Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X488_LEIDO

TriTrypDb:

LdBPK_310520.1 , LdCL_310010700 , LDHU3_31.0750

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X488

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X488

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	70	74	PF00656	0.593
CLV_NRD_NRD_1	204	206	PF00675	0.651
CLV_NRD_NRD_1	225	227	PF00675	0.627
CLV_NRD_NRD_1	404	406	PF00675	0.720
CLV_NRD_NRD_1	47	49	PF00675	0.606
CLV_NRD_NRD_1	567	569	PF00675	0.614
CLV_PCSK_KEX2_1	204	206	PF00082	0.651
CLV_PCSK_KEX2_1	225	227	PF00082	0.627
CLV_PCSK_KEX2_1	404	406	PF00082	0.721
CLV_PCSK_KEX2_1	47	49	PF00082	0.606
CLV_PCSK_KEX2_1	531	533	PF00082	0.459
CLV_PCSK_KEX2_1	567	569	PF00082	0.628
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.459
CLV_PCSK_PC7_1	221	227	PF00082	0.612
CLV_PCSK_SKI1_1	197	201	PF00082	0.624
CLV_PCSK_SKI1_1	244	248	PF00082	0.583
CLV_PCSK_SKI1_1	307	311	PF00082	0.574
CLV_PCSK_SKI1_1	317	321	PF00082	0.597
CLV_PCSK_SKI1_1	452	456	PF00082	0.611
CLV_PCSK_SKI1_1	503	507	PF00082	0.539
CLV_PCSK_SKI1_1	630	634	PF00082	0.641
DEG_APCC_DBOX_1	306	314	PF00400	0.523
DEG_APCC_DBOX_1	327	335	PF00400	0.545
DOC_CYCLIN_yCln2_LP_2	342	348	PF00134	0.585
DOC_MAPK_gen_1	510	517	PF00069	0.570
DOC_MAPK_gen_1	531	538	PF00069	0.487
DOC_MAPK_MEF2A_6	531	538	PF00069	0.524
DOC_USP7_MATH_1	172	176	PF00917	0.654
DOC_USP7_MATH_1	179	183	PF00917	0.596
DOC_USP7_MATH_1	28	32	PF00917	0.725
DOC_USP7_MATH_1	403	407	PF00917	0.698
DOC_USP7_MATH_1	445	449	PF00917	0.650
DOC_USP7_MATH_1	497	501	PF00917	0.731
DOC_USP7_MATH_1	626	630	PF00917	0.636
DOC_USP7_MATH_1	67	71	PF00917	0.621
DOC_USP7_MATH_1	87	91	PF00917	0.643
DOC_USP7_UBL2_3	463	467	PF12436	0.616
DOC_WW_Pin1_4	101	106	PF00397	0.586
DOC_WW_Pin1_4	15	20	PF00397	0.691
DOC_WW_Pin1_4	185	190	PF00397	0.639
DOC_WW_Pin1_4	259	264	PF00397	0.683
DOC_WW_Pin1_4	291	296	PF00397	0.584
DOC_WW_Pin1_4	492	497	PF00397	0.647
LIG_14-3-3_CanoR_1	180	189	PF00244	0.621
LIG_14-3-3_CanoR_1	204	212	PF00244	0.618
LIG_14-3-3_CanoR_1	225	234	PF00244	0.587
LIG_14-3-3_CanoR_1	244	249	PF00244	0.481
LIG_14-3-3_CanoR_1	307	315	PF00244	0.561
LIG_14-3-3_CanoR_1	360	368	PF00244	0.660
LIG_14-3-3_CanoR_1	389	396	PF00244	0.578
LIG_14-3-3_CanoR_1	404	412	PF00244	0.648
LIG_14-3-3_CanoR_1	421	427	PF00244	0.501
LIG_14-3-3_CanoR_1	452	457	PF00244	0.588
LIG_14-3-3_CanoR_1	628	633	PF00244	0.677
LIG_14-3-3_CanoR_1	89	93	PF00244	0.650
LIG_14-3-3_CanoR_1	99	107	PF00244	0.753
LIG_BRCT_BRCA1_1	90	94	PF00533	0.608
LIG_BRCT_BRCA1_2	90	96	PF00533	0.686
LIG_FHA_1	245	251	PF00498	0.559
