LeishMANIAdb
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Sodium stibogluconate resistance protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sodium stibogluconate resistance protein, putative
Gene product:
sodium stibogluconate resistance protein, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A3S7X4A3_LEIDO
TriTrypDb:
LdBPK_073400.1 , LdBPK_310951.1 , LdCL_310016100 , LDHU3_31.1500
Length:
621

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X4A3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X4A3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 121 125 PF00656 0.821
CLV_C14_Caspase3-7 130 134 PF00656 0.711
CLV_C14_Caspase3-7 81 85 PF00656 0.704
CLV_NRD_NRD_1 305 307 PF00675 0.648
CLV_NRD_NRD_1 540 542 PF00675 0.667
CLV_NRD_NRD_1 577 579 PF00675 0.619
CLV_NRD_NRD_1 615 617 PF00675 0.568
CLV_PCSK_KEX2_1 524 526 PF00082 0.715
CLV_PCSK_KEX2_1 539 541 PF00082 0.422
CLV_PCSK_PC1ET2_1 524 526 PF00082 0.737
CLV_PCSK_PC1ET2_1 539 541 PF00082 0.422
CLV_PCSK_PC7_1 535 541 PF00082 0.605
CLV_PCSK_SKI1_1 21 25 PF00082 0.562
CLV_PCSK_SKI1_1 214 218 PF00082 0.511
CLV_PCSK_SKI1_1 231 235 PF00082 0.619
CLV_PCSK_SKI1_1 324 328 PF00082 0.564
CLV_PCSK_SKI1_1 525 529 PF00082 0.673
CLV_PCSK_SKI1_1 535 539 PF00082 0.492
CLV_PCSK_SKI1_1 56 60 PF00082 0.596
DEG_APCC_DBOX_1 353 361 PF00400 0.687
DOC_MAPK_MEF2A_6 146 154 PF00069 0.627
DOC_MAPK_MEF2A_6 553 560 PF00069 0.581
DOC_PP1_RVXF_1 368 375 PF00149 0.708
DOC_PP1_SILK_1 612 617 PF00149 0.489
DOC_PP2B_LxvP_1 478 481 PF13499 0.741
DOC_SPAK_OSR1_1 30 34 PF12202 0.556
DOC_USP7_MATH_1 347 351 PF00917 0.610
DOC_USP7_MATH_1 391 395 PF00917 0.532
DOC_USP7_MATH_1 445 449 PF00917 0.549
DOC_USP7_MATH_1 461 465 PF00917 0.450
DOC_USP7_MATH_1 567 571 PF00917 0.485
DOC_USP7_MATH_1 603 607 PF00917 0.534
DOC_USP7_MATH_2 334 340 PF00917 0.609
DOC_USP7_MATH_2 424 430 PF00917 0.597
DOC_USP7_UBL2_3 255 259 PF12436 0.577
DOC_WW_Pin1_4 387 392 PF00397 0.568
DOC_WW_Pin1_4 420 425 PF00397 0.674
LIG_14-3-3_CanoR_1 265 270 PF00244 0.640
LIG_14-3-3_CanoR_1 30 39 PF00244 0.606
LIG_14-3-3_CanoR_1 301 308 PF00244 0.422
LIG_14-3-3_CanoR_1 4 9 PF00244 0.729
LIG_14-3-3_CanoR_1 415 421 PF00244 0.615
LIG_14-3-3_CanoR_1 427 431 PF00244 0.437
LIG_Actin_WH2_2 437 455 PF00022 0.618
LIG_AP2alpha_1 50 54 PF02296 0.606
LIG_BIR_III_2 84 88 PF00653 0.668
LIG_BRCT_BRCA1_1 267 271 PF00533 0.620
LIG_BRCT_BRCA1_1 63 67 PF00533 0.560
LIG_CSL_BTD_1 388 391 PF09270 0.624
LIG_EH1_1 608 616 PF00400 0.522
LIG_FHA_1 143 149 PF00498 0.660
LIG_FHA_1 201 207 PF00498 0.545
LIG_FHA_1 264 270 PF00498 0.647
LIG_FHA_1 53 59 PF00498 0.502
LIG_FHA_1 592 598 PF00498 0.446
LIG_FHA_2 30 36 PF00498 0.604
LIG_FHA_2 469 475 PF00498 0.709
LIG_GBD_Chelix_1 611 619 PF00786 0.501
