SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X4A8_LEIDO

TriTrypDb:

LdBPK_311060.1 , LdCL_310017200 , LDHU3_31.1770

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X4A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4A8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.589
CLV_C14_Caspase3-7	249	253	PF00656	0.585
CLV_C14_Caspase3-7	297	301	PF00656	0.535
CLV_C14_Caspase3-7	352	356	PF00656	0.585
CLV_NRD_NRD_1	217	219	PF00675	0.348
CLV_NRD_NRD_1	279	281	PF00675	0.381
CLV_NRD_NRD_1	492	494	PF00675	0.587
CLV_NRD_NRD_1	533	535	PF00675	0.633
CLV_PCSK_KEX2_1	211	213	PF00082	0.389
CLV_PCSK_KEX2_1	279	281	PF00082	0.392
CLV_PCSK_KEX2_1	492	494	PF00082	0.589
CLV_PCSK_KEX2_1	533	535	PF00082	0.667
CLV_PCSK_KEX2_1	80	82	PF00082	0.377
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.389
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.377
CLV_PCSK_SKI1_1	132	136	PF00082	0.324
CLV_PCSK_SKI1_1	27	31	PF00082	0.578
CLV_PCSK_SKI1_1	322	326	PF00082	0.294
CLV_PCSK_SKI1_1	338	342	PF00082	0.361
CLV_PCSK_SKI1_1	365	369	PF00082	0.326
CLV_PCSK_SKI1_1	66	70	PF00082	0.477
CLV_PCSK_SKI1_1	76	80	PF00082	0.319
DEG_Nend_Nbox_1	1	3	PF02207	0.664
DOC_CYCLIN_RxL_1	188	199	PF00134	0.518
DOC_CYCLIN_RxL_1	319	326	PF00134	0.553
DOC_MAPK_DCC_7	327	336	PF00069	0.589
DOC_MAPK_gen_1	327	336	PF00069	0.589
DOC_MAPK_gen_1	76	86	PF00069	0.544
DOC_MAPK_HePTP_8	324	336	PF00069	0.589
DOC_MAPK_MEF2A_6	327	336	PF00069	0.589
DOC_MAPK_MEF2A_6	80	88	PF00069	0.532
DOC_MAPK_RevD_3	63	77	PF00069	0.536
DOC_PP2B_LxvP_1	86	89	PF13499	0.530
DOC_USP7_MATH_1	227	231	PF00917	0.569
DOC_USP7_MATH_1	253	257	PF00917	0.589
DOC_USP7_MATH_1	294	298	PF00917	0.500
DOC_USP7_MATH_1	299	303	PF00917	0.457
DOC_USP7_MATH_1	409	413	PF00917	0.527
DOC_USP7_MATH_1	448	452	PF00917	0.589
DOC_USP7_MATH_1	48	52	PF00917	0.614
DOC_USP7_MATH_1	93	97	PF00917	0.586
DOC_USP7_UBL2_3	76	80	PF12436	0.516
DOC_WW_Pin1_4	167	172	PF00397	0.490
DOC_WW_Pin1_4	431	436	PF00397	0.577
DOC_WW_Pin1_4	446	451	PF00397	0.589
DOC_WW_Pin1_4	5	10	PF00397	0.583
DOC_WW_Pin1_4	516	521	PF00397	0.761
DOC_WW_Pin1_4	91	96	PF00397	0.574
LIG_14-3-3_CanoR_1	138	143	PF00244	0.482
LIG_14-3-3_CanoR_1	15	22	PF00244	0.607
LIG_14-3-3_CanoR_1	327	332	PF00244	0.568
LIG_14-3-3_CanoR_1	66	74	PF00244	0.494
LIG_Actin_WH2_2	50	68	PF00022	0.519
LIG_BIR_III_4	25	29	PF00653	0.643
LIG_BIR_III_4	355	359	PF00653	0.589
LIG_eIF4E_1	173	179	PF01652	0.513
LIG_FHA_1	100	106	PF00498	0.552
LIG_FHA_1	249	255	PF00498	0.496
LIG_FHA_1	426	432	PF00498	0.560
LIG_FHA_1	457	463	PF00498	0.589
LIG_FHA_1	57	63	PF00498	0.405
LIG_FHA_1	85	91	PF00498	0.551
LIG_FHA_2	187	193	PF00498	0.523
LIG_FHA_2	200	206	PF00498	0.471
LIG_FHA_2	92	98	PF00498	0.542
LIG_Integrin_RGD_1	437	439	PF01839	0.296
LIG_Integrin_RGD_1	81	83	PF01839	0.343
LIG_LIR_Gen_1	102	112	PF02991	0.496
LIG_LIR_Gen_1	127	135	PF02991	0.490
LIG_LIR_Gen_1	18	29	PF02991	0.579
LIG_LIR_Gen_1	449	458	PF02991	0.565
LIG_LIR_Nem_3	102	107	PF02991	0.504
LIG_LIR_Nem_3	127	131	PF02991	0.490
LIG_LIR_Nem_3	140	145	PF02991	0.490
LIG_LIR_Nem_3	170	176	PF02991	0.528
LIG_LIR_Nem_3	18	24	PF02991	0.596
LIG_LIR_Nem_3	449	455	PF02991	0.565
LIG_LIR_Nem_3	477	483	PF02991	0.406
LIG_LYPXL_S_1	172	176	PF13949	0.313
LIG_LYPXL_yS_3	173	176	PF13949	0.513
LIG_NRBOX	320	326	PF00104	0.480
LIG_Pex14_1	224	228	PF04695	0.490
LIG_Pex14_1	536	540	PF04695	0.608
LIG_PTB_Apo_2	407	414	PF02174	0.561
LIG_SH2_CRK	128	132	PF00017	0.561
LIG_SH2_CRK	452	456	PF00017	0.549
LIG_SH2_CRK	485	489	PF00017	0.539
LIG_SH2_NCK_1	115	119	PF00017	0.588
LIG_SH2_NCK_1	228	232	PF00017	0.561
LIG_SH2_NCK_1	476	480	PF00017	0.521
LIG_SH2_SRC	206	209	PF00017	0.527
LIG_SH2_SRC	281	284	PF00017	0.527
LIG_SH2_SRC	369	372	PF00017	0.589
LIG_SH2_STAP1	115	119	PF00017	0.589
LIG_SH2_STAP1	206	210	PF00017	0.527
LIG_SH2_STAP1	476	480	PF00017	0.434
LIG_SH2_STAP1	74	78	PF00017	0.537
LIG_SH2_STAT5	175	178	PF00017	0.490
LIG_SH2_STAT5	472	475	PF00017	0.489
LIG_SH2_STAT5	480	483	PF00017	0.358
LIG_SH3_3	120	126	PF00018	0.571
LIG_SH3_3	168	174	PF00018	0.510
LIG_SH3_3	194	200	PF00018	0.490
LIG_SH3_3	398	404	PF00018	0.585
MOD_CDC14_SPxK_1	434	437	PF00782	0.449
MOD_CDK_SPxK_1	431	437	PF00069	0.449
MOD_CK1_1	127	133	PF00069	0.507
MOD_CK1_1	20	26	PF00069	0.535
MOD_CK1_1	268	274	PF00069	0.536
MOD_CK1_1	4	10	PF00069	0.565
MOD_CK1_1	425	431	PF00069	0.553
MOD_CK1_1	516	522	PF00069	0.766
MOD_CK2_1	137	143	PF00069	0.415
MOD_CK2_1	186	192	PF00069	0.526
MOD_CK2_1	199	205	PF00069	0.471
MOD_CK2_1	424	430	PF00069	0.588
MOD_CK2_1	488	494	PF00069	0.644
MOD_Cter_Amidation	277	280	PF01082	0.376
MOD_GlcNHglycan	180	183	PF01048	0.344
MOD_GlcNHglycan	229	232	PF01048	0.330
MOD_GlcNHglycan	266	270	PF01048	0.311
MOD_GlcNHglycan	296	299	PF01048	0.337
MOD_GlcNHglycan	300	304	PF01048	0.324
MOD_GlcNHglycan	424	427	PF01048	0.334
MOD_GlcNHglycan	441	444	PF01048	0.355
MOD_GlcNHglycan	446	449	PF01048	0.295
MOD_GlcNHglycan	515	518	PF01048	0.780
MOD_GlcNHglycan	91	94	PF01048	0.342
MOD_GSK3_1	1	8	PF00069	0.583
MOD_GSK3_1	133	140	PF00069	0.602
MOD_GSK3_1	323	330	PF00069	0.527
MOD_GSK3_1	386	393	PF00069	0.561
MOD_GSK3_1	418	425	PF00069	0.589
MOD_GSK3_1	426	433	PF00069	0.496
MOD_GSK3_1	444	451	PF00069	0.539
MOD_GSK3_1	474	481	PF00069	0.444
MOD_GSK3_1	515	522	PF00069	0.769
MOD_GSK3_1	535	542	PF00069	0.598
MOD_GSK3_1	89	96	PF00069	0.507
MOD_N-GLC_1	285	290	PF02516	0.327
MOD_N-GLC_1	409	414	PF02516	0.330
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	254	259	PF00069	0.496
MOD_NEK2_1	42	47	PF00069	0.474
MOD_NEK2_1	468	473	PF00069	0.561
MOD_PK_1	474	480	PF00069	0.486
MOD_PKA_2	137	143	PF00069	0.482
MOD_PKA_2	14	20	PF00069	0.614
MOD_PKA_2	456	462	PF00069	0.529
MOD_Plk_1	17	23	PF00069	0.645
MOD_Plk_1	186	192	PF00069	0.449
MOD_Plk_1	285	291	PF00069	0.456
MOD_Plk_1	345	351	PF00069	0.449
MOD_Plk_1	409	415	PF00069	0.533
MOD_Plk_1	466	472	PF00069	0.507
MOD_Plk_2-3	186	192	PF00069	0.471
MOD_Plk_4	17	23	PF00069	0.645
MOD_Plk_4	285	291	PF00069	0.458
MOD_Plk_4	390	396	PF00069	0.488
MOD_Plk_4	42	48	PF00069	0.494
MOD_Plk_4	468	474	PF00069	0.520
MOD_Plk_4	478	484	PF00069	0.356
MOD_Plk_4	496	502	PF00069	0.572
MOD_Plk_4	535	541	PF00069	0.609
MOD_ProDKin_1	167	173	PF00069	0.490
MOD_ProDKin_1	431	437	PF00069	0.577
MOD_ProDKin_1	446	452	PF00069	0.589
MOD_ProDKin_1	5	11	PF00069	0.581
MOD_ProDKin_1	516	522	PF00069	0.757
MOD_ProDKin_1	91	97	PF00069	0.574
TRG_DiLeu_BaEn_1	58	63	PF01217	0.548
TRG_DiLeu_BaEn_4	463	469	PF01217	0.507
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.530
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.561
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.527
TRG_ENDOCYTIC_2	128	131	PF00928	0.507
TRG_ENDOCYTIC_2	173	176	PF00928	0.508
TRG_ENDOCYTIC_2	281	284	PF00928	0.589
TRG_ENDOCYTIC_2	369	372	PF00928	0.527
TRG_ENDOCYTIC_2	452	455	PF00928	0.549
TRG_ENDOCYTIC_2	485	488	PF00928	0.529
TRG_ER_diArg_1	279	281	PF00400	0.449
TRG_ER_diArg_1	532	534	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM8	Leptomonas seymouri	52%	71%
A0A1X0NJ79	Trypanosomatidae	38%	95%
A4HJ86	Leishmania braziliensis	77%	100%
A4I6N0	Leishmania infantum	99%	100%
C9ZM67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	88%
E9B1Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q6F7	Leishmania major	92%	100%
V5BPH7	Trypanosoma cruzi	40%	86%