LIG_FHA_1	389	395	PF00498	0.576
LIG_FHA_1	408	414	PF00498	0.646
LIG_FHA_1	610	616	PF00498	0.634
LIG_FHA_2	212	218	PF00498	0.602
LIG_FHA_2	236	242	PF00498	0.647
LIG_FHA_2	333	339	PF00498	0.584
LIG_FHA_2	509	515	PF00498	0.566
LIG_FHA_2	586	592	PF00498	0.618
LIG_Integrin_RGD_1	397	399	PF01839	0.681
LIG_LIR_Gen_1	128	134	PF02991	0.493
LIG_LIR_Nem_3	128	132	PF02991	0.483
LIG_SH2_SRC	545	548	PF00017	0.482
LIG_SH2_STAT5	256	259	PF00017	0.639
LIG_SH2_STAT5	347	350	PF00017	0.551
LIG_SH2_STAT5	508	511	PF00017	0.604
LIG_SH2_STAT5	545	548	PF00017	0.454
LIG_SH3_3	102	108	PF00018	0.570
LIG_SH3_3	147	153	PF00018	0.620
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.493
LIG_SUMO_SIM_anti_2	427	433	PF11976	0.636
LIG_SUMO_SIM_par_1	533	539	PF11976	0.518
LIG_TRAF2_1	471	474	PF00917	0.628
LIG_TRFH_1	320	324	PF08558	0.634
MOD_CDK_SPK_2	259	264	PF00069	0.683
MOD_CDK_SPxxK_3	185	192	PF00069	0.634
MOD_CK1_1	188	194	PF00069	0.684
MOD_CK1_1	224	230	PF00069	0.558
MOD_CK1_1	305	311	PF00069	0.552
MOD_CK1_1	356	362	PF00069	0.751
MOD_CK1_1	364	370	PF00069	0.592
MOD_CK1_1	407	413	PF00069	0.676
MOD_CK1_1	422	428	PF00069	0.543
MOD_CK1_1	459	465	PF00069	0.588
MOD_CK1_1	501	507	PF00069	0.506
MOD_CK1_1	575	581	PF00069	0.662
MOD_CK1_1	631	637	PF00069	0.637
MOD_CK1_1	95	101	PF00069	0.651
MOD_CK2_1	211	217	PF00069	0.608
MOD_CK2_1	26	32	PF00069	0.533
MOD_CK2_1	326	332	PF00069	0.676
MOD_CK2_1	338	344	PF00069	0.488
MOD_CK2_1	585	591	PF00069	0.598
MOD_CK2_1	8	14	PF00069	0.704
MOD_GlcNHglycan	139	142	PF01048	0.586
MOD_GlcNHglycan	163	166	PF01048	0.706
MOD_GlcNHglycan	174	177	PF01048	0.662
MOD_GlcNHglycan	183	186	PF01048	0.557
MOD_GlcNHglycan	228	231	PF01048	0.641
MOD_GlcNHglycan	274	277	PF01048	0.601
MOD_GlcNHglycan	3	6	PF01048	0.628
MOD_GlcNHglycan	37	40	PF01048	0.631
MOD_GlcNHglycan	377	380	PF01048	0.685
MOD_GlcNHglycan	399	402	PF01048	0.777
MOD_GlcNHglycan	406	409	PF01048	0.719
MOD_GlcNHglycan	442	445	PF01048	0.703
MOD_GlcNHglycan	500	503	PF01048	0.591
MOD_GlcNHglycan	570	573	PF01048	0.641
MOD_GlcNHglycan	574	577	PF01048	0.613
MOD_GlcNHglycan	588	591	PF01048	0.509
MOD_GlcNHglycan	633	636	PF01048	0.685
MOD_GlcNHglycan	69	72	PF01048	0.682
MOD_GlcNHglycan	79	82	PF01048	0.569
MOD_GlcNHglycan	83	86	PF01048	0.539
MOD_GSK3_1	181	188	PF00069	0.598
MOD_GSK3_1	200	207	PF00069	0.581
MOD_GSK3_1	211	218	PF00069	0.587
MOD_GSK3_1	221	228	PF00069	0.539
MOD_GSK3_1	23	30	PF00069	0.700
MOD_GSK3_1	259	266	PF00069	0.740
MOD_GSK3_1	279	286	PF00069	0.404
MOD_GSK3_1	305	312	PF00069	0.559
MOD_GSK3_1	33	40	PF00069	0.650
MOD_GSK3_1	332	339	PF00069	0.535
MOD_GSK3_1	364	371	PF00069	0.599
MOD_GSK3_1	403	410	PF00069	0.700
MOD_GSK3_1	452	459	PF00069	0.570
MOD_GSK3_1	497	504	PF00069	0.560
MOD_GSK3_1	568	575	PF00069	0.643
MOD_GSK3_1	596	603	PF00069	0.580
MOD_GSK3_1	77	84	PF00069	0.642
MOD_GSK3_1	88	95	PF00069	0.547
MOD_N-GLC_1	305	310	PF02516	0.630
MOD_N-GLC_1	332	337	PF02516	0.634
MOD_N-GLC_1	361	366	PF02516	0.604
MOD_N-GLC_1	389	394	PF02516	0.713
MOD_N-GLC_1	452	457	PF02516	0.593
MOD_N-GLC_1	626	631	PF02516	0.671
MOD_N-GLC_1	67	72	PF02516	0.594
MOD_N-GLC_2	255	257	PF02516	0.630
MOD_NEK2_1	215	220	PF00069	0.514
MOD_NEK2_1	234	239	PF00069	0.627
MOD_NEK2_1	353	358	PF00069	0.575
MOD_NEK2_1	419	424	PF00069	0.615
MOD_NEK2_1	432	437	PF00069	0.553
MOD_NEK2_1	619	624	PF00069	0.706
MOD_NEK2_1	76	81	PF00069	0.668
MOD_NEK2_1	88	93	PF00069	0.565
MOD_PIKK_1	204	210	PF00454	0.636
MOD_PIKK_1	256	262	PF00454	0.551
MOD_PIKK_1	283	289	PF00454	0.501
MOD_PIKK_1	389	395	PF00454	0.731
MOD_PIKK_1	98	104	PF00454	0.700
MOD_PKA_1	204	210	PF00069	0.627
MOD_PKA_1	225	231	PF00069	0.649
MOD_PKA_1	404	410	PF00069	0.685
MOD_PKA_1	568	574	PF00069	0.605
MOD_PKA_2	179	185	PF00069	0.607
MOD_PKA_2	204	210	PF00069	0.627
MOD_PKA_2	224	230	PF00069	0.472
MOD_PKA_2	251	257	PF00069	0.633
MOD_PKA_2	263	269	PF00069	0.609
MOD_PKA_2	388	394	PF00069	0.711
MOD_PKA_2	403	409	PF00069	0.745
MOD_PKA_2	43	49	PF00069	0.646
MOD_PKA_2	88	94	PF00069	0.636
MOD_PKA_2	98	104	PF00069	0.755
MOD_Plk_1	146	152	PF00069	0.545
MOD_Plk_1	279	285	PF00069	0.533
MOD_Plk_1	305	311	PF00069	0.628
MOD_Plk_1	364	370	PF00069	0.592
MOD_Plk_1	389	395	PF00069	0.576
MOD_Plk_1	432	438	PF00069	0.559
MOD_Plk_1	452	458	PF00069	0.579
MOD_Plk_1	474	480	PF00069	0.602
MOD_Plk_1	513	519	PF00069	0.608
MOD_Plk_1	67	73	PF00069	0.594
MOD_Plk_2-3	332	338	PF00069	0.587
MOD_Plk_2-3	474	480	PF00069	0.678
MOD_Plk_4	128	134	PF00069	0.472
MOD_Plk_4	211	217	PF00069	0.532
MOD_Plk_4	279	285	PF00069	0.512
MOD_Plk_4	338	344	PF00069	0.706
MOD_ProDKin_1	101	107	PF00069	0.586
MOD_ProDKin_1	15	21	PF00069	0.690
MOD_ProDKin_1	185	191	PF00069	0.638
MOD_ProDKin_1	259	265	PF00069	0.684
MOD_ProDKin_1	291	297	PF00069	0.585
MOD_ProDKin_1	492	498	PF00069	0.646
MOD_SUMO_rev_2	140	150	PF00179	0.626
MOD_SUMO_rev_2	457	465	PF00179	0.597
MOD_SUMO_rev_2	70	77	PF00179	0.619
TRG_DiLeu_BaEn_2	279	285	PF01217	0.523
TRG_ER_diArg_1	403	405	PF00400	0.656
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA33	Leptomonas seymouri	45%	100%
A4HJ28	Leishmania braziliensis	63%	100%
A4I6K7	Leishmania infantum	99%	100%
E9B1K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6L3	Leishmania major	92%	100%