LIG_Integrin_RGD_1 122 124 PF01839 0.748
LIG_LIR_Gen_1 174 183 PF02991 0.569
LIG_LIR_Gen_1 226 235 PF02991 0.703
LIG_LIR_Gen_1 290 299 PF02991 0.430
LIG_LIR_Gen_1 605 615 PF02991 0.566
LIG_LIR_Nem_3 149 154 PF02991 0.603
LIG_LIR_Nem_3 163 168 PF02991 0.356
LIG_LIR_Nem_3 17 23 PF02991 0.631
LIG_LIR_Nem_3 174 178 PF02991 0.406
LIG_LIR_Nem_3 226 230 PF02991 0.688
LIG_LIR_Nem_3 290 294 PF02991 0.454
LIG_LIR_Nem_3 298 302 PF02991 0.556
LIG_LIR_Nem_3 464 469 PF02991 0.634
LIG_LIR_Nem_3 605 611 PF02991 0.492
LIG_PCNA_yPIPBox_3 301 312 PF02747 0.383
LIG_Pex14_2 50 54 PF04695 0.606
LIG_SH2_CRK 165 169 PF00017 0.555
LIG_SH2_CRK 20 24 PF00017 0.621
LIG_SH2_CRK 227 231 PF00017 0.667
LIG_SH2_CRK 283 287 PF00017 0.531
LIG_SH2_CRK 291 295 PF00017 0.450
LIG_SH2_CRK 299 303 PF00017 0.402
LIG_SH2_CRK 312 316 PF00017 0.387
LIG_SH2_GRB2like 312 315 PF00017 0.379
LIG_SH2_GRB2like 542 545 PF00017 0.508
LIG_SH2_SRC 312 315 PF00017 0.379
LIG_SH2_SRC 542 545 PF00017 0.464
LIG_SH2_STAP1 312 316 PF00017 0.387
LIG_SH2_STAP1 469 473 PF00017 0.656
LIG_SH2_STAT3 37 40 PF00017 0.614
LIG_SH2_STAT5 175 178 PF00017 0.586
LIG_SH2_STAT5 195 198 PF00017 0.252
LIG_SH2_STAT5 283 286 PF00017 0.421
LIG_SH2_STAT5 291 294 PF00017 0.379
LIG_SH2_STAT5 337 340 PF00017 0.581
LIG_SH2_STAT5 37 40 PF00017 0.476
LIG_SH2_STAT5 432 435 PF00017 0.618
LIG_SH2_STAT5 542 545 PF00017 0.508
LIG_SH3_3 147 153 PF00018 0.576
LIG_SH3_3 385 391 PF00018 0.670
LIG_SH3_3 439 445 PF00018 0.642
LIG_SH3_3 493 499 PF00018 0.805
LIG_SH3_3 89 95 PF00018 0.747
LIG_SUMO_SIM_anti_2 439 445 PF11976 0.637
LIG_TRAF2_1 25 28 PF00917 0.552
LIG_TYR_ITIM 18 23 PF00017 0.609
LIG_TYR_ITIM 225 230 PF00017 0.659
LIG_UBA3_1 206 214 PF00899 0.572
LIG_UBA3_1 342 348 PF00899 0.564
LIG_UBA3_1 572 579 PF00899 0.474
LIG_UBA3_1 610 617 PF00899 0.557
LIG_WRC_WIRS_1 371 376 PF05994 0.697
MOD_CDK_SPxxK_3 420 427 PF00069 0.674
MOD_CK1_1 250 256 PF00069 0.628
MOD_CK1_1 300 306 PF00069 0.613
MOD_CK1_1 364 370 PF00069 0.633
MOD_CK1_1 414 420 PF00069 0.616
MOD_CK1_1 516 522 PF00069 0.729
MOD_CK2_1 29 35 PF00069 0.598
MOD_CK2_1 387 393 PF00069 0.437
MOD_CK2_1 420 426 PF00069 0.551
MOD_CK2_1 452 458 PF00069 0.398
MOD_CK2_1 468 474 PF00069 0.670
MOD_GlcNHglycan 118 121 PF01048 0.779
MOD_GlcNHglycan 127 130 PF01048 0.758
MOD_GlcNHglycan 236 239 PF01048 0.684
MOD_GlcNHglycan 241 245 PF01048 0.661
MOD_GlcNHglycan 384 387 PF01048 0.733
MOD_GlcNHglycan 393 396 PF01048 0.455
MOD_GlcNHglycan 492 495 PF01048 0.775
MOD_GlcNHglycan 517 521 PF01048 0.772
MOD_GlcNHglycan 580 583 PF01048 0.612
MOD_GlcNHglycan 585 588 PF01048 0.546
MOD_GlcNHglycan 62 66 PF01048 0.545
MOD_GSK3_1 138 145 PF00069 0.622
MOD_GSK3_1 196 203 PF00069 0.546
MOD_GSK3_1 259 266 PF00069 0.671
MOD_GSK3_1 356 363 PF00069 0.743
MOD_GSK3_1 387 394 PF00069 0.561
MOD_GSK3_1 426 433 PF00069 0.592
MOD_GSK3_1 547 554 PF00069 0.629
MOD_GSK3_1 591 598 PF00069 0.410
MOD_N-GLC_1 411 416 PF02516 0.656
MOD_N-GLC_1 591 596 PF02516 0.452
MOD_NEK2_1 105 110 PF00069 0.647
MOD_NEK2_1 198 203 PF00069 0.559
MOD_NEK2_1 269 274 PF00069 0.578
MOD_NEK2_1 295 300 PF00069 0.586
MOD_NEK2_1 360 365 PF00069 0.697
MOD_NEK2_1 382 387 PF00069 0.725
MOD_NEK2_1 452 457 PF00069 0.591
MOD_NEK2_1 50 55 PF00069 0.544
MOD_NEK2_1 572 577 PF00069 0.505
MOD_NEK2_2 138 143 PF00069 0.590
MOD_NEK2_2 445 450 PF00069 0.544
MOD_NMyristoyl 1 7 PF02799 0.796
MOD_PIKK_1 200 206 PF00454 0.544
MOD_PIKK_1 365 371 PF00454 0.721
MOD_PIKK_1 414 420 PF00454 0.659
MOD_PK_1 4 10 PF00069 0.782
MOD_PKA_1 578 584 PF00069 0.609
MOD_PKA_2 29 35 PF00069 0.598
MOD_PKA_2 3 9 PF00069 0.735
MOD_PKA_2 300 306 PF00069 0.431
MOD_PKA_2 414 420 PF00069 0.619
MOD_PKA_2 426 432 PF00069 0.437
MOD_PKA_2 490 496 PF00069 0.771
MOD_Plk_1 551 557 PF00069 0.600
MOD_Plk_4 100 106 PF00069 0.661
MOD_Plk_4 171 177 PF00069 0.560
MOD_Plk_4 208 214 PF00069 0.488
MOD_Plk_4 265 271 PF00069 0.638
MOD_Plk_4 445 451 PF00069 0.591
MOD_Plk_4 567 573 PF00069 0.455
MOD_Plk_4 610 616 PF00069 0.613
MOD_ProDKin_1 387 393 PF00069 0.565
MOD_ProDKin_1 420 426 PF00069 0.677
MOD_SUMO_rev_2 141 148 PF00179 0.530
TRG_DiLeu_BaEn_1 585 590 PF01217 0.361
TRG_DiLeu_BaLyEn_6 163 168 PF01217 0.565
TRG_DiLeu_BaLyEn_6 337 342 PF01217 0.532
TRG_DiLeu_BaLyEn_6 395 400 PF01217 0.477
TRG_DiLeu_BaLyEn_6 532 537 PF01217 0.600
TRG_ENDOCYTIC_2 164 167 PF00928 0.532
TRG_ENDOCYTIC_2 175 178 PF00928 0.410
TRG_ENDOCYTIC_2 195 198 PF00928 0.246
TRG_ENDOCYTIC_2 20 23 PF00928 0.614
TRG_ENDOCYTIC_2 227 230 PF00928 0.673
TRG_ENDOCYTIC_2 282 285 PF00928 0.554
TRG_ENDOCYTIC_2 291 294 PF00928 0.415
TRG_ENDOCYTIC_2 299 302 PF00928 0.357
TRG_ENDOCYTIC_2 312 315 PF00928 0.379
TRG_ENDOCYTIC_2 469 472 PF00928 0.604
TRG_ER_diArg_1 540 542 PF00400 0.513
TRG_NLS_Bipartite_1 524 543 PF00514 0.675
TRG_NLS_MonoCore_2 537 542 PF00514 0.620
TRG_NLS_MonoExtN_4 535 542 PF00514 0.623
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.552
TRG_Pf-PMV_PEXEL_1 454 458 PF00026 0.350

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 99% 100%
A0A3Q8ISI8 Leishmania donovani 95% 100%
A4HJ70 Leishmania braziliensis 61% 99%
A4HJ71 Leishmania braziliensis 64% 99%
A4HJ73 Leishmania braziliensis 64% 100%
A4HJW7 Leishmania braziliensis 59% 100%
A4I6I2 Leishmania infantum 99% 100%
A4I6L8 Leishmania infantum 98% 100%
E8NHD1 Leishmania infantum 97% 100%
E8NHD2 Leishmania infantum 93% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q6G7 Leishmania major 87% 100%
Q4Q6G8 Leishmania major 89% 100%
Q4Q6H0 Leishmania major 87% 100%
Q9BHE5 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS