRbox_2 1 3 PF02207 0.608
DEG_SCF_TRCP1_1 35 40 PF00400 0.670
DEG_SPOP_SBC_1 532 536 PF00917 0.675
DOC_CKS1_1 307 312 PF01111 0.713
DOC_CYCLIN_RxL_1 149 157 PF00134 0.568
DOC_CYCLIN_RxL_1 510 519 PF00134 0.663
DOC_CYCLIN_yCln2_LP_2 237 243 PF00134 0.590
DOC_CYCLIN_yCln2_LP_2 327 333 PF00134 0.569
DOC_MAPK_gen_1 190 196 PF00069 0.464
DOC_MAPK_MEF2A_6 293 300 PF00069 0.694
DOC_MAPK_MEF2A_6 436 443 PF00069 0.634
DOC_PP2B_LxvP_1 237 240 PF13499 0.661
DOC_PP2B_LxvP_1 413 416 PF13499 0.677
DOC_PP4_FxxP_1 261 264 PF00568 0.677
DOC_USP7_MATH_1 231 235 PF00917 0.748
DOC_USP7_MATH_1 243 247 PF00917 0.685
DOC_USP7_MATH_1 408 412 PF00917 0.686
DOC_USP7_MATH_1 422 426 PF00917 0.567
DOC_USP7_MATH_1 454 458 PF00917 0.698
DOC_USP7_MATH_1 459 463 PF00917 0.640
DOC_USP7_MATH_1 532 536 PF00917 0.715
DOC_USP7_MATH_1 537 541 PF00917 0.714
DOC_USP7_MATH_1 546 550 PF00917 0.724
DOC_WW_Pin1_4 10 15 PF00397 0.638
DOC_WW_Pin1_4 160 165 PF00397 0.679
DOC_WW_Pin1_4 18 23 PF00397 0.690
DOC_WW_Pin1_4 286 291 PF00397 0.593
DOC_WW_Pin1_4 306 311 PF00397 0.677
DOC_WW_Pin1_4 342 347 PF00397 0.681
DOC_WW_Pin1_4 392 397 PF00397 0.664
DOC_WW_Pin1_4 472 477 PF00397 0.690
DOC_WW_Pin1_4 503 508 PF00397 0.695
DOC_WW_Pin1_4 539 544 PF00397 0.779
DOC_WW_Pin1_4 560 565 PF00397 0.599
LIG_14-3-3_CanoR_1 102 111 PF00244 0.677
LIG_14-3-3_CanoR_1 301 305 PF00244 0.749
LIG_14-3-3_CanoR_1 317 324 PF00244 0.562
LIG_14-3-3_CanoR_1 377 385 PF00244 0.634
LIG_14-3-3_CanoR_1 412 416 PF00244 0.769
LIG_14-3-3_CanoR_1 478 484 PF00244 0.628
LIG_14-3-3_CanoR_1 527 531 PF00244 0.664
LIG_14-3-3_CanoR_1 624 632 PF00244 0.507
LIG_EH_1 48 52 PF12763 0.640
LIG_FHA_1 301 307 PF00498 0.707
LIG_FHA_1 346 352 PF00498 0.710
LIG_FHA_1 426 432 PF00498 0.667
LIG_FHA_1 517 523 PF00498 0.737
LIG_FHA_2 247 253 PF00498 0.673
LIG_FHA_2 30 36 PF00498 0.586
LIG_FHA_2 421 427 PF00498 0.679
LIG_FHA_2 542 548 PF00498 0.590
LIG_Integrin_RGD_1 223 225 PF01839 0.763
LIG_Integrin_RGD_1 578 580 PF01839 0.715
LIG_LIR_Apic_2 260 264 PF02991 0.675
LIG_LIR_Apic_2 343 347 PF02991 0.678
LIG_LIR_Gen_1 2 11 PF02991 0.636
LIG_LIR_Gen_1 369 375 PF02991 0.594
LIG_LIR_Gen_1 395 404 PF02991 0.662
LIG_LIR_Gen_1 461 472 PF02991 0.575
LIG_LIR_Gen_1 623 632 PF02991 0.589
LIG_LIR_Gen_1 93 104 PF02991 0.638
LIG_LIR_Nem_3 105 111 PF02991 0.583
LIG_LIR_Nem_3 179 185 PF02991 0.588
LIG_LIR_Nem_3 2 6 PF02991 0.627
LIG_LIR_Nem_3 209 215 PF02991 0.618
LIG_LIR_Nem_3 369 374 PF02991 0.595
LIG_LIR_Nem_3 389 393 PF02991 0.601
LIG_LIR_Nem_3 395 401 PF02991 0.607
LIG_LIR_Nem_3 529 533 PF02991 0.584
LIG_LIR_Nem_3 623 628 PF02991 0.578
LIG_LIR_Nem_3 93 99 PF02991 0.647
LIG_MYND_1 472 476 PF01753 0.604
LIG_PCNA_yPIPBox_3 317 328 PF02747 0.672
LIG_Pex14_2 621 625 PF04695 0.572
LIG_PTAP_UEV_1 415 420 PF05743 0.592
LIG_REV1ctd_RIR_1 180 188 PF16727 0.564
LIG_SH2_CRK 212 216 PF00017 0.624
LIG_SH2_CRK 344 348 PF00017 0.675
LIG_SH2_NCK_1 344 348 PF00017 0.675
LIG_SH2_NCK_1 96 100 PF00017 0.673
LIG_SH2_STAP1 533 537 PF00017 0.592
LIG_SH2_STAT5 3 6 PF00017 0.661
LIG_SH2_STAT5 96 99 PF00017 0.679
LIG_SH3_2 147 152 PF14604 0.650
LIG_SH3_2 19 24 PF14604 0.604
LIG_SH3_2 329 334 PF14604 0.681
LIG_SH3_2 543 548 PF14604 0.674
LIG_SH3_3 13 19 PF00018 0.597
LIG_SH3_3 144 150 PF00018 0.650
LIG_SH3_3 153 159 PF00018 0.587
LIG_SH3_3 161 167 PF00018 0.551
LIG_SH3_3 212 218 PF00018 0.626
LIG_SH3_3 304 310 PF00018 0.720
LIG_SH3_3 326 332 PF00018 0.688
LIG_SH3_3 390 396 PF00018 0.664
LIG_SH3_3 413 419 PF00018 0.593
LIG_SH3_3 442 448 PF00018 0.666
LIG_SH3_3 473 479 PF00018 0.666
LIG_SH3_3 480 486 PF00018 0.672
LIG_SH3_3 540 546 PF00018 0.697
LIG_SUMO_SIM_anti_2 234 239 PF11976 0.667
LIG_SUMO_SIM_par_1 479 484 PF11976 0.628
LIG_TRAF2_1 418 421 PF00917 0.674
LIG_TRAF2_2 310 315 PF00917 0.689
LIG_UBA3_1 631 635 PF00899 0.594
LIG_WRC_WIRS_1 258 263 PF05994 0.686
LIG_WRC_WIRS_1 3 8 PF05994 0.634
LIG_WW_3 149 153 PF00397 0.650
MOD_CDC14_SPxK_1 21 24 PF00782 0.692
MOD_CDC14_SPxK_1 475 478 PF00782 0.695
MOD_CDK_SPK_2 10 15 PF00069 0.568
MOD_CDK_SPK_2 505 510 PF00069 0.591
MOD_CDK_SPxK_1 18 24 PF00069 0.686
MOD_CDK_SPxK_1 472 478 PF00069 0.694
MOD_CDK_SPxxK_3 286 293 PF00069 0.592
MOD_CDK_SPxxK_3 306 313 PF00069 0.616
MOD_CDK_SPxxK_3 503 510 PF00069 0.707
MOD_CDK_SPxxK_3 541 548 PF00069 0.589
MOD_CDK_SPxxK_3 560 567 PF00069 0.598
MOD_CK1_1 10 16 PF00069 0.687
MOD_CK1_1 226 232 PF00069 0.707
MOD_CK1_1 246 252 PF00069 0.560
MOD_CK1_1 273 279 PF00069 0.740
MOD_CK1_1 280 286 PF00069 0.664
MOD_CK1_1 345 351 PF00069 0.717
MOD_CK1_1 357 363 PF00069 0.603
MOD_CK1_1 366 372 PF00069 0.596
MOD_CK1_1 373 379 PF00069 0.509
MOD_CK1_1 411 417 PF00069 0.707
MOD_CK1_1 425 431 PF00069 0.560
MOD_CK1_1 44 50 PF00069 0.586
MOD_CK1_1 484 490 PF00069 0.702
MOD_CK1_1 526 532 PF00069 0.795
MOD_CK1_1 536 542 PF00069 0.616
MOD_CK1_1 549 555 PF00069 0.610
MOD_CK1_1 560 566 PF00069 0.597
MOD_CK2_1 165 171 PF00069 0.706
MOD_CK2_1 366 372 PF00069 0.681
MOD_CK2_1 399 405 PF00069 0.567
MOD_CK2_1 414 420 PF00069 0.625
MOD_Cter_Amidation 171 174 PF01082 0.700
MOD_GlcNHglycan 241 244 PF01048 0.772
MOD_GlcNHglycan 245 248 PF01048 0.723
MOD_GlcNHglycan 275 278 PF01048 0.694
MOD_GlcNHglycan 282 285 PF01048 0.624
MOD_GlcNHglycan 33 38 PF01048 0.672
MOD_GlcNHglycan 356 359 PF01048 0.732
MOD_GlcNHglycan 366 369 PF01048 0.716
MOD_GlcNHglycan 385 388 PF01048 0.504
MOD_GlcNHglycan 416 419 PF01048 0.673
MOD_GlcNHglycan 483 486 PF01048 0.673
MOD_GlcNHglycan 530 533 PF01048 0.754
MOD_GlcNHglycan 535 538 PF01048 0.672
MOD_GlcNHglycan 539 542 PF01048 0.649
MOD_GlcNHglycan 625 628 PF01048 0.486
MOD_GlcNHglycan 67 70 PF01048 0.676
MOD_GlcNHglycan 8 12 PF01048 0.679
MOD_GSK3_1 150 157 PF00069 0.602
MOD_GSK3_1 239 246 PF00069 0.771
MOD_GSK3_1 273 280 PF00069 0.770
MOD_GSK3_1 29 36 PF00069 0.657
MOD_GSK3_1 313 320 PF00069 0.602
MOD_GSK3_1 342 349 PF00069 0.705
MOD_GSK3_1 362 369 PF00069 0.503
MOD_GSK3_1 37 44 PF00069 0.640
MOD_GSK3_1 392 399 PF00069 0.616
MOD_GSK3_1 425 432 PF00069 0.625
MOD_GSK3_1 443 450 PF00069 0.511
MOD_GSK3_1 481 488 PF00069 0.821
MOD_GSK3_1 51 58 PF00069 0.522
MOD_GSK3_1 516 523 PF00069 0.810
MOD_GSK3_1 528 535 PF00069 0.612
MOD_GSK3_1 537 544 PF00069 0.631
MOD_GSK3_1 546 553 PF00069 0.752
MOD_GSK3_1 585 592 PF00069 0.792
MOD_N-GLC_1 176 181 PF02516 0.630
MOD_N-GLC_1 270 275 PF02516 0.622
MOD_N-GLC_1 558 563 PF02516 0.711
MOD_N-GLC_1 570 575 PF02516 0.608
MOD_N-GLC_2 117 119 PF02516 0.613
MOD_NEK2_1 300 305 PF00069 0.710
MOD_NEK2_1 51 56 PF00069 0.584
MOD_NEK2_1 520 525 PF00069 0.659
MOD_NEK2_1 528 533 PF00069 0.584
MOD_NEK2_1 550 555 PF00069 0.750
MOD_NEK2_1 7 12 PF00069 0.645
MOD_NEK2_2 257 262 PF00069 0.625
MOD_PIKK_1 263 269 PF00454 0.689
MOD_PIKK_1 300 306 PF00454 0.710
MOD_PIKK_1 317 323 PF00454 0.555
MOD_PIKK_1 346 352 PF00454 0.688
MOD_PIKK_1 594 600 PF00454 0.577
MOD_PIKK_1 97 103 PF00454 0.660
MOD_PKA_2 273 279 PF00069 0.709
MOD_PKA_2 300 306 PF00069 0.692
MOD_PKA_2 376 382 PF00069 0.631
MOD_PKA_2 411 417 PF00069 0.674
MOD_PKA_2 459 465 PF00069 0.572
MOD_PKA_2 488 494 PF00069 0.585
MOD_PKA_2 526 532 PF00069 0.661
MOD_PKA_2 623 629 PF00069 0.496
MOD_Plk_1 208 214 PF00069 0.531
MOD_Plk_1 396 402 PF00069 0.560
MOD_Plk_1 448 454 PF00069 0.714
MOD_Plk_1 546 552 PF00069 0.699
MOD_Plk_1 557 563 PF00069 0.708
MOD_Plk_2-3 176 182 PF00069 0.540
MOD_Plk_2-3 2 8 PF00069 0.632
MOD_Plk_2-3 29 35 PF00069 0.587
MOD_Plk_4 118 124 PF00069 0.723
MOD_Plk_4 2 8 PF00069 0.632
MOD_Plk_4 370 376 PF00069 0.644
MOD_Plk_4 425 431 PF00069 0.577
MOD_ProDKin_1 10 16 PF00069 0.640
MOD_ProDKin_1 160 166 PF00069 0.681
MOD_ProDKin_1 18 24 PF00069 0.693
MOD_ProDKin_1 286 292 PF00069 0.592
MOD_ProDKin_1 306 312 PF00069 0.680
MOD_ProDKin_1 342 348 PF00069 0.679
MOD_ProDKin_1 392 398 PF00069 0.664
MOD_ProDKin_1 472 478 PF00069 0.694
MOD_ProDKin_1 503 509 PF00069 0.693
MOD_ProDKin_1 539 545 PF00069 0.775
MOD_ProDKin_1 560 566 PF00069 0.598
MOD_SUMO_rev_2 171 179 PF00179 0.671
TRG_DiLeu_BaEn_1 34 39 PF01217 0.622
TRG_DiLeu_BaEn_2 1 7 PF01217 0.629
TRG_DiLeu_BaEn_4 180 186 PF01217 0.493
TRG_ENDOCYTIC_2 212 215 PF00928 0.625
TRG_ENDOCYTIC_2 3 6 PF00928 0.661
TRG_ENDOCYTIC_2 464 467 PF00928 0.806
TRG_ENDOCYTIC_2 96 99 PF00928 0.679
TRG_ER_diArg_1 173 175 PF00400 0.695
TRG_ER_diArg_1 193 196 PF00400 0.376
TRG_ER_diArg_1 24 27 PF00400 0.682
TRG_ER_diArg_1 509 512 PF00400 0.589
TRG_NLS_Bipartite_1 173 194 PF00514 0.588
TRG_Pf-PMV_PEXEL_1 102 107 PF00026 0.623

Homologs

Protein Taxonomy Sequence identity Coverage
A4I6N3 Leishmania infantum 99% 100%
E9B1Q6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
Q4Q6F4 Leishmania major 79% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS